LOCUS       NM_000044              10667 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens androgen receptor (AR), transcript variant 1, mRNA.
ACCESSION   NM_000044 NM_001424175
VERSION     NM_000044.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10667)
  AUTHORS   Yang,Y., Huang,J.W. and Yu,W.W.
  TITLE     Androgen Receptor Promotes Lung Cancer Metastasis by Modifying the
            miR23a-3p/EPHB2 Pathway
  JOURNAL   Curr Med Sci 44 (5), 954-963 (2024)
   PUBMED   39390216
  REMARK    GeneRIF: Androgen Receptor Promotes Lung Cancer Metastasis by
            Modifying the miR23a-3p/EPHB2 Pathway.
REFERENCE   2  (bases 1 to 10667)
  AUTHORS   Yang,X., Guo,Z., Sun,F., Li,W., Alfano,A., Shimelis,H., Chen,M.,
            Brodie,A.M.H., Chen,H., Xiao,Z., Veenstra,T.D. and Qiu,Y.
  TITLE     Novel membrane-associated androgen receptor splice variant
            potentiates proliferative and survival responses in prostate cancer
            cells
  JOURNAL   J Biol Chem 286 (41), 36152-36160 (2011)
   PUBMED   21878636
  REMARK    GeneRIF: the membrane-associated AR8 isoform may contribute to
            castration resistance by potentiating AR-mediated proliferative and
            survival responses to hormones and growth factors.
REFERENCE   3  (bases 1 to 10667)
  AUTHORS   Watson,P.A., Chen,Y.F., Balbas,M.D., Wongvipat,J., Socci,N.D.,
            Viale,A., Kim,K. and Sawyers,C.L.
  TITLE     Constitutively active androgen receptor splice variants expressed
            in castration-resistant prostate cancer require full-length
            androgen receptor
  JOURNAL   Proc Natl Acad Sci U S A 107 (39), 16759-16765 (2010)
   PUBMED   20823238
REFERENCE   4  (bases 1 to 10667)
  AUTHORS   Sun,S., Sprenger,C.C., Vessella,R.L., Haugk,K., Soriano,K.,
            Mostaghel,E.A., Page,S.T., Coleman,I.M., Nguyen,H.M., Sun,H.,
            Nelson,P.S. and Plymate,S.R.
  TITLE     Castration resistance in human prostate cancer is conferred by a
            frequently occurring androgen receptor splice variant
  JOURNAL   J Clin Invest 120 (8), 2715-2730 (2010)
   PUBMED   20644256
REFERENCE   5  (bases 1 to 10667)
  AUTHORS   Guo,Z., Yang,X., Sun,F., Jiang,R., Linn,D.E., Chen,H., Chen,H.,
            Kong,X., Melamed,J., Tepper,C.G., Kung,H.J., Brodie,A.M.,
            Edwards,J. and Qiu,Y.
  TITLE     A novel androgen receptor splice variant is up-regulated during
            prostate cancer progression and promotes androgen
            depletion-resistant growth
  JOURNAL   Cancer Res 69 (6), 2305-2313 (2009)
   PUBMED   19244107
REFERENCE   6  (bases 1 to 10667)
  AUTHORS   Hu,R., Dunn,T.A., Wei,S., Isharwal,S., Veltri,R.W., Humphreys,E.,
            Han,M., Partin,A.W., Vessella,R.L., Isaacs,W.B., Bova,G.S. and
            Luo,J.
  TITLE     Ligand-independent androgen receptor variants derived from splicing
            of cryptic exons signify hormone-refractory prostate cancer
  JOURNAL   Cancer Res 69 (1), 16-22 (2009)
   PUBMED   19117982
REFERENCE   7  (bases 1 to 10667)
  AUTHORS   Ahrens-Fath,I., Politz,O., Geserick,C. and Haendler,B.
  TITLE     Androgen receptor function is modulated by the tissue-specific AR45
            variant
  JOURNAL   FEBS J 272 (1), 74-84 (2005)
   PUBMED   15634333
  REMARK    GeneRIF: data suggest an important role of AR45 in modulating AR
            function and add a novel level of complexity to the mode of action
            of androgens
REFERENCE   8  (bases 1 to 10667)
  AUTHORS   Gottlieb,B. and Trifiro,M.A.
  TITLE     Androgen Insensitivity Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301602
REFERENCE   9  (bases 1 to 10667)
  AUTHORS   La Spada,A.
  TITLE     Spinal and Bulbar Muscular Atrophy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301508
REFERENCE   10 (bases 1 to 10667)
  AUTHORS   Wooster,R., Mangion,J., Eeles,R., Smith,S., Dowsett,M., Averill,D.,
            Barrett-Lee,P., Easton,D.F., Ponder,B.A. and Stratton,M.R.
  TITLE     A germline mutation in the androgen receptor gene in two brothers
            with breast cancer and Reifenstein syndrome
  JOURNAL   Nat Genet 2 (2), 132-134 (1992)
   PUBMED   1303262
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049564.11, BC132975.1,
            AF321915.1, M20132.1, AL356358.19 and AA505591.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Dec 3, 2024 this sequence version replaced
            NM_001424175.1, NM_000044.5.
            
            Summary: The androgen receptor gene is more than 90 kb long and
            codes for a protein that has 3 major functional domains: the
            N-terminal domain, DNA-binding domain, and androgen-binding domain.
            The protein functions as a steroid-hormone activated transcription
            factor. Upon binding the hormone ligand, the receptor dissociates
            from accessory proteins, translocates into the nucleus, dimerizes,
            and then stimulates transcription of androgen responsive genes.
            This gene contains 2 polymorphic trinucleotide repeat segments that
            encode polyglutamine and polyglycine tracts in the N-terminal
            transactivation domain of its protein. Expansion of the
            polyglutamine tract from the normal 9-34 repeats to the pathogenic
            38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also
            known as Kennedy's disease). Mutations in this gene are also
            associated with complete androgen insensitivity (CAIS). Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1, also known as AR-FL in
            PMID:20823238) represents the longest transcript and encodes the
            longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M20132.1, BC132975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374690.9/ ENSP00000363822.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-674               AL049564.11        102963-103636
            675-1296            BC132975.1         12-633
            1297-2546           AF321915.1         249-1498
            2547-3994           BC132975.1         1866-3313
            3995-4316           M20132.1           3228-3549
            4317-10311          AL356358.19        73715-79709
            10312-10667         AA505591.1         6-361               c
FEATURES             Location/Qualifiers
     source          1..10667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..10667
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /note="androgen receptor"
                     /db_xref="GeneID:367"
                     /db_xref="HGNC:HGNC:644"
                     /db_xref="MIM:313700"
     exon            1..2742
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /inference="alignment:Splign:2.1.0"
     CDS             1127..3889
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dihydrotestosterone receptor; nuclear receptor subfamily 3
                     group C member 4"
                     /codon_start=1
                     /product="androgen receptor isoform 1"
                     /protein_id="NP_000035.2"
                     /db_xref="CCDS:CCDS14387.1"
                     /db_xref="GeneID:367"
                     /db_xref="HGNC:HGNC:644"
                     /db_xref="MIM:313700"
                     /translation="MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEA
                     ASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRR
                     GPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAA
                     PSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAP
                     TSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVP
                     PAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAG
                     SSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENP
                     LDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGPC
                     GGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGM
                     VSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDE
                     ASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAG
                     MTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIE
                     PGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQY
                     SWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWL
                     QITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRR
                     FYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKP
                     IYFHTQ"
     exon            2743..2894
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3011
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3299
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3444
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3575
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3733
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..10667
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10190..10195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /note="hexamer: GATAAA"
     polyA_site      10223
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /note="major polyA site"
     regulatory      10419..10424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /note="hexamer: ATTAAA"
     polyA_site      10448
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /note="major polyA site"
     regulatory      10650..10655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /note="hexamer: AAGAAA"
     polyA_site      10667
                     /gene="AR"
                     /gene_synonym="AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4;
                     SBMA; SMAX1; TFM"
                     /note="major polyA site"
ORIGIN      
        1 agcgccccct ccgagatccc ggggagccag cttgctggga gagcgggacg gtccggagca
       61 agcccagagg cagaggaggc gacagaggga aaaagggccg agctagccgc tccagtgctg
      121 tacaggagcc gaagggacgc accacgccag ccccagcccg gctccagcga cagccaacgc
      181 ctcttgcagc gcggcggctt cgaagccgcc gcccggagct gccctttcct cttcggtgaa
      241 gtttttaaaa gctgctaaag actcggagga agcaaggaaa gtgcctggta ggactgacgg
      301 ctgcctttgt cctcctcctc tccaccccgc ctccccccac cctgccttcc ccccctcccc
      361 cgtcttctct cccgcagctg cctcagtcgg ctactctcag ccaacccccc tcaccaccct
      421 tctccccacc cgcccccccg cccccgtcgg cccagcgctg ccagcccgag tttgcagaga
      481 ggtaactccc tttggctgcg agcgggcgag ctagctgcac attgcaaaga aggctcttag
      541 gagccaggcg actggggagc ggcttcagca ctgcagccac gacccgcctg gttaggctgc
      601 acgcggagag aaccctctgt tttcccccac tctctctcca cctcctcctg ccttccccac
      661 cccgagtgcg gagccagaga tcaaaagatg aaaaggcagt caggtcttca gtagccaaaa
      721 aacaaaacaa acaaaaacaa aaaagccgaa ataaaagaaa aagataataa ctcagttctt
      781 atttgcacct acttcagtgg acactgaatt tggaaggtgg aggattttgt ttttttcttt
      841 taagatctgg gcatcttttg aatctaccct tcaagtatta agagacagac tgtgagccta
      901 gcagggcaga tcttgtccac cgtgtgtctt cttctgcacg agactttgag gctgtcagag
      961 cgctttttgc gtggttgctc ccgcaagttt ccttctctgg agcttcccgc aggtgggcag
     1021 ctagctgcag cgactaccgc atcatcacag cctgttgaac tcttctgagc aagagaaggg
     1081 gaggcggggt aagggaagta ggtggaagat tcagccaagc tcaaggatgg aagtgcagtt
     1141 agggctggga agggtctacc ctcggccgcc gtccaagacc taccgaggag ctttccagaa
     1201 tctgttccag agcgtgcgcg aagtgatcca gaacccgggc cccaggcacc cagaggccgc
     1261 gagcgcagca cctcccggcg ccagtttgct gctgctgcag cagcagcagc agcagcagca
     1321 gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcaagaga ctagccccag
     1381 gcagcagcag cagcagcagg gtgaggatgg ttctccccaa gcccatcgta gaggccccac
     1441 aggctacctg gtcctggatg aggaacagca accttcacag ccgcagtcgg ccctggagtg
     1501 ccaccccgag agaggttgcg tcccagagcc tggagccgcc gtggccgcca gcaaggggct
     1561 gccgcagcag ctgccagcac ctccggacga ggatgactca gctgccccat ccacgttgtc
     1621 cctgctgggc cccactttcc ccggcttaag cagctgctcc gctgacctta aagacatcct
     1681 gagcgaggcc agcaccatgc aactccttca gcaacagcag caggaagcag tatccgaagg
     1741 cagcagcagc gggagagcga gggaggcctc gggggctccc acttcctcca aggacaatta
     1801 cttagggggc acttcgacca tttctgacaa cgccaaggag ttgtgtaagg cagtgtcggt
     1861 gtccatgggc ctgggtgtgg aggcgttgga gcatctgagt ccaggggaac agcttcgggg
     1921 ggattgcatg tacgccccac ttttgggagt tccacccgct gtgcgtccca ctccttgtgc
     1981 cccattggcc gaatgcaaag gttctctgct agacgacagc gcaggcaaga gcactgaaga
     2041 tactgctgag tattcccctt tcaagggagg ttacaccaaa gggctagaag gcgagagcct
     2101 aggctgctct ggcagcgctg cagcagggag ctccgggaca cttgaactgc cgtctaccct
     2161 gtctctctac aagtccggag cactggacga ggcagctgcg taccagagtc gcgactacta
     2221 caactttcca ctggctctgg ccggaccgcc gccccctccg ccgcctcccc atccccacgc
     2281 tcgcatcaag ctggagaacc cgctggacta cggcagcgcc tgggcggctg cggcggcgca
     2341 gtgccgctat ggggacctgg cgagcctgca tggcgcgggt gcagcgggac ccggttctgg
     2401 gtcaccctca gccgccgctt cctcatcctg gcacactctc ttcacagccg aagaaggcca
     2461 gttgtatgga ccgtgtggtg gtggtggggg tggtggcggc ggcggcggcg gcggcggcgg
     2521 cggcggcggc ggcggcggcg gcggcgaggc gggagctgta gccccctacg gctacactcg
     2581 gccccctcag gggctggcgg gccaggaaag cgacttcacc gcacctgatg tgtggtaccc
     2641 tggcggcatg gtgagcagag tgccctatcc cagtcccact tgtgtcaaaa gcgaaatggg
     2701 cccctggatg gatagctact ccggacctta cggggacatg cgtttggaga ctgccaggga
     2761 ccatgttttg cccattgact attactttcc accccagaag acctgcctga tctgtggaga
     2821 tgaagcttct gggtgtcact atggagctct cacatgtgga agctgcaagg tcttcttcaa
     2881 aagagccgct gaagggaaac agaagtacct gtgcgccagc agaaatgatt gcactattga
     2941 taaattccga aggaaaaatt gtccatcttg tcgtcttcgg aaatgttatg aagcagggat
     3001 gactctggga gcccggaagc tgaagaaact tggtaatctg aaactacagg aggaaggaga
     3061 ggcttccagc accaccagcc ccactgagga gacaacccag aagctgacag tgtcacacat
     3121 tgaaggctat gaatgtcagc ccatctttct gaatgtcctg gaagccattg agccaggtgt
     3181 agtgtgtgct ggacacgaca acaaccagcc cgactccttt gcagccttgc tctctagcct
     3241 caatgaactg ggagagagac agcttgtaca cgtggtcaag tgggccaagg ccttgcctgg
     3301 cttccgcaac ttacacgtgg acgaccagat ggctgtcatt cagtactcct ggatggggct
     3361 catggtgttt gccatgggct ggcgatcctt caccaatgtc aactccagga tgctctactt
     3421 cgcccctgat ctggttttca atgagtaccg catgcacaag tcccggatgt acagccagtg
     3481 tgtccgaatg aggcacctct ctcaagagtt tggatggctc caaatcaccc cccaggaatt
     3541 cctgtgcatg aaagcactgc tactcttcag cattattcca gtggatgggc tgaaaaatca
     3601 aaaattcttt gatgaacttc gaatgaacta catcaaggaa ctcgatcgta tcattgcatg
     3661 caaaagaaaa aatcccacat cctgctcaag acgcttctac cagctcacca agctcctgga
     3721 ctccgtgcag cctattgcga gagagctgca tcagttcact tttgacctgc taatcaagtc
     3781 acacatggtg agcgtggact ttccggaaat gatggcagag atcatctctg tgcaagtgcc
     3841 caagatcctt tctgggaaag tcaagcccat ctatttccac acccagtgaa gcattggaaa
     3901 ccctatttcc ccaccccagc tcatgccccc tttcagatgt cttctgcctg ttataactct
     3961 gcactactcc tctgcagtgc cttggggaat ttcctctatt gatgtacagt ctgtcatgaa
     4021 catgttcctg aattctattt gctgggcttt ttttttctct ttctctcctt tctttttctt
     4081 cttccctccc tatctaaccc tcccatggca ccttcagact ttgcttccca ttgtggctcc
     4141 tatctgtgtt ttgaatggtg ttgtatgcct ttaaatctgt gatgatcctc atatggccca
     4201 gtgtcaagtt gtgcttgttt acagcactac tctgtgccag ccacacaaac gtttacttat
     4261 cttatgccac gggaagttta gagagctaag attatctggg gaaatcaaaa caaaaacaag
     4321 caaacaaaaa aaaaaagcaa aaacaaaaca aaaaataagc caaaaaacct tgctagtgtt
     4381 ttttcctcaa aaataaataa ataaataaat aaatacgtac atacatacac acatacatac
     4441 aaacatatag aaatccccaa agaggccaat agtgacgaga aggtgaaaat tgcaggccca
     4501 tggggagtta ctgatttttt catctcctcc ctccacggga gactttattt tctgccaatg
     4561 gctattgcca ttagagggca gagtgacccc agagctgagt tgggcagggg ggtggacaga
     4621 gaggagagga caaggagggc aatggagcat cagtacctgc ccacagcctt ggtccctggg
     4681 ggctagactg ctcaactgtg gagcaattca ttatactgaa aatgtgcttg ttgttgaaaa
     4741 tttgtctgca tgttaatgcc tcacccccaa acccttttct ctctcactct ctgcctccaa
     4801 cttcagattg actttcaata gtttttctaa gacctttgaa ctgaatgttc tcttcagcca
     4861 aaacttggcg acttccacag aaaagtctga ccactgagaa gaaggagagc agagatttaa
     4921 ccctttgtaa ggccccattt ggatccaggt ctgctttctc atgtgtgagt cagggaggag
     4981 ctggagccag aggagaagaa aatgatagct tggctgttct cctgcttagg acactgactg
     5041 aatagttaaa ctctcactgc cactaccttt tccccacctt taaaagacct gaatgaagtt
     5101 ttctgccaaa ctccgtgaag ccacaagcac cttatgtcct cccttcagtg ttttgtgggc
     5161 ctgaatttca tcacactgca tttcagccat ggtcatcaag cctgtttgct tcttttgggc
     5221 atgttcacag attctctgtt aagagccccc accaccaaga aggttagcag gccaacagct
     5281 ctgacatcta tctgtagatg ccagtagtca caaagatttc ttaccaactc tcagatcgct
     5341 ggagccctta gacaaactgg aaagaaggca tcaaagggat caggcaagct gggcgtcttg
     5401 cccttgtccc ccagagatga taccctccca gcaagtggag aagttctcac ttccttcttt
     5461 agagcagcta aaggggctac ccagatcagg gttgaagaga aaactcaatt accagggtgg
     5521 gaagaatgaa ggcactagaa ccagaaaccc tgcaaatgct cttcttgtca cccagcatat
     5581 ccacctgcag aagtcatgag aagagagaag gaacaaagag gagactctga ctactgaatt
     5641 aaaatcttca gcggcaaagc ctaaagccag atggacacca tctggtgagt ttactcatca
     5701 tcctcctctg ctgctgattc tgggctctga cattgcccat actcactcag attccccacc
     5761 tttgttgctg cctcttagtc agagggaggc caaaccattg agactttcta cagaaccatg
     5821 gcttctttcg gaaaggtctg gttggtgtgg ctccaatact ttgccaccca tgaactcagg
     5881 gtgtgccctg ggacactggt tttatatagt cttttggcac acctgtgttc tgttgacttc
     5941 gttcttcaag cccaagtgca agggaaaatg tccacctact ttctcatctt ggcctctgcc
     6001 tccttactta gctcttaatc tcatctgttg aactcaagaa atcaagggcc agtcatcaag
     6061 ctgcccattt taattgattc actctgtttg ttgagaggat agtttctgag tgacatgata
     6121 tgatccacaa gggtttcctt ccctgatttc tgcattgata ttaatagcca aacgaacttc
     6181 aaaacagctt taaataacaa gggagagggg aacctaagat gagtaatatg ccaatccaag
     6241 actgctggag aaaactaaag ctgacaggtt ccctttttgg ggtgggatag acatgttctg
     6301 gttttcttta ttattacaca atctggctca tgtacaggat cacttttagc tgttttaaac
     6361 agaaaaaaat atccaccact cttttcagtt acactaggtt acattttaat aggtccttta
     6421 catctgtttt ggaatgattt tcatcttttg tgatacacag attgaattat atcattttca
     6481 tatctctcct tgtaaatact agaagctctc ctttacattt ctctatcaaa tttttcatct
     6541 ttatgggttt cccaattgtg actcttgtct tcatgaatat atgtttttca tttgcaaaag
     6601 ccaaaaatca gtgaaacagc agtgtaatta aaagcaacaa ctggattact ccaaatttcc
     6661 aaatgacaaa actagggaaa aatagcctac acaagccttt aggcctactc tttctgtgct
     6721 tgggtttgag tgaacaaagg agattttagc ttggctctgt tctcccatgg atgaaaggag
     6781 gaggattttt tttttctttt ggccattgat gttctagcca atgtaattga cagaagtctc
     6841 attttgcatg cgctctgctc tacaaacaga gttggtatgg ttggtatact gtactcacct
     6901 gtgagggact ggccactcag acccacttag ctggtgagct agaagatgag gatcactcac
     6961 tggaaaagtc acaaggacca tctccaaaca agttggcagt gctcgatgtg gacgaagagt
     7021 gaggaagaga aaaagaagga gcaccaggga gaaggctccg tctgtgctgg gcagcagaca
     7081 gctgccagga tcacgaactc tgtagtcaaa gaaaagagtc gtgtggcagt ttcagctctc
     7141 gttcattggg cagctcgcct aggcccagcc tctgagctga catgggagtt gttggattct
     7201 ttgtttcata gctttttcta tgccataggc aatattgttg ttcttggaaa gtttattatt
     7261 tttttaactc ccttactctg agaaagggat attttgaagg actgtcatat atctttgaaa
     7321 aaagaaaatc tgtaatacat atatttttat gtatgttcac tggcactaaa aaatatagag
     7381 agcttcattc tgtcctttgg gtagttgctg aggtaattgt ccaggttgaa aaataatgtg
     7441 ctgatgctag agtccctctc tgtccatact ctacttctaa atacatatag gcatacatag
     7501 caagttttat ttgacttgta ctttaagaga aaatatgtcc accatccaca tgatgcacaa
     7561 atgagctaac attgagcttc aagtagcttc taagtgtttg tttcattagg cacagcacag
     7621 atgtggcctt tccccccttc tctcccttga tatctggcag ggcataaagg cccaggccac
     7681 ttcctctgcc ccttcccagc cctgcaccaa agctgcattt caggagactc tctccagaca
     7741 gcccagtaac tacccgagca tggcccctgc atagccctgg aaaaataaga ggctgactgt
     7801 ctacgaatta tcttgtgcca gttgcccagg tgagagggca ctgggccaag ggagtggttt
     7861 tcatgtttga cccactacaa ggggtcatgg gaatcaggaa tgccaaagca ccagatcaaa
     7921 tccaaaactt aaagtcaaaa taagccattc agcatgttca gtttcttgga aaaggaagtt
     7981 tctacccctg atgcctttgt aggcagatct gttctcacca ttaatctttt tgaaaatctt
     8041 ttaaagcagt ttttaaaaag agagatgaaa gcatcacatt atataaccaa agattacatt
     8101 gtacctgcta agataccaaa attcataagg gcaggggggg agcaagcatt agtgcctctt
     8161 tgataagctg tccaaagaca gactaaagga ctctgctggt gactgactta taagagcttt
     8221 gtgggttttt ttttccctaa taatatacat gtttagaaga attgaaaata atttcgggaa
     8281 aatgggatta tgggtccttc actaagtgat tttataagca gaactggctt tccttttctc
     8341 tagtagttgc tgagcaaatt gttgaagctc catcattgca tggttggaaa tggagctgtt
     8401 cttagccact gtgtttgcta gtgcccatgt tagcttatct gaagatgtga aacccttgct
     8461 gataagggag catttaaagt actagatttt gcactagagg gacagcaggc agaaatcctt
     8521 atttctgccc actttggatg gcacaaaaag ttatctgcag ttgaaggcag aaagttgaaa
     8581 tacattgtaa atgaatattt gtatccatgt ttcaaaattg aaatatatat atatatatat
     8641 atatatatat atatatatat atagtgtgtg tgtgtgttct gatagcttta actttctctg
     8701 catctttata tttggttcca gatcacacct gatgccatgt acttgtgaga gaggatgcag
     8761 ttttgttttg gaagctctct cagaacaaac aagacacctg gattgatcag ttaactaaaa
     8821 gttttctccc ctattgggtt tgacccacag gtcctgtgaa ggagcagagg gataaaaaga
     8881 gtagaggaca tgatacattg tactttacta gttcaagaca gatgaatgtg gaaagcataa
     8941 aaactcaatg gaactgactg agatttacca cagggaaggc ccaaacttgg ggccaaaagc
     9001 ctacccaagt gattgaccag tggcccccta atgggacctg agctgttgga agaagagaac
     9061 tgttccttgg tcttcaccat ccttgtgaga gaagggcagt ttcctgcatt ggaacctgga
     9121 gcaagcgctc tatctttcac acaaattccc tcacctgaga ttgaggtgct cttgttactg
     9181 ggtgtctgtg tgctgtaatt ctggttttgg atatgttctg taaagatttt gacaaatgaa
     9241 aatgtgtttt tctctgttaa aacttgtcag agtactagaa gttgtatctc tgtaggtgca
     9301 ggtccatttc tgcccacagg tagggtgttt ttctttgatt aagagattga cacttctgtt
     9361 gcctaggacc tcccaactca accatttcta ggtgaaggca gaaaaatcca cattagttac
     9421 tcctcttcag acatttcagc tgagataaca aatcttttgg aattttttca cccatagaaa
     9481 gagtggtaga tatttgaatt tagcaggtgg agtttcatag taaaaacagc ttttgactca
     9541 gctttgattt atcctcattt gatttggcca gaaagtaggt aatatgcatt gattggcttc
     9601 tgattccaat tcagtatagc aaggtgctag gttttttcct ttccccacct gtctcttagc
     9661 ctggggaatt aaatgagaag ccttagaatg ggtggccctt gtgacctgaa acacttccca
     9721 cataagctac ttaacaagat tgtcatggag ctgcagattc cattgcccac caaagactag
     9781 aacacacaca tatccataca ccaaaggaaa gacaattctg aaatgctgtt tctctggtgg
     9841 ttccctctct ggctgctgcc tcacagtatg ggaacctgta ctctgcagag gtgacaggcc
     9901 agatttgcat tatctcacaa ccttagccct tggtgctaac tgtcctacag tgaagtgcct
     9961 ggggggttgt cctatcccat aagccacttg gatgctgaca gcagccacca tcagaatgac
    10021 ccacgcaaaa aaaagaaaaa aaaaattaaa aagtcccctc acaacccagt gacacctttc
    10081 tgctttcctc tagactggaa cattgattag ggagtgcctc agacatgaca ttcttgtgct
    10141 gtccttggaa ttaatctggc agcaggaggg agcagactat gtaaacagag ataaaaatta
    10201 attttcaata ttgaaggaaa aaagaaataa gaagagagag agaaagaaag catcacacaa
    10261 agattttctt aaaagaaaca attttgcttg aaatctcttt agatggggct catttctcac
    10321 ggtggcactt ggcctccact gggcagcagg accagctcca agcgctagtg ttctgttctc
    10381 tttttgtaat cttggaatct tttgttgctc taaatacaat taaaaatggc agaaacttgt
    10441 ttgttggact acatgtgtga ctttgggtct gtctctgcct ctgctttcag aaatgtcatc
    10501 cattgtgtaa aatattggct tactggtctg ccagctaaaa cttggccaca tcccctgtta
    10561 tggctgcagg atcgagttat tgttaacaaa gagacccaag aaaagctgct aatgtcctct
    10621 tatcattgtt gttaatttgt taaaacataa agaaatctaa aatttca
//
