LOCUS       NM_001039479            5417 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens apoptosis resistant E3 ubiquitin protein ligase 1
            (AREL1), transcript variant 1, mRNA.
ACCESSION   NM_001039479
VERSION     NM_001039479.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5417)
  AUTHORS   Li,Y., Song,Y. and Liang,Y.
  TITLE     AREL1 resists the apoptosis induced by TGF-beta by inhibiting SMAC
            in vascular endothelial cells
  JOURNAL   J Biochem Mol Toxicol 37 (10), e23439 (2023)
   PUBMED   37522329
  REMARK    GeneRIF: AREL1 resists the apoptosis induced by TGF-beta by
            inhibiting SMAC in vascular endothelial cells.
REFERENCE   2  (bases 1 to 5417)
  AUTHORS   Rydbirk,R., Folke,J., Busato,F., Roche,E., Chauhan,A.S.,
            Lokkegaard,A., Hejl,A.M., Bode,M., Blaabjerg,M., Moller,M.,
            Danielsen,E.H., Brudek,T., Pakkenberg,B., Tost,J. and Aznar,S.
  TITLE     Epigenetic modulation of AREL1 and increased HLA expression in
            brains of multiple system atrophy patients
  JOURNAL   Acta Neuropathol Commun 8 (1), 29 (2020)
   PUBMED   32151281
  REMARK    GeneRIF: Epigenetic modulation of AREL1 and increased HLA
            expression in brains of multiple system atrophy patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5417)
  AUTHORS   Singh,S., Ng,J., Nayak,D. and Sivaraman,J.
  TITLE     Structural insights into a HECT-type E3 ligase AREL1 and its
            ubiquitination activities in vitro
  JOURNAL   J Biol Chem 294 (52), 19934-19949 (2019)
   PUBMED   31732561
  REMARK    GeneRIF: The AREL1 HECT domain assembled Lys(33)-, Lys(48)-, and
            Lys(63)-linked polyubiquitin chains. E701A substitution in the
            AREL1 HECT domain substantially increased its
            autopolyubiquitination and SMAC ubiquitination activity, whereas
            deletion of the last three amino acids at the C terminus completely
            abrogated AREL1 autoubiquitination and reduced SMAC ubiquitination.
REFERENCE   4  (bases 1 to 5417)
  AUTHORS   Lear,T.B., McKelvey,A.C., Evankovich,J.W., Rajbhandari,S.,
            Coon,T.A., Dunn,S.R., Londino,J.D., McVerry,B.J., Zhang,Y.,
            Valenzi,E., Burton,C.L., Gordon,R., Gingras,S., Lockwood,K.C.,
            Jurczak,M.J., Lafyatis,R., Shlomchik,M.J., Liu,Y. and Chen,B.B.
  TITLE     KIAA0317 regulates pulmonary inflammation through SOCS2 degradation
  JOURNAL   JCI Insight 4 (19), 129110 (2019)
   PUBMED   31578312
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5417)
  AUTHORS   Lear,T., McKelvey,A.C., Rajbhandari,S., Dunn,S.R., Coon,T.A.,
            Connelly,W., Zhao,J.Y., Kass,D.J., Zhang,Y., Liu,Y. and Chen,B.B.
  TITLE     Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through
            SUMO-E3 ligase PIAS4
  JOURNAL   J Exp Med 213 (6), 1029-1046 (2016)
   PUBMED   27162139
  REMARK    GeneRIF: new protein isoform encoded by KIAA0317, termed
            fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates
            the TGFbeta signaling pathway through the site-specific
            ubiquitination of PIAS4.
REFERENCE   6  (bases 1 to 5417)
  AUTHORS   Michel,M.A., Elliott,P.R., Swatek,K.N., Simicek,M., Pruneda,J.N.,
            Wagstaff,J.L., Freund,S.M. and Komander,D.
  TITLE     Assembly and specific recognition of k29- and k33-linked
            polyubiquitin
  JOURNAL   Mol Cell 58 (1), 95-109 (2015)
   PUBMED   25752577
REFERENCE   7  (bases 1 to 5417)
  AUTHORS   Kim,J.B., Kim,S.Y., Kim,B.M., Lee,H., Kim,I., Yun,J., Jo,Y., Oh,T.,
            Jo,Y., Chae,H.D. and Shin,D.Y.
  TITLE     Identification of a novel anti-apoptotic E3 ubiquitin ligase that
            ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC,
            HtrA2, and ARTS
  JOURNAL   J Biol Chem 288 (17), 12014-12021 (2013)
   PUBMED   23479728
REFERENCE   8  (bases 1 to 5417)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI459956.1, BC032944.2, AB002315.1 and AC007956.5.
            
            On Nov 22, 2018 this sequence version replaced NM_001039479.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK304217.1, SRR1803617.12469.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356357.9/ ENSP00000348714.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               BI459956.1         34-195
            163-501             BC032944.2         191-529
            502-3611            AB002315.1         492-3601
            3612-5417           AC007956.5         44222-46027         c
FEATURES             Location/Qualifiers
     source          1..5417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..5417
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /note="apoptosis resistant E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:9870"
                     /db_xref="HGNC:HGNC:20363"
                     /db_xref="MIM:615380"
     exon            1..148
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            149..436
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            437..497
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..2953
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /EC_number="2.3.2.26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fibrosis-inducing E3 ligase 1; apoptosis-resistant
                     HECT-type E3 ubiquitin transferase 1"
                     /codon_start=1
                     /product="apoptosis-resistant E3 ubiquitin protein ligase
                     1 isoform 1"
                     /protein_id="NP_001034568.1"
                     /db_xref="CCDS:CCDS41971.1"
                     /db_xref="GeneID:9870"
                     /db_xref="HGNC:HGNC:20363"
                     /db_xref="MIM:615380"
                     /translation="MFYVIGGITVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDR
                     TIYDYVRGNYLDPRSCKVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHI
                     SHVELAVEIPVTQEVLQEPNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQP
                     GMVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTNNSMSLRDEHNYTLSIHEL
                     GPQEEESTGVSFEKSVTSNRQTFQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVL
                     SEDEKNIVERNVSTSGVSIYFEAYLYNATNCSSTPWHLPPMHMTSSQRRPSTAVDEED
                     EDSPSECHTPEKVKKPKKVYCYVSPKQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGP
                     DPVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQREL
                     RQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRR
                     EWFELICKALFDTTNQLFTRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYES
                     SLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELV
                     FAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKG
                     LNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVV
                     SSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTHSTLPTAHTCFNQLCLPT
                     YDSYEEVHRMLQLAISEGCEGFGML"
     exon            498..724
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            725..962
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1132
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1313
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1561
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1639
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1781
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1903
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1979
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2089
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2269
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2395
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2525
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2584
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2674
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2850
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..5417
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5400..5405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /note="hexamer: AATAAA"
     polyA_site      5417
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /note="major polyA site"
ORIGIN      
        1 aatcccccga gccggttccc aggccgggtg gagaccaact ctggggtctg ttggtgggag
       61 agtggggagc ccgtcttctg ctgagtgctg ccgccccttc ccaggacagc ggaggtggaa
      121 cttcgtcgcg ctgcaacccc cggctcggga tcctggggcg tcctttggca gtcgattgca
      181 ccctgcacta gagagaagtc caggaatgat atattcttgg gctgtatttc tctaccctgg
      241 agttcatcca gttcatccca gaaacactga cctgattact gtgacaaagt ctgatggata
      301 gaccctttct gttgaccttg tggcgttttt ctttcatgtg gaagttggaa gacaaggtga
      361 aaggggccaa aagttacctg ctttggtgaa taggagtgct ctacttggtt ctcagaacat
      421 gggccctcgt ttaaagctgc agctgtgatc ctcggctgtc tgttggcatt gacgggacct
      481 gatgttttac gttattggtg gaatcacagt gtctgtggtt gcattcttct tcacaattaa
      541 gttcctcttt gagcttgccg cacgtgtagt cagcttcctc cagaatgagg accgcgagcg
      601 ccgaggggac cggactattt atgactacgt gcggggaaat tacctggatc cccggtcttg
      661 caaagtctcc tgggattgga aggaccccta tgaggtgggc cacagcatgg ccttccgagt
      721 gcatttattc tataagaacg ggcagccttt ccctgcacat cggcctgtgg gactaagagt
      781 tcacatctct catgtcgagc tagcagtgga aattccagtg acccaggaag tccttcagga
      841 gcccaattcc aacgtagtaa aagtggcctt cactgtgcgc aaggctgggc gttatgaaat
      901 cacagtgaag cttggtggat taaatgtggc atatagtccc tactacaaaa tttttcaacc
      961 tggaatggtg gttccttcta agaccaaaat tgtgtgccac ttttctactc ttgtattgac
     1021 ctgtgggcag ccgcacaccc ttcaaatagt accccgagat gagtatgata atcccaccaa
     1081 caattccatg tccttgagag atgagcacaa ttacaccttg tccattcatg agctcggccc
     1141 tcaagaagaa gagagtactg gtgtctcatt tgagaaatca gtaacatcca acaggcagac
     1201 tttccaggtg ttcttgcgac tcaccctgca ttctcgaggc tgcttccatg cttgcatttc
     1261 ataccaaaat cagccaatca ataatggtga atttgacatt attgtcctaa gtgaggatga
     1321 gaagaatatc gtcgaacgca atgtgtccac ttcaggcgtg agcatttact ttgaggctta
     1381 tctttataat gctaccaact gtagcagcac tccatggcac ctgccaccca tgcacatgac
     1441 ctcttcccag cgccggccat ccactgctgt tgacgaggaa gatgaagact cgccctctga
     1501 gtgccacacc cctgagaagg tgaagaaacc gaagaaggtg tactgctatg tgtcaccaaa
     1561 gcaattctca gtgaaggagt tctacctgaa gatcatcccc tggcgccttt acaccttccg
     1621 agtgtgtcca ggaacaaaat tttcatacct tggtcctgac cctgtccata agctgctcac
     1681 actggtggtg gatgatggca ttcaacctcc tgtggagctc agctgtaagg agaggaacat
     1741 tctagcagcc acttttatcc gctccctgca taagaacata ggaggctctg agacctttca
     1801 ggacaaggtg aactttttcc agcgagagct tcggcaggta catatgaaaa gaccacattc
     1861 caaagtcacc ctgaaggtca gcagacatgc cttgttggaa tcgtctctga aagccactcg
     1921 gaatttctcc atctcagatt ggagcaagaa ctttgaggtt gttttccagg atgaagaagc
     1981 tctggactgg ggagggcctc gccgggaatg gtttgagcta atctgcaaag cactatttga
     2041 taccaccaat cagctcttca cccggttcag tgacaacaac caagcattag tgcatcccaa
     2101 ccctaatcgc cccgctcatc tgcgcctgaa aatgtatgag tttgcgggac ggctcgtggg
     2161 caagtgtctc tatgagtcct ctctaggagg agcctacaag cagttggtcc gagctcgctt
     2221 cacccgctct ttcctggccc aaatcatagg actgcgtatg cattacaagt actttgaaac
     2281 agatgaccca gaattctaca aatctaaagt ttgttttatc ctcaacaatg acatgagtga
     2341 gatggagctg gtctttgcag aagagaaata taataaatca ggtcaattgg ataaggttgt
     2401 agaactcatg acaggtggag ctcaaactcc agtcaccaat gcgaataaaa tcttctattt
     2461 aaatttgctg gcccaatatc ggctggccag tcaagtgaaa gaggaggtgg aacatttcct
     2521 aaaaggcctg aatgaattgg tccctgagaa ccttttggct atttttgatg agaatgagct
     2581 tgagctgctg atgtgtggga ctggagacat cagtgtgtct gacttcaaag cccatgcagt
     2641 agttgttggt ggctcatggc atttcagaga aaaggtcatg aggtggtttt ggactgtggt
     2701 ttccagtctg acccaggagg agttggctcg gctacttcag ttcacaacag gctcctctca
     2761 gctaccacct ggaggctttg ccgccctctg tccctcattt cagattattg ccgctccgac
     2821 ccatagcacg ctgcctactg cacacacatg ttttaaccag ctgtgcctcc ctacatatga
     2881 ctcctatgaa gaggtgcaca ggatgctgca gctggccatc agcgagggtt gcgagggctt
     2941 tggcatgctc tgaccactct cctgtcatcc agttggctcc catgctctct ggagcttctg
     3001 ggcgcaagtt acagacatca taaccactga tcctaacaca cataaccatc agccagaaga
     3061 tgccgcatgc tcccctgtgt ctggaggatt ttgtcaccta caagccttgt ctttacctca
     3121 cctgctccct gcccatatct accacaggcc actttggcat ggtatgtaag ctgagctctt
     3181 cattctgtca tgagaagagg accatgctgc tatcatttat ttggtccttt gaagatctca
     3241 gtagctgagg gagatggcac acggggctca gccctgttgg gaaactggtg tggagaccct
     3301 taaatccaca ctgtgctcca aaactccctc tgctgatact ccttggagac accctctttg
     3361 gccctcacta cttgaccaga ctggtacttg agtccttctc atgggtgggg tgattgcctc
     3421 ttctcatcag gagccaggag agagggggac agataggagg tggcccatag gagcagtccc
     3481 gctgcacaat ggtaggcata ggccatggca ctggactgcc tctaaggact gctaaaaaga
     3541 atattttttt gtggtgtcag aactggaaaa agcactttcc cttcgggcat ttctggaaat
     3601 gattattaat ccacaaagaa gaactctgta agctttttct tgaattgtag ccagtgagaa
     3661 aagcagatag actgaagaat atgaaggata gctgagctgt agcctccaga gtggggcatg
     3721 cctaggcata tggctggctt ggagactact gatgcttttc cctgagtttg ttattggcac
     3781 tgaagtatgg ccggcttggg ccactgactt ccccattatg tagtctgcta aaagctgggg
     3841 atcctttagc attctactga agaaaatttt gtagcaaaag attagaacag taagaatagt
     3901 atgccagcaa tccctgattc tctctctgct tggtgttctc tggcagcact aagacaaagg
     3961 aacagggact aggagtttac gtgcttatca caggtccttg gcgtcaggac actagggatg
     4021 aacatggagg tgatatgtta cacagtaaac acctgccaac ccctgtactc ccctttgctc
     4081 catcagttat caggaaggag aactaaggag ggaggaagct tattaggttc actgttgaat
     4141 gatgattgaa gagtacctgc tgctgtatct tggaagatga caacatcctt tttcattact
     4201 gtttgattga aaataatttc aagattcaaa atctcattga cttcccaaat ttgtgttttt
     4261 aagaaggctt tgctgcaagc taccattccc aatggggcag tcaactctga gaatattaca
     4321 agccatcttt attgccaaaa ccagcaagta cacagagtcc tgaaacaagg caggactttg
     4381 gcaatgcctt ggcctcctgg aagcatgtct gagccctcct gttcgcaggg atcatgagga
     4441 acaagccctc ctgagctgct acagttcctg cctgacctca gtctttcgca gtcatcattt
     4501 gtcctttctt ggcacatggg tgctgacctc actcatcctt ggggtccggg atccagcatc
     4561 agggtctcta taccccagga tcctccatgc cacatggtca ctgctctcct cagggaccag
     4621 gacaaggtgc tgctgcttgc ccaaatgttt tcccatggga tatgtaccgg aaggtttatc
     4681 accaccctgg gaaacataat gctgcccctt gggcccagaa aggggtttcc agctgggggc
     4741 acgtggactg gttctgctgt ttttggcagt cgcttttctg aattctcccc tccggcagcc
     4801 ttccagagac tgatcctgga gattgagttg attgtcttgg ctagacctgt cattttaagc
     4861 tctagtcata gcactttttc agagcatctt aggcaccatt gcaacccaac cagggaagct
     4921 gcatccctgt ggtggtcctt aggcaccagt ctttgttaaa caaaaccctt tggcactatt
     4981 gtggttttct attctctgtc tgaactctat tcaaaagtat ctttgctctc ttgggccttt
     5041 tcttttactg ttttgttttt tttttttcta atcctgcttt catactagcc agtgtgggga
     5101 aaaggtacaa tatgtcaaag agatgagaga gtgttatttc ttgggcaatt ttctattagt
     5161 gtttcttatt ttggccagtt cttttattta tgtccttgtg acccaggtac ttggggggcc
     5221 agctaccctt ctggcctttt agcgtctttg aaggagacca gacatgagtg aatacctagg
     5281 agagtgtcag catgtttctg gaaaattggc agagaccaag ccctgctgca gattcgtcag
     5341 gccaggtgaa agggccaggc agttgcagct gatgatgtaa atattttgta cagtagataa
     5401 ataaatgttt aaaagaa
//
