LOCUS       NM_173039               1835 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens aquaporin 11 (AQP11), transcript variant 1, mRNA.
ACCESSION   NM_173039
VERSION     NM_173039.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1835)
  AUTHORS   Amro,Z., Collins-Praino,L.E. and Yool,A.J.
  TITLE     Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte
            and neuronal cell lines in response to oxidative and inflammatory
            stressors
  JOURNAL   Biosci Rep 44 (3) (2024)
   PUBMED   38451099
  REMARK    GeneRIF: Protective roles of peroxiporins AQP0 and AQP11 in human
            astrocyte and neuronal cell lines in response to oxidative and
            inflammatory stressors.
REFERENCE   2  (bases 1 to 1835)
  AUTHORS   Price,M.E., Fishler,K.P., Muff-Luett,M., Mauch,T.J., Brunelli,L.
            and Euteneuer,J.C.
  TITLE     Variants in AQP11 may result in autosomal recessive bilateral
            cystic renal dysgenesis
  JOURNAL   Am J Med Genet A 191 (2), 612-616 (2023)
   PUBMED   36420936
  REMARK    GeneRIF: Variants in AQP11 may result in autosomal recessive
            bilateral cystic renal dysgenesis.
REFERENCE   3  (bases 1 to 1835)
  AUTHORS   Zhang,C., Luo,D., Xie,H., Yang,Q., Liu,D., Tang,L., Zhang,J.,
            Li,W., Tian,H., Lu,L., Sun,X., Xu,G.T. and Zhang,J.
  TITLE     Aquaporin 11 alleviates retinal Muller intracellular edema through
            water efflux in diabetic retinopathy
  JOURNAL   Pharmacol Res 187, 106559 (2023)
   PUBMED   36403720
  REMARK    GeneRIF: Aquaporin 11 alleviates retinal Muller intracellular edema
            through water efflux in diabetic retinopathy.
REFERENCE   4  (bases 1 to 1835)
  AUTHORS   Fruhbeck,G., Balaguer,I., Mendez-Gimenez,L., Valenti,V.,
            Becerril,S., Catalan,V., Gomez-Ambrosi,J., Silva,C., Salvador,J.,
            Calamita,G., Malagon,M.M. and Rodriguez,A.
  TITLE     Aquaporin-11 Contributes to TGF-beta1-Induced Endoplasmic Reticulum
            Stress in Human Visceral Adipocytes: Role in Obesity-Associated
            Inflammation
  JOURNAL   Cells 9 (6), 1403 (2020)
   PUBMED   32512939
  REMARK    GeneRIF: Aquaporin-11 Contributes to TGF-beta1-Induced Endoplasmic
            Reticulum Stress in Human Visceral Adipocytes: Role in
            Obesity-Associated Inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1835)
  AUTHORS   Rashdan,N.A. and Pattillo,C.B.
  TITLE     Hydrogen peroxide in the ER: A tale of triage
  JOURNAL   Redox Biol 28, 101358 (2020)
   PUBMED   31685402
  REMARK    GeneRIF: Hydrogen peroxide in the ER: A tale of triage.
REFERENCE   6  (bases 1 to 1835)
  AUTHORS   Kuriyama,H., Kawamoto,S., Ishida,N., Ohno,I., Mita,S.,
            Matsuzawa,Y., Matsubara,K. and Okubo,K.
  TITLE     Molecular cloning and expression of a novel human aquaporin from
            adipose tissue with glycerol permeability
  JOURNAL   Biochem Biophys Res Commun 241 (1), 53-58 (1997)
   PUBMED   9405233
REFERENCE   7  (bases 1 to 1835)
  AUTHORS   Kuwahara,M., Gu,Y., Ishibashi,K., Marumo,F. and Sasaki,S.
  TITLE     Mercury-sensitive residues and pore site in AQP3 water channel
  JOURNAL   Biochemistry 36 (46), 13973-13978 (1997)
   PUBMED   9369468
REFERENCE   8  (bases 1 to 1835)
  AUTHORS   Raina,S., Preston,G.M., Guggino,W.B. and Agre,P.
  TITLE     Molecular cloning and characterization of an aquaporin cDNA from
            salivary, lacrimal, and respiratory tissues
  JOURNAL   J Biol Chem 270 (4), 1908-1912 (1995)
   PUBMED   7530250
REFERENCE   9  (bases 1 to 1835)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 1835)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB028147.1, BJ994586.1 and CX867790.1.
            
            On May 17, 2019 this sequence version replaced NM_173039.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.135840.1,
                                           SRR5189667.102331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313578.4/ ENSP00000318770.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1134              AB028147.1         266-1399
            1135-1680           BJ994586.1         1-546               c
            1681-1835           CX867790.1         30-184              c
FEATURES             Location/Qualifiers
     source          1..1835
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..1835
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
                     /note="aquaporin 11"
                     /db_xref="GeneID:282679"
                     /db_xref="HGNC:HGNC:19940"
                     /db_xref="MIM:609914"
     exon            1..659
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..856
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     AQP-11"
                     /codon_start=1
                     /product="aquaporin-11 isoform 1"
                     /protein_id="NP_766627.1"
                     /db_xref="CCDS:CCDS8251.1"
                     /db_xref="GeneID:282679"
                     /db_xref="HGNC:HGNC:19940"
                     /db_xref="MIM:609914"
                     /translation="MSPLLGLRSELQDTCTSLGLMLSVVLLMGLARVVARQQLHRPVA
                     HAFVLEFLATFQLCCCTHELQLLSEQHPAHPTWTLTLVYFFSLVHGLTLVGTSSNPCG
                     VMMQMMLGGMSPETGAVRLLAQLVSALCSRYCTSALWSLGLTQYHVSERSFACKNPIR
                     VDLLKAVITEAVCSFLFHSALLHFQEVRTKLRIHLLAALITFLVYAGGSLTGAVFNPA
                     LALSLHFMCFDEAFPQFFIVYWLAPSLGILLMILMFSFFLPWLHNNHTINKKE"
     exon            660..776
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1835
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1112..1117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
                     /note="hexamer: TATAAA"
     polyA_site      1128
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
                     /note="major polyA site"
     regulatory      1176..1181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
                     /note="hexamer: AGTAAA"
     polyA_site      1198
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
                     /note="major polyA site"
     regulatory      1225..1230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
                     /note="hexamer: AATGAA"
     regulatory      1244..1249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
                     /note="hexamer: TATAAA"
     polyA_site      1250
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
     polyA_site      1270
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
     regulatory      1753..1758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
                     /note="hexamer: ATTAAA"
     polyA_site      1779
                     /gene="AQP11"
                     /gene_synonym="AQPX1"
ORIGIN      
        1 agagccggag cccgcaaccc gctcaggcgg cgacggagcc atgtcgccgc tgctggggct
       61 ccggtccgag ctgcaggaca cctgcacctc gctgggactg atgctgtcgg tggtgctgct
      121 catggggctg gcccgcgtag tcgcccggca gcagctgcac aggccggtgg cccacgcctt
      181 cgtcctggag tttctagcca ccttccagct ctgctgctgc acccacgagc tgcaactgct
      241 gagcgaacag caccccgcgc accccacctg gacgctgacg ctcgtctact tcttctcgct
      301 tgtgcatggc ctgactctgg tgggcacgtc cagcaacccg tgcggcgtga tgatgcagat
      361 gatgctgggg ggcatgtccc ccgagacggg tgcggtgagg ctattggctc agctggttag
      421 tgccctgtgc agcaggtact gcacaagcgc cttgtggagc ttgggtctga cccagtatca
      481 cgtcagcgag aggagcttcg cttgcaagaa tcccatccga gtcgacttgc tcaaagcggt
      541 catcacagag gccgtctgct cctttctctt ccacagcgct ctgctgcact tccaggaagt
      601 ccgaaccaag cttcgtatcc acctgctggc tgcactcatc acctttttgg tctatgcagg
      661 aggaagtcta acaggagctg tatttaatcc agctttggca ctttcgctac atttcatgtg
      721 ttttgatgaa gcattccctc agttttttat agtatactgg ctggctcctt ctttaggtat
      781 attgttgatg attttgatgt tcagcttttt ccttccatgg ctgcataaca accatacaat
      841 taataaaaag gaataactgt tccaaagact cagactaaca tacaggacag tccagctgga
      901 tgtgataaag attttatcac ctcatatgga aaacaccggc tgcactggat tcatcagtgt
      961 taacttcctt tgaggaagct gccttatagt tttcatcact gggactttaa aaaaaaatta
     1021 ctgtgaaaat gaggtattct gtacttctca gttaagactt gttctttgag tgatgtatta
     1081 aatgctgcta gaaaagcctc attacattaa atataaatca atcttaaatg ataattgtta
     1141 actttgatga aaaacgagta caggatgaga agggaagtaa aggtgatagt aagatcaacg
     1201 aatttgtgta tcaagtgtca cccaaatgaa cagaattttt aactataaaa gtacaaggcg
     1261 tcaacttaca gaactgggga gaggatactt tcagccacca cctcacaaaa tgataccatc
     1321 aagcagtgtc atctttcaac aggaaagttg cttttagaag tagaatatat attcactcac
     1381 atgcaagcga tttcctacat tttaagtaca ttaaaatcta atacctaaaa tagtttctct
     1441 aaatagacaa tctcactagc tccagccaag tggttattct ttaatagaat ataataaaac
     1501 aaaacaccca tacaaagtca ggatttaagc ttttcacatt ctcctttgaa ccaacagcta
     1561 gctaccttat gaagtaggga gggcatgtat ttttaatctc cattttacag ataaggaaac
     1621 taagcctaga tgggtttgct gccctggctt agatcacata gagccaaata ccatctctag
     1681 tcttcaactt caatccaaaa attcttctcg gtcacgatta tgactaaagg gaaatcaagg
     1741 gttcatagaa acattaaata ctttataata acgttaaaac ttgtttagaa attaactagt
     1801 attttttgag gtttaaagaa ccttccagtt ttact
//
