LOCUS       NM_001169               1325 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens aquaporin 8 (AQP8), mRNA.
ACCESSION   NM_001169
VERSION     NM_001169.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1325)
  AUTHORS   Shen,Z., Sheng,H., Zhao,J., Xu,J., Cai,Z., Zhang,H., Guo,Z.,
            Liu,J., Liang,H., Tan,L., Gan,S., Huang,J. and Zhu,S.
  TITLE     AQP8 Modulates Mitochondrial H2O2 Transport to Influence Glioma
            Proliferation
  JOURNAL   Cancer Invest 42 (4), 345-356 (2024)
   PUBMED   38742677
  REMARK    GeneRIF: AQP8 Modulates Mitochondrial H2O2 Transport to Influence
            Glioma Proliferation.
REFERENCE   2  (bases 1 to 1325)
  AUTHORS   Lin,C., He,H., Kim,J.J., Zheng,X., Huang,Z. and Dai,N.
  TITLE     Osmotic pressure induces translocation of aquaporin-8 by P38 and
            JNK MAPK signaling pathways in patients with functional
            constipation
  JOURNAL   Dig Liver Dis 55 (8), 1049-1059 (2023)
   PUBMED   36792433
  REMARK    GeneRIF: Osmotic pressure induces translocation of aquaporin-8 by
            P38 and JNK MAPK signaling pathways in patients with functional
            constipation.
REFERENCE   3  (bases 1 to 1325)
  AUTHORS   Capiglioni,A.M., Capitani,M.C., Marrone,J. and Marinelli,R.A.
  TITLE     Adenoviral Transfer of Human Aquaporin-8 Gene to Mouse Liver
            Improves Ammonia-Derived Ureagenesis
  JOURNAL   Cells 12 (11), 1535 (2023)
   PUBMED   37296655
  REMARK    GeneRIF: Adenoviral Transfer of Human Aquaporin-8 Gene to Mouse
            Liver Improves Ammonia-Derived Ureagenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1325)
  AUTHORS   Cai,Z., Shen,Z., Zhao,J., Zhang,H., Guo,Z., Xia,Q., Liang,H.,
            Liu,J., Tan,L., Sheng,H. and Zhu,S.
  TITLE     AQP8 may affect glioma proliferation and growth by regulating
            GSK-3beta phosphorylation and nuclear transport of beta-catenin
  JOURNAL   Int J Dev Neurosci 83 (4), 333-345 (2023)
   PUBMED   37081713
  REMARK    GeneRIF: AQP8 may affect glioma proliferation and growth by
            regulating GSK-3beta phosphorylation and nuclear transport of
            beta-catenin.
REFERENCE   5  (bases 1 to 1325)
  AUTHORS   Capiglioni,A.M., Muller,G.L., Marrone,J., Alvarez,M.L. and
            Marinelli,R.A.
  TITLE     Enhanced ammonia detoxification to urea in hepatocytes transduced
            with human aquaporin-8 gene
  JOURNAL   Biotechnol Bioeng 118 (11), 4331-4337 (2021)
   PUBMED   34292591
REFERENCE   6  (bases 1 to 1325)
  AUTHORS   Kuwahara,M., Gu,Y., Ishibashi,K., Marumo,F. and Sasaki,S.
  TITLE     Mercury-sensitive residues and pore site in AQP3 water channel
  JOURNAL   Biochemistry 36 (46), 13973-13978 (1997)
   PUBMED   9369468
REFERENCE   7  (bases 1 to 1325)
  AUTHORS   Harrington,D.J., Adachi,K. and Royer,W.E. Jr.
  TITLE     The high resolution crystal structure of deoxyhemoglobin S
  JOURNAL   J Mol Biol 272 (3), 398-407 (1997)
   PUBMED   9325099
  REMARK    GeneRIF: The crystal structure of deoxyhemoglobin S, 2HBS,
            demonstrates the interaction of the mutant valine with another
            hemoglobin tetramer and provides insights into formation of the
            intracellular sickle cell fiber.
REFERENCE   8  (bases 1 to 1325)
  AUTHORS   Raina,S., Preston,G.M., Guggino,W.B. and Agre,P.
  TITLE     Molecular cloning and characterization of an aquaporin cDNA from
            salivary, lacrimal, and respiratory tissues
  JOURNAL   J Biol Chem 270 (4), 1908-1912 (1995)
   PUBMED   7530250
REFERENCE   9  (bases 1 to 1325)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 1325)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008741.7, AB013456.1 and
            BC040630.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001169.2.
            
            Summary: Aquaporin 8 (AQP8) is a water channel protein. Aquaporins
            are a family of small integral membrane proteins related to the
            major intrinsic protein (MIP or AQP0).  Aquaporin 8 mRNA is found
            in pancreas and colon but not other tissues. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF067797.1, AB013456.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219660.6/ ENSP00000219660.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC008741.7         129603-129619       c
            18-486              AB013456.1         3-471
            487-1325            BC040630.1         438-1276
FEATURES             Location/Qualifiers
     source          1..1325
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1"
     gene            1..1325
                     /gene="AQP8"
                     /gene_synonym="AQP-8"
                     /note="aquaporin 8"
                     /db_xref="GeneID:343"
                     /db_xref="HGNC:HGNC:642"
                     /db_xref="MIM:603750"
     exon            1..111
                     /gene="AQP8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..885
                     /gene="AQP8"
                     /gene_synonym="AQP-8"
                     /codon_start=1
                     /product="aquaporin-8"
                     /protein_id="NP_001160.2"
                     /db_xref="CCDS:CCDS10626.1"
                     /db_xref="GeneID:343"
                     /db_xref="HGNC:HGNC:642"
                     /db_xref="MIM:603750"
                     /translation="MSGEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLG
                     SALFIFIGCLSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLI
                     GGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVA
                     EIILTTLLALAVCMGAINEKTKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPA
                     VVANHWNFHWIYWLGPLLAGLLVGLLIRCFIGDGKTRLILKAR"
     exon            112..359
                     /gene="AQP8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            360..486
                     /gene="AQP8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            487..701
                     /gene="AQP8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            702..836
                     /gene="AQP8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1325
                     /gene="AQP8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1300..1305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AQP8"
                     /gene_synonym="AQP-8"
                     /note="hexamer: AATAAA"
     polyA_site      1325
                     /gene="AQP8"
                     /gene_synonym="AQP-8"
                     /note="major polyA site"
ORIGIN      
        1 agcaggtcct gtccctagga gataagagta tcttgcacag caggtgcagg tttcccagca
       61 gctcaggcaa gagtccgatg tttgtgccat ctgatcctga tgtctggaga gatagccatg
      121 tgtgagcctg aatttggcaa tgacaaggcc agggagccga gcgtgggtgg caggtggcga
      181 gtgtcctggt acgaacggtt tgtgcagcca tgtctggtcg aactgctggg ctctgctctc
      241 ttcatcttca tcgggtgcct gtcggtcatt gagaatggga cggacactgg gctgctgcag
      301 ccggccctgg cccacgggct ggctttgggg ctcgtgattg ccacgctggg gaatatcagt
      361 ggtggacact tcaaccctgc ggtgtccctg gcagccatgc tgatcggagg cctcaacctg
      421 gtgatgctcc tcccgtactg ggtctcacag ctgctcgggg ggatgctcgg ggctgccttg
      481 gccaaggcgg tgagtcctga ggagaggttc tggaatgcat ctggggcggc ctttgtgaca
      541 gtccaggagc aggggcaggt ggcaggggcg ttggtggcag agatcatcct gacgacgctg
      601 ctggccctgg ctgtatgcat gggtgccatc aatgagaaga caaagggccc tctggccccg
      661 ttctccatcg gctttgccgt caccgtggat atcctggctg ggggccctgt gtctggaggc
      721 tgcatgaatc ccgcccgtgc ttttggacct gcggtggtgg ccaaccactg gaacttccac
      781 tggatctact ggctgggccc actcctggct ggcctgcttg ttggactgct cattaggtgc
      841 ttcattggag atgggaagac ccgcctcatc ctgaaggctc ggtgaagcag agctcgtggg
      901 attcctgctg ctccaggtgt cctcagctca cctgtcccag actgaggaca ggggagttcc
      961 tgcatttcct gccagggcag aggcccagag gagcgacccc ctgcttccac tgcttgggcc
     1021 tgctttctca gatagactga ctgctgagga ggctctaggt tcttggaatt cctttgtgct
     1081 catcagagac cccagcctgg ggaacacgct gcccgcactg cccagagagc agtgcaaaca
     1141 ccacaacacg agcgtgtttc ttgagaggaa tgtccccgag ttggacaagg aggctgtttc
     1201 tgcacatcag ctcatttccc gcaccccatt tcttgcttga ttgctttgtt gggggcctgg
     1261 ccacttcctt gcttctcaag ctgacaattc tcactttgca ataaatagtc cagtgtttcc
     1321 ttcca
//
