LOCUS       NP_001654                175 aa            linear   PRI 27-APR-2025
DEFINITION  ADP-ribosylation factor 6 [Homo sapiens].
ACCESSION   NP_001654
VERSION     NP_001654.1
DBSOURCE    REFSEQ: accession NM_001663.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 175)
  AUTHORS   Hong,P., Xu,T., Xu,J., Chen,W., Hu,H., Chen,J., Li,L., Zheng,C.,
            Li,B., Liu,J., Dai,W., Li,E., Zhang,F. and Xu,W.
  TITLE     CD24 promotes metastasis and chemoresistance by directly targeting
            Arf6-ERK pathway in esophageal squamous cell carcinoma
  JOURNAL   Cancer Lett 594, 216994 (2024)
   PUBMED   38801885
  REMARK    GeneRIF: CD24 promotes metastasis and chemoresistance by directly
            targeting Arf6-ERK pathway in esophageal squamous cell carcinoma.
REFERENCE   2  (residues 1 to 175)
  AUTHORS   Jiang,C., Zhou,P., Zhang,X., Ma,N., Hu,Y., Zhang,M., Ghonaim,A.H.,
            Li,H., Dong,L., Zeng,W., Li,C., Lang,Y., Sun,Y., He,Q. and Li,W.
  TITLE     ARF6 promotes Streptococcus suis suilysin induced apoptosis in
            HBMECs
  JOURNAL   Int J Biol Macromol 268 (Pt 2), 131839 (2024)
   PUBMED   38663699
  REMARK    GeneRIF: ARF6 promotes Streptococcus suis suilysin induced
            apoptosis in HBMECs.
REFERENCE   3  (residues 1 to 175)
  AUTHORS   Jiang,S., Han,X., Liu,T., He,Y., Zhao,Z., Liu,T., Cheng,S.,
            Zhang,J., Duan,L., Liu,Y., Cheng,T., Liu,Y., Ye,Q. and Gao,S.
  TITLE     HUNK inhibits cargo uptake and lysosomal traffic in the caveolar
            pathway via the AGAP3/ARF6
  JOURNAL   Sci Bull (Beijing) 69 (2), 173-178 (2024)
   PUBMED   38071109
  REMARK    GeneRIF: HUNK inhibits cargo uptake and lysosomal traffic in the
            caveolar pathway via the AGAP3/ARF6.
REFERENCE   4  (residues 1 to 175)
  AUTHORS   Wang,J., Zheng,L.F., Ren,S., Li,D.L., Chen,C., Sun,H.H., Liu,L.Y.,
            Guo,H. and Zhao,T.J.
  TITLE     ARF6 plays a general role in targeting palmitoylated proteins from
            the Golgi to the plasma membrane
  JOURNAL   J Cell Sci 136 (15) (2023)
   PUBMED   37461827
REFERENCE   5  (residues 1 to 175)
  AUTHORS   Zhu,Y., Wang,X., He,Z., Zhao,P., Ren,H. and Qi,Z.
  TITLE     Enterovirus 71 enters human brain microvascular endothelial cells
            through an ARF6-mediated endocytic pathway
  JOURNAL   J Med Virol 95 (7), e28915 (2023)
   PUBMED   37417384
  REMARK    GeneRIF: Enterovirus 71 enters human brain microvascular
            endothelial cells through an ARF6-mediated endocytic pathway.
REFERENCE   6  (residues 1 to 175)
  AUTHORS   D'Souza-Schorey,C. and Stahl,P.D.
  TITLE     Myristoylation is required for the intracellular localization and
            endocytic function of ARF6
  JOURNAL   Exp Cell Res 221 (1), 153-159 (1995)
   PUBMED   7589240
REFERENCE   7  (residues 1 to 175)
  AUTHORS   D'Souza-Schorey,C., Li,G., Colombo,M.I. and Stahl,P.D.
  TITLE     A regulatory role for ARF6 in receptor-mediated endocytosis
  JOURNAL   Science 267 (5201), 1175-1178 (1995)
   PUBMED   7855600
REFERENCE   8  (residues 1 to 175)
  AUTHORS   Welsh,C.F., Moss,J. and Vaughan,M.
  TITLE     ADP-ribosylation factors: a family of approximately 20-kDa guanine
            nucleotide-binding proteins that activate cholera toxin
  JOURNAL   Mol Cell Biochem 138 (1-2), 157-166 (1994)
   PUBMED   7898460
REFERENCE   9  (residues 1 to 175)
  AUTHORS   Tsuchiya,M., Price,S.R., Tsai,S.C., Moss,J. and Vaughan,M.
  TITLE     Molecular identification of ADP-ribosylation factor mRNAs and their
            expression in mammalian cells
  JOURNAL   J Biol Chem 266 (5), 2772-2777 (1991)
   PUBMED   1993656
REFERENCE   10 (residues 1 to 175)
  AUTHORS   Stearns,T., Willingham,M.C., Botstein,D. and Kahn,R.A.
  TITLE     ADP-ribosylation factor is functionally and physically associated
            with the Golgi complex
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1238-1242 (1990)
   PUBMED   2105501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA217686.1, BC008918.2,
            BM838197.1 and BC030291.1.
            
            Summary: This gene encodes a member of the human ARF gene family,
            which is part of the RAS superfamily. The ARF genes encode small
            guanine nucleotide-binding proteins that stimulate the
            ADP-ribosyltransferase activity of cholera toxin and play a role in
            vesicular trafficking and as activators of phospholipase D. The
            product of this gene is localized to the plasma membrane, and
            regulates vesicular trafficking, remodelling of membrane lipids,
            and signaling pathways that lead to actin remodeling. A pseudogene
            of this gene is located on chromosome 7. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.549175.1,
                                           SRR1163658.414775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298316.7/ ENSP00000298316.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..175
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.3"
     Protein         1..175
                     /product="ADP-ribosylation factor 6"
                     /EC_number="3.6.5.2"
                     /note="ADP ribosylation factor 6"
                     /calculated_mol_wt=19951
     Region          1..175
                     /region_name="ARF"
                     /note="ARF-like small GTPases; ARF, ADP-ribosylation
                     factor; smart00177"
                     /db_xref="CDD:128474"
     Site            20..27
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206716"
     Site            order(22..23,27,31,43..50,72,77)
                     /site_type="other"
                     /note="putative GAP interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206716"
     Site            order(23..28,41,44,66,122..123,125,155..156)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206716"
     Site            32..47
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206716"
     Site            37..38
                     /site_type="active"
                     /note="QS Arf6 conserved motif [active]"
                     /db_xref="CDD:206716"
     Site            order(44..48,53,63,67,73,75..77)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206716"
     Site            44
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206716"
     Site            order(45..52,62,73,76..77)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206716"
     Site            47..62
                     /site_type="active"
                     /note="interswitch region [active]"
                     /db_xref="CDD:206716"
     Site            63..66
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206716"
     Site            65..80
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206716"
     Site            122..125
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206716"
     Site            155..157
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206716"
     CDS             1..175
                     /gene="ARF6"
                     /coded_by="NM_001663.4:558..1085"
                     /db_xref="CCDS:CCDS9695.1"
                     /db_xref="GeneID:382"
                     /db_xref="HGNC:HGNC:659"
                     /db_xref="MIM:600464"
ORIGIN      
        1 mgkvlskifg nkemrilmlg ldaagkttil yklklgqsvt tiptvgfnve tvtyknvkfn
       61 vwdvggqdki rplwrhyytg tqglifvvdc adrdridear qelhriindr emrdaiilif
      121 ankqdlpdam kpheiqeklg ltrirdrnwy vqpscatsgd glyegltwlt snyks
//
