LOCUS       NM_032389               2773 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF GTPase activating protein 2 (ARFGAP2), transcript
            variant 1, mRNA.
ACCESSION   NM_032389
VERSION     NM_032389.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2773)
  AUTHORS   Pevzner,I., Strating,J., Lifshitz,L., Parnis,A., Glaser,F.,
            Herrmann,A., Brugger,B., Wieland,F. and Cassel,D.
  TITLE     Distinct role of subcomplexes of the COPI coat in the regulation of
            ArfGAP2 activity
  JOURNAL   Traffic 13 (6), 849-856 (2012)
   PUBMED   22375848
  REMARK    GeneRIF: analysis of the distinct role of subcomplexes of the COPI
            coat in the regulation of ArfGAP2 activity
REFERENCE   2  (bases 1 to 2773)
  AUTHORS   Kartberg,F., Asp,L., Dejgaard,S.Y., Smedh,M.,
            Fernandez-Rodriguez,J., Nilsson,T. and Presley,J.F.
  TITLE     ARFGAP2 and ARFGAP3 are essential for COPI coat assembly on the
            Golgi membrane of living cells
  JOURNAL   J Biol Chem 285 (47), 36709-36720 (2010)
   PUBMED   20858901
  REMARK    GeneRIF: ARFGAP2 and ARFGAP3 are essential for COPI coat assembly
            on the Golgi membrane of living cells.
REFERENCE   3  (bases 1 to 2773)
  AUTHORS   Saitoh,A., Shin,H.W., Yamada,A., Waguri,S. and Nakayama,K.
  TITLE     Three homologous ArfGAPs participate in coat protein I-mediated
            transport
  JOURNAL   J Biol Chem 284 (20), 13948-13957 (2009)
   PUBMED   19299515
  REMARK    GeneRIF: ArfGAP1, ArfGAP2, and ArfGAP3 have overlapping roles in
            regulating COPI function in Golgi-to-ER retrograde transport.
REFERENCE   4  (bases 1 to 2773)
  AUTHORS   Weimer,C., Beck,R., Eckert,P., Reckmann,I., Moelleken,J.,
            Brugger,B. and Wieland,F.
  TITLE     Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI
            trafficking
  JOURNAL   J Cell Biol 183 (4), 725-735 (2008)
   PUBMED   19015319
  REMARK    GeneRIF: Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in
            COPI trafficking
REFERENCE   5  (bases 1 to 2773)
  AUTHORS   Frigerio,G., Grimsey,N., Dale,M., Majoul,I. and Duden,R.
  TITLE     Two human ARFGAPs associated with COP-I-coated vesicles
  JOURNAL   Traffic 8 (11), 1644-1655 (2007)
   PUBMED   17760859
  REMARK    GeneRIF: human ARFGAP2 and ARFGAP3 are associated with COP-I-coated
            vesicles and function in COP I traffic
REFERENCE   6  (bases 1 to 2773)
  AUTHORS   Schmid,E.M., Ford,M.G., Burtey,A., Praefcke,G.J., Peak-Chew,S.Y.,
            Mills,I.G., Benmerah,A. and McMahon,H.T.
  TITLE     Role of the AP2 beta-appendage hub in recruiting partners for
            clathrin-coated vesicle assembly
  JOURNAL   PLoS Biol 4 (9), e262 (2006)
   PUBMED   16903783
REFERENCE   7  (bases 1 to 2773)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 2773)
  AUTHORS   Watson,P.J., Frigerio,G., Collins,B.M., Duden,R. and Owen,D.J.
  TITLE     Gamma-COP appendage domain - structure and function
  JOURNAL   Traffic 5 (2), 79-88 (2004)
   PUBMED   14690497
REFERENCE   9  (bases 1 to 2773)
  AUTHORS   Ohira,M., Morohashi,A., Nakamura,Y., Isogai,E., Furuya,K.,
            Hamano,S., Machida,T., Aoyama,M., Fukumura,M., Miyazaki,K.,
            Suzuki,Y., Sugano,S., Hirato,J. and Nakagawara,A.
  TITLE     Neuroblastoma oligo-capping cDNA project: toward the understanding
            of the genesis and biology of neuroblastoma
  JOURNAL   Cancer Lett 197 (1-2), 63-68 (2003)
   PUBMED   12880961
  REMARK    Review article
REFERENCE   10 (bases 1 to 2773)
  AUTHORS   Singh,J., Itahana,Y., Parrinello,S., Murata,K. and Desprez,P.Y.
  TITLE     Molecular cloning and characterization of a zinc finger protein
            involved in Id-1-stimulated mammary epithelial cell growth
  JOURNAL   J Biol Chem 276 (15), 11852-11858 (2001)
   PUBMED   11278321
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090589.9.
            
            On Aug 31, 2019 this sequence version replaced NM_032389.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030148.2, AL834337.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524782.6/ ENSP00000434442.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC090589.9         67253-67350         c
            99-217              AC090589.9         66987-67105         c
            218-290             AC090589.9         66322-66394         c
            291-422             AC090589.9         65653-65784         c
            423-506             AC090589.9         65486-65569         c
            507-588             AC090589.9         64230-64311         c
            589-645             AC090589.9         63897-63953         c
            646-698             AC090589.9         62752-62804         c
            699-835             AC090589.9         62135-62271         c
            836-967             AC090589.9         61897-62028         c
            968-1096            AC090589.9         58594-58722         c
            1097-1231           AC090589.9         58380-58514         c
            1232-1358           AC090589.9         57231-57357         c
            1359-1452           AC090589.9         56977-57070         c
            1453-1571           AC090589.9         56739-56857         c
            1572-2773           AC090589.9         54772-55973         c
FEATURES             Location/Qualifiers
     source          1..2773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..2773
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /note="ARF GTPase activating protein 2"
                     /db_xref="GeneID:84364"
                     /db_xref="HGNC:HGNC:13504"
                     /db_xref="MIM:606908"
     exon            1..98
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1592
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 289, ID1 regulated; GTPase-activating
                     protein ZNF289; ADP ribosylation factor GTPase activating
                     protein 2"
                     /codon_start=1
                     /product="ADP-ribosylation factor GTPase-activating
                     protein 2 isoform 1"
                     /protein_id="NP_115765.2"
                     /db_xref="CCDS:CCDS7926.1"
                     /db_xref="GeneID:84364"
                     /db_xref="HGNC:HGNC:13504"
                     /db_xref="MIM:606908"
                     /translation="MAAEPNKTEIQTLFKRLRAVPTNKACFDCGAKNPSWASITYGVF
                     LCIDCSGVHRSLGVHLSFIRSTELDSNWNWFQLRCMQVGGNANATAFFRQHGCTANDA
                     NTKYNSRAAQMYREKIRQLGSAALARHGTDLWIDNMSSAVPNHSPEKKDSDFFTEHTQ
                     PPAWDAPATEPSGTQQPAPSTESSGLAQPEHGPNTDLLGTSPKASLELKSSIIGKKKP
                     AAAKKGLGAKKGLGAQKVSSQSFSEIERQAQVAEKLREQQAADAKKQAEESMVASMRL
                     AYQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSRSSVSHSVLSEMQVIEQETPVS
                     AKSSRSQLDLFDDVGTFASGPPKYKDNPFSLGESFGSRWDTDAAWGMDRVEEKEPEVT
                     ISSIRPISERATNRREVESRSSGLESSEARQKFAGAKAISSDMFFGREVDAEYEARSR
                     LQQLSGSSAISSSDLFGDMDGAHGAGSVSLGNVLPTADIAQFKQGVKSVAGKMAVLAN
                     GVMNSLQDRYGSY"
     exon            99..217
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            218..290
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            291..422
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            423..506
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            507..588
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            589..645
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            646..698
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            699..835
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            836..967
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1096
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1231
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1358
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1452
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1571
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..2773
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2730..2735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /note="hexamer: AATAAA"
     polyA_site      2773
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /note="major polyA site"
ORIGIN      
        1 gcggttgtgt ctgggaagga gagaaaatgg cggcggagcc gaacaagacc gaaatccaga
       61 ctctttttaa gaggcttcgc gcagttccaa ccaacaaggc ctgtttcgac tgcggcgcca
      121 agaatccgag ttgggccagc atcacgtacg gtgttttctt gtgcattgac tgttccgggg
      181 tgcaccgctc cctgggcgtc catctgagct tcatcaggtc cacagagttg gattccaact
      241 ggaactggtt ccagctgagg tgtatgcagg tcggcgggaa tgccaatgcg acggcttttt
      301 ttcgccaaca tggatgcaca gccaatgatg ccaacaccaa atataatagc cgagctgccc
      361 agatgtaccg ggagaagatc cggcagctgg ggagtgcggc cctggctagg catggcactg
      421 atctttggat agacaacatg agtagtgccg ttcctaatca ctccccagag aagaaggact
      481 ctgatttctt cacagaacac actcaacccc ctgcctggga tgcgccagcc actgagcctt
      541 cagggaccca gcagccagcc ccgtctacag agagcagtgg cctggcacag ccggagcatg
      601 gccccaacac agacctgctt ggcacctcac ccaaagcctc actggaactg aaaagctcca
      661 tcattggcaa gaagaagcca gcagcagcta agaaagggct gggtgccaag aaaggcctag
      721 gggcccagaa ggtgagcagc cagagcttca gtgagattga gcggcaggct caggtggcag
      781 agaagctccg tgagcagcag gcagccgatg ccaagaagca ggcggaggag tccatggtcg
      841 cctccatgcg tctggcctac caggagctcc agattgatcg taagaaagag gaaaagaagc
      901 tacagaatct ggaagggaag aagcgagagc aggcagaaag gttgggcatg ggcttggtat
      961 cccgaagctc tgtctcccac tccgtgctgt ctgagatgca ggtgattgag caggaaaccc
     1021 cagtgagtgc aaaatcctct cgctcgcagc tggacttgtt tgacgatgtt ggtactttcg
     1081 cctctggacc cccaaagtac aaggacaatc ccttttcctt aggggaaagc tttggctccc
     1141 gctgggatac agatgctgcc tggggtatgg acagggtaga ggagaaggag ccagaagtga
     1201 ccatctcaag catccggcct atttcagaaa gagccacaaa ccggagggaa gtggagagcc
     1261 ggagctcagg cctcgagtct agtgaggcgc gtcagaaatt cgcaggagcc aaagccatct
     1321 catctgacat gttctttggg cgggaggtgg atgcagagta tgaggccagg tctcggctgc
     1381 agcagctctc aggcagcagt gccatcagct cttcagacct ctttggggac atggatggag
     1441 ctcacggagc aggaagtgta tctctgggga acgtgctgcc tacagcggac attgcccagt
     1501 ttaagcaggg tgtcaagtct gtggctggga aaatggctgt gctggccaat ggtgtgatga
     1561 attccttgca ggatcgctac ggttcctact gatccgagct ctgtgactca ggcttacgat
     1621 ggtgacggca acaagaactc cacagttccc aggctgggga tgctttgcct tgtggaagct
     1681 ggggaggatt tgttacttcg tatgtgtggt gtgtgtgtgg ggtggccttt gaggcgctca
     1741 ctcctgtgag gggaatggtc agtaccagcc cttgtcctct gcctgtggac tgagcccttt
     1801 attccctctc acaccaccct ccgtgtgtta gactcttgtc cttctgtcct gcccccacag
     1861 ctgctgctca cttatcctgc catactggga aagggggttc ccccacgatg gcttattctg
     1921 ggtccagact ttccccaggt agggaaagcg gaaggtagaa ggcttttttt gctggctcta
     1981 gggttcttct agttcgaggc cttgggtccc catcctctgg aaccaggggg aggcctggaa
     2041 ggagttcact gtagacccgt cccatgggga aagaggctgc ggacttgctg ctgctgctgc
     2101 tgccagtggc ctcttctggg tgccaggaga ggggaaggac ctttgtctgg gcgttaccaa
     2161 gggctggaaa ctttacctgg tacctaaagg tttcatttgg gatcagaccg gagacccttg
     2221 ggttctcccg tctcaccacc cctttctaca gtaagcactt ggaagattgt ttcagggtgt
     2281 ctcagggtcc ctctgtacca tctgctgtgg aatgcaggac cctctgtgac attctttatc
     2341 ccttcttccc cgggttggtg gccatggagg gtcttgtctg ctgtgattcg actctggatg
     2401 ctgtgagctt gatgctggcc agggaagcag aggatgtgag aggcagaggc aggctcctgg
     2461 ggctgagctc cttcctctgc atcattctgg gcttggcctg gacagcaccc gccagtgaga
     2521 gctgtgggcc tcaccctctg gcagctgagc caagcactgt cattcttggt gccatcttcc
     2581 cctgccgcac cggcagtctc agcccagccc ccacctttgg gttgtaggtt gggctcccaa
     2641 gcaacacaga ccactcttcc ccttgcccct cccccagagg gacttgactt tctttctgga
     2701 ctgtttgtat tgaaacaaag tggtgtcaaa ataaagcccc tgcagggcct ggctccctgt
     2761 tggtctgagt gaa
//
