LOCUS       NM_080429               1814 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens aquaporin 10 (AQP10), mRNA.
ACCESSION   NM_080429
VERSION     NM_080429.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1814)
  AUTHORS   Truelsen,S.F., Missel,J.W., Gotfryd,K., Pedersen,P.A., Gourdon,P.,
            Lindorff-Larsen,K. and Helix-Nielsen,C.
  TITLE     The role of water coordination in the pH-dependent gating of hAQP10
  JOURNAL   Biochim Biophys Acta Biomembr 1864 (1), 183809 (2022)
   PUBMED   34699768
  REMARK    GeneRIF: The role of water coordination in the pH-dependent gating
            of hAQP10.
REFERENCE   2  (bases 1 to 1814)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1814)
  AUTHORS   Gotfryd,K., Mosca,A.F., Missel,J.W., Truelsen,S.F., Wang,K.,
            Spulber,M., Krabbe,S., Helix-Nielsen,C., Laforenza,U., Soveral,G.,
            Pedersen,P.A. and Gourdon,P.
  TITLE     Human adipose glycerol flux is regulated by a pH gate in AQP10
  JOURNAL   Nat Commun 9 (1), 4749 (2018)
   PUBMED   30420639
  REMARK    GeneRIF: in human adipocytes, the decreased pH observed during
            lipolysis (fat burning) correlates with increased glycerol release
            and stimulation of aquaglyceroporin AQP10.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1814)
  AUTHORS   Jin,Z., Cha,S.H., Choi,Y.S., Kim,Y.I., Choi,S.A. and Yeo,S.G.
  TITLE     Expression of CXCL4 and aquaporin 3 and 10 mRNAs in patients with
            otitis media with effusion
  JOURNAL   Int J Pediatr Otorhinolaryngol 81, 33-37 (2016)
   PUBMED   26810286
  REMARK    GeneRIF: Expression of CXCL4 and aquaporin 3 and 10 mRNAs in middle
            ear effusion is associated with the pathophysiology of otitis media
            with effusion.
REFERENCE   5  (bases 1 to 1814)
  AUTHORS   Garneau,A.P., Carpentier,G.A., Marcoux,A.A., Frenette-Cotton,R.,
            Simard,C.F., Remus-Borel,W., Caron,L., Jacob-Wagner,M., Noel,M.,
            Powell,J.J., Belanger,R., Cote,F. and Isenring,P.
  TITLE     Aquaporins Mediate Silicon Transport in Humans
  JOURNAL   PLoS One 10 (8), e0136149 (2015)
   PUBMED   26313002
  REMARK    GeneRIF: the human aquaglyceroporins, i.e., AQP3, AQP7, AQP9 and
            AQP10 can act as silicon transporters in both Xenopus laevis
            oocytes and HEK-293 cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1814)
  AUTHORS   Kuriyama,H., Kawamoto,S., Ishida,N., Ohno,I., Mita,S.,
            Matsuzawa,Y., Matsubara,K. and Okubo,K.
  TITLE     Molecular cloning and expression of a novel human aquaporin from
            adipose tissue with glycerol permeability
  JOURNAL   Biochem Biophys Res Commun 241 (1), 53-58 (1997)
   PUBMED   9405233
REFERENCE   7  (bases 1 to 1814)
  AUTHORS   Kuwahara,M., Gu,Y., Ishibashi,K., Marumo,F. and Sasaki,S.
  TITLE     Mercury-sensitive residues and pore site in AQP3 water channel
  JOURNAL   Biochemistry 36 (46), 13973-13978 (1997)
   PUBMED   9369468
REFERENCE   8  (bases 1 to 1814)
  AUTHORS   Raina,S., Preston,G.M., Guggino,W.B. and Agre,P.
  TITLE     Molecular cloning and characterization of an aquaporin cDNA from
            salivary, lacrimal, and respiratory tissues
  JOURNAL   J Biol Chem 270 (4), 1908-1912 (1995)
   PUBMED   7530250
REFERENCE   9  (bases 1 to 1814)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 1814)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354980.16 and AL162591.16.
            
            On Nov 26, 2018 this sequence version replaced NM_080429.2.
            
            Summary: This gene encodes a member of the aquaglyceroporin family
            of integral membrane proteins. Members of this family function as
            water-permeable channels in the epithelia of organs that absorb and
            excrete water. This protein was shown to function as a
            water-selective channel, and could also permeate neutral solutes
            such as glycerol and urea. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB066105.1, BC069607.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324978.8/ ENSP00000318355.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AL354980.16        91946-92113
            169-295             AL354980.16        92786-92912
            296-433             AL354980.16        93835-93972
            434-552             AL354980.16        94094-94212
            553-770             AL354980.16        94442-94659
            771-1207            AL354980.16        95135-95571
            1208-1814           AL162591.16        198561-199167       c
FEATURES             Location/Qualifiers
     source          1..1814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1814
                     /gene="AQP10"
                     /gene_synonym="AQPA_HUMAN"
                     /note="aquaporin 10"
                     /db_xref="GeneID:89872"
                     /db_xref="HGNC:HGNC:16029"
                     /db_xref="MIM:606578"
     exon            1..168
                     /gene="AQP10"
                     /gene_synonym="AQPA_HUMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..969
                     /gene="AQP10"
                     /gene_synonym="AQPA_HUMAN"
                     /note="small intestine aquaporin; AQP-10;
                     aquaglyceroporin-10"
                     /codon_start=1
                     /product="aquaporin-10"
                     /protein_id="NP_536354.2"
                     /db_xref="CCDS:CCDS1065.1"
                     /db_xref="GeneID:89872"
                     /db_xref="HGNC:HGNC:16029"
                     /db_xref="MIM:606578"
                     /translation="MVFTQAPAEIMGHLRIRSLLARQCLAEFLGVFVLMLLTQGAVAQ
                     AVTSGETKGNFFTMFLAGSLAVTIAIYVGGNVSGAHLNPAFSLAMCIVGRLPWVKLPI
                     YILVQLLSAFCASGATYVLYHDALQNYTGGNLTVTGPKETASIFATYPAPYLSLNNGF
                     LDQVLGTGMLIVGLLAILDRRNKGVPAGLEPVVVGMLILALGLSMGANCGIPLNPARD
                     LGPRLFTYVAGWGPEVFSAGNGWWWVPVVAPLVGATVGTATYQLLVALHHPEGPEPAQ
                     DLVSAQHKASELETPASAQMLECKL"
     exon            169..295
                     /gene="AQP10"
                     /gene_synonym="AQPA_HUMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            296..433
                     /gene="AQP10"
                     /gene_synonym="AQPA_HUMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            434..552
                     /gene="AQP10"
                     /gene_synonym="AQPA_HUMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            553..770
                     /gene="AQP10"
                     /gene_synonym="AQPA_HUMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1814
                     /gene="AQP10"
                     /gene_synonym="AQPA_HUMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1791..1796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AQP10"
                     /gene_synonym="AQPA_HUMAN"
                     /note="hexamer: ATTAAA"
     polyA_site      1814
                     /gene="AQP10"
                     /gene_synonym="AQPA_HUMAN"
                     /note="major polyA site"
ORIGIN      
        1 gtgcagtgac agtgtgccta tgcagacaga gggagcagtg aatagcaata gggtgtttcc
       61 accatggtct tcactcaggc cccggctgaa atcatgggcc acctccggat acgcagcctc
      121 ctggcccggc agtgcctggc agagtttctg ggtgtgtttg tactcatgct cctcacccaa
      181 ggagctgtgg cccaggctgt caccagtgga gaaaccaaag gcaacttctt caccatgttt
      241 ctggctggct ctctggccgt tacgatagcc atctacgtgg gtggtaacgt ctcaggggcc
      301 cacctgaatc cagccttctc cctggccatg tgcatcgttg gacgcctccc ctgggtcaag
      361 ctccccattt acatcttggt gcagttgctg tctgctttct gtgcttcggg agccacctat
      421 gttctctacc atgatgccct acagaactat acaggtggga acctgacagt gactggcccc
      481 aaggagacag cctccatttt tgccacctat cctgccccct atctgtccct gaacaatggc
      541 ttcctggatc aggttctggg cactgggatg ctgattgtgg ggctcttggc catcctggac
      601 agacggaaca agggagtccc tgcgggtctg gagcctgtgg tggtggggat gctgatcctg
      661 gccctcgggt tatccatggg tgccaactgc gggattccac tcaaccctgc ccgggacctg
      721 ggcccacgtc tcttcaccta cgtggctggc tggggtcctg aagtcttcag tgctggtaat
      781 ggctggtggt gggtgcctgt ggtggcccct ctggtggggg ccaccgttgg cacagccact
      841 taccagctgt tggtggctct gcaccaccct gagggcccag agccagctca ggatctggtg
      901 tctgctcaac acaaagcctc agagttggaa actcctgcct cagctcagat gctggagtgt
      961 aagctatgat taggacaacc ctcacttcac tcatggaccc tggagccagc cactgacccc
     1021 gcctgggaac aacagtcatt cttcctcttt gttaatgtgc cagaacctgg gaggcttctc
     1081 tgtttatctg tttggcatcc cttcctccta aactaagaag gatcctggac agggagaagt
     1141 ggaggaggat aaggtaccag gactcaggct tctcatcccc tcctcccgca aagcggtttt
     1201 ctgaccctca gggcctctcg gaatgtagtt gctcgaggta accgctagag ggtgcgcacc
     1261 tggatgctgg atggggacgg ctgcgggcat ctgcagggtg gagggggcca ccatccagtg
     1321 tagggcacaa ccctggggac tgccctccat agcctgtccc gactgccgac tcctagctct
     1381 catcgcctcg gcgcctccca ccttcaccct ctcggggatg cctccccaag agggtagtta
     1441 ggggtgggga agccgcctcc acccaggggg cgtggtgggg gcggagggaa ggagggcggc
     1501 ggggcacaga gacagagagc aaggctgtga aactgaggca ccgttcctag acatctcggt
     1561 gctgtgtcgt tcattcaagg agagttgaga tacagtgaaa tgagccaggg cgaggaggga
     1621 gggtgaagga acggagggcg ggcggctccg aggagcgaga gtcgggctga gggcaacctg
     1681 gcgccaggga aaattctggt tattcaccac ttctacagct ctcctgccgc tccctgcaga
     1741 ggatgctcgt tttgcagaga aggcagtgtt cctctattcc cttcttccga attaaaaata
     1801 ccccctcaga gcga
//
