LOCUS       NM_001662               1032 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF GTPase 5 (ARF5), mRNA.
ACCESSION   NM_001662
VERSION     NM_001662.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1032)
  AUTHORS   Kulasekaran,G., Chaineau,M., Piscopo,V.E.C., Verginelli,F.,
            Fotouhi,M., Girard,M., Tang,Y., Dali,R., Lo,R., Stifani,S. and
            McPherson,P.S.
  TITLE     An Arf/Rab cascade controls the growth and invasiveness of
            glioblastoma
  JOURNAL   J Cell Biol 220 (2) (2021)
   PUBMED   33443570
  REMARK    GeneRIF: An Arf/Rab cascade controls the growth and invasiveness of
            glioblastoma.
REFERENCE   2  (bases 1 to 1032)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1032)
  AUTHORS   Fernandez-Chamorro,J., Francisco-Velilla,R., Ramajo,J. and
            Martinez-Salas,E.
  TITLE     Rab1b and ARF5 are novel RNA-binding proteins involved in FMDV
            IRES-driven RNA localization
  JOURNAL   Life Sci Alliance 2 (1), e201800131 (2019)
   PUBMED   30655362
  REMARK    GeneRIF: ARF5 and Rab1b exhibit RNA-binding capacity, suggesting a
            role for domain 3 of the IRES in RNA localization into specific
            cellular compartments.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1032)
  AUTHORS   Egerer,J., Emmerich,D., Fischer-Zirnsak,B., Chan,W.L.,
            Meierhofer,D., Tuysuz,B., Marschner,K., Sauer,S., Barr,F.A.,
            Mundlos,S. and Kornak,U.
  TITLE     GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi
            Targeting
  JOURNAL   J Invest Dermatol 135 (10), 2368-2376 (2015)
   PUBMED   26000619
  REMARK    GeneRIF: GORAB missense mutation disrupt ARF5 binding in Golgi
            apparatus in patients, with genetic skin diseases.
REFERENCE   5  (bases 1 to 1032)
  AUTHORS   Yu,J., Chia,J., Canning,C.A., Jones,C.M., Bard,F.A. and
            Virshup,D.M.
  TITLE     WLS retrograde transport to the endoplasmic reticulum during Wnt
            secretion
  JOURNAL   Dev Cell 29 (3), 277-291 (2014)
   PUBMED   24768165
REFERENCE   6  (bases 1 to 1032)
  AUTHORS   Orcl,L., Palmer,D.J., Amherdt,M. and Rothman,J.E.
  TITLE     Coated vesicle assembly in the Golgi requires only coatomer and ARF
            proteins from the cytosol
  JOURNAL   Nature 364 (6439), 732-734 (1993)
   PUBMED   8355790
REFERENCE   7  (bases 1 to 1032)
  AUTHORS   Helms,J.B., Palmer,D.J. and Rothman,J.E.
  TITLE     Two distinct populations of ARF bound to Golgi membranes
  JOURNAL   J Cell Biol 121 (4), 751-760 (1993)
   PUBMED   8491770
REFERENCE   8  (bases 1 to 1032)
  AUTHORS   Lee,F.J., Moss,J. and Vaughan,M.
  TITLE     Human and Giardia ADP-ribosylation factors (ARFs) complement ARF
            function in Saccharomyces cerevisiae
  JOURNAL   J Biol Chem 267 (34), 24441-24445 (1992)
   PUBMED   1447192
REFERENCE   9  (bases 1 to 1032)
  AUTHORS   Tsuchiya,M., Price,S.R., Tsai,S.C., Moss,J. and Vaughan,M.
  TITLE     Molecular identification of ADP-ribosylation factor mRNAs and their
            expression in mammalian cells
  JOURNAL   J Biol Chem 266 (5), 2772-2777 (1991)
   PUBMED   1993656
REFERENCE   10 (bases 1 to 1032)
  AUTHORS   Stearns,T., Willingham,M.C., Botstein,D. and Kahn,R.A.
  TITLE     ADP-ribosylation factor is functionally and physically associated
            with the Golgi complex
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1238-1242 (1990)
   PUBMED   2105501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC000357.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001662.3.
            
            Summary: This gene is a member of the human ADP-ribosylation factor
            (ARF) gene family. These genes encode small guanine
            nucleotide-binding proteins that stimulate the
            ADP-ribosyltransferase activity of cholera toxin and play a role in
            vesicular trafficking and as activators of phospholipase D. The
            gene products include 6 ARF proteins and 11 ARF-like proteins and
            constitute 1 family of the RAS superfamily. The ARF proteins are
            categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and
            ARF5) and class III (ARF6). The members of each class share a
            common gene organization. [provided by RefSeq, Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033104.1, SRR3476690.883380.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000000233.10/ ENSP00000000233.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AC000357.1         33999-34153
            156-236             AC000357.1         34671-34751
            237-346             AC000357.1         35073-35182
            347-418             AC000357.1         35654-35725
            419-544             AC000357.1         36551-36676
            545-1032            AC000357.1         36801-37288
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..1032
                     /gene="ARF5"
                     /note="ARF GTPase 5"
                     /db_xref="GeneID:381"
                     /db_xref="HGNC:HGNC:658"
                     /db_xref="MIM:103188"
     exon            1..155
                     /gene="ARF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..631
                     /gene="ARF5"
                     /note="ADP ribosylation factor 5"
                     /codon_start=1
                     /product="ADP-ribosylation factor 5"
                     /protein_id="NP_001653.1"
                     /db_xref="CCDS:CCDS34745.1"
                     /db_xref="GeneID:381"
                     /db_xref="HGNC:HGNC:658"
                     /db_xref="MIM:103188"
                     /translation="MGLTVSALFSRIFGKKQMRILMVGLDAAGKTTILYKLKLGEIVT
                     TIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVQE
                     SADELQKMLQEDELRDAVLLVFANKQDMPNAMPVSELTDKLGLQHLRSRTWYVQATCA
                     TQGTGLYDGLDWLSHELSKR"
     exon            156..236
                     /gene="ARF5"
                     /inference="alignment:Splign:2.1.0"
     exon            237..346
                     /gene="ARF5"
                     /inference="alignment:Splign:2.1.0"
     exon            347..418
                     /gene="ARF5"
                     /inference="alignment:Splign:2.1.0"
     exon            419..544
                     /gene="ARF5"
                     /inference="alignment:Splign:2.1.0"
     exon            545..1032
                     /gene="ARF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1011..1016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF5"
                     /note="hexamer: AATAAA"
     polyA_site      1032
                     /gene="ARF5"
                     /note="major polyA site"
ORIGIN      
        1 ctgctgctgc tgcgccccat ccccccgcgg ccggccagtt ccagcccgca ccccgcgtcg
       61 gtgcccgcgc ccctccccgg gccccgccat gggcctcacc gtgtccgcgc tcttttcgcg
      121 gatcttcggg aagaagcaga tgcggattct catggttggc ttggatgcgg ctggcaagac
      181 cacaatcctg tacaaactga agttggggga gattgtcacc accatcccaa ccataggctt
      241 caatgtagaa acagtggaat ataagaacat ctgtttcaca gtctgggacg tgggaggcca
      301 ggacaagatt cggcctctgt ggcggcacta cttccagaac actcagggcc tcatctttgt
      361 ggtggacagt aatgaccggg agcgggtcca agaatctgct gatgaactcc agaagatgct
      421 gcaggaggac gagctgcggg atgcagtgct gctggtattt gccaacaagc aggacatgcc
      481 caacgccatg cccgtgagcg agctgactga caagctgggg ctacagcact tacgcagccg
      541 cacgtggtat gtccaggcca cctgtgccac ccaaggcaca ggtctgtacg atggtctgga
      601 ctggctgtcc cacgagctgt caaagcgcta accagccagg ggcaggcccc tgatgcccgg
      661 aagctcctgc gtgcatcccc gggatgacca gactcccgga ctcctcaggc agtgcccttt
      721 cctcccactt ttcctccccc atagccacag gcctctgctc ctgctcctgc ctgcatgttc
      781 tctctgttgt tggagcctgg agccttgctc tctgggcaca gaggggtcca ctctcctgcc
      841 tgctgggacc tatggaaggg gcttcctggc caaggccccc tcttccagag gaggagcagg
      901 gatctgggtt tccttttttt tttctgtttt gggtgtactc taggggccag gttgggaggg
      961 ggaaggtgag ggcttcgggt ggtgctataa tgtggcactg gatcttgagt aataaatttg
     1021 ctgtggtttg ta
//
