LOCUS       NM_198998               1063 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens aquaporin 12A (AQP12A), mRNA.
ACCESSION   NM_198998 XM_351526
VERSION     NM_198998.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1063)
  AUTHORS   Eiseler,K., Dropmann,L.M., Bugert,P., Ewers,M. and Witt,H.
  TITLE     Genetic analysis of the aquaporin water channels AQP12A and AQP12B
            in patients with chronic pancreatitis
  JOURNAL   Pancreatology 22 (8), 1079-1083 (2022)
   PUBMED   36167651
  REMARK    GeneRIF: Genetic analysis of the aquaporin water channels AQP12A
            and AQP12B in patients with chronic pancreatitis.
REFERENCE   2  (bases 1 to 1063)
  AUTHORS   Calvanese,L., Pellegrini-Calace,M. and Oliva,R.
  TITLE     In silico study of human aquaporin AQP11 and AQP12 channels
  JOURNAL   Protein Sci 22 (4), 455-466 (2013)
   PUBMED   23359558
  REMARK    GeneRIF: Built accurate 3D-models for AQP11 and AQP12 and
            comprehensively compared their sequence and structure to other
            known aquaporins.
REFERENCE   3  (bases 1 to 1063)
  AUTHORS   Itoh,T., Rai,T., Kuwahara,M., Ko,S.B., Uchida,S., Sasaki,S. and
            Ishibashi,K.
  TITLE     Identification of a novel aquaporin, AQP12, expressed in pancreatic
            acinar cells
  JOURNAL   Biochem Biophys Res Commun 330 (3), 832-838 (2005)
   PUBMED   15809071
  REMARK    GeneRIF: a role of AQP12 in digestive enzyme secretion such as
            maturation and exocytosis of secretory granules
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011298.7 and AB040748.1.
            
            On May 17, 2019 this sequence version replaced NM_198998.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040748.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337801.9/ ENSP00000337144.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC011298.7         115733-115762       c
            31-1063             AB040748.1         52-1084
FEATURES             Location/Qualifiers
     source          1..1063
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..1063
                     /gene="AQP12A"
                     /gene_synonym="AQP-12; AQP12; AQPX2"
                     /note="aquaporin 12A"
                     /db_xref="GeneID:375318"
                     /db_xref="HGNC:HGNC:19941"
                     /db_xref="MIM:609789"
     exon            1..171
                     /gene="AQP12A"
                     /gene_synonym="AQP-12; AQP12; AQPX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..936
                     /gene="AQP12A"
                     /gene_synonym="AQP-12; AQP12; AQPX2"
                     /note="aquaporin X2; aquaporin 12"
                     /codon_start=1
                     /product="putative aquaporin-12A"
                     /protein_id="NP_945349.1"
                     /db_xref="GeneID:375318"
                     /db_xref="HGNC:HGNC:19941"
                     /db_xref="MIM:609789"
                     /translation="MAGLNVSLSFFFATFALCEAARRASKALLPVGAYEVFAREAMRT
                     LVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEQSLPGTLLK
                     LAAQGLGMQAACTLMRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFC
                     FHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLE
                     YVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPA
                     KGSSVREPGRSGVEGPHSS"
     exon            172..619
                     /gene="AQP12A"
                     /gene_synonym="AQP-12; AQP12; AQPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..736
                     /gene="AQP12A"
                     /gene_synonym="AQP-12; AQP12; AQPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            737..1063
                     /gene="AQP12A"
                     /gene_synonym="AQP-12; AQP12; AQPX2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcccctcag gtgtcctgca ggcacagctc ctcggggggc ccaggccgat ggcaggtctt
       61 aacgtgtccc tctccttctt ctttgccacc ttcgccctct gtgaggcggc caggcgggcc
      121 tccaaggccc tgctcccagt gggcgcctat gaagtcttcg cccgggaggc gatgaggacg
      181 ctggtcgagc tcgggccctg ggctggggac tttgggcctg acctgctgct caccctgctc
      241 ttcctgctct tcctggcgca cggggtcacc ttggacgggg cctcggccaa ccccactgtg
      301 tccctgcagg agttcctcat ggccgagcag tctctgcctg gcacgctgtt gaagctggcg
      361 gcacaggggc tgggcatgca ggccgcctgc accctgatgc gcctctgctg ggcctgggag
      421 ctcagtgacc tgcacctgct gcagagcctc atggcccaga gctgcagctc ggccctgcgc
      481 acatccgtgc cccacggggc gcttgtggag gccgcctgcg ccttttgttt ccatctgacc
      541 ctcctgcacc tgcggcacag tcctcccgcc tacagcgggc ccgctgtggc tctgttggtc
      601 accgtcacgg cctacacggc cgggcccttc acgtctgcct tcttcaaccc tgccctggcc
      661 gcctctgtga cctttgcctg ctcgggacac accttactgg agtacgtgca ggtgtactgg
      721 ctgggccctc tgacagggat ggtcctggct gtgctgctgc accagggccg ccttccccac
      781 cttttccaga ggaacctgtt ctacggccag aagaacaagt accgagcacc ccgagggaag
      841 ccggccccgg cctcagggga cacccagacc cctgcaaagg ggtccagtgt ccgggagcct
      901 gggcgcagtg gtgttgaggg gccacattcc agctgagtgg ccttgctctg tgtgagcccc
      961 gtgcgagggc cctgcttgta gctggaccct ggaaccttct gtagctaaga gggaatcctg
     1021 gccccctccc cagaagccat ttgtcaataa accatttcta aga
//
