LOCUS       NM_001659               4041 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF GTPase 3 (ARF3), transcript variant 1, mRNA.
ACCESSION   NM_001659
VERSION     NM_001659.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4041)
  AUTHORS   Dos Santos Henrique,S., Franca,M.J., Silva Junior,R.C.,
            Santos,M.L.S.F. and do Valle,D.A.
  TITLE     Neurodevelopmental disorder associated with gene ARF3: A case
            report
  JOURNAL   Am J Med Genet A 194 (9), e63658 (2024)
   PUBMED   38712921
REFERENCE   2  (bases 1 to 4041)
  AUTHORS   Sandilands,E., Freckmann,E.C., Cumming,E.M., Roman-Fernandez,A.,
            McGarry,L., Anand,J., Galbraith,L., Mason,S., Patel,R., Nixon,C.,
            Cartwright,J., Leung,H.Y., Blyth,K. and Bryant,D.M.
  TITLE     The small GTPase ARF3 controls invasion modality and metastasis by
            regulating N-cadherin levels
  JOURNAL   J Cell Biol 222 (4) (2023)
   PUBMED   36880595
  REMARK    GeneRIF: The small GTPase ARF3 controls invasion modality and
            metastasis by regulating N-cadherin levels.
REFERENCE   3  (bases 1 to 4041)
  AUTHORS   Fasano,G., Muto,V., Radio,F.C., Venditti,M., Mosaddeghzadeh,N.,
            Coppola,S., Paradisi,G., Zara,E., Bazgir,F., Ziegler,A.,
            Chillemi,G., Bertuccini,L., Tinari,A., Vetro,A., Pantaleoni,F.,
            Pizzi,S., Conti,L.A., Petrini,S., Bruselles,A., Prandi,I.G.,
            Mancini,C., Chandramouli,B., Barth,M., Bris,C., Milani,D.,
            Selicorni,A., Macchiaiolo,M., Gonfiantini,M.V., Bartuli,A.,
            Mariani,R., Curry,C.J., Guerrini,R., Slavotinek,A., Iascone,M.,
            Dallapiccola,B., Ahmadian,M.R., Lauri,A. and Tartaglia,M.
  TITLE     Dominant ARF3 variants disrupt Golgi integrity and cause a
            neurodevelopmental disorder recapitulated in zebrafish
  JOURNAL   Nat Commun 13 (1), 6841 (2022)
   PUBMED   36369169
  REMARK    GeneRIF: Dominant ARF3 variants disrupt Golgi integrity and cause a
            neurodevelopmental disorder recapitulated in zebrafish.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4041)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4041)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4041)
  AUTHORS   Lee,F.J., Moss,J. and Vaughan,M.
  TITLE     Human and Giardia ADP-ribosylation factors (ARFs) complement ARF
            function in Saccharomyces cerevisiae
  JOURNAL   J Biol Chem 267 (34), 24441-24445 (1992)
   PUBMED   1447192
REFERENCE   7  (bases 1 to 4041)
  AUTHORS   Lee,C.M., Haun,R.S., Tsai,S.C., Moss,J. and Vaughan,M.
  TITLE     Characterization of the human gene encoding ADP-ribosylation factor
            1, a guanine nucleotide-binding activator of cholera toxin
  JOURNAL   J Biol Chem 267 (13), 9028-9034 (1992)
   PUBMED   1577740
REFERENCE   8  (bases 1 to 4041)
  AUTHORS   Tsai,S.C., Haun,R.S., Tsuchiya,M., Moss,J. and Vaughan,M.
  TITLE     Isolation and characterization of the human gene for
            ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding
            protein activator of cholera toxin
  JOURNAL   J Biol Chem 266 (34), 23053-23059 (1991)
   PUBMED   1744102
REFERENCE   9  (bases 1 to 4041)
  AUTHORS   Stearns,T., Willingham,M.C., Botstein,D. and Kahn,R.A.
  TITLE     ADP-ribosylation factor is functionally and physically associated
            with the Golgi complex
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1238-1242 (1990)
   PUBMED   2105501
REFERENCE   10 (bases 1 to 4041)
  AUTHORS   Bobak,D.A., Nightingale,M.S., Murtagh,J.J., Price,S.R., Moss,J. and
            Vaughan,M.
  TITLE     Molecular cloning, characterization, and expression of human
            ADP-ribosylation factors: two guanine nucleotide-dependent
            activators of cholera toxin
  JOURNAL   Proc Natl Acad Sci U S A 86 (16), 6101-6105 (1989)
   PUBMED   2474826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073610.17.
            
            On Nov 23, 2018 this sequence version replaced NM_001659.2.
            
            Summary: ADP-ribosylation factor 3 (ARF3) is a member of the human
            ARF gene family. These genes encode small guanine
            nucleotide-binding proteins that stimulate the
            ADP-ribosyltransferase activity of cholera toxin and play a role in
            vesicular trafficking and as activators of phospholipase D. The
            gene products include 6 ARF proteins and 11 ARF-like proteins and
            constitute one family of the RAS superfamily. The ARF proteins are
            categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and
            ARF5) and class III (ARF6) and members of each class share a common
            gene organization. [provided by RefSeq, Oct 2022].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1-10 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M74491.1, SRR3476690.1025705.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256682.9/ ENSP00000256682.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC073610.17        75382-75559         c
            179-419             AC073610.17        59020-59260         c
            420-530             AC073610.17        58069-58179         c
            531-655             AC073610.17        57727-57851         c
            656-4041            AC073610.17        53795-57180         c
FEATURES             Location/Qualifiers
     source          1..4041
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..4041
                     /gene="ARF3"
                     /note="ARF GTPase 3"
                     /db_xref="GeneID:377"
                     /db_xref="HGNC:HGNC:654"
                     /db_xref="MIM:103190"
     exon            1..178
                     /gene="ARF3"
                     /inference="alignment:Splign:2.1.0"
     exon            179..419
                     /gene="ARF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..817
                     /gene="ARF3"
                     /note="isoform a is encoded by transcript variant 1; small
                     GTP binding protein; ADP ribosylation factor 3"
                     /codon_start=1
                     /product="ADP-ribosylation factor 3 isoform a"
                     /protein_id="NP_001650.1"
                     /db_xref="CCDS:CCDS8774.1"
                     /db_xref="GeneID:377"
                     /db_xref="HGNC:HGNC:654"
                     /db_xref="MIM:103190"
                     /translation="MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVT
                     TIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNE
                     AREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCA
                     TSGDGLYEGLDWLANQLKNKK"
     exon            420..530
                     /gene="ARF3"
                     /inference="alignment:Splign:2.1.0"
     exon            531..655
                     /gene="ARF3"
                     /inference="alignment:Splign:2.1.0"
     exon            656..4041
                     /gene="ARF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1051..1056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF3"
                     /note="hexamer: AACAAA"
     polyA_site      1058
                     /gene="ARF3"
     regulatory      3537..3542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF3"
                     /note="hexamer: ATTAAA"
     polyA_site      3555
                     /gene="ARF3"
                     /note="major polyA site"
     regulatory      4019..4024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF3"
                     /note="hexamer: AATAAA"
     polyA_site      4041
                     /gene="ARF3"
ORIGIN      
        1 gcacagctcc agtcgccgtc gcggcttccg gtgctaggtg gagggaagga aggagggagc
       61 cggggagtgg gccagggcag cagccgggct gaagtcggct tggggagcca gagggagcgg
      121 agcggaacct gcggggcaga ggcggcggcc gcagcggcgc agctgatagc aggaacagga
      181 tcaagtcttc cataccaggg accaggccaa aaccagactg ccactgcccc tacttgggcc
      241 ccactgtccc cagaaagcag ctgctgtgat catgggcaat atctttggaa accttctcaa
      301 gagcctgatt gggaagaagg agatgcgcat cctgatggtg ggcctggatg ccgcaggaaa
      361 gaccaccatc ctatacaagc tgaaactcgg ggagatcgtc accaccatcc ctaccattgg
      421 gttcaatgtg gagacagtgg agtataagaa catcagcttt acagtgtggg atgtgggtgg
      481 ccaggacaag attcgacccc tctggagaca ctacttccag aacacccaag ggttgatatt
      541 tgtggtcgac agcaatgatc gggagcgagt aaatgaggcc cgggaagagc tgatgagaat
      601 gctggcggag gacgagctcc gggatgctgt actccttgtc tttgcaaaca aacaggatct
      661 gcctaatgct atgaacgctg ctgagatcac agacaagctg ggcctgcatt cccttcgtca
      721 ccgtaactgg tacattcagg ccacctgtgc caccagcggg gacgggctgt acgaaggcct
      781 ggactggctg gccaatcagc tcaaaaacaa gaagtgaaag ccagacagcc ctaacaaagc
      841 accccaccca cccctgacat acctactgtc accctgcccc agtcctaccc cttcctctcc
      901 atgcaagtgt ggccagggcc ctgggtatca tgtccacatg cccagcaaga gccttgcctc
      961 ccctgcctcc cctccttttt cctgtccacc tatatgacca atccctaatt gctgtcctga
     1021 tgatgagtca ttccaattta ctggatttaa aacaaaaagt tgttacggtt tcatggggtg
     1081 gcccctctct ctctcaccct ctgggtttcg ggaggtcgag tggggtattc tctttgtttg
     1141 gcagtggttg ctgtcctctt ggcatctgag tcctttccct gtccccacaa gcccttctac
     1201 tccctgtttg cctttccttt gccaccctct ccctgtttta catggaaatt gcacgggcct
     1261 ctctgtgttt gcgtgcatgt gtgcgcctgt atatacatgt atagagagat atatttgtgg
     1321 gggccggggg gagcggggag ggggtggagt gaagctcagg gcttgcagcc aggacactgc
     1381 ccactggagc ctgtcatctg ccccttccgt gttggtgaga ttaagggaag aaggtgggag
     1441 ggcattagtc aagccggact gccccagtct ttgactggtt accctcctct ctgcaggtag
     1501 gtttttctgg atgataggac agatgatgga ttcttcacca ccattttcct tgtactcttc
     1561 tctccaccct tcttagggct ggaggatggc atttatctct agatgactgt tcccaaggag
     1621 atgccactct gctctgcctt actgttggga aggagagagg aacccactca ctcttatcag
     1681 cttagagtgt tcaactgatc cttccccacc atcttcagat ctgttcctct ggagcttgac
     1741 tggggggtgg ggatggcaag tccatggtgt gtgttaggga cccagggcat tgggggaagg
     1801 gaggcgaagg cctgaggttt tccatcttca ttctcttttg ttattaggag aaggtgaggc
     1861 atgggccaat cccattcctg ccttccagtg ccccaccacc cttctgatct taggggttgg
     1921 atgggtcatc tgtccttggt cagaattttc tcaccctagt actcctactg gcctgaccag
     1981 ggctgactgg gtattctaat gaggagctgg gaagtggggt gacatagctg accttagtat
     2041 caacccccct cttctccaac tcttgttttc tagtccagga tatgctaaag gacgaagatt
     2101 ttctattgtt tccaggccct cagaccatcc ttgctgtccc ttcaccctcc atgcccctgc
     2161 catcctcact cacttctcat aaatggatct gggggttaga gtggaggaaa taaaatcctg
     2221 aagtggttgt cagtgcttgt gggatgcagt ggtcttcagg attctccccg cattattatg
     2281 tagttgttca gaagctgttg ctactgcgtc tctctgtctg cagggggcac ttgttcctga
     2341 ggtcctcgcc tgggtcctga cttctgtagt ttctgtgaag acgtggctgt cctgtgggct
     2401 cctgtgtgtg ctggctgcgc cctgagctcc gagacagctg cccataacct gctaaggtca
     2461 gggcccaggg ccccccacag catggctgag ggaccccttc ccagtagggc tgtcccaagc
     2521 cccactccat ggggccaggt ttcctggcca cttttgttga tagcagatgg atcaatatta
     2581 gtaaccccat ccaagattga actgtgaaag agaggttcca ggggtatctc cctcagtgcc
     2641 agttacttag tgatgtgtta cccaggatgc agcaggtgtg tgcaggtatc ttgctctcta
     2701 ggcctgtgtg tgtgtgtgag tgtgtgtgta tatgggtgtg ggtgtgtttg tgtgtggtgg
     2761 ttgtgggggg ggtgttggag gttctatttc atttaaaaat gtattcattt ccctggcccc
     2821 acagatgctt ccctccatac tttttatttg ctctgtttcc tcagatttat tttgtcttgc
     2881 cccattgcct ctccttcctt gaactctttc cttttcaatc tcaactcatt cactgctgtt
     2941 gctcatttgc ccttttccat gtattttttc ctacttagga ttttccactc tatctttgtg
     3001 gttcatgagg actttgcctc ttctcctgcc tcattccctg actttctcta gttagatgtc
     3061 agtcctaaat aggttttcct cacttcaggc ctcacccctc accttgtttt tttgggggct
     3121 ccagggacca atctggggct ggaaatgtta ggaggttgcc ttggtgctgc cccagatctg
     3181 tccagcaggg ggcagtaagt gatcttggta gtatccctgg ctgctaagcc cttggcaggg
     3241 gtggtccttt ctacattccc attcacttaa cagctctttt gggattgggt gtttcattcc
     3301 atttctgccc actccctctc ctctcctctc tggtaggttt aattttatgc tttccctgat
     3361 tccagctttc tgcttcctga ggactcccgc tccccccacc ccaaagtttg tctgtggtgt
     3421 tatagtggta actgcagttc ctcctctgga atgtagactg tatatgttta ataactcacc
     3481 ttctctatcc ttgctcaaaa tgtgggataa cgcgatgact gtgaccctgg ttggaaatta
     3541 aacttgtttt atgcagcttt ggagccgacc ttcatctttg ctgtgcagca gccgtgggac
     3601 agtagtttca tggtgagggg agtcctgttt ctggtccctc tctccatagt gctccttctt
     3661 tcagcaaagg ggtaaaaggc acacttgatt gatagagagt aaggttatgg aggaacttag
     3721 tgccactcca cactggttat ttcttcccat cataccccgc ggcgggggag cccaaatgaa
     3781 ttgggcatca gagtgtgagg gcttcgtgac tttcctcctc tagttctaaa gggtttaaac
     3841 ctgaaatcag ctgtatttct cacctgttgg tagactgtat ggacttcact ggctgaaggg
     3901 ccctgaactt ggagggcccc atgtgcctct actctcagat ctcctcagcc ttgcacatga
     3961 ggtgcttcta gtttgaacag agaccccctc actagtctag ttctggactt tggcagtgaa
     4021 taaacatgaa ggataaacgt c
//
