LOCUS       NM_001040118            5156 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens ArfGAP with RhoGAP domain, ankyrin repeat and PH
            domain 1 (ARAP1), transcript variant 3, mRNA.
ACCESSION   NM_001040118
VERSION     NM_001040118.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5156)
  AUTHORS   Suzuki,K., Okawa,Y., Akter,S., Ito,H. and Shiba,Y.
  TITLE     Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate
            incorporation of CD63 in multivesicular bodies
  JOURNAL   Biol Open 13 (5) (2024)
   PUBMED   38682696
  REMARK    GeneRIF: Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate
            incorporation of CD63 in multivesicular bodies.
REFERENCE   2  (bases 1 to 5156)
  AUTHORS   Shao,A., Lopez,A.J., Chen,J., Tham,A., Javier,S., Quiroz,A.,
            Frick,S., Levine,E.M., Lloyd,K.C.K., Leonard,B.C., Murphy,C.J.,
            Glaser,T.M. and Moshiri,A.
  TITLE     Arap1 loss causes retinal pigment epithelium phagocytic dysfunction
            and subsequent photoreceptor death
  JOURNAL   Dis Model Mech 15 (7) (2022)
   PUBMED   35758026
  REMARK    GeneRIF: Arap1 loss causes retinal pigment epithelium phagocytic
            dysfunction and subsequent photoreceptor death.
REFERENCE   3  (bases 1 to 5156)
  AUTHORS   Bailetti,D., Sentinelli,F., Prudente,S., Cimini,F.A., Barchetta,I.,
            Totaro,M., Di Costanzo,A., Barbonetti,A., Leonetti,F., Cavallo,M.G.
            and Baroni,M.G.
  TITLE     Deep Resequencing of 9 Candidate Genes Identifies a Role for ARAP1
            and IGF2BP2 in Modulating Insulin Secretion Adjusted for Insulin
            Resistance in Obese Southern Europeans
  JOURNAL   Int J Mol Sci 23 (3), 1221 (2022)
   PUBMED   35163144
  REMARK    GeneRIF: Deep Resequencing of 9 Candidate Genes Identifies a Role
            for ARAP1 and IGF2BP2 in Modulating Insulin Secretion Adjusted for
            Insulin Resistance in Obese Southern Europeans.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5156)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 5156)
  AUTHORS   Li,X., Ma,T.K., Wen,S., Li,L.L., Xu,L., Zhu,X.W., Zhang,C.X.,
            Liu,N., Wang,X. and Fan,Q.L.
  TITLE     LncRNA ARAP1-AS2 promotes high glucose-induced human proximal
            tubular cell injury via persistent transactivation of the EGFR by
            interacting with ARAP1
  JOURNAL   J Cell Mol Med 24 (22), 12994-13009 (2020)
   PUBMED   32969198
  REMARK    GeneRIF: LncRNA ARAP1-AS2 promotes high glucose-induced human
            proximal tubular cell injury via persistent transactivation of the
            EGFR by interacting with ARAP1.
REFERENCE   6  (bases 1 to 5156)
  AUTHORS   Cuthbert,E.J., Davis,K.K. and Casanova,J.E.
  TITLE     Substrate specificities and activities of AZAP family Arf GAPs in
            vivo
  JOURNAL   Am J Physiol Cell Physiol 294 (1), C263-C270 (2008)
   PUBMED   18003747
  REMARK    GeneRIF: ARAP1 acts primarily on Arf6 in vivo.
REFERENCE   7  (bases 1 to 5156)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   8  (bases 1 to 5156)
  AUTHORS   Ahn,J., Chung,K.S., Kim,D.U., Won,M., Kim,L., Kim,K.S., Nam,M.,
            Choi,S.J., Kim,H.C., Yoon,M., Chae,S.K. and Hoe,K.L.
  TITLE     Systematic identification of hepatocellular proteins interacting
            with NS5A of the hepatitis C virus
  JOURNAL   J Biochem Mol Biol 37 (6), 741-748 (2004)
   PUBMED   15607035
REFERENCE   9  (bases 1 to 5156)
  AUTHORS   Miura,K., Jacques,K.M., Stauffer,S., Kubosaki,A., Zhu,K.,
            Hirsch,D.S., Resau,J., Zheng,Y. and Randazzo,P.A.
  TITLE     ARAP1: a point of convergence for Arf and Rho signaling
  JOURNAL   Mol Cell 9 (1), 109-119 (2002)
   PUBMED   11804590
REFERENCE   10 (bases 1 to 5156)
  AUTHORS   Krugmann,S., Anderson,K.E., Ridley,S.H., Risso,N., McGregor,A.,
            Coadwell,J., Davidson,K., Eguinoa,A., Ellson,C.D., Lipp,P.,
            Manifava,M., Ktistakis,N., Painter,G., Thuring,J.W., Cooper,M.A.,
            Lim,Z.Y., Holmes,A.B., Dove,S.K., Michell,R.H., Grewal,A.,
            Nazarian,A., Erdjument-Bromage,H., Tempst,P., Stephens,L.R. and
            Hawkins,P.T.
  TITLE     Identification of ARAP3, a novel PI3K effector regulating both Arf
            and Rho GTPases, by selective capture on phosphoinositide affinity
            matrices
  JOURNAL   Mol Cell 9 (1), 95-108 (2002)
   PUBMED   11804589
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003065.2, AY553630.1 and
            BC008315.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001040118.2.
            
            Summary: The protein encoded by this gene contains SAM, ARF-GAP,
            RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology
            (PH) domains. In vitro, this protein displays RHO-GAP and
            phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP
            activity. The encoded protein associates with the Golgi, and the
            ARF-GAP activity mediates changes in the Golgi and the formation of
            filopodia. It is thought to regulate the cell-specific trafficking
            of a receptor protein involved in apoptosis. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2008].
            
            Transcript Variant: This variant (3) is the longest transcript and
            it encodes the longest protein (isoform c).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY553630.1, SRR11853567.5885.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393609.8/ ENSP00000377233.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AP003065.2         148430-148448       c
            20-5150             AY553630.1         16-5146
            5151-5156           BC008315.1         2380-2385
FEATURES             Location/Qualifiers
     source          1..5156
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..5156
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain 1"
                     /db_xref="GeneID:116985"
                     /db_xref="HGNC:HGNC:16925"
                     /db_xref="MIM:606646"
     exon            1..81
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            82..164
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            165..717
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..4561
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /note="isoform c is encoded by transcript variant 3;
                     ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology
                     domains-containing protein 1; arf-GAP with Rho-GAP domain,
                     ANK repeat and PH domain-containing protein 1;
                     centaurin-delta-2"
                     /codon_start=1
                     /product="arf-GAP with Rho-GAP domain, ANK repeat and PH
                     domain-containing protein 1 isoform c"
                     /protein_id="NP_001035207.1"
                     /db_xref="CCDS:CCDS41687.1"
                     /db_xref="GeneID:116985"
                     /db_xref="HGNC:HGNC:16925"
                     /db_xref="MIM:606646"
                     /translation="MAEAGDAALSVAEWLRALHLEQYTGLFEQHGLVWATECQGLSDT
                     RLMDMGMLLPGHRRRILAGLLRAHTSPAPAPRPTPRPVPMKRHIFRSPPVPATPPEPL
                     PTTTEDEGLPAAPPIPPRRSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPP
                     RTGPPRLLVSLPTKEEESLLPSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPK
                     PVRLFPEFDDSDYDEVPEEGPGAPARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGD
                     DQGDEEEDDHAYEGVPNGGWHTSSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWL
                     DKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKFEVIT
                     NNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDRAGSLELR
                     GFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDRRSFDLTTPYRIFS
                     FSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWASINLC
                     VVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPS
                     EALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQALL
                     GCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVV
                     LPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRA
                     SEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLAED
                     LLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRKLQELSI
                     QGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPV
                     IVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSA
                     LKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH
                     LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEEL
                     RKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTL
                     EILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAM
                     EAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQ
                     RPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCC
                     DTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSV
                     AAFTADPLSLLRNV"
     exon            718..887
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            888..955
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1086
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1230
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1300
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1421
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1624
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1731
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1931
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2017
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2200
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2375
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2510
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2646
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2749
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2945
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..2997
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3161
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3374
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3480
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3628
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3715
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3784
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..3902
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            3903..4016
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            4017..4162
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4195
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            4196..4278
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4329
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            4330..4393
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..4543
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     exon            4544..5156
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5133..5138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /note="hexamer: AATATA"
     polyA_site      5156
                     /gene="ARAP1"
                     /gene_synonym="CENTD2; cnt-d2"
                     /note="major polyA site"
ORIGIN      
        1 gctgcaattt ggcggtggcg gtgtaagtcg gtggcggcgc cggtacgcct ggtccccgcg
       61 tggagtcttt actcaaaaca gctcccgcct caggccgaga tgaggagccc ttcagaatag
      121 ctgctgtctc tgggaggacc cgggcgtcct tggcagccca gctgctctgg acaaagccct
      181 gccagtcagg cctccgctgg caggaaccat ggcagaggct ggggatgctg cgctatcggt
      241 ggccgagtgg ctgcgggcat tgcacctgga gcagtacacg gggctctttg agcagcatgg
      301 cctggtgtgg gccactgagt gccaaggcct cagcgacacc cgcctgatgg acatgggcat
      361 gctactccct ggtcaccgcc gccgcatcct ggctggcctg ctccgtgccc atacctcacc
      421 ggcccctgca ccccgcccca ccccacggcc tgtgcccatg aagcgccaca tcttccgctc
      481 accacctgtg cctgccactc cacccgagcc gctgcccacc actacagagg atgaggggct
      541 ccccgctgcc ccacccatcc cgccccggag gagctgcctt ccgcccacct gcttcaccac
      601 cccatccaca gctgccccag accctgtgct gcccccgctg cctgctaagc ggcatttggc
      661 agagctgagc gttccacccg tgccgccccg caccggaccc ccccgcctgc tggtgagcct
      721 gcccactaag gaggaggagt cattgctgcc atcattatca tcccctcccc agccacagtc
      781 tgaggagccc ctgtccaccc tcccccaggg gcctccccag cctccctctc cacctccctg
      841 ccccccggag atacctccaa agccggtacg cctgttccca gagttcgatg actctgacta
      901 cgatgaggtc ccagaggagg ggccgggggc cccagccaga gtgatgacca agaaggagga
      961 gcccccaccg agccgagtcc cacgggccgt gcgcgtggcc agtctgctga gcgagggaga
     1021 ggaactgtct ggggacgacc aaggggatga ggaagaggat gaccacgcct atgagggcgt
     1081 ccccaatggc ggatggcata ccagcagcct gagcttgtcc ttgcccagca caatagctgc
     1141 gccacacccc atggacgggc cgcctggggg ctccaccccc gtcacaccag tcatcaaggc
     1201 tggctggctg gacaagaacc caccgcaggg atcttacatc tatcagaaac gatgggtgag
     1261 actggatact gatcacctgc gatactttga cagtaacaag gacgcttact ctaagcgctt
     1321 tatctctgtg gcctgcatct cccacgtggc tgccatcggg gaccagaagt ttgaagtgat
     1381 cacaaacaac cgaacctttg ccttccgggc agagagtgat gtggagcgga aggagtggat
     1441 gcaggccctg cagcaggcca tggctgagca gcgtgcccgg gcccggctct ctagcgctta
     1501 tctgctggga gttccaggct cagagcagcc tgaccgcgct ggcagcctgg agcttcgtgg
     1561 cttcaagaat aagctgtacg tggccgtggt cggggacaaa gtgcagctct acaagaatct
     1621 agaggagtac cacctgggca ttggcatcac cttcatcgac atgagcgtgg gcaacgtgaa
     1681 ggaagtggac cggcgcagct tcgacctcac cacgccctac cgcatcttca gcttctctgc
     1741 tgactcagag ctagagaagg agcagtggtt ggaggccatg cagggagcca tcgctgaggc
     1801 cctgtctacc tcggaggtgg ccgagcgcat ctgggctgca gcccccaaca ggttctgtgc
     1861 tgactgcggg gctcctcagc ctgactgggc ctccatcaac ctctgtgttg ttatctgcaa
     1921 gcgctgtgca ggggagcacc gtggcctggg cgctggcgtc tccaaggtgc ggagcctgaa
     1981 gatggacagg aaggtgtgga cagaaacact tatcgagctc ttcttacagc tggggaatgg
     2041 cgctgggaac cgcttctggg cagccaacgt gccccccagt gaggccctgc agcccagcag
     2101 cagccccagc acccggcggt gccacctgga ggccaagtac cgtgagggca agtaccgccg
     2161 ctaccacccg ctctttggca accaggagga gctggacaag gccctgtgtg ctgcagtcac
     2221 caccacagac ctggctgaga cccaggcgct cctgggctgt ggggctggga tcaactgctt
     2281 ctcgggggac cctgaggccc ccacgcccct ggctcttgca gagcaggcgg ggcagacgct
     2341 gcagatggaa ttccttcgga acaaccggac cacagaggtg cctcggctgg actcgatgaa
     2401 gcccctggaa aagcactact cagttgtcct gccgaccgtg agccacagtg gcttcctcta
     2461 caagactgcc tctgccggca agctgctaca ggaccgccgg gcccgggaag agttcagccg
     2521 gcgctggtgt gtccttggtg acggggtcct gagctacttt gagaatgagc gggcagtgac
     2581 ccccaatgga gagattcggg ccagcgagat tgtgtgcctg gcagtgcccc ctcctgacac
     2641 ccatggcttt gagcacacct ttgaggtgta cacggaggga gaacggctgt acctgtttgg
     2701 gctggagagt gcggagcagg ctcatgagtg ggtcaagtgt attgctaagg cattcgtgcc
     2761 tcccctagcc gaggatctgc tggcccggga ttttgagcgg ctgggacgcc taccctacaa
     2821 agctggcctg agcctacagc gggcccagga gggctggttc tctctcagtg gctcggagct
     2881 ccgtgctgtc ttcccggagg ggccctgcga agagccgctg caactacgga aactgcagga
     2941 gctttccatc cagggggaca gtgagaacca ggtgctggtg ctggtggagc gaaggaggac
     3001 actgtacata cagggcgagc ggcggctgga cttcatgggt tggctggggg ccatccagaa
     3061 agcagccgcc agcatggggg acacgctgtc ggagcagcag cttggggact cggatatccc
     3121 ggtgatcgtg taccgctgtg tggactacat cacgcagtgc ggcctgacct ccgagggcat
     3181 ctaccgcaag tgtgggcaga catcgaagac acagcggctg ctggagagcc tgcggcagga
     3241 tgcgcgctct gtgcacctca aggagggcga gcagcacgtg gatgatgttt cctcggcgct
     3301 caagcgcttc ctgcgcgacc tgcctgatgg gctcttcact cgcgcccagc gcctaacctg
     3361 gctggaggcc tcagagattg aggacgagga ggagaaggtc tccaggtacc gagagctgct
     3421 ggtgcggctg ccccctgtca accgggccac agtgaaggcc cttatcagcc acctgtactg
     3481 tgttcagtgc ttctcagaca cgaaccagat gaacgtgcac aacctggcaa ttgtgtttgg
     3541 gcccacgctc ttccagacag atgggcagga ctacaaggct ggccgtgtgg tggaagacct
     3601 cattaaccac tatgtggtgg tgtttagtgt ggatgaggaa gagctcagga agcagcggga
     3661 ggagatcact gccattgtga agatgcgcgt ggctggcact gccagtggga cccagcatgc
     3721 cggtgacttc atctgcacag tgtatctgga agagaagaag gcagagactg agcagcatat
     3781 caaggtccca gcatccatga ctgctgagga gctcaccctg gagatcctgg atcgccggaa
     3841 cgtgggcatc agggagaagg actattggac ctgctttgag gtcaacgaga gggaggaggc
     3901 agagcgcccc ctgcactttg cggagaaggt gctgcccatc ctgcacgggc tgggcacgga
     3961 cagccacctg gtggtgaaga agcaccaggc catggaggcc atgctgctgt acctggccag
     4021 ccgtgtcggt gacaccaagc atggcatgat gaagttccgt gaggaccgca gcctcctggg
     4081 cctgggcctg ccctcaggtg gcttccacga tcgctacttc atcctcaaca gcagctgctt
     4141 gcggctctac aaggaggtcc ggagccagag gccgtggagc ggggcccctg agaccagtca
     4201 ccggcctgag aaggagtggc ctattaagag tctcaaagtc tacctgggag tgaagaagaa
     4261 actcaggcca cccacctgct ggggcttcac agtggtgcat gagacagaga aacatgagaa
     4321 gcagcagtgg tacctctgct gtgacacaca gatggagctc cgggagtggt tcgctacctt
     4381 tctgtttgtg cagcatgacg gcctggtgtg gccctcagag ccctcacgcg tgtcccgggc
     4441 agtgcctgag gtccggctgg gtagtgtgtc actgatcccc cttcgaggta gtgaaaatga
     4501 aatgcgccgg agtgtggctg ccttcaccgc ggaccctctg tctcttctgc gcaacgtctg
     4561 agcacaggag cccatccttg gctctaggat tccgccgctg gaagccttct gttcagacac
     4621 cccttatgct ccaaggcctg atgtgagcca gcggggggtg catgggaaac tgcaccccac
     4681 aacccacatc ctccatcctg actgcagcat ggggttcccc ggcaggggtg ggaggcagca
     4741 ggggtcagcc tgggcaggaa cctctcccaa ctctgtccag gtgttcagac ctcttggccc
     4801 aacctgctca ccccaccggg ttcactgtcc ttgtggggct ggagagatgg gcataagtca
     4861 ggaacttggg aggaccacca ccctttcaga ggcgtgaggc cctggggccc tgccggaagg
     4921 gagccccctg ctcctcccaa caaactccag aacagcagaa agcgggtgct gtagaggagc
     4981 actcagctca cggggaggga gctcttggct gagcttctac agggctgaga gctgcgcttt
     5041 ggggacttca gccttccttc cagtctgggc tgagtggggg gtccagacta cctgatgccc
     5101 cttccccaat ttggggactt tttgataata taaatatatc tgtatatttt acccta
//
