LOCUS       NM_032042               4684 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ARB2 cotranscriptional regulator A (ARB2A), transcript
            variant 1, mRNA.
ACCESSION   NM_032042
VERSION     NM_032042.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4684)
  AUTHORS   Sallis,S., Berube-Simard,F.A., Grondin,B., Leduc,E., Azouz,F.,
            Belanger,C. and Pilon,N.
  TITLE     The CHARGE syndrome-associated protein FAM172A controls AGO2
            nuclear import
  JOURNAL   Life Sci Alliance 6 (8), e202302133 (2023)
   PUBMED   37221016
  REMARK    GeneRIF: The CHARGE syndrome-associated protein FAM172A controls
            AGO2 nuclear import.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4684)
  AUTHORS   Xu,P.P., Zeng,S., Xia,X.T., Ye,Z.H., Li,M.F., Chen,M.Y., Xia,T.,
            Xu,J.J., Jiao,Q., Liu,L., Li,L.X. and Guo,M.G.
  TITLE     FAM172A promotes follicular thyroid carcinogenesis and may be a
            marker of FTC
  JOURNAL   Endocr Relat Cancer 27 (11), 657-669 (2020)
   PUBMED   33095186
  REMARK    GeneRIF: FAM172A promotes follicular thyroid carcinogenesis and may
            be a marker of FTC.
REFERENCE   3  (bases 1 to 4684)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4684)
  AUTHORS   Chen,Y., Liu,P., Shen,D., Liu,H., Xu,L., Wang,J., Shen,D., Sun,H.
            and Wu,H.
  TITLE     FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling
  JOURNAL   Biol Open 9 (2) (2020)
   PUBMED   31988090
  REMARK    GeneRIF: FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK
            signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4684)
  AUTHORS   Zhao,H., Wang,Y., Liu,Y., Hao,X., Wei,H. and Xie,W.
  TITLE     The Effect of Protein FAM172A on Proliferation in HepG2 Cells and
            Investigation of the Possible Molecular Mechanism
  JOURNAL   Anal Cell Pathol (Amst) 2019, 5901083 (2019)
   PUBMED   31915594
  REMARK    GeneRIF: FAM172A recombinant protein could induce proliferation of
            HepG2 cells, in which the MAPK/ERK and PI3K/Akt signaling pathways
            might be involved. The role of FAM172A in HepG2 cell proliferation
            also indicated its possible involvement in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4684)
  AUTHORS   Li,M.F., Zhang,R., Guo,M.G., Li,L.X., Lu,H.K., Lu,J.X. and Jia,W.P.
  TITLE     FAM172A protein promotes the proliferation of human papillary
            thyroid carcinoma cells via the p38 mitogen-activated protein
            kinase pathway
  JOURNAL   Mol Med Rep 13 (1), 353-358 (2016)
   PUBMED   26573560
  REMARK    GeneRIF: FAM172A protein is expressed at high levels in human
            papillary thyroid carcinoma, which may promote cell proliferation
            via activation of the p38 MAPK signaling pathway.
REFERENCE   7  (bases 1 to 4684)
  AUTHORS   Li,L., Dong,X., Leong,M.C., Zhou,W., Yang,Z., Chen,F., Bao,Y.,
            Jia,W. and Hu,R.
  TITLE     Identification of the novel protein FAM172A, and its up-regulation
            by high glucose in human aortic smooth muscle cells
  JOURNAL   Int J Mol Med 26 (4), 483-490 (2010)
   PUBMED   20818486
  REMARK    GeneRIF: FAM172 protein expression in human aortic smooth muscle
            cells was up-regulated by high glucose levels in a
            concentration-dependent and time-course manner.
REFERENCE   8  (bases 1 to 4684)
  AUTHORS   Li,L.X., Zhou,W.B., Tao,Z., Deng,W.J., Liang,W.C., Yang,Z.H.,
            Ye,W.W., Bao,Y.Q., Jia,W.P. and Hu,R.M.
  TITLE     [Effect of FAM172A protein on apoptosis and proliferation in HEK293
            cells]
  JOURNAL   Zhonghua Yi Xue Za Zhi 90 (34), 2424-2427 (2010)
   PUBMED   21092515
  REMARK    GeneRIF: FAM172A protein promotes cell proliferation, inhibits cell
            apoptosis and facilitates S-phase entry in HEK293 cells.
REFERENCE   9  (bases 1 to 4684)
  AUTHORS   Li,L.X., Tao,Z., Dong,X.H., Liang,W.C., Yang,Z.H., Mou,B.,
            Bao,Y.Q., Wang,C., Jia,W.P. and Hu,R.M.
  TITLE     [Molecular cloning of a novel gene, C5orf21 gene and its roles in
            diabetic macroangiopathy]
  JOURNAL   Zhonghua Yi Xue Za Zhi 89 (36), 2574-2577 (2009)
   PUBMED   20137623
  REMARK    GeneRIF: The changes of C5orf21 gene expression are correlated with
            diabetic macroangiopathy.
REFERENCE   10 (bases 1 to 4684)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC324758.1, AK312930.1, BC020584.2, BC012007.1, BP398089.1 and
            W15296.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032042.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.283211.1,
                                           SRR1803616.84872.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395965.8/ ENSP00000379294.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                DC324758.1         37-95
            60-1422             AK312930.1         1-1363
            1423-1935           BC020584.2         1261-1773
            1936-2704           BC020584.2         1775-2543
            2705-2705           BC012007.1         1134-1134
            2706-4340           BC020584.2         2545-4179
            4341-4683           BP398089.1         109-451
            4684-4684           W15296.1           5-5                 c
FEATURES             Location/Qualifiers
     source          1..4684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..4684
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /note="ARB2 cotranscriptional regulator A"
                     /db_xref="GeneID:83989"
                     /db_xref="HGNC:HGNC:25365"
     exon            1..153
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /inference="alignment:Splign:2.1.0"
     exon            154..277
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1422
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein FAM172A; cotranscriptional regulator
                     FAM172A; family with sequence similarity 172 member A;
                     cotranscriptional regulator ARB2A"
                     /codon_start=1
                     /product="cotranscriptional regulator ARB2A isoform 1
                     precursor"
                     /protein_id="NP_114431.2"
                     /db_xref="CCDS:CCDS4069.1"
                     /db_xref="GeneID:83989"
                     /db_xref="HGNC:HGNC:25365"
                     /translation="MSISLSSLILLPIWINMAQIQQGGPDEKEKTTALKDLLSRIDLD
                     ELMKKDEPPLDFPDTLEGFEYAFNEKGQLRHIKTGEPFVFNYREDLHRWNQKRYEALG
                     EIITKYVYELLEKDCNLKKVSIPVDATESEPKSFIFMSEDALTNPQKLMVLIHGSGVV
                     RAGQWARRLIINEDLDSGTQIPFIKRAVAEGYGVIVLNPNENYIEVEKPKIHVQSSSD
                     SSDEPAEKRERKDKVSKETKKRRDFYEKYRNPQREKEMMQLYIRENGSPEEHAIYVWD
                     HFIAQAAAENVFFVAHSYGGLAFVELMIQREADVKNKVTAVALTDSVHNVWHQEAGKT
                     IREWMRENCCNWVSSSEPLDTSVESMLPDCPRVSAGTDRHELTSWKSFPSIFKFFTEA
                     SEAKTSSLKPAVTRRSHRIKHEEL"
     exon            278..379
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /inference="alignment:Splign:2.1.0"
     exon            380..480
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /inference="alignment:Splign:2.1.0"
     exon            481..546
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /inference="alignment:Splign:2.1.0"
     exon            547..738
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /inference="alignment:Splign:2.1.0"
     exon            739..957
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1077
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1194
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1279
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..4684
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4318..4323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /note="hexamer: AATAAA"
     polyA_site      4340
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /note="major polyA site"
     regulatory      4662..4667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
                     /note="hexamer: AATAAA"
     polyA_site      4684
                     /gene="ARB2A"
                     /gene_synonym="C5orf21; FAM172A; Toupee"
ORIGIN      
        1 gaagaccccg gaagtgcaac tcgaacttgg tcggggcgcg gatcccgaga gggaaagtca
       61 taacaaccgc acgagggagt tcgactggcg aactggaagg ccacgcctcc tcccgcctgc
      121 cccctcagcc ctgtggctgg gggcagagct cagactgtct tctgaagatt gatgtctatt
      181 tccttgagct ctttaatttt gttgccaatt tggataaaca tggcacaaat ccagcaggga
      241 ggtccagatg aaaaagaaaa gactaccgca ctgaaagatt tattatctag gatagatttg
      301 gatgaactaa tgaaaaaaga tgaaccgcct cttgattttc ctgataccct ggaaggattt
      361 gaatatgctt ttaatgaaaa gggacagtta agacacataa aaactgggga accatttgtt
      421 tttaactacc gggaagattt acacagatgg aaccagaaaa gatacgaggc tctaggagag
      481 atcatcacga agtatgtata tgagctcctg gaaaaggatt gtaatttgaa aaaagtatct
      541 attccagtag atgccactga gagtgaacca aagagtttta tctttatgag tgaggatgct
      601 ttgacaaatc cacagaaact gatggtttta attcatggta gtggtgttgt cagggcaggg
      661 cagtgggcta gaagacttat tataaatgaa gatctggaca gtggcacaca gataccgttt
      721 attaaaagag ctgtggctga aggatatgga gtaatagtac taaatcccaa tgaaaactat
      781 attgaagtag aaaagccgaa gatacacgta cagtcatcat ctgatagttc agatgaacca
      841 gcagaaaaac gggaaagaaa agataaagtt tctaaagaaa caaagaagcg acgtgatttc
      901 tatgagaagt atcgtaaccc ccaaagagaa aaagaaatga tgcaattgta tatcagagaa
      961 aatggttctc ctgaagaaca tgcaatctat gtttgggatc atttcatagc tcaggctgct
     1021 gctgagaatg tgtttttcgt tgctcacagc tatggaggac ttgcttttgt tgaactgatg
     1081 attcaacgag aagccgatgt aaaaaataag gtaactgctg tggcattgac agactctgtt
     1141 cacaatgtgt ggcatcaaga agctggcaaa acgattcgag aatggatgag agagaactgt
     1201 tgtaattggg tctctagctc agaaccatta gacacatcag tggagtccat gctacctgat
     1261 tgcccccggg tctcagcagg caccgaccgt cacgagctaa cttcctggaa gagctttccg
     1321 tctattttca aattctttac cgaagcctca gaggccaaga ccagctccct gaagccggct
     1381 gtgacgcgcc gctcccaccg catcaagcac gaagagctgt aagaggagcg agcgcgacgg
     1441 gggaggccgc cctggcgcac ccacccgcac gcctcctcac tgcttgtgtc gagcggactc
     1501 ccagcccctc attagattgt tttcttccca gagcccaggg tcgtgatata tacatctaaa
     1561 tagcgttttg cattatttct agatgagtgc aactgtcaaa gcaatatggg ttcactggtc
     1621 gtgcttcctg cgggctgagc gcgggctgag cgctgccagt cagcgctcac attaaggctg
     1681 acagcgccct gcctggctcg gccggcgaag ctctaattgc cctgaaggag accgcgcggg
     1741 cgctgcgggt ccggcggcgt cggcgcggtc ctagcgcccg ccgtagcgga gccgctgctg
     1801 cttccccctc cttaatcatg tccatctttc cccgctctca actggagcaa acttctattc
     1861 cagacttcag atttccattt tcactaggtt tttccctgag ggcatcttat tacccacctc
     1921 tttttttttt tttttaagga agttccacac acactccaaa gccgatttca aattcagaac
     1981 ctgaatgcca tgatgtacca tgtagtttgg ggaatgcaaa ttgttctctc cctgttttca
     2041 tttcgggacc agaaaaaaaa acaactctgc ataaaaatct ataaagtact gaatccgcat
     2101 tactgctgaa aatccttttg ccagctaatt gtgagagttt acacaagtct ctgatttcag
     2161 aagagactgt taaaaccaaa acaatgatgg gcagctcttt taagtgtagg tgtgaaggtc
     2221 ccattttcaa tggaatttcc aactgttatc actgggattg actttacttt ttaaacacat
     2281 aatgtgtact gtgtggcatt gtaatttaga tataacacac ttaagttttg ctttttaaat
     2341 ctctctgtgg agaaaggttg ttgttaatcc tttccagaat gatctattct gagctttcct
     2401 ggagttaggc ccttctaggg agagaatttt tttattgtca tcaggaaacg aaacctttgt
     2461 gctctgcagc ctttttcttc tgaaaggcta agtggggcta aaattatcct tttagttttc
     2521 tgctttaaca agaagagaag gacttggtgt gaaagaattt cttctctcag tccaatggta
     2581 taatttttag cactccgctt cctctgtagg gtttagccct acagtttgaa caattatttt
     2641 aatccagcta agatgtggcc aacactgtga aatacaggag atgttaaggt tttgctgact
     2701 tttagattaa aatcttaaaa tttcacatta tattttaatt acttgaaaag tttaattacc
     2761 tagtaaagat tgtttctaat agatgagaac ataaatttaa tagttttcat ccttttttaa
     2821 agtgtgtgca acaattaata tgcctgcctt atttgaggac atgataaaat gtacccaaaa
     2881 tgacttcgaa ctgtctaatg cctcagaaaa gtaacttaaa atcaaccact tcgtgcttaa
     2941 atgtttttat attatgaacc gatttcaaca agttttaaag ctgttaatat ctcattgctg
     3001 tgtttgacat acaagtacat tcattggttc tatagtctta atgatgacaa attaaagatg
     3061 ttttttcagt gctcaggtat gcatatattt tcgtgttact taagcaaaat caactatata
     3121 ggaggaaaaa tcaaaatggc attttattca gctaccagat ggcttaaaat gagtaaaccc
     3181 caacaacatc aagcacattt gtctgtgata ttgacccttt ttatccaatc attactattt
     3241 tagaagtagt ggtgaactgt gtaaaataat ggtatcttca gcagtgttcc ggaatcttag
     3301 ttgagggaca aacattcctt ccagtgagag attcaagaat tgatgtgaat tgaatatatt
     3361 tttcaaggta ttataaattg tgttgtgttt tcagtataag aaaatgttga caggaaacaa
     3421 ttttatagca tttataaaaa accaacactt gtgcaatgct aaattggcga agcttctgca
     3481 cctgaattag agcacaataa atatgctgtt tataaaccaa atcactgcta ttccttctct
     3541 gaaatcatct ctcctctttt taaaccttta cttatagcta gaataaatca ctatttaatt
     3601 gcctctaata ctttaaaact actggatggt taggcctggt ttaactattt atggagagct
     3661 atttgcaaac ttaagttgtg taaatgtaat ttctacttgt gaatctgagc tgtagcagcc
     3721 cagagggagc taggcaaact attccagacc accaactgat aagtgatcag attctttgta
     3781 atgtaggatt ttttaacctg ttgattatgg gtttgttgat ataaatgtaa taatgttcac
     3841 ctcgattttc ctggagtaac aaccagcgtt ggtagtagcc cacctgcatg aggacggcca
     3901 gtgttaacaa tatttttgtt ctgatcttct tccccatttt tgtttcctca aacaggtttt
     3961 taggagagtg gagatttaaa gtcaggatgt ggccttttta ttttaattat atacttaatt
     4021 cttagaacaa gtagaatggg aaaggagtga ctgataaatc taagattcaa aatagtcccg
     4081 tcgaaactta aaggccagat tattgctttg gagctttcta taggtactag ccatcccgtc
     4141 gttaaatgtt ttcatggata tttgaaaaga agaccatgta cctttaataa ctgttctttt
     4201 ctcgagtttc tgcctcgtgc tttgacctgg attgcattat tattgtttat gcgaagtaaa
     4261 aaaaaaaaag gaaagcacaa gcttttcctg tatattatat ttccatttcc attttaaaat
     4321 aaaaacaatt ttcccaacaa cagcggtgtt attattcttg ctcagaagaa ttcttgctta
     4381 ttcaccaatt gcatagagat tttttaaagc aaaaacataa aaggaaggat gagacagcat
     4441 ccgtcaatat tttaaacctt ctggctactt tttatttctg ttagtattgc tgtaaggtaa
     4501 tatcctaact ttagttgagt cactatttgg cttgcacctt ttacaaagct aacatttcta
     4561 agacagttgt ttttaatatc taaaatatct ccttagcaag gaaatctgaa caacctatca
     4621 attaaattgt tgttttataa aatacacttg aatatgccat aaataaatgt gttttccaag
     4681 agga
//
