LOCUS       NM_001663               3875 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF GTPase 6 (ARF6), mRNA.
ACCESSION   NM_001663
VERSION     NM_001663.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3875)
  AUTHORS   Hong,P., Xu,T., Xu,J., Chen,W., Hu,H., Chen,J., Li,L., Zheng,C.,
            Li,B., Liu,J., Dai,W., Li,E., Zhang,F. and Xu,W.
  TITLE     CD24 promotes metastasis and chemoresistance by directly targeting
            Arf6-ERK pathway in esophageal squamous cell carcinoma
  JOURNAL   Cancer Lett 594, 216994 (2024)
   PUBMED   38801885
  REMARK    GeneRIF: CD24 promotes metastasis and chemoresistance by directly
            targeting Arf6-ERK pathway in esophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 3875)
  AUTHORS   Jiang,C., Zhou,P., Zhang,X., Ma,N., Hu,Y., Zhang,M., Ghonaim,A.H.,
            Li,H., Dong,L., Zeng,W., Li,C., Lang,Y., Sun,Y., He,Q. and Li,W.
  TITLE     ARF6 promotes Streptococcus suis suilysin induced apoptosis in
            HBMECs
  JOURNAL   Int J Biol Macromol 268 (Pt 2), 131839 (2024)
   PUBMED   38663699
  REMARK    GeneRIF: ARF6 promotes Streptococcus suis suilysin induced
            apoptosis in HBMECs.
REFERENCE   3  (bases 1 to 3875)
  AUTHORS   Jiang,S., Han,X., Liu,T., He,Y., Zhao,Z., Liu,T., Cheng,S.,
            Zhang,J., Duan,L., Liu,Y., Cheng,T., Liu,Y., Ye,Q. and Gao,S.
  TITLE     HUNK inhibits cargo uptake and lysosomal traffic in the caveolar
            pathway via the AGAP3/ARF6
  JOURNAL   Sci Bull (Beijing) 69 (2), 173-178 (2024)
   PUBMED   38071109
  REMARK    GeneRIF: HUNK inhibits cargo uptake and lysosomal traffic in the
            caveolar pathway via the AGAP3/ARF6.
REFERENCE   4  (bases 1 to 3875)
  AUTHORS   Wang,J., Zheng,L.F., Ren,S., Li,D.L., Chen,C., Sun,H.H., Liu,L.Y.,
            Guo,H. and Zhao,T.J.
  TITLE     ARF6 plays a general role in targeting palmitoylated proteins from
            the Golgi to the plasma membrane
  JOURNAL   J Cell Sci 136 (15) (2023)
   PUBMED   37461827
REFERENCE   5  (bases 1 to 3875)
  AUTHORS   Zhu,Y., Wang,X., He,Z., Zhao,P., Ren,H. and Qi,Z.
  TITLE     Enterovirus 71 enters human brain microvascular endothelial cells
            through an ARF6-mediated endocytic pathway
  JOURNAL   J Med Virol 95 (7), e28915 (2023)
   PUBMED   37417384
  REMARK    GeneRIF: Enterovirus 71 enters human brain microvascular
            endothelial cells through an ARF6-mediated endocytic pathway.
REFERENCE   6  (bases 1 to 3875)
  AUTHORS   D'Souza-Schorey,C. and Stahl,P.D.
  TITLE     Myristoylation is required for the intracellular localization and
            endocytic function of ARF6
  JOURNAL   Exp Cell Res 221 (1), 153-159 (1995)
   PUBMED   7589240
REFERENCE   7  (bases 1 to 3875)
  AUTHORS   D'Souza-Schorey,C., Li,G., Colombo,M.I. and Stahl,P.D.
  TITLE     A regulatory role for ARF6 in receptor-mediated endocytosis
  JOURNAL   Science 267 (5201), 1175-1178 (1995)
   PUBMED   7855600
REFERENCE   8  (bases 1 to 3875)
  AUTHORS   Welsh,C.F., Moss,J. and Vaughan,M.
  TITLE     ADP-ribosylation factors: a family of approximately 20-kDa guanine
            nucleotide-binding proteins that activate cholera toxin
  JOURNAL   Mol Cell Biochem 138 (1-2), 157-166 (1994)
   PUBMED   7898460
REFERENCE   9  (bases 1 to 3875)
  AUTHORS   Tsuchiya,M., Price,S.R., Tsai,S.C., Moss,J. and Vaughan,M.
  TITLE     Molecular identification of ADP-ribosylation factor mRNAs and their
            expression in mammalian cells
  JOURNAL   J Biol Chem 266 (5), 2772-2777 (1991)
   PUBMED   1993656
REFERENCE   10 (bases 1 to 3875)
  AUTHORS   Stearns,T., Willingham,M.C., Botstein,D. and Kahn,R.A.
  TITLE     ADP-ribosylation factor is functionally and physically associated
            with the Golgi complex
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1238-1242 (1990)
   PUBMED   2105501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA217686.1, BC008918.2,
            BM838197.1 and BC030291.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001663.3.
            
            Summary: This gene encodes a member of the human ARF gene family,
            which is part of the RAS superfamily. The ARF genes encode small
            guanine nucleotide-binding proteins that stimulate the
            ADP-ribosyltransferase activity of cholera toxin and play a role in
            vesicular trafficking and as activators of phospholipase D. The
            product of this gene is localized to the plasma membrane, and
            regulates vesicular trafficking, remodelling of membrane lipids,
            and signaling pathways that lead to actin remodeling. A pseudogene
            of this gene is located on chromosome 7. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.549175.1,
                                           SRR1163658.414775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298316.7/ ENSP00000298316.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA217686.1         61-81
            22-1295             BC008918.2         1-1274
            1296-1794           BM838197.1         19-517
            1795-3875           BC030291.1         568-2648
FEATURES             Location/Qualifiers
     source          1..3875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.3"
     gene            1..3875
                     /gene="ARF6"
                     /note="ARF GTPase 6"
                     /db_xref="GeneID:382"
                     /db_xref="HGNC:HGNC:659"
                     /db_xref="MIM:600464"
     exon            1..76
                     /gene="ARF6"
                     /inference="alignment:Splign:2.1.0"
     exon            77..3875
                     /gene="ARF6"
                     /inference="alignment:Splign:2.1.0"
     CDS             558..1085
                     /gene="ARF6"
                     /EC_number="3.6.5.2"
                     /note="ADP ribosylation factor 6"
                     /codon_start=1
                     /product="ADP-ribosylation factor 6"
                     /protein_id="NP_001654.1"
                     /db_xref="CCDS:CCDS9695.1"
                     /db_xref="GeneID:382"
                     /db_xref="HGNC:HGNC:659"
                     /db_xref="MIM:600464"
                     /translation="MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPT
                     VGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQE
                     LHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGD
                     GLYEGLTWLTSNYKS"
     regulatory      3854..3859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF6"
                     /note="hexamer: AATAAA"
     polyA_site      3875
                     /gene="ARF6"
                     /note="major polyA site"
ORIGIN      
        1 ccggcagcgg cggcggcaga actgggagga ggagttggag gccggaggga gcccgcgctc
       61 ggggcggcgg ctggaggcag cgcaccgagt tcccgcgagg atccatgacc tgacggggcc
      121 ccggagccgc gctgcctctc gggtgtcctg ggtcggtggg gagcccagtg ctcgcaggcc
      181 ggcgggcggg ccggagggct gcagtctccc tcgcggtgag aggaaggcgg aggagcggga
      241 accgcggcgg cgctcgcgcg gcgcctgcgg ggggaagggc agttccgggc cgggccgcgc
      301 ctcagcaggg cggcggctcc cagcgcagtc tcagggcccg ggtggcggcg gcgactggag
      361 aaatcaagtt gtgcggtcgg tgatgcccga gtgagcgggg ggcctgggcc tctgccctta
      421 ggaggcaact cccacgcagg ccgcaaaggc gctctcgcgg ccgagaggct tcgtttcggt
      481 ttcgcggcgg cggcggcgtt gttggctgag gggacccggg acacctgaat gcccccggcc
      541 ccggctcctc cgacgcgatg gggaaggtgc tatccaaaat cttcgggaac aaggaaatgc
      601 ggatcctcat gttgggcctg gacgcggccg gcaagacaac aatcctgtac aagttgaagc
      661 tgggccagtc ggtgaccacc attcccactg tgggtttcaa cgtggagacg gtgacttaca
      721 aaaatgtcaa gttcaacgta tgggatgtgg gcggccagga caagatccgg ccgctctggc
      781 ggcattacta cactgggacc caaggtctca tcttcgtagt ggactgcgcc gaccgcgacc
      841 gcatcgatga ggctcgccag gagctgcacc gcattatcaa tgaccgggag atgagggacg
      901 ccataatcct catcttcgcc aacaagcagg acctgcccga tgccatgaaa ccccacgaga
      961 tccaggagaa actgggcctg acccggattc gggacaggaa ctggtatgtg cagccctcct
     1021 gtgccacctc aggggacgga ctctatgagg ggctcacatg gttaacctct aactacaaat
     1081 cttaatgagc attctccacc catcccctgg aaggagagaa atcaaaaacc cattcatagg
     1141 attatcgcca ccatcacctc tttcaattgc cactttctct tcttttgaat ttgaactctg
     1201 gagttactgt tctacagttt ggcggggacg gggcttgggg gttttctctt ttgtttgttt
     1261 ccctttcttt ttcctttttt tttttttttt ttttttgttg gctttgcgtt aggatgctct
     1321 gatctgacat ttgacatgaa cacaaagttg ctagatgctc ttgttgactt ccagcagatg
     1381 ggatggggga aacacagcag ttcttggtaa agtcctttgt aataatagtt tgattttttt
     1441 atttcgagag aatctttcat tttcctatgt atgctttttt ccttttttgc ccagtttcct
     1501 tatcacttgc tgtagatggc ttattttgca ttcatgcaga ctatgttgca agtctgtttc
     1561 atctagtaaa ctgaaaatta ttgcttaatc aaactgccgt ttgtctttta tatttaaggc
     1621 cttccccccc cttccttatg agttctaact tagtaatttc aaatgtgacc ttttatatct
     1681 aagaccagta tagtaaactt agcccacagt ggcaaataat gagtaatatt gtaatatgtt
     1741 ccagttgcac ctcagtatgt taaacaggta atgtaagaag ttctctgaaa tgtcagcaag
     1801 taagttctga aacacatcat gcatgagtag gaataaaacc caagttcccc ataacgtaga
     1861 taacttaatg ctgcataaaa atatgaaagt gtaacccatg aaggacactt tttctttcca
     1921 ctgcaaagtt agccactttg ctgtttttcc tcttttttaa actttgaaaa tagactcttt
     1981 ccagaaattg gagcaataat ggtgttacca cacacagatt aaataatttg tagatatttt
     2041 aagtgacttt tgggcaaaac tggaatgtat acttttacct tgtttcaaac acctaagacc
     2101 agtaatttaa aaattactaa aaggtttact ttgttcatta ataaaacatt taacaattca
     2161 aattatatgc accttttacc tagttgaaaa aaatacacat tcctgttttc acattatagc
     2221 aactgattaa gctgaagctg taagtcattt tttatagatg agtgatccgc atctccatca
     2281 attagaacac tggaaaagat gttttataaa agaggtattt aattttgttt gtaggattaa
     2341 ctcatgcaaa taataaaaaa gatatcctgt tggttcaata gtacactgtc tcctttaagg
     2401 aaggaagcgt gatgaatgaa tgatgtgtag acttgaggga tgactattaa aggggacgta
     2461 ggatgaagag aaagaaccta cagatgacaa tgaatgtaaa cttatttttc ttcatgtgta
     2521 agcagtgtgc tcgctggtga tatccagatc ctaacaagat tacttggtta gctggttagg
     2581 accagtaact ggattgcgac cactatgata atattttgaa ccaaatgtta atgcttgatg
     2641 cagaattgta aagcagcatc tggttcctat atagccttaa ggattaattt tagtgatcct
     2701 caaggaatta aatagggaat ttcagaaatg tagactgcaa aggcagtata caggaaaagg
     2761 tggagtgggt tttgtttatg agggtgtctg aaaactaaaa ttgagcggga tatcatggta
     2821 tagttggaca gtattggtcc ttcacacttt ggccatattg tataatggag cttttaccaa
     2881 agatgtatga gaagtgtaag actataaaaa aatgaactat tcaaagtaaa actcttaaca
     2941 aacattttac ttaaagcaga tgcaaaaggg tattctcatg taggctcctg ttggtgcaga
     3001 gggatttttt tgatttcagg atacaactaa agtacgaagt tctcagtttc actttagtag
     3061 aaagagctct agaaatgagg ctgataaaca catctaagaa cactggttgc tttctaaaat
     3121 ttccaaagct ccaccataaa tgtaattttt agtgtttcaa atgattgcat tttaaagtat
     3181 ataaatatgg gttatccaat atcaatgcta tagtaacatc ctgaaacaaa acaagcacaa
     3241 aggtataaat gcctaaactg gaggaaactt gaaaccctca tgttaaatct taaatgtagt
     3301 atttctaact tgtgaagaca gattggtagg cagccatttt tttgtgtctt aaaataactg
     3361 ggggcatagt taaaatttta tacatcaagt gattgctatt attgaatgtt gcaggtgaga
     3421 tgtggttatt tttagtttat ttgaaatgtt tgactggaaa ggggggaggg ggaagcaaat
     3481 atttgaaatt tggaaaaccc taaacctttt ggtaagaaat tgtaattttc acttaaaatt
     3541 ttctttaagg atataagagg tttataattg atgtagttaa attgaacaat aaccattggt
     3601 gactggagca ggtaattata gcctgcagaa aaaattatct aagaatttta aaaataagat
     3661 cctgaagttg tttaattgca tccatttctg tatttatgtg aatttataaa ctgcagtaag
     3721 ttttgaatga ggttaatctt gtttaatata agtaaatgag tctgtagact gtgatctccc
     3781 caaactaaaa agtacagtac ttggaattgt gttctttatg gttgtagtgt tggtaaagca
     3841 ctaatatgca gaaaataaag gaattacaca gtgca
//
