LOCUS       NM_022481               5258 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ArfGAP with RhoGAP domain, ankyrin repeat and PH
            domain 3 (ARAP3), mRNA.
ACCESSION   NM_022481
VERSION     NM_022481.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5258)
  AUTHORS   Chu,J.Y., McCormick,B., Sundaram,K., Hardisty,G., Karmakar,U.,
            Pumpe,C., Krull,E., Lucas,C.D., Amado-Azevedo,J., Hordijk,P.L.,
            Caporali,A., Mellor,H., Baillie,J.K., Rossi,A.G. and Vermeren,S.
  TITLE     ARAP3 protects from excessive formylated peptide-induced
            microvascular leakage by acting on endothelial cells and
            neutrophils
  JOURNAL   J Pathol 263 (3), 347-359 (2024)
   PUBMED   38734878
  REMARK    GeneRIF: ARAP3 protects from excessive formylated peptide-induced
            microvascular leakage by acting on endothelial cells and
            neutrophils.
REFERENCE   2  (bases 1 to 5258)
  AUTHORS   Zhang,Y., Ge,L., Xu,L., Liu,Y., Wang,J., Liu,C., Zhao,H., Xing,L.,
            Wang,J. and Wu,B.
  TITLE     Structural Insights Uncover the Specific Phosphoinositide
            Recognition by the PH1 Domain of Arap3
  JOURNAL   Int J Mol Sci 24 (2), 1125 (2023)
   PUBMED   36674645
  REMARK    GeneRIF: Structural Insights Uncover the Specific Phosphoinositide
            Recognition by the PH1 Domain of Arap3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5258)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5258)
  AUTHORS   Bao,H., Li,F., Wang,C., Wang,N., Jiang,Y., Tang,Y., Wu,J. and
            Shi,Y.
  TITLE     Structural Basis for the Specific Recognition of RhoA by the Dual
            GTPase-activating Protein ARAP3
  JOURNAL   J Biol Chem 291 (32), 16709-16719 (2016)
   PUBMED   27311713
  REMARK    GeneRIF: Structural Basis for the Specific Recognition of RhoA by
            the Dual GTPase-activating Protein ARAP3.
REFERENCE   5  (bases 1 to 5258)
  AUTHORS   Cerhan,J.R., Berndt,S.I., Vijai,J., Ghesquieres,H., McKay,J.,
            Wang,S.S., Wang,Z., Yeager,M., Conde,L., de Bakker,P.I.,
            Nieters,A., Cox,D., Burdett,L., Monnereau,A., Flowers,C.R., De
            Roos,A.J., Brooks-Wilson,A.R., Lan,Q., Severi,G., Melbye,M., Gu,J.,
            Jackson,R.D., Kane,E., Teras,L.R., Purdue,M.P., Vajdic,C.M.,
            Spinelli,J.J., Giles,G.G., Albanes,D., Kelly,R.S., Zucca,M.,
            Bertrand,K.A., Zeleniuch-Jacquotte,A., Lawrence,C., Hutchinson,A.,
            Zhi,D., Habermann,T.M., Link,B.K., Novak,A.J., Dogan,A.,
            Asmann,Y.W., Liebow,M., Thompson,C.A., Ansell,S.M., Witzig,T.E.,
            Weiner,G.J., Veron,A.S., Zelenika,D., Tilly,H., Haioun,C.,
            Molina,T.J., Hjalgrim,H., Glimelius,B., Adami,H.O., Bracci,P.M.,
            Riby,J., Smith,M.T., Holly,E.A., Cozen,W., Hartge,P., Morton,L.M.,
            Severson,R.K., Tinker,L.F., North,K.E., Becker,N., Benavente,Y.,
            Boffetta,P., Brennan,P., Foretova,L., Maynadie,M., Staines,A.,
            Lightfoot,T., Crouch,S., Smith,A., Roman,E., Diver,W.R., Offit,K.,
            Zelenetz,A., Klein,R.J., Villano,D.J., Zheng,T., Zhang,Y.,
            Holford,T.R., Kricker,A., Turner,J., Southey,M.C., Clavel,J.,
            Virtamo,J., Weinstein,S., Riboli,E., Vineis,P., Kaaks,R.,
            Trichopoulos,D., Vermeulen,R.C., Boeing,H., Tjonneland,A.,
            Angelucci,E., Di Lollo,S., Rais,M., Birmann,B.M., Laden,F.,
            Giovannucci,E., Kraft,P., Huang,J., Ma,B., Ye,Y., Chiu,B.C.,
            Sampson,J., Liang,L., Park,J.H., Chung,C.C., Weisenburger,D.D.,
            Chatterjee,N., Fraumeni,J.F. Jr., Slager,S.L., Wu,X., de
            Sanjose,S., Smedby,K.E., Salles,G., Skibola,C.F., Rothman,N. and
            Chanock,S.J.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for diffuse large B cell lymphoma
  JOURNAL   Nat Genet 46 (11), 1233-1238 (2014)
   PUBMED   25261932
REFERENCE   6  (bases 1 to 5258)
  AUTHORS   I,S.T., Nie,Z., Stewart,A., Najdovska,M., Hall,N.E., He,H.,
            Randazzo,P.A. and Lock,P.
  TITLE     ARAP3 is transiently tyrosine phosphorylated in cells attaching to
            fibronectin and inhibits cell spreading in a RhoGAP-dependent
            manner
  JOURNAL   J Cell Sci 117 (Pt 25), 6071-6084 (2004)
   PUBMED   15546919
  REMARK    GeneRIF: ARAP3 has a role in integrin-mediated tyrosine kinase
            signalling pathways controlling Rho GTPases and cell spreading
REFERENCE   7  (bases 1 to 5258)
  AUTHORS   Kowanetz,K., Husnjak,K., Holler,D., Kowanetz,M., Soubeyran,P.,
            Hirsch,D., Schmidt,M.H.H., Pavelic,K., De Camilli,P., Randazzo,P.A.
            and Dikic,I.
  TITLE     CIN85 associates with multiple effectors controlling intracellular
            trafficking of epidermal growth factor receptors
  JOURNAL   Mol Biol Cell 15 (7), 3155-3166 (2004)
   PUBMED   15090612
REFERENCE   8  (bases 1 to 5258)
  AUTHORS   Reinhard,C., Schweikert,M., Wieland,F.T. and Nickel,W.
  TITLE     Functional reconstitution of COPI coat assembly and disassembly
            using chemically defined components
  JOURNAL   Proc Natl Acad Sci U S A 100 (14), 8253-8257 (2003)
   PUBMED   12832619
  REMARK    GeneRIF: The catalytic domain of ARF-GAP alone is sufficient to
            initiate uncoating of liposome-derived COPI-coated vesicles.
            ARF-GAP activity is not required for COPI coat assembly & does not
            seem to be an essential coat component of COPI vesicles.
REFERENCE   9  (bases 1 to 5258)
  AUTHORS   Santy,L.C. and Casanova,J.E.
  TITLE     GTPase signaling: bridging the GAP between ARF and Rho
  JOURNAL   Curr Biol 12 (10), R360-R362 (2002)
   PUBMED   12015138
REFERENCE   10 (bases 1 to 5258)
  AUTHORS   Krugmann,S., Anderson,K.E., Ridley,S.H., Risso,N., McGregor,A.,
            Coadwell,J., Davidson,K., Eguinoa,A., Ellson,C.D., Lipp,P.,
            Manifava,M., Ktistakis,N., Painter,G., Thuring,J.W., Cooper,M.A.,
            Lim,Z.Y., Holmes,A.B., Dove,S.K., Michell,R.H., Grewal,A.,
            Nazarian,A., Erdjument-Bromage,H., Tempst,P., Stephens,L.R. and
            Hawkins,P.T.
  TITLE     Identification of ARAP3, a novel PI3K effector regulating both Arf
            and Rho GTPases, by selective capture on phosphoinositide affinity
            matrices
  JOURNAL   Mol Cell 9 (1), 95-108 (2002)
   PUBMED   11804589
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX489939.1, AJ310567.1,
            BC025757.1 and AK024718.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022481.5.
            
            Summary: This gene encodes a phosphoinositide binding protein
            containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin
            homology domains. The ARF-GAP and RHO-GAP domains cooperate in
            mediating rearrangements in the cell cytoskeleton and cell shape.
            It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP
            protein. An alternatively spliced transcript has been found for
            this gene, but its biological validity has not been determined.
            [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ310567.1, AK290052.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239440.9/ ENSP00000239440.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-536               BX489939.1         5-540
            537-1244            AJ310567.1         490-1197
            1245-1495           BC025757.1         1526-1776
            1496-5257           AJ310567.1         1449-5210
            5258-5258           AK024718.1         1147-1147
FEATURES             Location/Qualifiers
     source          1..5258
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..5258
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain 3"
                     /db_xref="GeneID:64411"
                     /db_xref="HGNC:HGNC:24097"
                     /db_xref="MIM:606647"
     exon            1..58
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            59..599
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..4710
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /note="ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin
                     homology domains-containing protein 3; phosphoinositide
                     binding protein; PtdIns(3,4,5)P3-binding protein; Arf and
                     Rho GAP adapter protein 3; centaurin-delta-3"
                     /codon_start=1
                     /product="arf-GAP with Rho-GAP domain, ANK repeat and PH
                     domain-containing protein 3"
                     /protein_id="NP_071926.4"
                     /db_xref="CCDS:CCDS4266.1"
                     /db_xref="GeneID:64411"
                     /db_xref="HGNC:HGNC:24097"
                     /db_xref="MIM:606647"
                     /translation="MAAPQDLDIAVWLATVHLEQYADTFRRHGLATAGAARGLGHEEL
                     KQLGISATGHRKRILRLLQTGTEEGSLDPKSDSAMEPSPSPAPQAQPPKPVPKPRTVF
                     GGLSGPATTQRPGLSPALGGPGVSRSPEPSPRPPPLPTSSSEQSSALNTVEMMPNSIY
                     FGLDSRGRAQAAQDKAPDSSQISAPTPALRPTTGTVHIMDPGCLYYGVQPVGTPGAPD
                     RRESRGVCQGRAEHRLSRQDLEAREDAGYASLELPGDSTLLSPTLETEETSDDLISPY
                     ASFSFTADRLTPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPL
                     TAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQRLLGHPRPPQP
                     PRPLRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSR
                     SFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRQCADCG
                     SSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDR
                     ANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHPQYPDHSQLLQALCAAV
                     ARPNLLKNMTQLLCVEAFEGEEPWFPPAPDGSCPGLLPSDPSPGVYNEVVVRATYSGF
                     LYCSPVSNKAGPSPPRRGRDAPPRLWCVLGAALEMFASENSPEPLSLIQPQDIVCLGV
                     SPPPTDPGDRFPFSFELILAGGRIQHFGTDGADSLEAWTSAVGKWFSPLSCHQLLGPG
                     LLRLGRLWLRSPSHTAPAPGLWLSGFGLLRGDHLFLCSAPGPGPPAPEDMVHLRRLQE
                     ISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFTAWNAAIGGAAGGGGTGLQEQQM
                     SRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPGEHF
                     VEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPRVNRRT
                     LATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVF
                     DIDSDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLPDNCVTLKVSPTLTAEE
                     LTNQVLEMRGTAAGMDLWVTFEIREHGELERPLHPKEKVLEQALQWCQLPEPCSASLL
                     LKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLGSRFQERFFLLRGRCLLLLKEK
                     KSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLILEKMHLYLSCTDEDEMWDWTTSI
                     LKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRT
                     LSMFFPMKSSQGSVEEQEELEEPVYEEPVYEEVGAFPELIQDTSTSFSTTREWTVKPE
                     NPLTSQKSLDQPFLSKSSTLGQEERPPEPPPGPPSKSSPQARGSLEEQLLQELSSLIL
                     RKGETTAGLGSPSQPSSPQSPSPTGLPTQTPGFPTQPPCTSSPPSSQPLT"
     exon            600..661
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..773
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..977
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1047
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1168
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1353
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1460
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1660
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1746
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1929
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2065
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2182
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2324
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2427
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2647
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2711
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2875
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3088
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3194
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3342
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3411
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3486
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3601
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3602..3730
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3731..3864
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3865..3947
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..3983
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3984..4047
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4185
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4186..4224
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..5258
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5237..5242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /note="hexamer: AATAAA"
     polyA_site      5258
                     /gene="ARAP3"
                     /gene_synonym="CENTD3; DRAG1"
                     /note="major polyA site"
ORIGIN      
        1 acccagaacc tcggacgagc ggcgggcacc cgcgagcgga cggcggccgc gtagtgagca
       61 atggcctgag cccccatggc tgcccctcag gacctggaca tcgctgtgtg gctggccacg
      121 gtgcacctgg agcagtatgc agacacgttc cgacggcatg gcctggctac agcaggtgca
      181 gcccggggcc tgggccacga ggagttgaag cagttgggca tcagcgccac agggcaccgg
      241 aaacgcattc tacgcctgct acagacaggc accgaagagg gctccctgga tcccaaatca
      301 gatagtgcca tggaaccatc ccccagccca gccccgcaag cccagccccc taagcccgtg
      361 ccgaagccca ggaccgtgtt tggtggactc agtggccctg ccaccactca gagacctggg
      421 ctgagcccag ccctcggggg accaggagtg tccaggagcc cagagcccag cccaaggcct
      481 cctcctctcc ccacttcctc ctctgagcag tcttcagccc taaatactgt ggagatgatg
      541 cctaattcca tctacttcgg cctggactca agaggcaggg cacaggcagc tcaggacaag
      601 gccccagaca gctcccaaat ctctgccccc acccctgccc tcaggcccac aacaggcaca
      661 gtgcacatca tggatcctgg ttgcctgtac tatggtgtcc aacctgtggg gactccagga
      721 gcccccgaca gaagagagag cagaggtgtt tgtcagggca gggctgaaca caggctcagc
      781 agacaggatc tggaggcacg ggaggatgct ggctatgcca gccttgagct acctggagac
      841 tccaccctct tatcgcccac cctggaaaca gaggagacca gtgatgacct catttcaccc
      901 tatgccagct tctccttcac ggcagaccgc ctcacgcccc tgctcagtgg ctggctagac
      961 aagctctccc ctcagggaaa ctatgtcttc cagagacgct ttgtgcagtt caatgggagg
     1021 agtctgatgt actttggcag tgacaaggac cccttcccta agggtgtgat acctttgact
     1081 gccattgaga tgacccgcag cagcaaggac aacaagttcc aggtcatcac cggccagagg
     1141 gtgttcgtgt tccgcacaga gagcgaggct cagcgggaca tgtggtgctc cacgctgcag
     1201 tcctgtctga aggagcagcg cctcctgggc cacccccggc ccccccaacc accccgaccc
     1261 ctccgcacgg gcatgctgga gctgcgtgga cacaaggcca aggtgtttgc tgccttgagc
     1321 cctggagagc tggcactgta caagagtgag caggccttct ctctgggcat cgggatctgc
     1381 ttcatcgaac tgcagggctg cagcgtccgg gagaccaaga gtcgaagctt tgacctgctc
     1441 acaccccatc gctgcttcag cttcacagcc gagtctgggg gtgctcggca gagctgggcg
     1501 gccgctctgc aggaagcagt aaccgagacc ctgtctgact acgaggtggc tgagaagatc
     1561 tggtctaatc gggccaaccg gcagtgtgcg gactgtgggt cctcccgccc agattgggct
     1621 gctgtcaatt tgggggtggt catctgcaag cagtgtgcag gtcagcaccg ggccctgggt
     1681 tctgggatct ccaaggtgca gagcctgaag ctggacacga gtgtctggag taatgagata
     1741 gtacagttat tcattgtcct gggaaatgat cgtgccaacc gcttctgggc agggacccta
     1801 cccccaggtg agggactaca tccagatgcg acccctggcc cccggggaga gttcatctcc
     1861 cgaaagtacc gtctgggtct cttccggaag ccccaccctc agtacccaga tcatagccag
     1921 cttctccagg cactgtgtgc agctgtggca agacccaacc tgctgaagaa catgacccag
     1981 ctcctctgtg ttgaggcctt tgaaggcgag gagccctggt tccccccagc ccctgatggc
     2041 agctgccctg gcctcttgcc ctcagacccc tcccctggtg tgtacaatga ggtggtggtg
     2101 cgtgctactt acagcggctt cctgtactgc agtcccgtca gcaacaaagc tggaccctca
     2161 ccccctcgca ggggccggga tgctcccccg cgcctttggt gtgtgctggg agcagctctg
     2221 gaaatgtttg catcggaaaa cagccctgaa cccctcagcc tcatacagcc ccaggatatt
     2281 gtatgtctgg gtgtgagccc cccacccact gacccaggtg acaggttccc cttttccttt
     2341 gagctcatcc tcgctggggg gaggatccag cattttggca cagatggagc tgacagtctg
     2401 gaggcctgga ctagtgctgt gggcaagtgg ttctccccgc tgagctgcca ccagctgctg
     2461 ggccccgggc tgctgcggct gggccgccta tggctgcggt ccccctccca tacagccccg
     2521 gcccctggtc tctggctgtc agggtttggc ctccttcgtg gtgaccacct cttcctgtgc
     2581 tcagcgccgg gcccaggccc cccagcccct gaggacatgg tgcatctgcg gcggctacag
     2641 gagatcagtg tggtttctgc agctgacacc ccagataaga aagagcattt ggtcctggtg
     2701 gagacaggaa ggaccctgta tctgcaagga gagggccggc tggacttcac ggcatggaac
     2761 gcagccattg ggggcgcggc tggtgggggc ggcacagggc tgcaggagca gcagatgagc
     2821 cggggtgaca tccccatcat cgtggatgcc tgcatcagtt ttgttaccca gcatgggctc
     2881 cggctggaag gtgtataccg gaaagggggc gctcgtgccc gcagcctgag actcctggct
     2941 gagttccgtc gggatgcccg gtcggtgaag ctccgaccag gggagcactt tgtggaggat
     3001 gtcactgaca cactcaaacg cttctttcgt gagctcgatg accctgtgac ctctgcacgg
     3061 ttgctgcctc gctggaggga ggctgctgag ctgccccaga agaatcagcg cctggagaaa
     3121 tataaagatg tgattggctg cctgccgcgg gtcaaccgcc gcacactggc caccctcatt
     3181 gggcatctct atcgggtgca gaaatgtgcg gctctaaacc agatgtgcac gcggaacttg
     3241 gctctgctgt ttgcacccag cgtgttccag acggatgggc gaggggagca cgaggtgcga
     3301 gtgctgcaag agctcattga tggctacatc tctgtctttg atatcgattc tgaccaggta
     3361 gctcagattg acttggaggt cagtcttatc accacctgga aggacgtgca gctgtctcag
     3421 gctggagacc tcatcatgga agtttatata gagcagcagc tcccagacaa ctgtgtcacc
     3481 ctgaaggtgt ccccaaccct gactgctgag gagctgacta accaggtact ggagatgcgg
     3541 gggacagcag ctgggatgga cttgtgggtg acttttgaga ttcgcgagca tggggagctg
     3601 gagcggccac tgcatcccaa ggaaaaggtc ttagagcagg ctttacaatg gtgccagctc
     3661 ccagagccct gctcagcttc cctgctcttg aaaaaagtcc ccctggccca agctggctgc
     3721 ctcttcacag gtatccgacg tgagagccca cgggtggggc tgttgcggtg tcgtgaggag
     3781 ccacctcgct tgctgggaag ccgcttccag gagaggttct ttctgctgcg tggccgctgc
     3841 ctgctgctgc tcaaggagaa gaaaagctct aaaccagaac gggagtggcc tttggaaggt
     3901 gccaaggtct acctgggaat ccgcaagaag ttaaagcccc caacaccgtg gggcttcaca
     3961 ttgatactag agaagatgca cctctacttg tcctgcactg acgaggatga aatgtgggat
     4021 tggaccacca gcatccttaa agcccagcac gatgaccagc agccagtggt cttacgacgc
     4081 cattcctcct ctgaccttgc ccgtcagaag tttggcacta tgcctttgct gcctatccgt
     4141 ggggatgaca gtggagccac cctcctctct gccaatcaga ccctgcggcg actacacaac
     4201 cggaggaccc tgtccatgtt ctttccaatg aagtcatccc aggggtctgt ggaggagcaa
     4261 gaggagctgg aggagcctgt gtacgaggag ccagtgtatg aggaagtagg ggccttccct
     4321 gagttgatcc aggacacttc tacctccttc tccaccacac gggagtggac agtgaagcca
     4381 gagaaccccc tcaccagcca gaagtcattg gatcaaccct ttctctccaa gtcaagcacc
     4441 cttggccagg aggagaggcc acctgagccc cctccaggcc ccccttcaaa gagcagtccc
     4501 caggcacggg ggtccctaga ggaacagctg ctccaggagc tcagcagcct catcctgagg
     4561 aaaggagaga ccactgcagg cctgggaagt ccttcccagc catccagccc ccaatccccc
     4621 agccccactg gccttccaac acagacacct ggcttcccca cccaaccccc atgcacttcc
     4681 agtccaccct ccagccagcc cctcacatga ccctaggacc agcagtctga gagggtaggt
     4741 accagaagac ccagaaactc ttatcgtggc actgttgcag cttcctctgc cctggctgga
     4801 aagactccag aatccagtgt ggtgctgtgg aaggagcact ggactaaagg cttcagtggc
     4861 tgcgtgtccc aggacaggtc atggcccctc tctgggccca gcccatttat ctataccatg
     4921 aggtaactga agtaaggaga gcagtgaatg tcaaactgtg tttcttagag ccataagccc
     4981 cacatattat ccctgaacaa gggcagctcc tgctttatat atttgatacg taggggttcc
     5041 atgagagatt ttgggtttta aaggaatggt tttactgcat taaagaaaaa aaatgctttg
     5101 gaaaccagag gcctgggtga tgttaaagtc tatcctgtcc cacttcctac attctgggac
     5161 taccgtgaag cctggagtag ggagagcgag tttgggagct gggactcggg gagtcaaaaa
     5221 tagatgagta attgtcaata aacctgggaa ccaaaaga
//
