LOCUS       NM_015193               2950 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens activity regulated cytoskeleton associated protein
            (ARC), transcript variant 1, mRNA.
ACCESSION   NM_015193 XM_001126618
VERSION     NM_015193.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2950)
  AUTHORS   Yakout,D.W., Shroff,A., Wei,W., Thaker,V., Allen,Z.D., Sajish,M.,
            Nazarko,T.Y. and Mabb,A.M.
  TITLE     Tau regulates Arc stability in neuronal dendrites via a
            proteasome-sensitive but ubiquitin-independent pathway
  JOURNAL   J Biol Chem 300 (5), 107237 (2024)
   PUBMED   38552740
  REMARK    GeneRIF: Tau regulates Arc stability in neuronal dendrites via a
            proteasome-sensitive but ubiquitin-independent pathway.
REFERENCE   2  (bases 1 to 2950)
  AUTHORS   An,S., Yao,Y., Wu,J., Hu,H., Wu,J., Sun,M., Li,J., Zhang,Y., Li,L.,
            Qiu,W., Li,Y., Deng,Z., Fang,H., Gong,S., Huang,Q., Chen,Z. and
            Zeng,Z.
  TITLE     Gut-derived 4-hydroxyphenylacetic acid attenuates sepsis-induced
            acute kidney injury by upregulating ARC to inhibit necroptosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166876 (2024)
   PUBMED   37714058
  REMARK    GeneRIF: Gut-derived 4-hydroxyphenylacetic acid attenuates
            sepsis-induced acute kidney injury by upregulating ARC to inhibit
            necroptosis.
REFERENCE   3  (bases 1 to 2950)
  AUTHORS   Yang,L., Liu,W., Shi,L., Wu,J., Zhang,W., Chuang,Y.A.,
            Redding-Ochoa,J., Kirkwood,A., Savonenko,A.V. and Worley,P.F.
  TITLE     NMDA Receptor-Arc Signaling Is Required for Memory Updating and Is
            Disrupted in Alzheimer's Disease
  JOURNAL   Biol Psychiatry 94 (9), 706-720 (2023)
   PUBMED   36796600
  REMARK    GeneRIF: NMDA Receptor-Arc Signaling Is Required for Memory
            Updating and Is Disrupted in Alzheimer's Disease.
            Erratum:[Biol Psychiatry. 2023 Nov 1;94(9):760. doi:
            10.1016/j.biopsych.2023.08.012.. PMID: 37778866]
REFERENCE   4  (bases 1 to 2950)
  AUTHORS   Chen,T., Xu,Y.P., Chen,Y., Sun,S., Yan,Z.Z. and Wang,Y.H.
  TITLE     Arc regulates brain damage and neuroinflammation via Sirt1
            signaling following subarachnoid hemorrhage
  JOURNAL   Brain Res Bull 203, 110780 (2023)
   PUBMED   37820952
  REMARK    GeneRIF: Arc regulates brain damage and neuroinflammation via Sirt1
            signaling following subarachnoid hemorrhage.
REFERENCE   5  (bases 1 to 2950)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2950)
  AUTHORS   Bloomer,W.A., VanDongen,H.M. and VanDongen,A.M.
  TITLE     Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds
            to spectrin and associates with nuclear promyelocytic leukemia
            (PML) bodies
  JOURNAL   Brain Res 1153, 20-33 (2007)
   PUBMED   17466953
REFERENCE   7  (bases 1 to 2950)
  AUTHORS   Dynes,J.L. and Steward,O.
  TITLE     Dynamics of bidirectional transport of Arc mRNA in neuronal
            dendrites
  JOURNAL   J Comp Neurol 500 (3), 433-447 (2007)
   PUBMED   17120280
  REMARK    GeneRIF: Arc/MS2 mRNA assembles into particles that move
            independently, bidirectionally, and intermittently. These
            observations identify several phases of Arc mRNA movement that
            serve as potential points for regulating Arc mRNA localization.
REFERENCE   8  (bases 1 to 2950)
  AUTHORS   Lacor,P.N., Buniel,M.C., Chang,L., Fernandez,S.J., Gong,Y.,
            Viola,K.L., Lambert,M.P., Velasco,P.T., Bigio,E.H., Finch,C.E.,
            Krafft,G.A. and Klein,W.L.
  TITLE     Synaptic targeting by Alzheimer's-related amyloid beta oligomers
  JOURNAL   J Neurosci 24 (45), 10191-10200 (2004)
   PUBMED   15537891
REFERENCE   9  (bases 1 to 2950)
  AUTHORS   Haug,K., Kremerskothen,J., Hallmann,K., Sander,T., Dullinger,J.,
            Rau,B., Beyenburg,S., Lentze,M.J., Barnekow,A., Elger,C.E.,
            Propping,P. and Heils,A.
  TITLE     Mutation screening of the chromosome 8q24.3-human
            activity-regulated cytoskeleton-associated gene (ARC) in idiopathic
            generalized epilepsy
  JOURNAL   Mol Cell Probes 14 (4), 255-260 (2000)
   PUBMED   10970730
REFERENCE   10 (bases 1 to 2950)
  AUTHORS   Kremerskothen,J. and Barnekow,A.
  TITLE     Human activity-regulated cytoskeleton-associated gene (ARC) maps to
            chromosome 8q24
  JOURNAL   Chromosome Res 8 (7), 655 (2000)
   PUBMED   11117363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP006547.1 and BC012321.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015193.4.
            
            CCDS Note: This CCDS ID represents the protein described in PMIDs:
            10970730 and 17466953. This transcript is supported by BC075802.1.
            It should be noted this transcript is predicted to undergo
            nonsense-mediated mRNA decay (NMD). However, the protein is
            represented because it was detected endogenously PMID: 17466953. It
            is likely that the majority of transcripts representing this
            variant will undergo NMD, while some low level of NMD escape may
            allow for the expression of this protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012321.1, SRR1660807.232290.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356613.4/ ENSP00000349022.2
            NMD candidate          :: PMID: 17466953
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AP006547.1         2272-2289           c
            19-1065             BC012321.1         16-1062
            1066-1066           AP006547.1         1224-1224           c
            1067-2950           BC012321.1         1064-2947
FEATURES             Location/Qualifiers
     source          1..2950
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2950
                     /gene="ARC"
                     /gene_synonym="Arg3.1; hArc"
                     /note="activity regulated cytoskeleton associated protein"
                     /db_xref="GeneID:23237"
                     /db_xref="HGNC:HGNC:648"
                     /db_xref="MIM:612461"
     exon            1..1996
                     /gene="ARC"
                     /gene_synonym="Arg3.1; hArc"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1399
                     /gene="ARC"
                     /gene_synonym="Arg3.1; hArc"
                     /note="ARC/ARG3.1; activity-regulated gene 3.1 protein
                     homolog"
                     /codon_start=1
                     /product="activity-regulated cytoskeleton-associated
                     protein"
                     /protein_id="NP_056008.1"
                     /db_xref="CCDS:CCDS34950.1"
                     /db_xref="GeneID:23237"
                     /db_xref="HGNC:HGNC:648"
                     /db_xref="MIM:612461"
                     /translation="MELDHRTSGGLHAYPGPRGGQVAKPNVILQIGKCRAEMLEHVRR
                     THRHLLAEVSKQVERELKGLHRSVGKLESNLDGYVPTSDSQRWKKSIKACLCRCQETI
                     ANLERWVKREMHVWREVFYRLERWADRLESTGGKYPVGSESARHTVSVGVGGPESYCH
                     EADGYDYTVSPYAITPPPAAGELPGQEPAEAQQYQPWVPGEDGQPSPGVDTQIFEDPR
                     EFLSHLEEYLRQVGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSE
                     GTLSREAIQRELDLPQKQGEPLDQFLWRKRDLYQTLYVDADEEEIIQYVVGTLQPKLK
                     RFLRHPLPKTLEQLIQRGMEVQDDLEQAAEPAGPHLPVEDEAETLTPAPNSESVASDR
                     TQPE"
     exon            1997..2141
                     /gene="ARC"
                     /gene_synonym="Arg3.1; hArc"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2950
                     /gene="ARC"
                     /gene_synonym="Arg3.1; hArc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2932..2937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARC"
                     /gene_synonym="Arg3.1; hArc"
                     /note="hexamer: AATAAA"
     polyA_site      2950
                     /gene="ARC"
                     /gene_synonym="Arg3.1; hArc"
                     /note="major polyA site"
ORIGIN      
        1 gcagagctcg ggcgcggcgt cctccctccg cagcagccga gccggacctg cctccccggg
       61 cgtgctccgc cggccccgcc gccggcccgc agcgacagac aggcgctccc cgcagctccg
      121 cacgggaccc aggccgccgg accccagcgc cggaccaccc tctgtccgcc ccgaggagtt
      181 tgccgcctgc cggagcacct gcgcacagat ggagctggac caccggacca gcggcgggct
      241 ccacgcctac cccgggccgc ggggcgggca ggtggccaag cccaacgtga tcctgcagat
      301 cgggaagtgc cgggccgaga tgctggagca cgtgcggcgg acgcaccggc acctgctggc
      361 cgaggtgtcc aagcaggtgg agcgcgagct gaaggggctg caccggtcgg tcgggaagct
      421 ggagagcaac ctggacggct acgtgcccac gagcgactcg cagcgctgga agaagtccat
      481 caaggcctgc ctgtgccgct gccaggagac catcgccaac ctggagcgct gggtcaagcg
      541 cgagatgcac gtgtggcgcg aggtgttcta ccgcctggag cgctgggccg accgcctgga
      601 gtccacgggc ggcaagtacc cggtgggcag cgagtcagcc cgccacaccg tttccgtggg
      661 cgtggggggt cccgagagct actgccacga ggcagacggc tacgactaca ccgtcagccc
      721 ctacgccatc accccgcccc cagccgctgg cgagctgccc gggcaggagc ccgccgaggc
      781 ccagcagtac cagccgtggg tccccggcga ggacgggcag cccagccccg gcgtggacac
      841 gcagatcttc gaggaccctc gagagttcct gagccaccta gaggagtact tgcggcaggt
      901 gggcggctct gaggagtact ggctgtccca gatccagaat cacatgaacg ggccggccaa
      961 gaagtggtgg gagttcaagc agggctccgt gaagaactgg gtggagttca agaaggagtt
     1021 cctgcagtac agcgagggca cgctgtcccg agaggccatc cagcgcgagc tggacctgcc
     1081 gcagaagcag ggcgagccgc tggaccagtt cctgtggcgc aagcgggacc tgtaccagac
     1141 gctctacgtg gacgcggacg aggaggagat catccagtac gtggtgggca ccctgcagcc
     1201 caagctcaag cgtttcctgc gccaccccct gcccaagacc ctggagcagc tcatccagag
     1261 gggcatggag gtgcaggatg acctggagca ggcggccgag ccggccggcc cccacctccc
     1321 ggtggaggat gaggcggaga ccctcacgcc cgcccccaac agcgagtccg tggccagtga
     1381 ccggacccag cccgagtaga gggcatcccg gagcccccag cctgcccact acatccagcc
     1441 tgtggctttg cccaccagga cttttgagct ggggctgact cctgcagggg aagccctggt
     1501 ccagctgggt gccccctcga gctccgggcg gactcgcaca cactcgtgtc atccagatgt
     1561 gagcaccgca cccagcggca aagagccctc ccccctgcag ggctccaccc atcaccctcc
     1621 ctccgtctgt ctttccggcc tggaccccac cctccacact ctcaggccat cacagaacac
     1681 cccagcttcc tcattctgct acaacaccca ggccctctgg acatccagaa aaccaagtgt
     1741 ccggatggca ggggccagcg gccaccaagc tcatgggaca cccagagcag aagctagggc
     1801 agagccaatg ctgagggagc ctcgacttcc ggcgccgccg ccctctcccg gcatccgcag
     1861 agccagctga cgccctccct gcctcccagg gcagctggcc agcctcgggc agcgcggccc
     1921 cctcctccca ggggagagta gaagtcgcac acgcagcaga gcagacctga tgtcccggtg
     1981 cttcctggcc cctcagctcc agtgattcac gcccgcctgg agaagaatca gagctcagct
     2041 catgactcac ccatggcagg cggagggtcc cagaggggct gagtcctcaa atccggctga
     2101 ggcagcagct ggcaccatca gagccaggag agtgacaaca ggtctcaagg ttcccacaaa
     2161 gtctttgctg ctgtgctggg caccacccac ccctcacctt gcaggctgcc tgcgtgggag
     2221 gcgaagtccc aggacagccc agaggggggc tacagagagg agtcggctgc agcagagggc
     2281 aggagcccca gcttagccct gagcgccagc gcgaggacca gggcctgcca ctaagcccgc
     2341 cccgctggcc gccagctgcc cgtccccaga gccactgcag caggagtcgg gccctgcctc
     2401 cctcccagca gggaaacccc gcccgctgcc aggccatcct ctctgccaga ggctttcatg
     2461 agccccaagg ctggggccac agctcctacc cctgcccagc agccctgagc tcagctgcag
     2521 gaaggacatc ccagaagcca tggctcctgg ggcgcttcca ggcattctgc cctgccccga
     2581 caccagaacc ctggtgctgg tgggccacta gcgtctgcag cctaagcagg tgctggctca
     2641 gggttcatcg ttctgccttg tccactgggg gaccagccct gcagaccact ctgacaagtc
     2701 ttcagcccac accctgccag ccccacagat tttatttttg cacataagcc ataaccaatc
     2761 ctcaaggctg gcacaggctt tggggaagcc ctggagcctg tgaagaccct ggaaacctca
     2821 tgaggctgtg gccaacccct gccccttgcc ccacacagac caggccttaa atgtcggtcc
     2881 aggccctgtg caccttaccc cagagacaga ctctttttgt aagattttgt taataaaaca
     2941 ctgaaacttc
//
