LOCUS       NM_001102467            1099 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens aquaporin 12B (AQP12B), mRNA.
ACCESSION   NM_001102467 XM_001131634 XM_927405
VERSION     NM_001102467.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1099)
  AUTHORS   Eiseler,K., Dropmann,L.M., Bugert,P., Ewers,M. and Witt,H.
  TITLE     Genetic analysis of the aquaporin water channels AQP12A and AQP12B
            in patients with chronic pancreatitis
  JOURNAL   Pancreatology 22 (8), 1079-1083 (2022)
   PUBMED   36167651
  REMARK    GeneRIF: Genetic analysis of the aquaporin water channels AQP12A
            and AQP12B in patients with chronic pancreatitis.
REFERENCE   2  (bases 1 to 1099)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011298.7.
            
            On Dec 14, 2018 this sequence version replaced NM_001102467.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC157895.1, DN831573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2151405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407834.4/ ENSP00000384894.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-655               AC011298.7         124743-125397
            656-772             AC011298.7         127160-127276
            773-1099            AC011298.7         130884-131210
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..1099
                     /gene="AQP12B"
                     /gene_synonym="INSSA3"
                     /note="aquaporin 12B"
                     /db_xref="GeneID:653437"
                     /db_xref="HGNC:HGNC:6096"
     exon            1..655
                     /gene="AQP12B"
                     /gene_synonym="INSSA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..972
                     /gene="AQP12B"
                     /gene_synonym="INSSA3"
                     /note="insulin synthesis associated 3; AQP-12B"
                     /codon_start=1
                     /product="putative aquaporin-12B"
                     /protein_id="NP_001095937.1"
                     /db_xref="CCDS:CCDS46560.1"
                     /db_xref="GeneID:653437"
                     /db_xref="HGNC:HGNC:6096"
                     /translation="MAGLNVSLSFFFATFTLCEAARRASKALLPVGAYEVFAREAVGA
                     VQLGACFLEMRTLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFL
                     MAEESLPGTLLKLAAQGLGMQAACTLTRLCWAWELSDLHLLQSLMAQSCSSALRTSVP
                     HGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAAS
                     VTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGK
                     PAPASGDTQTPAKGSSVREPGRSGVEGPHSS"
     exon            656..772
                     /gene="AQP12B"
                     /gene_synonym="INSSA3"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1099
                     /gene="AQP12B"
                     /gene_synonym="INSSA3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcccctcag gtgtcctgca ggcacagcat ctcggggggc ccaggccgat ggcaggtctt
       61 aacgtgtccc tctccttctt ctttgccacc ttcaccctct gtgaggcagc caggcgggcc
      121 tccaaggccc tgctcccagt gggcgcctat gaagtcttcg cccgggaggc ggtgggcgcg
      181 gtgcagctcg gggcctgctt cctggagatg aggacgctgg tcgagctcgg gccctgggct
      241 ggggactttg ggcctgacct gctgctcacc ctgctcttcc tgctcttcct ggcgcacggg
      301 gtcaccttgg acggggcctc ggccaacccc accgtgtccc tgcaggagtt cctcatggcc
      361 gaggagtctc tgcctggcac gctgctgaag ctggcggcac aggggctggg catgcaggcc
      421 gcctgcaccc tgacgcgcct ctgctgggcc tgggagctca gtgacctgca cctgctgcag
      481 agcctcatgg cccagagctg cagctcggcc ctgcgcacat ccgtgcccca cggggcgctt
      541 gtggaggccg cctgcgcctt ttgtttccat ctgaccctcc tgcacctgcg gcacagtcct
      601 cccgcctaca gcgggcccgc tgtggctctg ttggtcaccg tcacggccta cacggccggg
      661 cccttcacgt ctgccttctt caaccctgcc ctggccgcct ctgtgacctt tgcctgctcg
      721 ggacacacct tactggagta cgtgcaggtg tactggctgg gccctctgac agggatggtc
      781 ctggctgtgc tgctgcacca gggccgcctt ccccaccttt tccagaggaa cctgttctac
      841 ggccagaaga acaagtaccg agcaccccga gggaagccgg ccccggcctc aggggacacc
      901 cagacccctg caaaggggtc cagtgtccgg gagcctgggc gcagtggtgt tgaggggcca
      961 cattccagct gagtggcctt gctctgtgtg agccccgtgc gagggccctg cttgtagctg
     1021 gaccctggaa ccttctgtag ctaagaggga atcctggccc cctccccaga agccatttgt
     1081 caataaacca tttctaaga
//
