LOCUS       NM_001658               1840 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ARF GTPase 1 (ARF1), transcript variant 4, mRNA.
ACCESSION   NM_001658
VERSION     NM_001658.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Ishiguro,T., Noda,M., Nishikawa,M., Nagata,K.I. and Ito,H.
  TITLE     Variations associated with neurodevelopmental disorders affect ARF1
            function and cortical development
  JOURNAL   J Biochem 176 (5), 347-357 (2024)
   PUBMED   39052890
  REMARK    GeneRIF: Variations associated with neurodevelopmental disorders
            affect ARF1 function and cortical development.
REFERENCE   2  (bases 1 to 1840)
  AUTHORS   Zhou,J., Zhang,L., Peng,J., Zhang,X., Zhang,F., Wu,Y., Huang,A.,
            Du,F., Liao,Y., He,Y., Xie,Y., Gu,L., Kuang,C., Ou,W., Xie,M.,
            Tu,T., Pang,J., Zhang,D., Guo,K., Feng,Y., Yin,S., Cao,Y., Li,T.
            and Jiang,Y.
  TITLE     Astrocytic LRP1 enables mitochondria transfer to neurons and
            mitigates brain ischemic stroke by suppressing ARF1 lactylation
  JOURNAL   Cell Metab 36 (9), 2054-2068 (2024)
   PUBMED   38906140
  REMARK    GeneRIF: Astrocytic LRP1 enables mitochondria transfer to neurons
            and mitigates brain ischemic stroke by suppressing ARF1
            lactylation.
REFERENCE   3  (bases 1 to 1840)
  AUTHORS   Mu,Q., Wang,X., Huang,K., Xia,B., Bi,S. and Kong,Y.
  TITLE     THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through the
            miR-320d/ARF1 axis
  JOURNAL   FASEB J 38 (13), e23772 (2024)
   PUBMED   38963337
  REMARK    GeneRIF: THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through
            the miR-320d/ARF1 axis.
REFERENCE   4  (bases 1 to 1840)
  AUTHORS   Hirschenberger,M., Lepelley,A., Rupp,U., Klute,S., Hunszinger,V.,
            Koepke,L., Merold,V., Didry-Barca,B., Wondany,F., Bergner,T.,
            Moreau,T., Rodero,M.P., Rosler,R., Wiese,S., Volpi,S., Gattorno,M.,
            Papa,R., Lynch,S.A., Haug,M.G., Houge,G., Wigby,K.M., Sprague,J.,
            Lenberg,J., Read,C., Walther,P., Michaelis,J., Kirchhoff,F., de
            Oliveira Mann,C.C., Crow,Y.J. and Sparrer,K.M.J.
  TITLE     ARF1 prevents aberrant type I interferon induction by regulating
            STING activation and recycling
  JOURNAL   Nat Commun 14 (1), 6770 (2023)
   PUBMED   37914730
  REMARK    GeneRIF: ARF1 prevents aberrant type I interferon induction by
            regulating STING activation and recycling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1840)
  AUTHORS   de Sainte Agathe,J.M., Pode-Shakked,B., Naudion,S., Michaud,V.,
            Arveiler,B., Fergelot,P., Delmas,J., Keren,B., Poirsier,C.,
            Alkuraya,F.S., Tabarki,B., Bend,E., Davis,K., Bebin,M.,
            Thompson,M.L., Bryant,E.M., Wagner,M., Hannibal,I., Lenberg,J.,
            Krenn,M., Wigby,K.M., Friedman,J.R., Iascone,M., Cereda,A.,
            Miao,T., LeGuern,E., Argilli,E., Sherr,E., Caluseriu,O.,
            Tidwell,T., Bayrak-Toydemir,P., Hagedorn,C., Brugger,M., Vill,K.,
            Morneau-Jacob,F.D., Chung,W., Weaver,K.N., Owens,J.W., Husami,A.,
            Chaudhari,B.P., Stone,B.S., Burns,K., Li,R., de Lange,I.M.,
            Biehler,M., Ginglinger,E., Gerard,B., Stottmann,R.W. and
            Trimouille,A.
  TITLE     ARF1-related disorder: phenotypic and molecular spectrum
  JOURNAL   J Med Genet 60 (10), 999-1005 (2023)
   PUBMED   37185208
  REMARK    GeneRIF: ARF1-related disorder: phenotypic and molecular spectrum.
REFERENCE   6  (bases 1 to 1840)
  AUTHORS   Lee,C.M., Haun,R.S., Tsai,S.C., Moss,J. and Vaughan,M.
  TITLE     Characterization of the human gene encoding ADP-ribosylation factor
            1, a guanine nucleotide-binding activator of cholera toxin
  JOURNAL   J Biol Chem 267 (13), 9028-9034 (1992)
   PUBMED   1577740
REFERENCE   7  (bases 1 to 1840)
  AUTHORS   Serafini,T., Orci,L., Amherdt,M., Brunner,M., Kahn,R.A. and
            Rothman,J.E.
  TITLE     ADP-ribosylation factor is a subunit of the coat of Golgi-derived
            COP-coated vesicles: a novel role for a GTP-binding protein
  JOURNAL   Cell 67 (2), 239-253 (1991)
   PUBMED   1680566
REFERENCE   8  (bases 1 to 1840)
  AUTHORS   Kahn,R.A., Kern,F.G., Clark,J., Gelmann,E.P. and Rulka,C.
  TITLE     Human ADP-ribosylation factors. A functionally conserved family of
            GTP-binding proteins
  JOURNAL   J Biol Chem 266 (4), 2606-2614 (1991)
   PUBMED   1899243
REFERENCE   9  (bases 1 to 1840)
  AUTHORS   Stearns,T., Willingham,M.C., Botstein,D. and Kahn,R.A.
  TITLE     ADP-ribosylation factor is functionally and physically associated
            with the Golgi complex
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1238-1242 (1990)
   PUBMED   2105501
REFERENCE   10 (bases 1 to 1840)
  AUTHORS   Bobak,D.A., Nightingale,M.S., Murtagh,J.J., Price,S.R., Moss,J. and
            Vaughan,M.
  TITLE     Molecular cloning, characterization, and expression of human
            ADP-ribosylation factors: two guanine nucleotide-dependent
            activators of cholera toxin
  JOURNAL   Proc Natl Acad Sci U S A 86 (16), 6101-6105 (1989)
   PUBMED   2474826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK000620.1 and BF337061.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001658.3.
            
            Summary: ADP-ribosylation factor 1 (ARF1) is a member of the human
            ARF gene family. The family members encode small guanine
            nucleotide-binding proteins that stimulate the
            ADP-ribosyltransferase activity of cholera toxin and play a role in
            vesicular trafficking as activators of phospholipase D. The gene
            products, including 6 ARF proteins and 11 ARF-like proteins,
            constitute a family of the RAS superfamily. The ARF proteins are
            categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and
            ARF5) and class III (ARF6), and members of each class share a
            common gene organization. The ARF1 protein is localized to the
            Golgi apparatus and has a central role in intra-Golgi transport.
            Multiple alternatively spliced transcript variants encoding the
            same protein have been found for this gene. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (4) has an alternate and shorter
            5' UTR, as compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000620.1, BC011358.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272102.10/ ENSP00000272102.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1837              AK000620.1         49-1885
            1838-1840           BF337061.1         612-614
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..1840
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /note="ARF GTPase 1"
                     /db_xref="GeneID:375"
                     /db_xref="HGNC:HGNC:652"
                     /db_xref="MIM:103180"
     exon            1..58
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /inference="alignment:Splign:2.1.0"
     exon            59..243
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..641
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /EC_number="3.6.5.2"
                     /note="ADP ribosylation factor 1"
                     /codon_start=1
                     /product="ADP-ribosylation factor 1"
                     /protein_id="NP_001649.1"
                     /db_xref="CCDS:CCDS1565.1"
                     /db_xref="GeneID:375"
                     /db_xref="HGNC:HGNC:652"
                     /db_xref="MIM:103180"
                     /translation="MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVT
                     TIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNE
                     AREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCA
                     TSGDGLYEGLDWLSNQLRNQK"
     exon            244..354
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /inference="alignment:Splign:2.1.0"
     exon            355..479
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /inference="alignment:Splign:2.1.0"
     exon            480..1840
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1734..1739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /note="hexamer: AATACA"
     polyA_site      1753
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /note="major polyA site"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /note="hexamer: AATAAA"
     polyA_site      1840
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /note="major polyA site"
ORIGIN      
        1 agagccgcca tcttgtggga gcaaaaccaa cgcctggctc ggagcagcag cctctgaggt
       61 gtccctggcc agtgtccttc cacctgtcca caagcatggg gaacatcttc gccaacctct
      121 tcaagggcct ttttggcaaa aaagaaatgc gcatcctcat ggtgggcctg gatgctgcag
      181 ggaagaccac gatcctctac aagcttaagc tgggtgagat cgtgaccacc attcccacca
      241 taggcttcaa cgtggaaacc gtggagtaca agaacatcag cttcactgtg tgggacgtgg
      301 gtggccagga caagatccgg cccctgtggc gccactactt ccagaacaca caaggcctga
      361 tcttcgtggt ggacagcaat gacagagagc gtgtgaacga ggcccgtgag gagctcatga
      421 ggatgctggc cgaggacgag ctccgggatg ctgtcctcct ggtgttcgcc aacaagcagg
      481 acctccccaa cgccatgaat gcggccgaga tcacagacaa gctggggctg cactcactac
      541 gccacaggaa ctggtacatt caggccacct gcgccaccag cggcgacggg ctctatgaag
      601 gactggactg gctgtccaat cagctccgga accagaagtg aacgcgaccc ccctccctct
      661 cactcctctt gccctctgct ttactctcat gtggcaaacg tgcggctcgt ggtgtgagtg
      721 ccagaagctg cctccgtggt ttggtcaccg tgtgcatcgc accgtgctgt aaatgtggca
      781 gacgcagcct gcggccaggc tttttattta atgtaaatag tttttgtttc caatgaggca
      841 gtttctggta ctcctatgca atattactca gcttttttta ttgtaaaaag aaaaatcaac
      901 tcactgttca gtgctgagag gggatgtagg cccatgggca cctggcctcc aggagtcgct
      961 gtgttgggag agccggccac gcccttggct ttagagctgt gttgaaatcc attttggtgg
     1021 ttggttttta acccaaactc agtgcatttt ttaaaatagt taagaatcca agtcgagaac
     1081 acttgaacac acagaaggga gaccccgcct agcatagatt tgcagttacg gcctggatgc
     1141 cagtcgccag cccagctgtt cccctcggga acatgaggtg gtggtggcgc agcagactgc
     1201 gatcaattct gcatggtcac agtagagatc cccgcaactc gcttgtcctt gggtcaccct
     1261 gcattccata gccatgtgct tgtccctgtg ctcccacggt tcccaggggc caggctggga
     1321 gcccacagcc accccactat gccgcaggcc gccctaccca ccttcaggca gcctatggga
     1381 cgcagggccc catctgtccc tcggtcgccg tgtggccaga gtgggtccgt cgtccccaac
     1441 actcgtgctc gctcagacac tttggcagga tgtctggggc ctcaccagca ggagcgcgtg
     1501 caagccgggc aggcggtcca cctagaccca cagcccctcg ggagcacccc acctctgtgt
     1561 gtgatgtagc tttctctccc tcagcctgca agggtccgat ttgccatcga aaaagacaac
     1621 ctctactttt ttcttttgta ttttgataaa cactgaagct ggagctgtta aatttatctt
     1681 ggggaaacct cagaactggt ctatttggtg tcgtggaacc tcttactgct ttcaatacac
     1741 gattagtaat caactgtttt gtatacttgt tttcagtttt catttcgaca aacaagcact
     1801 gtaattatag ctattagaat aaaatctctt aactatttca
//
