LOCUS       NM_001660               1596 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF GTPase 4 (ARF4), mRNA.
ACCESSION   NM_001660 XM_941555
VERSION     NM_001660.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1596)
  AUTHORS   Zhang,L., Fang,Z., Zhu,Q., Yang,S., Fu,J., Sun,Z., Lu,G., Wei,C.,
            Zhang,Z., Lee,K., Zhong,Y., Liu,R. and He,J.C.
  TITLE     Cholesterol 25-Hydroxylase Protects Against Diabetic Kidney Disease
            by Regulating ADP Ribosylation Factor 4
  JOURNAL   Adv Sci (Weinh) 11 (29), e2309642 (2024)
   PUBMED   38816950
  REMARK    GeneRIF: Cholesterol 25-Hydroxylase Protects Against Diabetic
            Kidney Disease by Regulating ADP Ribosylation Factor 4.
REFERENCE   2  (bases 1 to 1596)
  AUTHORS   Fu,J., Lou,X., Wan,S., Zhao,X., Chen,Z., Zhu,M., Guo,L., Wu,D. and
            Wang,S.
  TITLE     microRNA-196a-3p inhibits cell proliferation and promotes cell
            apoptosis by targeting ADP ribosylation factor 4 in diffuse large
            B-cell lymphoma
  JOURNAL   Oncol Rep 45 (2), 764-775 (2021)
   PUBMED   33416178
  REMARK    GeneRIF: microRNA196a3p inhibits cell proliferation and promotes
            cell apoptosis by targeting ADP ribosylation factor 4 in diffuse
            large Bcell lymphoma.
REFERENCE   3  (bases 1 to 1596)
  AUTHORS   Zhang,Q., Wu,L., Bai,B., Li,D., Xiao,P., Li,Q., Zhang,Z., Wang,H.,
            Li,L. and Jiang,Q.
  TITLE     Quantitative Proteomics Reveals Association of Neuron Projection
            Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease
  JOURNAL   Mol Cell Proteomics 20, 100007 (2021)
   PUBMED   33561610
  REMARK    GeneRIF: Quantitative Proteomics Reveals Association of Neuron
            Projection Development Genes ARF4, KIF5B, and RAB8A With
            Hirschsprung Disease.
REFERENCE   4  (bases 1 to 1596)
  AUTHORS   Dejgaard,S.Y. and Presley,J.F.
  TITLE     Class II Arfs require a brefeldin-A-sensitive factor for Golgi
            association
  JOURNAL   Biochem Biophys Res Commun 530 (1), 301-306 (2020)
   PUBMED   32828303
  REMARK    GeneRIF: Class II Arfs require a brefeldin-A-sensitive factor for
            Golgi association.
REFERENCE   5  (bases 1 to 1596)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1596)
  AUTHORS   Vorobieva,N., Protopopov,A., Protopopova,M., Kashuba,V.,
            Allikmets,R.L., Modi,W., Zabarovsky,E.R., Klein,G., Kisselev,L. and
            Graphodatsky,A.
  TITLE     Localization of human ARF2 and NCK genes and 13 other NotI-linking
            clones to chromosome 3 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 68 (1-2), 91-94 (1995)
   PUBMED   7956370
REFERENCE   7  (bases 1 to 1596)
  AUTHORS   Lee,F.J., Moss,J. and Vaughan,M.
  TITLE     Human and Giardia ADP-ribosylation factors (ARFs) complement ARF
            function in Saccharomyces cerevisiae
  JOURNAL   J Biol Chem 267 (34), 24441-24445 (1992)
   PUBMED   1447192
REFERENCE   8  (bases 1 to 1596)
  AUTHORS   Kahn,R.A., Kern,F.G., Clark,J., Gelmann,E.P. and Rulka,C.
  TITLE     Human ADP-ribosylation factors. A functionally conserved family of
            GTP-binding proteins
  JOURNAL   J Biol Chem 266 (4), 2606-2614 (1991)
   PUBMED   1899243
REFERENCE   9  (bases 1 to 1596)
  AUTHORS   Monaco,L., Murtagh,J.J., Newman,K.B., Tsai,S.C., Moss,J. and
            Vaughan,M.
  TITLE     Selective amplification of an mRNA and related pseudogene for a
            human ADP-ribosylation factor, a guanine nucleotide-dependent
            protein activator of cholera toxin
  JOURNAL   Proc Natl Acad Sci U S A 87 (6), 2206-2210 (1990)
   PUBMED   2107548
REFERENCE   10 (bases 1 to 1596)
  AUTHORS   Stearns,T., Willingham,M.C., Botstein,D. and Kahn,R.A.
  TITLE     ADP-ribosylation factor is functionally and physically associated
            with the Golgi complex
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1238-1242 (1990)
   PUBMED   2105501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA259855.1 and BC003364.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001660.3.
            
            Summary: This gene is a member of the human ARF gene family whose
            members encode small guanine nucleotide-binding proteins that
            stimulate the ADP-ribosyltransferase activity of cholera toxin and
            play a role in vesicular trafficking and as activators of
            phospholipase D. The gene products include 5 ARF proteins and 11
            ARF-like proteins and constitute one family of the RAS superfamily.
            The ARF proteins are categorized as class I, class II and class
            III; this gene is a class II member. The members of each class
            share a common gene organization. The ARF4 gene spans approximately
            12kb and contains six exons and five introns. This gene is the most
            divergent member of the human ARFs. Conflicting map positions at
            3p14 or 3p21 have been reported for this gene. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1001558.1,
                                           SRR3476690.1024844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303436.11/ ENSP00000306010.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA259855.1         145-153
            10-1596             BC003364.1         1-1587
FEATURES             Location/Qualifiers
     source          1..1596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..1596
                     /gene="ARF4"
                     /gene_synonym="ARF2"
                     /note="ARF GTPase 4"
                     /db_xref="GeneID:378"
                     /db_xref="HGNC:HGNC:655"
                     /db_xref="MIM:601177"
     exon            1..271
                     /gene="ARF4"
                     /gene_synonym="ARF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..747
                     /gene="ARF4"
                     /gene_synonym="ARF2"
                     /note="ADP-ribosylation factor 2; ADP ribosylation factor
                     4"
                     /codon_start=1
                     /product="ADP-ribosylation factor 4"
                     /protein_id="NP_001651.1"
                     /db_xref="CCDS:CCDS2884.1"
                     /db_xref="GeneID:378"
                     /db_xref="HGNC:HGNC:655"
                     /db_xref="MIM:601177"
                     /translation="MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVT
                     TIPTIGFNVETVEYKNICFTVWDVGGQDRIRPLWKHYFQNTQGLIFVVDSNDRERIQE
                     VADELQKMLLVDELRDAVLLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCA
                     TQGTGLYEGLDWLSNELSKR"
     exon            272..352
                     /gene="ARF4"
                     /gene_synonym="ARF2"
                     /inference="alignment:Splign:2.1.0"
     exon            353..462
                     /gene="ARF4"
                     /gene_synonym="ARF2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..534
                     /gene="ARF4"
                     /gene_synonym="ARF2"
                     /inference="alignment:Splign:2.1.0"
     exon            535..660
                     /gene="ARF4"
                     /gene_synonym="ARF2"
                     /inference="alignment:Splign:2.1.0"
     exon            661..1596
                     /gene="ARF4"
                     /gene_synonym="ARF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1575..1580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF4"
                     /gene_synonym="ARF2"
                     /note="hexamer: AATAAA"
     polyA_site      1596
                     /gene="ARF4"
                     /gene_synonym="ARF2"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcctag caggtcctct accggcttat tcctgtgccg gatcttcatc ggcacagggg
       61 ccactgagac gtttctgcct ccctctttct tcctccgctc tttctcttcc ctctcgttta
      121 gtttgcctgg gagcttgaaa ggagaaagca cggggtcgcc ccaaacccct tctgcttctg
      181 cccatcacaa gtgccactac cgccatgggc ctcactatct cctccctctt ctcccgacta
      241 tttggcaaga agcagatgcg cattttgatg gttggattgg atgctgctgg caagacaacc
      301 attctgtata aactgaagtt aggggagata gtcaccacca ttcctaccat tggttttaat
      361 gtggaaacag tagaatataa gaacatttgt ttcacagtat gggatgttgg tggtcaagat
      421 agaattaggc ctctctggaa gcattacttc cagaataccc agggtcttat ttttgtggta
      481 gatagcaacg atcgtgaaag aattcaggaa gtagcagatg agctgcagaa aatgcttctg
      541 gtagatgaat tgagagatgc agtgctgcta ctttttgcaa acaaacagga tttgccaaat
      601 gctatggcca tcagtgaaat gacagataaa ctagggcttc agtctcttcg taacagaaca
      661 tggtatgttc aagccacttg tgcaacacaa ggaactggtc tgtatgaagg acttgactgg
      721 ctgtcaaatg agctttcaaa acgttaaatg aaattggata tctaaccaag gacatgtttg
      781 ataaaattgg tctaggcttg ttacaacaaa attagtttgt atcttggtta ttaaacagta
      841 tctgggactg gtttgggcag aatattaaac ttattttgtt gccaattatt gtttaccgag
      901 tataatgttg ctatttagca atgtgcttgg ttttaaagaa attctccttg ggaaaaaagt
      961 atcctctttt aattttactt cccataagcg taaatgcctg gacatagctc ttgtgcaacc
     1021 tttaaataaa ttgttttgag tgttttttga gccccagaca aataatgttt taaagttatc
     1081 cccttgctac tttactgata cctttatcat tcctgagaca gtttgctaat ttaaaaatgt
     1141 agcattccat ttgtatttat ttctctccct tgccaaaaag attttctaat actgcttgta
     1201 ccagccagag aaagatccaa aacactactc agctctcttg cactgaggaa atttttcccc
     1261 ctacattgac tcctggccta catcagccaa acttaacctt ggtggggttt ggatttgata
     1321 gccaattagt tctgtgctgg ttgcaaagaa ttgatattta gatggttttt aatactcagc
     1381 agattgtctt cctttatatt gtgtcttttt tatgttgcat gttgcttttg ttatcagcct
     1441 gattttttgc tcagtatatg atagttctgc tgatgttttg tttattgggc agacatatct
     1501 tcattaagag tttttggaaa actcatcaaa ttcgatgaat acattttctt cataacccat
     1561 ttggaattat tcctaataaa atgataaaat acgtaa
//
