LOCUS       NM_001412930            4294 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF GTPase 3 (ARF3), transcript variant 9, mRNA.
ACCESSION   NM_001412930
VERSION     NM_001412930.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4294)
  AUTHORS   Dos Santos Henrique,S., Franca,M.J., Silva Junior,R.C.,
            Santos,M.L.S.F. and do Valle,D.A.
  TITLE     Neurodevelopmental disorder associated with gene ARF3: A case
            report
  JOURNAL   Am J Med Genet A 194 (9), e63658 (2024)
   PUBMED   38712921
REFERENCE   2  (bases 1 to 4294)
  AUTHORS   Sandilands,E., Freckmann,E.C., Cumming,E.M., Roman-Fernandez,A.,
            McGarry,L., Anand,J., Galbraith,L., Mason,S., Patel,R., Nixon,C.,
            Cartwright,J., Leung,H.Y., Blyth,K. and Bryant,D.M.
  TITLE     The small GTPase ARF3 controls invasion modality and metastasis by
            regulating N-cadherin levels
  JOURNAL   J Cell Biol 222 (4) (2023)
   PUBMED   36880595
  REMARK    GeneRIF: The small GTPase ARF3 controls invasion modality and
            metastasis by regulating N-cadherin levels.
REFERENCE   3  (bases 1 to 4294)
  AUTHORS   Fasano,G., Muto,V., Radio,F.C., Venditti,M., Mosaddeghzadeh,N.,
            Coppola,S., Paradisi,G., Zara,E., Bazgir,F., Ziegler,A.,
            Chillemi,G., Bertuccini,L., Tinari,A., Vetro,A., Pantaleoni,F.,
            Pizzi,S., Conti,L.A., Petrini,S., Bruselles,A., Prandi,I.G.,
            Mancini,C., Chandramouli,B., Barth,M., Bris,C., Milani,D.,
            Selicorni,A., Macchiaiolo,M., Gonfiantini,M.V., Bartuli,A.,
            Mariani,R., Curry,C.J., Guerrini,R., Slavotinek,A., Iascone,M.,
            Dallapiccola,B., Ahmadian,M.R., Lauri,A. and Tartaglia,M.
  TITLE     Dominant ARF3 variants disrupt Golgi integrity and cause a
            neurodevelopmental disorder recapitulated in zebrafish
  JOURNAL   Nat Commun 13 (1), 6841 (2022)
   PUBMED   36369169
  REMARK    GeneRIF: Dominant ARF3 variants disrupt Golgi integrity and cause a
            neurodevelopmental disorder recapitulated in zebrafish.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4294)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4294)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4294)
  AUTHORS   Lee,F.J., Moss,J. and Vaughan,M.
  TITLE     Human and Giardia ADP-ribosylation factors (ARFs) complement ARF
            function in Saccharomyces cerevisiae
  JOURNAL   J Biol Chem 267 (34), 24441-24445 (1992)
   PUBMED   1447192
REFERENCE   7  (bases 1 to 4294)
  AUTHORS   Lee,C.M., Haun,R.S., Tsai,S.C., Moss,J. and Vaughan,M.
  TITLE     Characterization of the human gene encoding ADP-ribosylation factor
            1, a guanine nucleotide-binding activator of cholera toxin
  JOURNAL   J Biol Chem 267 (13), 9028-9034 (1992)
   PUBMED   1577740
REFERENCE   8  (bases 1 to 4294)
  AUTHORS   Tsai,S.C., Haun,R.S., Tsuchiya,M., Moss,J. and Vaughan,M.
  TITLE     Isolation and characterization of the human gene for
            ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding
            protein activator of cholera toxin
  JOURNAL   J Biol Chem 266 (34), 23053-23059 (1991)
   PUBMED   1744102
REFERENCE   9  (bases 1 to 4294)
  AUTHORS   Stearns,T., Willingham,M.C., Botstein,D. and Kahn,R.A.
  TITLE     ADP-ribosylation factor is functionally and physically associated
            with the Golgi complex
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1238-1242 (1990)
   PUBMED   2105501
REFERENCE   10 (bases 1 to 4294)
  AUTHORS   Bobak,D.A., Nightingale,M.S., Murtagh,J.J., Price,S.R., Moss,J. and
            Vaughan,M.
  TITLE     Molecular cloning, characterization, and expression of human
            ADP-ribosylation factors: two guanine nucleotide-dependent
            activators of cholera toxin
  JOURNAL   Proc Natl Acad Sci U S A 86 (16), 6101-6105 (1989)
   PUBMED   2474826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073610.17.
            
            Summary: ADP-ribosylation factor 3 (ARF3) is a member of the human
            ARF gene family. These genes encode small guanine
            nucleotide-binding proteins that stimulate the
            ADP-ribosyltransferase activity of cholera toxin and play a role in
            vesicular trafficking and as activators of phospholipase D. The
            gene products include 6 ARF proteins and 11 ARF-like proteins and
            constitute one family of the RAS superfamily. The ARF proteins are
            categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and
            ARF5) and class III (ARF6) and members of each class share a common
            gene organization. [provided by RefSeq, Oct 2022].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1948046.1,
                                           SRR18074969.956910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC073610.17        75382-75559         c
            179-431             AC073610.17        74170-74422         c
            432-672             AC073610.17        59020-59260         c
            673-783             AC073610.17        58069-58179         c
            784-908             AC073610.17        57727-57851         c
            909-4294            AC073610.17        53795-57180         c
FEATURES             Location/Qualifiers
     source          1..4294
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..4294
                     /gene="ARF3"
                     /note="ARF GTPase 3"
                     /db_xref="GeneID:377"
                     /db_xref="HGNC:HGNC:654"
                     /db_xref="MIM:103190"
     exon            1..178
                     /gene="ARF3"
                     /inference="alignment:Splign:2.1.0"
     exon            179..431
                     /gene="ARF3"
                     /inference="alignment:Splign:2.1.0"
     exon            432..672
                     /gene="ARF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             525..1070
                     /gene="ARF3"
                     /note="isoform a is encoded by transcript variant 9; small
                     GTP binding protein; ADP ribosylation factor 3"
                     /codon_start=1
                     /product="ADP-ribosylation factor 3 isoform a"
                     /protein_id="NP_001399859.1"
                     /db_xref="GeneID:377"
                     /db_xref="HGNC:HGNC:654"
                     /db_xref="MIM:103190"
                     /translation="MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVT
                     TIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNE
                     AREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCA
                     TSGDGLYEGLDWLANQLKNKK"
     exon            673..783
                     /gene="ARF3"
                     /inference="alignment:Splign:2.1.0"
     exon            784..908
                     /gene="ARF3"
                     /inference="alignment:Splign:2.1.0"
     exon            909..4294
                     /gene="ARF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1304..1309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF3"
                     /note="hexamer: AACAAA"
     polyA_site      1311
                     /gene="ARF3"
     regulatory      3790..3795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF3"
                     /note="hexamer: ATTAAA"
     polyA_site      3808
                     /gene="ARF3"
                     /note="major polyA site"
     regulatory      4272..4277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF3"
                     /note="hexamer: AATAAA"
     polyA_site      4294
                     /gene="ARF3"
ORIGIN      
        1 gcacagctcc agtcgccgtc gcggcttccg gtgctaggtg gagggaagga aggagggagc
       61 cggggagtgg gccagggcag cagccgggct gaagtcggct tggggagcca gagggagcgg
      121 agcggaacct gcggggcaga ggcggcggcc gcagcggcgc agctgatagc aggaacaggc
      181 caggaggaat gtggtggtgg aggtggagga ttgtggtatg tggtcaggag tgagaagaaa
      241 tagtaaggcc gtcccggtga gggagaaatg taacctaaaa cctgtctctg ctgttgttgg
      301 attgggtcac ccctggtcta tggcatgaaa gttttattgg gaggagatct gctgcaagag
      361 tctgattgct tgggtcagtg caacaggaca gaatctagtc gctgcatacc tccttccctg
      421 tcctcaatca ggatcaagtc ttccatacca gggaccaggc caaaaccaga ctgccactgc
      481 ccctacttgg gccccactgt ccccagaaag cagctgctgt gatcatgggc aatatctttg
      541 gaaaccttct caagagcctg attgggaaga aggagatgcg catcctgatg gtgggcctgg
      601 atgccgcagg aaagaccacc atcctataca agctgaaact cggggagatc gtcaccacca
      661 tccctaccat tgggttcaat gtggagacag tggagtataa gaacatcagc tttacagtgt
      721 gggatgtggg tggccaggac aagattcgac ccctctggag acactacttc cagaacaccc
      781 aagggttgat atttgtggtc gacagcaatg atcgggagcg agtaaatgag gcccgggaag
      841 agctgatgag aatgctggcg gaggacgagc tccgggatgc tgtactcctt gtctttgcaa
      901 acaaacagga tctgcctaat gctatgaacg ctgctgagat cacagacaag ctgggcctgc
      961 attcccttcg tcaccgtaac tggtacattc aggccacctg tgccaccagc ggggacgggc
     1021 tgtacgaagg cctggactgg ctggccaatc agctcaaaaa caagaagtga aagccagaca
     1081 gccctaacaa agcaccccac ccacccctga catacctact gtcaccctgc cccagtccta
     1141 ccccttcctc tccatgcaag tgtggccagg gccctgggta tcatgtccac atgcccagca
     1201 agagccttgc ctcccctgcc tcccctcctt tttcctgtcc acctatatga ccaatcccta
     1261 attgctgtcc tgatgatgag tcattccaat ttactggatt taaaacaaaa agttgttacg
     1321 gtttcatggg gtggcccctc tctctctcac cctctgggtt tcgggaggtc gagtggggta
     1381 ttctctttgt ttggcagtgg ttgctgtcct cttggcatct gagtcctttc cctgtcccca
     1441 caagcccttc tactccctgt ttgcctttcc tttgccaccc tctccctgtt ttacatggaa
     1501 attgcacggg cctctctgtg tttgcgtgca tgtgtgcgcc tgtatataca tgtatagaga
     1561 gatatatttg tgggggccgg ggggagcggg gagggggtgg agtgaagctc agggcttgca
     1621 gccaggacac tgcccactgg agcctgtcat ctgccccttc cgtgttggtg agattaaggg
     1681 aagaaggtgg gagggcatta gtcaagccgg actgccccag tctttgactg gttaccctcc
     1741 tctctgcagg taggtttttc tggatgatag gacagatgat ggattcttca ccaccatttt
     1801 ccttgtactc ttctctccac ccttcttagg gctggaggat ggcatttatc tctagatgac
     1861 tgttcccaag gagatgccac tctgctctgc cttactgttg ggaaggagag aggaacccac
     1921 tcactcttat cagcttagag tgttcaactg atccttcccc accatcttca gatctgttcc
     1981 tctggagctt gactgggggg tggggatggc aagtccatgg tgtgtgttag ggacccaggg
     2041 cattggggga agggaggcga aggcctgagg ttttccatct tcattctctt ttgttattag
     2101 gagaaggtga ggcatgggcc aatcccattc ctgccttcca gtgccccacc acccttctga
     2161 tcttaggggt tggatgggtc atctgtcctt ggtcagaatt ttctcaccct agtactccta
     2221 ctggcctgac cagggctgac tgggtattct aatgaggagc tgggaagtgg ggtgacatag
     2281 ctgaccttag tatcaacccc cctcttctcc aactcttgtt ttctagtcca ggatatgcta
     2341 aaggacgaag attttctatt gtttccaggc cctcagacca tccttgctgt cccttcaccc
     2401 tccatgcccc tgccatcctc actcacttct cataaatgga tctgggggtt agagtggagg
     2461 aaataaaatc ctgaagtggt tgtcagtgct tgtgggatgc agtggtcttc aggattctcc
     2521 ccgcattatt atgtagttgt tcagaagctg ttgctactgc gtctctctgt ctgcaggggg
     2581 cacttgttcc tgaggtcctc gcctgggtcc tgacttctgt agtttctgtg aagacgtggc
     2641 tgtcctgtgg gctcctgtgt gtgctggctg cgccctgagc tccgagacag ctgcccataa
     2701 cctgctaagg tcagggccca gggcccccca cagcatggct gagggacccc ttcccagtag
     2761 ggctgtccca agccccactc catggggcca ggtttcctgg ccacttttgt tgatagcaga
     2821 tggatcaata ttagtaaccc catccaagat tgaactgtga aagagaggtt ccaggggtat
     2881 ctccctcagt gccagttact tagtgatgtg ttacccagga tgcagcaggt gtgtgcaggt
     2941 atcttgctct ctaggcctgt gtgtgtgtgt gagtgtgtgt gtatatgggt gtgggtgtgt
     3001 ttgtgtgtgg tggttgtggg gggggtgttg gaggttctat ttcatttaaa aatgtattca
     3061 tttccctggc cccacagatg cttccctcca tactttttat ttgctctgtt tcctcagatt
     3121 tattttgtct tgccccattg cctctccttc cttgaactct ttccttttca atctcaactc
     3181 attcactgct gttgctcatt tgcccttttc catgtatttt ttcctactta ggattttcca
     3241 ctctatcttt gtggttcatg aggactttgc ctcttctcct gcctcattcc ctgactttct
     3301 ctagttagat gtcagtccta aataggtttt cctcacttca ggcctcaccc ctcaccttgt
     3361 ttttttgggg gctccaggga ccaatctggg gctggaaatg ttaggaggtt gccttggtgc
     3421 tgccccagat ctgtccagca gggggcagta agtgatcttg gtagtatccc tggctgctaa
     3481 gcccttggca ggggtggtcc tttctacatt cccattcact taacagctct tttgggattg
     3541 ggtgtttcat tccatttctg cccactccct ctcctctcct ctctggtagg tttaatttta
     3601 tgctttccct gattccagct ttctgcttcc tgaggactcc cgctcccccc accccaaagt
     3661 ttgtctgtgg tgttatagtg gtaactgcag ttcctcctct ggaatgtaga ctgtatatgt
     3721 ttaataactc accttctcta tccttgctca aaatgtggga taacgcgatg actgtgaccc
     3781 tggttggaaa ttaaacttgt tttatgcagc tttggagccg accttcatct ttgctgtgca
     3841 gcagccgtgg gacagtagtt tcatggtgag gggagtcctg tttctggtcc ctctctccat
     3901 agtgctcctt ctttcagcaa aggggtaaaa ggcacacttg attgatagag agtaaggtta
     3961 tggaggaact tagtgccact ccacactggt tatttcttcc catcataccc cgcggcgggg
     4021 gagcccaaat gaattgggca tcagagtgtg agggcttcgt gactttcctc ctctagttct
     4081 aaagggttta aacctgaaat cagctgtatt tctcacctgt tggtagactg tatggacttc
     4141 actggctgaa gggccctgaa cttggagggc cccatgtgcc tctactctca gatctcctca
     4201 gccttgcaca tgaggtgctt ctagtttgaa cagagacccc ctcactagtc tagttctgga
     4261 ctttggcagt gaataaacat gaaggataaa cgtc
//
