LOCUS       NM_001024226            1925 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ARF GTPase 1 (ARF1), transcript variant 3, mRNA.
ACCESSION   NM_001024226
VERSION     NM_001024226.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1925)
  AUTHORS   Ishiguro,T., Noda,M., Nishikawa,M., Nagata,K.I. and Ito,H.
  TITLE     Variations associated with neurodevelopmental disorders affect ARF1
            function and cortical development
  JOURNAL   J Biochem 176 (5), 347-357 (2024)
   PUBMED   39052890
  REMARK    GeneRIF: Variations associated with neurodevelopmental disorders
            affect ARF1 function and cortical development.
REFERENCE   2  (bases 1 to 1925)
  AUTHORS   Zhou,J., Zhang,L., Peng,J., Zhang,X., Zhang,F., Wu,Y., Huang,A.,
            Du,F., Liao,Y., He,Y., Xie,Y., Gu,L., Kuang,C., Ou,W., Xie,M.,
            Tu,T., Pang,J., Zhang,D., Guo,K., Feng,Y., Yin,S., Cao,Y., Li,T.
            and Jiang,Y.
  TITLE     Astrocytic LRP1 enables mitochondria transfer to neurons and
            mitigates brain ischemic stroke by suppressing ARF1 lactylation
  JOURNAL   Cell Metab 36 (9), 2054-2068 (2024)
   PUBMED   38906140
  REMARK    GeneRIF: Astrocytic LRP1 enables mitochondria transfer to neurons
            and mitigates brain ischemic stroke by suppressing ARF1
            lactylation.
REFERENCE   3  (bases 1 to 1925)
  AUTHORS   Mu,Q., Wang,X., Huang,K., Xia,B., Bi,S. and Kong,Y.
  TITLE     THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through the
            miR-320d/ARF1 axis
  JOURNAL   FASEB J 38 (13), e23772 (2024)
   PUBMED   38963337
  REMARK    GeneRIF: THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through
            the miR-320d/ARF1 axis.
REFERENCE   4  (bases 1 to 1925)
  AUTHORS   Hirschenberger,M., Lepelley,A., Rupp,U., Klute,S., Hunszinger,V.,
            Koepke,L., Merold,V., Didry-Barca,B., Wondany,F., Bergner,T.,
            Moreau,T., Rodero,M.P., Rosler,R., Wiese,S., Volpi,S., Gattorno,M.,
            Papa,R., Lynch,S.A., Haug,M.G., Houge,G., Wigby,K.M., Sprague,J.,
            Lenberg,J., Read,C., Walther,P., Michaelis,J., Kirchhoff,F., de
            Oliveira Mann,C.C., Crow,Y.J. and Sparrer,K.M.J.
  TITLE     ARF1 prevents aberrant type I interferon induction by regulating
            STING activation and recycling
  JOURNAL   Nat Commun 14 (1), 6770 (2023)
   PUBMED   37914730
  REMARK    GeneRIF: ARF1 prevents aberrant type I interferon induction by
            regulating STING activation and recycling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1925)
  AUTHORS   de Sainte Agathe,J.M., Pode-Shakked,B., Naudion,S., Michaud,V.,
            Arveiler,B., Fergelot,P., Delmas,J., Keren,B., Poirsier,C.,
            Alkuraya,F.S., Tabarki,B., Bend,E., Davis,K., Bebin,M.,
            Thompson,M.L., Bryant,E.M., Wagner,M., Hannibal,I., Lenberg,J.,
            Krenn,M., Wigby,K.M., Friedman,J.R., Iascone,M., Cereda,A.,
            Miao,T., LeGuern,E., Argilli,E., Sherr,E., Caluseriu,O.,
            Tidwell,T., Bayrak-Toydemir,P., Hagedorn,C., Brugger,M., Vill,K.,
            Morneau-Jacob,F.D., Chung,W., Weaver,K.N., Owens,J.W., Husami,A.,
            Chaudhari,B.P., Stone,B.S., Burns,K., Li,R., de Lange,I.M.,
            Biehler,M., Ginglinger,E., Gerard,B., Stottmann,R.W. and
            Trimouille,A.
  TITLE     ARF1-related disorder: phenotypic and molecular spectrum
  JOURNAL   J Med Genet 60 (10), 999-1005 (2023)
   PUBMED   37185208
  REMARK    GeneRIF: ARF1-related disorder: phenotypic and molecular spectrum.
REFERENCE   6  (bases 1 to 1925)
  AUTHORS   Lee,C.M., Haun,R.S., Tsai,S.C., Moss,J. and Vaughan,M.
  TITLE     Characterization of the human gene encoding ADP-ribosylation factor
            1, a guanine nucleotide-binding activator of cholera toxin
  JOURNAL   J Biol Chem 267 (13), 9028-9034 (1992)
   PUBMED   1577740
REFERENCE   7  (bases 1 to 1925)
  AUTHORS   Serafini,T., Orci,L., Amherdt,M., Brunner,M., Kahn,R.A. and
            Rothman,J.E.
  TITLE     ADP-ribosylation factor is a subunit of the coat of Golgi-derived
            COP-coated vesicles: a novel role for a GTP-binding protein
  JOURNAL   Cell 67 (2), 239-253 (1991)
   PUBMED   1680566
REFERENCE   8  (bases 1 to 1925)
  AUTHORS   Kahn,R.A., Kern,F.G., Clark,J., Gelmann,E.P. and Rulka,C.
  TITLE     Human ADP-ribosylation factors. A functionally conserved family of
            GTP-binding proteins
  JOURNAL   J Biol Chem 266 (4), 2606-2614 (1991)
   PUBMED   1899243
REFERENCE   9  (bases 1 to 1925)
  AUTHORS   Stearns,T., Willingham,M.C., Botstein,D. and Kahn,R.A.
  TITLE     ADP-ribosylation factor is functionally and physically associated
            with the Golgi complex
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1238-1242 (1990)
   PUBMED   2105501
REFERENCE   10 (bases 1 to 1925)
  AUTHORS   Bobak,D.A., Nightingale,M.S., Murtagh,J.J., Price,S.R., Moss,J. and
            Vaughan,M.
  TITLE     Molecular cloning, characterization, and expression of human
            ADP-ribosylation factors: two guanine nucleotide-dependent
            activators of cholera toxin
  JOURNAL   Proc Natl Acad Sci U S A 86 (16), 6101-6105 (1989)
   PUBMED   2474826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK000620.1, BM844480.1 and
            BF337061.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001024226.1.
            
            Summary: ADP-ribosylation factor 1 (ARF1) is a member of the human
            ARF gene family. The family members encode small guanine
            nucleotide-binding proteins that stimulate the
            ADP-ribosyltransferase activity of cholera toxin and play a role in
            vesicular trafficking as activators of phospholipase D. The gene
            products, including 6 ARF proteins and 11 ARF-like proteins,
            constitute a family of the RAS superfamily. The ARF proteins are
            categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and
            ARF5) and class III (ARF6), and members of each class share a
            common gene organization. The ARF1 protein is localized to the
            Golgi apparatus and has a central role in intra-Golgi transport.
            Multiple alternatively spliced transcript variants encoding the
            same protein have been found for this gene. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (3) has an alternate and shorter
            5' UTR, as compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL543979.3, CX870712.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AK000620.1         49-99
            52-468              BM844480.1         1-417
            469-1922            AK000620.1         432-1885
            1923-1925           BF337061.1         612-614
FEATURES             Location/Qualifiers
     source          1..1925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..1925
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /note="ARF GTPase 1"
                     /db_xref="GeneID:375"
                     /db_xref="HGNC:HGNC:652"
                     /db_xref="MIM:103180"
     exon            1..143
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /inference="alignment:Splign:2.1.0"
     exon            144..328
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..726
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /EC_number="3.6.5.2"
                     /note="ADP ribosylation factor 1"
                     /codon_start=1
                     /product="ADP-ribosylation factor 1"
                     /protein_id="NP_001019397.1"
                     /db_xref="CCDS:CCDS1565.1"
                     /db_xref="GeneID:375"
                     /db_xref="HGNC:HGNC:652"
                     /db_xref="MIM:103180"
                     /translation="MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVT
                     TIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNE
                     AREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCA
                     TSGDGLYEGLDWLSNQLRNQK"
     exon            329..439
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /inference="alignment:Splign:2.1.0"
     exon            440..564
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /inference="alignment:Splign:2.1.0"
     exon            565..1925
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1819..1824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /note="hexamer: AATACA"
     polyA_site      1838
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /note="major polyA site"
     regulatory      1903..1908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /note="hexamer: AATAAA"
     polyA_site      1925
                     /gene="ARF1"
                     /gene_synonym="PVNH8"
                     /note="major polyA site"
ORIGIN      
        1 agagccgcca tcttgtggga gcaaaaccaa cgcctggctc ggagcagcag cctctgaggt
       61 gagggcgagg ggcgcgggcc ggtgtgggcc gcagagacgt tggagccggc gggggctggg
      121 gactggcctc ggggcgactt gaggtgtccc tggccagtgt ccttccacct gtccacaagc
      181 atggggaaca tcttcgccaa cctcttcaag ggcctttttg gcaaaaaaga aatgcgcatc
      241 ctcatggtgg gcctggatgc tgcagggaag accacgatcc tctacaagct taagctgggt
      301 gagatcgtga ccaccattcc caccataggc ttcaacgtgg aaaccgtgga gtacaagaac
      361 atcagcttca ctgtgtggga cgtgggtggc caggacaaga tccggcccct gtggcgccac
      421 tacttccaga acacacaagg cctgatcttc gtggtggaca gcaatgacag agagcgtgtg
      481 aacgaggccc gtgaggagct catgaggatg ctggccgagg acgagctccg ggatgctgtc
      541 ctcctggtgt tcgccaacaa gcaggacctc cccaacgcca tgaatgcggc cgagatcaca
      601 gacaagctgg ggctgcactc actacgccac aggaactggt acattcaggc cacctgcgcc
      661 accagcggcg acgggctcta tgaaggactg gactggctgt ccaatcagct ccggaaccag
      721 aagtgaacgc gacccccctc cctctcactc ctcttgccct ctgctttact ctcatgtggc
      781 aaacgtgcgg ctcgtggtgt gagtgccaga agctgcctcc gtggtttggt caccgtgtgc
      841 atcgcaccgt gctgtaaatg tggcagacgc agcctgcggc caggcttttt atttaatgta
      901 aatagttttt gtttccaatg aggcagtttc tggtactcct atgcaatatt actcagcttt
      961 ttttattgta aaaagaaaaa tcaactcact gttcagtgct gagaggggat gtaggcccat
     1021 gggcacctgg cctccaggag tcgctgtgtt gggagagccg gccacgccct tggctttaga
     1081 gctgtgttga aatccatttt ggtggttggt ttttaaccca aactcagtgc attttttaaa
     1141 atagttaaga atccaagtcg agaacacttg aacacacaga agggagaccc cgcctagcat
     1201 agatttgcag ttacggcctg gatgccagtc gccagcccag ctgttcccct cgggaacatg
     1261 aggtggtggt ggcgcagcag actgcgatca attctgcatg gtcacagtag agatccccgc
     1321 aactcgcttg tccttgggtc accctgcatt ccatagccat gtgcttgtcc ctgtgctccc
     1381 acggttccca ggggccaggc tgggagccca cagccacccc actatgccgc aggccgccct
     1441 acccaccttc aggcagccta tgggacgcag ggccccatct gtccctcggt cgccgtgtgg
     1501 ccagagtggg tccgtcgtcc ccaacactcg tgctcgctca gacactttgg caggatgtct
     1561 ggggcctcac cagcaggagc gcgtgcaagc cgggcaggcg gtccacctag acccacagcc
     1621 cctcgggagc accccacctc tgtgtgtgat gtagctttct ctccctcagc ctgcaagggt
     1681 ccgatttgcc atcgaaaaag acaacctcta cttttttctt ttgtattttg ataaacactg
     1741 aagctggagc tgttaaattt atcttgggga aacctcagaa ctggtctatt tggtgtcgtg
     1801 gaacctctta ctgctttcaa tacacgatta gtaatcaact gttttgtata cttgttttca
     1861 gttttcattt cgacaaacaa gcactgtaat tatagctatt agaataaaat ctcttaacta
     1921 tttca
//
