LOCUS       NM_018209               3250 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF GTPase activating protein 1 (ARFGAP1), transcript
            variant 1, mRNA.
ACCESSION   NM_018209
VERSION     NM_018209.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3250)
  AUTHORS   Rossi,S., Di Salvio,M., Bali,M., De Simone,A., Apolloni,S.,
            D'Ambrosi,N., Arisi,I., Cipressa,F., Cozzolino,M. and Cestra,G.
  TITLE     C9orf72 Toxic Species Affect ArfGAP-1 Function
  JOURNAL   Cells 12 (15), 2007 (2023)
   PUBMED   37566088
  REMARK    GeneRIF: C9orf72 Toxic Species Affect ArfGAP-1 Function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3250)
  AUTHORS   Meng,D., Yang,Q., Melick,C.H., Park,B.C., Hsieh,T.S., Curukovic,A.,
            Jeong,M.H., Zhang,J., James,N.G. and Jewell,J.L.
  TITLE     ArfGAP1 inhibits mTORC1 lysosomal localization and activation
  JOURNAL   EMBO J 40 (12), e106412 (2021)
   PUBMED   33988249
  REMARK    GeneRIF: ArfGAP1 inhibits mTORC1 lysosomal localization and
            activation.
REFERENCE   3  (bases 1 to 3250)
  AUTHORS   Feng,H.P., Cheng,H.Y., Hsiao,T.F., Lin,T.W., Hsu,J.W., Huang,L.H.
            and Yu,C.J.
  TITLE     ArfGAP1 acts as a GTPase-activating protein for human
            ADP-ribosylation factor-like 1 protein
  JOURNAL   FASEB J 35 (4), e21337 (2021)
   PUBMED   33715220
  REMARK    GeneRIF: ArfGAP1 acts as a GTPase-activating protein for human
            ADP-ribosylation factor-like 1 protein.
REFERENCE   4  (bases 1 to 3250)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3250)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3250)
  AUTHORS   Huber,I., Cukierman,E., Rotman,M., Aoe,T., Hsu,V.W. and Cassel,D.
  TITLE     Requirement for both the amino-terminal catalytic domain and a
            noncatalytic domain for in vivo activity of ADP-ribosylation factor
            GTPase-activating protein
  JOURNAL   J Biol Chem 273 (38), 24786-24791 (1998)
   PUBMED   9733781
REFERENCE   7  (bases 1 to 3250)
  AUTHORS   Mossessova,E., Gulbis,J.M. and Goldberg,J.
  TITLE     Structure of the guanine nucleotide exchange factor Sec7 domain of
            human arno and analysis of the interaction with ARF GTPase
  JOURNAL   Cell 92 (3), 415-423 (1998)
   PUBMED   9476900
REFERENCE   8  (bases 1 to 3250)
  AUTHORS   Aoe,T., Cukierman,E., Lee,A., Cassel,D., Peters,P.J. and Hsu,V.W.
  TITLE     The KDEL receptor, ERD2, regulates intracellular traffic by
            recruiting a GTPase-activating protein for ARF1
  JOURNAL   EMBO J 16 (24), 7305-7316 (1997)
   PUBMED   9405360
REFERENCE   9  (bases 1 to 3250)
  AUTHORS   Cukierman,E., Huber,I., Rotman,M. and Cassel,D.
  TITLE     The ARF1 GTPase-activating protein: zinc finger motif and Golgi
            complex localization
  JOURNAL   Science 270 (5244), 1999-2002 (1995)
   PUBMED   8533093
REFERENCE   10 (bases 1 to 3250)
  AUTHORS   Rothman,J.E.
  TITLE     Mechanisms of intracellular protein transport
  JOURNAL   Nature 372 (6501), 55-63 (1994)
   PUBMED   7969419
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC300118.1, AK223427.1,
            BC028233.1, BC000786.1 and AA565406.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018209.3.
            
            Summary: The protein encoded by this gene is a GTPase-activating
            protein, which associates with the Golgi apparatus and which
            interacts with ADP-ribosylation factor 1. The encoded protein
            promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is
            required for the dissociation of coat proteins from Golgi-derived
            membranes and vesicles. Dissociation of the coat proteins is
            required for the fusion of these vesicles with target compartments.
            The activity of this protein is stimulated by phosphoinosides and
            inhibited by phosphatidylcholine. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) lacks an in-frame exon and
            uses an alternate in-frame splice site in the 3' coding region,
            compared to variant 2. The encoded isoform (a) is shorter, compared
            to isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001629.1, SRR1660807.22273.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370283.9/ ENSP00000359306.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                DC300118.1         29-79
            52-898              AK223427.1         1-847
            899-946             BC028233.1         877-924
            947-2830            BC000786.1         1174-3057
            2831-3250           AA565406.1         8-427               c
FEATURES             Location/Qualifiers
     source          1..3250
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..3250
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /note="ARF GTPase activating protein 1"
                     /db_xref="GeneID:55738"
                     /db_xref="HGNC:HGNC:15852"
                     /db_xref="MIM:608377"
     exon            1..108
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     exon            109..172
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1333
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /note="isoform a is encoded by transcript variant 1;
                     ARF1-directed GTPase-activating protein; ADP ribosylation
                     factor GTPase activating protein 1"
                     /codon_start=1
                     /product="ADP-ribosylation factor GTPase-activating
                     protein 1 isoform a"
                     /protein_id="NP_060679.1"
                     /db_xref="CCDS:CCDS13515.1"
                     /db_xref="GeneID:55738"
                     /db_xref="HGNC:HGNC:15852"
                     /db_xref="MIM:608377"
                     /translation="MASPRTRKVLKEVRVQDENNVCFECGAFNPQWVSVTYGIWICLE
                     CSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLESQEDYDPCWSLQEK
                     YNSRAAALFRDKVVALAEGREWSLESSPAQNWTPPQPRTLPSMVHRVSGQPQSVTASS
                     DKAFEDWLNDDLGSYQGAQGNRYVGFGNTPPPQKKEDDFLNNAMSSLYSGWSSFTTGA
                     SRFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGKIFDDVSSGVSQLA
                     SKVQGVGSKGWRDVTTFFSGKAEGPLDSPSEGHSYQNSGLDHFQNSNIDQSFWETFGS
                     AEPTKTRKSPSSDSWTCADTSTERRSSDSWEVWGSASTNRNSNSDGGEGGEGTKKAVP
                     PAVPTDDGWDNQNW"
     exon            173..282
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     exon            283..454
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     exon            455..555
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     exon            556..642
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     exon            643..739
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     exon            740..796
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     exon            797..829
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     exon            830..886
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     exon            887..946
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1023
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..3250
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3228..3233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /note="hexamer: AATAAA"
     polyA_site      3250
                     /gene="ARFGAP1"
                     /gene_synonym="ARF1GAP; HRIHFB2281"
                     /note="major polyA site"
ORIGIN      
        1 ggaagctggt ggcggctggt gggcgaccgg gcgcatcctc attgcagtgc ggcggcccta
       61 cctcggccct ggcctgaccc cggcggccct gcccgcccct ccctccagca tcatggccag
      121 cccaagaacc aggaaggttc ttaaagaagt cagggtgcag gatgagaaca acgtttgttt
      181 tgagtgtggc gcgttcaatc ctcagtgggt cagtgtgacc tacggcatct ggatctgcct
      241 ggagtgctcg gggagacacc gcgggcttgg ggttcacctc agctttgtgc gctctgttac
      301 tatggacaag tggaaggaca ttgagcttga gaagatgaaa gctggtggga atgctaagtt
      361 ccgagagttc ctggagtctc aggaggatta cgatccttgc tggtccttgc aggagaagta
      421 caacagcaga gccgcggccc tctttaggga taaggtggtc gctctggccg aaggcagaga
      481 gtggtctctg gagtcatcac ctgcccagaa ctggacccca cctcagccca ggacgctgcc
      541 gtccatggtg caccgagtct ctggccagcc gcagagtgtg accgcctcct cggacaaggc
      601 ttttgaagac tggctgaatg atgacctcgg ctcctatcaa ggggcccagg ggaatcgcta
      661 cgtggggttt gggaacacgc caccgcctca gaagaaagaa gatgacttcc tcaacaacgc
      721 catgtcctcc ctgtactcgg gctggagcag cttcaccact ggagccagcc ggtttgcctc
      781 ggcagccaag gagggcgcta caaagtttgg atcccaagcg agtcagaagg cgtccgagct
      841 gggccacagc ctgaacgaga acgtcctcaa gcctgcgcag gagaaggtga aggagggaaa
      901 gatttttgat gatgtctcca gtggggtctc tcagttggcg tccaaggtcc agggagtcgg
      961 tagtaaggga tggcgggacg tcaccacctt tttttcgggg aaagcagagg gccccttgga
     1021 cagcccctcg gagggccaca gttatcagaa cagcggtctg gaccacttcc aaaacagcaa
     1081 catagaccag agcttctggg agacctttgg aagtgctgag cccaccaaga cccgcaagtc
     1141 cccgagcagc gacagctgga cgtgcgcgga cacctccacc gagaggagga gctcggacag
     1201 ctgggaggtg tggggctcgg cctccaccaa caggaacagc aacagcgacg gcggggaggg
     1261 cggggagggc accaagaagg cagtgccgcc ggccgtgccc actgatgatg gctgggacaa
     1321 ccagaactgg tagggcccac tgcgcccccg tccccagcgc ccccgggcga cttcgtgttt
     1381 gcactctgcc ctcgtcgttc ctcctccttc catttgaccc aagaatcagc aactgcagtg
     1441 tgaggacagc gtctcgggag gcaggaccct agggagaccc gggtgtgcgc cgcctgcgcg
     1501 tggggagtct tcggtgcgtg ggggcggctt gctgtccagc ctgtgtgggg gccgtcccgt
     1561 cccacactcc cctgggcatt cttggactca aggccggggc tctgcgtggc ttgctgggag
     1621 gtgggctgca gcacagaggc ctgtgactgc gttccagcgg ccagttcact acgcagtatc
     1681 tctggggcct gggaccagcc acgtgccgag ctgtcagcga cgtgaggtgt cccttctcgt
     1741 tgagatattt aactttggtt ttgctctagt tctttctttt tgaagagagt gactggagtg
     1801 gtaaagatgg aaatgctgga aatgatactg gcgctcacgc tgccatccga ccaccctcgg
     1861 ctcccgagtc cacgcctgcc tgggcctgtg ctgtcagacc cgcgtcggtc gtaaccctct
     1921 gtggctcccc tgcatcagca ccgtcccacc accaagttca ccaggttcac cagacacggc
     1981 ctccacaata gccacaccca cacctgagct gttctcagtg ctggaacttg accatcctgg
     2041 aacaccctgg aagaaaaagg agcgcagggt gggccctcgg ccctgatgca ggagggtgcg
     2101 atagcggacg tggccaggca ggaggggccg ggttcaggag ctgagcaggg gatgcctgtg
     2161 cgtggtgcct gggtctaggg aagctccagc cccaggatgg ggctgccctg cacaccggtg
     2221 cccgccacat gccaaccctc acctccccga ggactggatg atgtgctgcc acgtgtgact
     2281 cgtctccctt gtctgccctg tgtgaccctc agtcttggcc agccatgcat gcgcccgaag
     2341 ctcgtgcagt ttgtacgtga ggtgctctcc tccctgccac catgctcatc actctggcct
     2401 tggccatgct ccctggtcac cccacttccc ggtcgccgtc tgcagcactc ctggagcagc
     2461 ctgggccctt cagcccctgt gctcgtccca ccctagggac tcagccactt gcagaacagg
     2521 atgggaccga gatttcagcg agccctcctg gcgcccggtc ctccctgtgg gcaccagccc
     2581 tcttggtagc tggtgtggag ggccggtgtc cttggctgcc acggagggat ttgatcaccg
     2641 aagcagccac ctgctgtagt tggacctgag gtcagaggcg gggcatcaga ggctcaaggt
     2701 gctgagaagc caccgggaaa gcagccagca caaagggccc aggaagccag cccccgagag
     2761 ctgagcgtgg gggtctttga gtgtctttct ccaagctgag acgtgggcgg ccgcgtggta
     2821 tctcccgagg gctgcttgga ccctggtggg ctgagtgctc cgaggagggg tggactccac
     2881 cttggacagt gggatgtggt gttccacatg tgcctgtttc cacgccagca ccttgacttg
     2941 gcagcatgga gccaaggtct gtccccgccc aggagggtgc cttcctcggg ggtaggggga
     3001 cggcccactc tgccccaggg agtccctttt gatgggaagt gcagtcagca gcgtggaggt
     3061 gtctgggcca ccttcagaag gtggatgtgg tggccgagac cccgtccacg gagggtgatg
     3121 gcctttccct tctgcaggtg cgggcaggtg ggcctgggac cggtgctggg gcctctcctt
     3181 gctgtgtgtg agggcccagg tggaaggcgc ggacctgaca gcattccaat aaagcatacg
     3241 ggaacatgca
//
