LOCUS       NM_014691               9597 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens aquarius intron-binding spliceosomal factor (AQR),
            mRNA.
ACCESSION   NM_014691 XM_029045
VERSION     NM_014691.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9597)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 9597)
  AUTHORS   Song,C., Yan,H., Wang,H., Zhang,Y., Cao,H., Wan,Y., Kong,L.,
            Chen,S., Xu,H., Pan,B., Zhang,J., Fan,G., Xin,H., Liang,Z., Jia,W.
            and Tian,X.L.
  TITLE     AQR is a novel type 2 diabetes-associated gene that regulates
            signaling pathways critical for glucose metabolism
  JOURNAL   J Genet Genomics 45 (2), 111-120 (2018)
   PUBMED   29502958
  REMARK    GeneRIF: Our study suggests that AQR is a novel type 2
            diabetes-associated gene that regulates signaling pathways critical
            for glucose metabolism.
REFERENCE   3  (bases 1 to 9597)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 9597)
  AUTHORS   Zhang,X., Yan,C., Hang,J., Finci,L.I., Lei,J. and Shi,Y.
  TITLE     An Atomic Structure of the Human Spliceosome
  JOURNAL   Cell 169 (5), 918-929 (2017)
   PUBMED   28502770
REFERENCE   5  (bases 1 to 9597)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   6  (bases 1 to 9597)
  AUTHORS   Silva,L.K., Blanton,R.E., Parrado,A.R., Melo,P.S., Morato,V.G.,
            Reis,E.A., Dias,J.P., Castro,J.M., Vasconcelos,P.F., Goddard,K.A.,
            Barreto,M.L., Reis,M.G. and Teixeira,M.G.
  TITLE     Dengue hemorrhagic fever is associated with polymorphisms in JAK1
  JOURNAL   Eur J Hum Genet 18 (11), 1221-1227 (2010)
   PUBMED   20588308
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 9597)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 9597)
  AUTHORS   Hirose,T., Ideue,T., Nagai,M., Hagiwara,M., Shu,M.D. and
            Steitz,J.A.
  TITLE     A spliceosomal intron binding protein, IBP160, links
            position-dependent assembly of intron-encoded box C/D snoRNP to
            pre-mRNA splicing
  JOURNAL   Mol Cell 23 (5), 673-684 (2006)
   PUBMED   16949364
REFERENCE   9  (bases 1 to 9597)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 9597)
  AUTHORS   Sam,M., Wurst,W., Kluppel,M., Jin,O., Heng,H. and Bernstein,A.
  TITLE     Aquarius, a novel gene isolated by gene trapping with an
            RNA-dependent RNA polymerase motif
  JOURNAL   Dev Dyn 212 (2), 304-317 (1998)
   PUBMED   9626505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018868.4.
            
            On Nov 23, 2018 this sequence version replaced NM_014691.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.51066.1,
                                           SRR1660807.30390.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000156471.10/ ENSP00000156471.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AC018868.4         155929-156132       c
            205-261             AC018868.4         150624-150680       c
            262-302             AC018868.4         147164-147204       c
            303-338             AC018868.4         139275-139310       c
            339-459             AC018868.4         134654-134774       c
            460-600             AC018868.4         130678-130818       c
            601-669             AC018868.4         128402-128470       c
            670-770             AC018868.4         127289-127389       c
            771-847             AC018868.4         125127-125203       c
            848-912             AC018868.4         120961-121025       c
            913-1029            AC018868.4         118708-118824       c
            1030-1143           AC018868.4         116648-116761       c
            1144-1247           AC018868.4         113425-113528       c
            1248-1350           AC018868.4         106722-106824       c
            1351-1471           AC018868.4         104648-104768       c
            1472-1613           AC018868.4         101428-101569       c
            1614-1792           AC018868.4         96525-96703         c
            1793-1960           AC018868.4         92935-93102         c
            1961-2130           AC018868.4         90726-90895         c
            2131-2372           AC018868.4         87012-87253         c
            2373-2519           AC018868.4         83949-84095         c
            2520-2589           AC018868.4         83287-83356         c
            2590-2700           AC018868.4         80053-80163         c
            2701-2810           AC018868.4         76605-76714         c
            2811-2946           AC018868.4         72916-73051         c
            2947-3156           AC018868.4         70915-71124         c
            3157-3294           AC018868.4         68892-69029         c
            3295-3366           AC018868.4         62325-62396         c
            3367-3554           AC018868.4         61067-61254         c
            3555-3726           AC018868.4         60218-60389         c
            3727-3897           AC018868.4         57142-57312         c
            3898-3983           AC018868.4         53914-53999         c
            3984-4158           AC018868.4         49257-49431         c
            4159-4272           AC018868.4         46432-46545         c
            4273-9597           AC018868.4         38172-43496         c
FEATURES             Location/Qualifiers
     source          1..9597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..9597
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /note="aquarius intron-binding spliceosomal factor"
                     /db_xref="GeneID:9716"
                     /db_xref="HGNC:HGNC:29513"
                     /db_xref="MIM:610548"
     exon            1..204
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..4587
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /EC_number="3.6.4.13"
                     /note="functional spliceosome-associated protein 164;
                     intron-binding protein aquarius; intron-binding protein of
                     160 kDa; aquarius homolog"
                     /codon_start=1
                     /product="RNA helicase aquarius"
                     /protein_id="NP_055506.1"
                     /db_xref="CCDS:CCDS42013.1"
                     /db_xref="GeneID:9716"
                     /db_xref="HGNC:HGNC:29513"
                     /db_xref="MIM:610548"
                     /translation="MAAPAQPKKIVAPTVSQINAEFVTQLACKYWAPHIKKKSPFDIK
                     VIEDIYEKEIVKSRFAIRKIMLLEFSQYLENYLWMNYSPEVSSKAYLMSICCMVNEKF
                     RENVPAWEIFKKKPDHFPFFFKHILKAALAETDGEFSLHEQTVLLLFLDHCFNSLEVD
                     LIRSQVQQLISLPMWMGLQLARLELELKKTPKLRKFWNLIKKNDEKMDPEAREQAYQE
                     RRFLSQLIQKFISVLKSVPLSEPVTMDKVHYCERFIELMIDLEALLPTRRWFNTILDD
                     SHLLVHCYLSNLVRREEDGHLFSQLLDMLKFYTGFEINDQTGNALTENEMTTIHYDRI
                     TSLQRAAFAHFPELYDFALSNVAEVDTRESLVKFFGPLSSNTLHQVASYLCLLPTLPK
                     NEDTTFDKEFLLELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCL
                     ALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWA
                     RMAQPIVAFTVVEVAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLIT
                     VRPTKPYGTKFDRRRPFIEQVGLVYVRGCEIQGMLDDKGRVIEDGPEPRPNLRGESRT
                     FRVFLDPNQYQQDMTNTIQNGAEDVYETFNIIMRRKPKENNFKAVLETIRNLMNTDCV
                     VPDWLHDIILGYGDPSSAHYSKMPNQIATLDFNDTFLSIEHLKASFPGHNVKVTVEDP
                     ALQIPPFRITFPVRSGKGKKRKDADVEDEDTEEAKTLIVEPHVIPNRGPYPYNQPKRN
                     TIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNFPEQRTLIVTHSN
                     QALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLARRIELLEEVKR
                     LQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYISKVKNKGSTLPDVTEVSTFFPFHE
                     YFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLVK
                     EAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRL
                     KRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNL
                     YNWRYKNLGNLPHVQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQNLGEA
                     EYVVALFMYMCLLGYPADKISILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDR
                     FQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFELTPAF
                     SQLTARPLHLHIIPTEPFPTTRKNGERPSHEVQIIKNMPQMANFVYNMYMHLIQTTHH
                     YHQTLLQLPPAMVEEGEEVQNQETELETEEEAMTVQADIIPSPTDTSCRQETPAFQTD
                     TTPSETGATSTPEAIPALSETTPTVVGAVSAPAEANTPQDATSAPEETK"
     exon            205..261
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            262..302
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            303..338
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            339..459
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            460..600
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            601..669
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            670..770
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            771..847
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            848..912
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1029
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1143
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1247
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1350
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1471
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1613
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1792
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1960
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2130
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2372
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2519
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2589
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2700
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2810
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2946
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3156
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3294
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3366
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3554
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3726
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            3727..3897
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..3983
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            3984..4158
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..4272
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..9597
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4733..4738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /note="hexamer: AATATA"
     polyA_site      4751
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /note="major polyA site"
     regulatory      4850..4855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /note="hexamer: ATTAAA"
     polyA_site      4870
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /note="major polyA site"
     regulatory      9572..9577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /note="hexamer: AGTAAA"
     polyA_site      9597
                     /gene="AQR"
                     /gene_synonym="fSAP164; IBP160"
                     /note="major polyA site"
ORIGIN      
        1 atccggcccg gagcgtttgt gcggcgcgga gttaagcgcc ccggcagtaa cttaagggaa
       61 gtggaccagg gttgccgctg cccagagcgg tcctttagtt tccactggag tggagggaag
      121 agtgctgcca tggcagcccc tgcgcagccc aagaagatcg tggcccctac ggtgtcccaa
      181 atcaatgcgg agttcgtgac ccagttagca tgtaaatact gggctcccca catcaagaag
      241 aaatcacctt ttgatataaa ggttattgaa gatatatatg aaaaagagat tgtcaaatca
      301 aggtttgcta ttagaaagat aatgctcttg gaatttagcc agtatcttga aaattatctc
      361 tggatgaatt attctcctga ggtatctagc aaggcctatt taatgtcaat ctgctgtatg
      421 gtgaatgaga agtttagaga aaacgtgcct gcatgggaga tttttaagaa gaagccagac
      481 cacttcccat tcttttttaa acacatcttg aaggcggcat tagctgaaac tgatggtgaa
      541 ttttcacttc atgaacagac agtcttacta ctttttcttg atcattgctt caatagtttg
      601 gaagtagact tgatacgaag tcaagtacag cagcttatct ccctcccaat gtggatgggc
      661 ttacagctgg cacgattgga attagaatta aaaaagacac ctaagctaag aaaattctgg
      721 aacttgatta aaaagaatga tgaaaagatg gatccagaag caagagaaca ggcatatcaa
      781 gagaggagat ttctttcaca actcatccag aagtttatct ctgtgctgaa atcagtccca
      841 ctttctgaac ctgtcactat ggacaaagtt cattactgtg aaagattcat tgaacttatg
      901 attgatctag aggccctgct acccacaagg cgctggttta ataccatcct ggatgattcc
      961 caccttctgg ttcactgtta cctttccaat cttgttcgta gagaagagga tggccatctt
     1021 ttttcccagc ttttggacat gcttaaattc tatactggtt ttgaaattaa tgaccaaact
     1081 ggaaatgctc tgacagagaa tgagatgacc acaattcact atgatagaat tacttctcta
     1141 cagagagctg cttttgcaca ttttcctgaa ctctatgatt ttgccctctc aaatgtggca
     1201 gaagtagata ctcgggagtc cttggtcaag ttttttggac ctcttagttc aaacacactc
     1261 caccaggtgg catcatacct ctgcttgttg ccaactcttc ctaaaaatga agacacaact
     1321 tttgataaag aatttcttct agaattgctg gtatctcgtc atgaacgtcg aatttctcag
     1381 attcagcagt tgaaccagat gcctttgtat ccaactgaga aaattatatg ggatgaaaat
     1441 attgtcccaa ctgagtacta ttctggagaa ggttgtcttg ctcttcccaa attgaatttg
     1501 cagtttttga ctcttcatga ctacctgcta aggaacttta acctcttccg cttagaatca
     1561 acttatgaaa ttcgtcagga cattgaagat agtgtcagca gaatgaagcc atggcaatct
     1621 gaatatggcg gtgtagtgtt tggtggttgg gcgcgaatgg cccagcccat tgtggctttc
     1681 actgtcgttg aagtggccaa acccaacata ggtgaaaact ggccaacccg agttcgtgca
     1741 gatgttacca taaatctcaa tgtcagagat cacatcaaag atgaatggga aggtcttcgt
     1801 aagcatgatg tatgcttttt aattaccgta cgtcccacaa aaccttatgg cactaagttt
     1861 gaccggagga gaccttttat tgagcaggtt ggcctggttt atgtcagagg ctgtgaaatt
     1921 cagggcatgc tggatgataa aggacgtgtc attgaagatg gacctgaacc cagacccaat
     1981 cttagaggag aatcaaggac atttagagtg tttttggatc caaaccagta tcaacaagat
     2041 atgaccaata ctatacaaaa tggagcagag gatgtgtatg aaacttttaa tataataatg
     2101 aggagaaaac caaaggaaaa taactttaag gctgtgctgg agactattcg gaacctgatg
     2161 aatactgatt gtgtggtacc tgactggctg cacgatatca ttttaggtta tggggaccca
     2221 agtagtgcac attattcgaa aatgcccaat cagattgcca cccttgattt caatgataca
     2281 tttctctcca ttgagcattt aaaagccagc ttccctggtc ataatgttaa agtaactgta
     2341 gaagaccctg ctctacaaat accccctttc aggataactt ttccagtaag aagtggaaaa
     2401 gggaagaaaa ggaaagatgc ggatgtggaa gatgaagaca ccgaggaagc aaaaacctta
     2461 attgttgagc cccatgttat tcctaatagg ggtccttatc cttataatca acccaaacgt
     2521 aatacgattc agttcactca tacacagata gaagccatcc gtgctggaat gcagcctggg
     2581 ctgactatgg ttgtgggccc acctggtaca ggcaaaacag atgtggcagt tcagatcata
     2641 tccaacatct accacaactt cccagaacag aggactctaa ttgttactca ttccaatcag
     2701 gccctaaacc agttgtttga gaaaatcatg gcattagaca ttgatgagcg ccacctactg
     2761 cgtcttggtc atggagaaga agagctggag acagagaaag atttcagcag gtatggaaga
     2821 gttaattatg ttctggctcg aagaatagaa cttttagaag aagtcaaacg attgcaaaag
     2881 agtctagggg ttccaggaga tgcctcatat acctgtgaaa ctgcaggcta tttcttctta
     2941 taccaggtaa tgtctcgctg ggaagagtat atcagcaaag tgaaaaataa aggtagtaca
     3001 ttgccagatg ttacggaagt ctccactttc ttccctttcc atgaatactt tgcaaatgct
     3061 cctcaaccca tttttaaagg aagatcttat gaagaagaca tggaaattgc tgaaggatgt
     3121 ttcaggcata ttaagaaaat ctttacgcag cttgaggaat tcagagcctc tgaattgctt
     3181 cgaagtggac tggacagatc taaatacctt ttagtgaaag aagccaaaat tattgctatg
     3241 acctgtactc atgctgcctt aaaacgacat gacttggtca agctaggttt caagtatgac
     3301 aacattttga tggaagaggc tgctcagatt ctggagatag aaacttttat ccctcttctt
     3361 ctacagaatc ctcaggatgg atttagccga ctaaaacgat ggattatgat tggcgatcat
     3421 caccagttac ctccagttat taagaacatg gcctttcaaa agtactcaaa catggagcag
     3481 tctctcttca ctcgctttgt tcgcgttgga gttccgactg ttgaccttga tgctcaaggg
     3541 agagccagag caagcttgtg caacctctac aactggcgat acaagaatct aggaaactta
     3601 ccccatgtgc agctcttgcc agagtttagt acagcaaatg ctggcttact gtatgacttc
     3661 cagctcatta atgttgaaga ttttcaagga gtgggagaat ctgaacctaa tccttacttc
     3721 tatcagaatc ttggagaggc agaatatgta gtagcacttt ttatgtacat gtgtttactt
     3781 ggttaccctg ctgacaaaat cagtattcta acaacatata atggccaaaa gcatcttatt
     3841 cgcgacatca tcaatagacg atgtggaaac aatccattga ttggaagacc aaacaaggtg
     3901 acaactgttg atagatttca aggtcaacag aatgactata ttcttctttc tctggtacga
     3961 accagggcag tgggccatct gagggatgtc cgtcgcttgg tagtggccat gtctagagcc
     4021 agacttggac tttatatctt cgccagagta tccctcttcc aaaactgttt tgaactgact
     4081 ccagctttca gtcagctcac agctcgcccc cttcatttgc atataattcc aacagaacct
     4141 ttcccaacta ctagaaagaa tggagagaga ccatctcatg aagtacaaat aataaaaaat
     4201 atgccccaga tggcaaactt tgtatacaac atgtacatgc atttgataca gactacacat
     4261 cattatcatc agactttatt acaactacca cctgctatgg tagaagaggg tgaggaagtt
     4321 caaaatcaag aaacagaatt ggaaacagaa gaagaggcca tgactgttca agctgacatc
     4381 atacccagtc caacagacac cagctgccgt caagaaactc cagcctttca aactgacacc
     4441 acccccagtg agacaggagc cacttccact ccagaagcca tccctgcttt atctgagacc
     4501 acccctactg tggtaggagc tgtatctgca ccggcagaag ctaacacacc tcaggatgcc
     4561 acatctgccc cggaagagac caagtagcca aactgtagtc cttctaaagg aggacatggc
     4621 agtcaaaaag tctgagtaaa gctgtttttt gtattttata tttgcttctg ccattttact
     4681 gtcactaatt aatgtttagt tcttatattt gttaactgat ttcggtgtct tgaatatatt
     4741 tttttaaatt atgtgtatga acaattctag tttcatttgt tcaatcagaa gagcaaataa
     4801 ccattccttt catgttttga tcactgagtg tgtctgtaat catacctaca ttaaaatcat
     4861 tttctatgaa tatataatat atacttcaca tttttagtga acttctctaa agaagaggac
     4921 agaatatact ggacttaacc acgaataccc ttgagtgtcc aaattgggaa ggaacttgtt
     4981 tcttctgtta tactatcaaa tgcttaaatt ctgtttcctt ttttcttacc tttgtttgct
     5041 gtctttatgt aaagatatta ttagcagtaa gatacaggtt tcttcaatct atcaaagtgg
     5101 ttacatgcat ttccttctct caaatcttag aatgccttag aatcacctaa gatgtctgtt
     5161 tattcttgag gcacacctca gactgaatga gtcagaatct caggattaga gcctaggaat
     5221 ctatatttta ggaggttctc cacaccacta atgtttgggt tgctggcaga gtggcatcag
     5281 ccaaggctgg ttaggctgag ccaggatttg tcatcagcta aataggagga ctctgccaaa
     5341 tcaatctggg caagaagcag gatcctgagt ctgggcaatg agagtcagag aacttaactc
     5401 ctgtgtgcag ggtagaattt tcccatggca gaaattctga gttttctgcc ttatttttct
     5461 tgggataacc agccacaagg agaccttcag gtaaaatgtg gttcaaatat gggaaggcag
     5521 aggtacctgg gaccttgcta ctcaagtatg atttgtgaac caacagcatc aacatcgtat
     5581 tgaagtttgt tatttataga aatgcagaag tttgggctct gctccaaacc tattaaatct
     5641 aaatctacat tgcaacaaag tccccaggtg attcacaggc actttgtagt ttgagaagca
     5701 ctgtactaag attactgtgt tgtcttcaca tgaatgaggc tataatgtag aattaccagt
     5761 gaatgtgact aatgttttct gacaagggac ctctgcttac aaggtccctg ggcatggtgc
     5821 ccagaactgg aaaaaaaaaa aaaaaaaagg aaatgtttat atgtatgtgt agaggggaaa
     5881 attgcccact agttctctat ttcccatttt gatcatctgc tagagtatct aaaggggagg
     5941 ggagcattta ccccagaatg tctcctctag tgcatccacc tatgggcctg gccatgtcca
     6001 aggaatcttt gaagaaacaa gcaagaactg cacactacca ttgaaatcct tctggtcctg
     6061 acattttgaa ggaatgattg cttcataggg aaattaaacc cagaaagtca agtcagttat
     6121 atttttgagt gactagtgtt tgctcagctc taccaggctg tgttgaatat ggtacagact
     6181 ctcattttat gatgtatcct actgcatcag gacatttgtg tcaatgtcag gtgatgaggg
     6241 gaaatgaaag tgatgagacg atgagaggag tgaaatacca aggacgcgat actaggaaac
     6301 ccaggtctat ttgttatcag agtaaggatc aagccagata gcctgttatg taatttctcc
     6361 gataaaagat tttgaaagca ggtgctgtgg gcatctgtat ggggaatcgc actcatagaa
     6421 ttattttcat ttgtaaatat ttggtatcag gccaagcaag ggaaagaagc tttactgtat
     6481 taccatcttt cctggaaaag attgattttt ctctctccct taggggatat gaggtatgat
     6541 acctgcaacc aaaataagct ggctgttaag tgctctctcc ttaactattg tccaagcaat
     6601 gtacatcact cttgcctaga tgagtgacca tacttttttc tttgctgctt ggtttttcta
     6661 tcactaaaaa gcaaatttag gtggaagatg gatgggtaag tcctttgtcc ttgtcaaaag
     6721 aatttagaaa gggtaaaggt ggtgggattt gaattctttt aaacggttta ttcattggaa
     6781 aggcaagtga gtggcagttg actgtagaat cttgggaatt tttgaaggaa tttaagagct
     6841 gtacttattt taaataatga ggaaacaatc agagagactt aaccagggtg gcaactatgg
     6901 aagagtgggg gtagaatcca agtctacagt tctacggcac tgctttgttt attttttcaa
     6961 tcaagcacac atgagggatt gcttaataaa ttcaagagtt ttctatatag tttgggatta
     7021 ctacagacac aggtactcta gccatgtgac tatttcagat tagtgttccc attgctctcc
     7081 atcctatttt tcatatctaa atgtgtcatg attttagaat ctctttgtaa agaaaaccaa
     7141 aaagagccat gcccaaaaga atgagcatga aatgaagcaa ttcaagtatt tagaatttct
     7201 tcttcttttt tttttttttt tttcaaaatt ctgagttaag aaagttcatt gccaacagtt
     7261 gaggataaat agctctattg atttaggcaa atgaatgaga agatttaaac atcatcaaga
     7321 ctcccaaagt tggtgtaata aaagttgaga tgttttgcta gatgctgaga gaaaaggcat
     7381 aaataggcca tttgtgctcc tgtaaacaaa tgaaattttg taatgatcaa gagacagcaa
     7441 gatattataa aacacacttt ggactcatcg agacctggct cagagttgta cctaatttgc
     7501 ttatcagcat ttggttagac cttagacaaa ttttataacc tctctaagcc cattttcttt
     7561 atctgtaaat aaaggaaaaa gatctgtttg gatttgggac aggagagttg tctgttttat
     7621 agggtaatgt ttatgaaaat aatttatcac ctaggtactt agtaaatacc agtttctgtc
     7681 tctgtttttc ttcaaagctt tgttgacaat gtaggatatt gccaactaat cctttgactt
     7741 gagtgcttag ccatgcccca atccaggcag catgaagaat gatcaagaag gggacaccta
     7801 gtggcagttg acctttgagg atctatctag gatcaggtta ctgatttggg acctctgaat
     7861 cagtacatca taacatcgag agtgatctct gccaaaatta aaattctgtc agaacagtat
     7921 aagcagaagg aagacattag gtctttctga aatatggagc tgataacttc tatcagttct
     7981 gaattctgta ctgtcccacc cccaaatcat ctatattgtt gcatgtgctt agctttgtgc
     8041 cttgaattgc tatttccttt ttatcttgca ctcagatggt atttttagag atgtttcttc
     8101 aatcaaaaca agataaagtt aaaaaaaaaa aaaaaacagt gacccttttg cataagccag
     8161 aagagcagtg ccttgcttcc tgtgaaaaat gcttggcagt tagcctgtgt aattatttag
     8221 caatcatgtt aatagatgtt taagaataat ggaactggag ctgtactgag ccaaggatgg
     8281 aaatgaagac atgtgagact attttttctt catccaccga tactcttcag ttacaaggat
     8341 ttaatttaaa agggttttaa ttaaatggaa tccagaagct ttggacgctc cagtttttct
     8401 tcttagagac aaaccctagc tcagtttcct ggagcttgac tcagaatgca gcatggtact
     8461 ccggactgac agtgtgccag ctttattcac ttatctctct accttttggc ttgcgtttat
     8521 ttcagggctg cctgacattt tgaccttatg tacaaagatg gccgatacga ttatttttca
     8581 tcatatatta cagaaaatac tactcttgaa aaatactctg agaaatatgt tctatggtca
     8641 gataagtttg ggaaacagtg aattattgtt cctcctttgc agaatcacaa tgcactgtta
     8701 gctaattaaa gactctcaga tgtcccactg gaaagaatca tgtttagctt tgtttaacct
     8761 agcatttccc aaacttatta gagcataaaa ctttgttttt gttttttttt aataagatag
     8821 gtagctattt ccttagaaca cagtttggga aactttttgt tcatttgttt taataagata
     8881 ccttaggtag ctatttcctt agaacacgag ccgggtgcag tggctcacgc ctgtaatccc
     8941 agcactttgg gaggcccagg cgggcggatc acctgaggtc aggagatcga gatcatccgg
     9001 cccaacatgg tgaaaccccg tctctactaa aaagacaaaa attagccagc catggtggca
     9061 ggcacctgta gtcctagcta ctgtggaggc tgaggcagga gaatcacttg aacccgggat
     9121 ggggaggttg cagtgagctg agatggcgcc actgtactcc agcctgggcg acgagcaaaa
     9181 actccttcaa aaaaaaaaaa aaaacataac ttaggtagct atttccttgg gaaccaatat
     9241 ctttacattg gctagaactg tgaatcgccc tttaaagata aagccccaaa atacattttt
     9301 tttccctaca ggtaaccaga gggtgaagta acagccgaag aggaaaccag aagtgaagtg
     9361 atttgtacaa aatgtcgtag tgtaatttat tgagtgtcat gtggtattaa tcgcaacatc
     9421 ctgaaaatgc aaatgaataa aagtttggtc aatgtaccat gacattcctt catgtgagcc
     9481 tcctaagaaa aggtcactga gcattctctg tttacatttt aattttagac tccagaattt
     9541 cacactaagt ttttcttctc atttcttatg cagtaaaaga agagtttgta tttccaa
//
