LOCUS       XM_047429062            3379 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens adaptor protein, phosphotyrosine
            interacting with PH domain and leucine zipper 2 (APPL2), transcript
            variant X5, mRNA.
ACCESSION   XM_047429062
VERSION     XM_047429062.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     gene            1..3379
                     /gene="APPL2"
                     /gene_synonym="DIP13B"
                     /note="adaptor protein, phosphotyrosine interacting with
                     PH domain and leucine zipper 2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 39
                     ESTs, 626 long SRA reads, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     4 samples with support for all annotated introns"
                     /db_xref="GeneID:55198"
                     /db_xref="HGNC:HGNC:18242"
                     /db_xref="MIM:606231"
     CDS             482..2365
                     /gene="APPL2"
                     /gene_synonym="DIP13B"
                     /codon_start=1
                     /product="DCC-interacting protein 13-beta isoform X3"
                     /protein_id="XP_047285018.1"
                     /db_xref="GeneID:55198"
                     /db_xref="HGNC:HGNC:18242"
                     /db_xref="MIM:606231"
                     /translation="MQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLH
                     YFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNDVCLFLE
                     HDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMM
                     EPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVSQQELL
                     SVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQP
                     RGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESRKENEEWICAIN
                     NISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNLKNSEMENENDKI
                     VPKATASLPEAEELIAPGTPIQFDIVLPATEFLDQNRGSRRTNPFGETEDESFPEAED
                     SLLQQMFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIFRMTESHLMVTSQSLR
                     LIDPQTQVSRANFELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFESNSEGE
                     KICYAINLGKEIIEVQKDPEALAQLMLSIPLTNDGKYVLLNDQPDDDDGNPNEHRGAE
                     SEA"
ORIGIN      
        1 acagtttgtt ccagagacag ataatgaggc aacagttcca gtacagtgtg aatcctgctg
       61 cgataggaac acaaatgcag ctttgagctc ctgcagcttg tacttcttca ggggcttatt
      121 ctcttgtcct tcagggctgt acgctgtgga ccaaagatca tgctcgctga tgagagccac
      181 cctgctggtg acctcagtgc tgccgaccca tttacatccc agccctgcca cattcctaca
      241 gtgggaggtt gaacacattt cttaaccttg atgagcctca gtttcatcat cagtaaaatg
      301 aagttaatgg aaccatggaa tctaccttgg agagttgcta gaagaattaa atgaagtcac
      361 atatgtttag tgcccagcac agcgtccagc acataggtgg tacagaactc gctctttact
      421 gagcgtgttt gaagaagatg ctggcaccct cacagactat accaaccagc tgctccaggc
      481 aatgcagcgc gtctatggag cccagaatga gatgtgcctg gccacacaac agctttctaa
      541 gcaactgctg gcatatgaaa aacagaactt tgctcttggc aaaggtgatg aagaagtaat
      601 ttcaacactc cactattttt ccaaagtggt ggatgagctt aatcttctcc atacagagct
      661 ggctaaacag ttggcagaca caatggttct acctatcata caattccgag aaaaggatct
      721 cacagaagta agcactttaa aggatctatt tggactcgct agcaatgatg tctgtttatt
      781 tttagagcat gacctctcaa tggcaaaata cagcaggctg cctaagaaaa aggagaatga
      841 gaaggtgaag accgaagtcg gaaaagaggt ggccgcggcc cggcggaagc agcacctctc
      901 ctcccttcag tactactgtg ccctcaacgc gctgcagtac agaaagcaaa tggccatgat
      961 ggagcccatg ataggctttg cccatggaca gattaacttt tttaagaagg gagcagagat
     1021 gttttccaaa cgtatggaca gctttttatc ctccgttgca gacatggttc aaagcattca
     1081 ggtagaactg gaagccgagg cggaaaagat gcgggtgtcc cagcaagaat tactttctgt
     1141 tgatgaatct gtttacactc cagactctga tgtggccgca ccacagatca acaggaacct
     1201 catccagaag gctggttacc ttaatcttag aaacaaaaca gggctggtca ccaccacctg
     1261 ggagaggctt tatttcttca cccaaggcgg gaatctcatg tgtcagccca ggggagccgt
     1321 ggctggaggt ttgatccagg acctggacaa ctgctcagtg atggccgtgg attgcgaaga
     1381 ccggcgctac tgcttccaga tcaccacgcc caatggaaaa tcgggaataa tcctccaggc
     1441 tgagagcaga aaggaaaatg aagagtggat atgtgcaata aacaacatct ccagacagat
     1501 ctacctgacc gacaaccctg aggcagtcgc gatcaagttg aatcagaccg ctctgcaagc
     1561 agtgactccc attacaagtt ttggaaaaaa acaagaaagc tcatgcccca gccagaacct
     1621 gaaaaattca gagatggaaa atgaaaatga caagattgtt cccaaagcaa cagccagtct
     1681 acctgaagca gaggagctga tcgcgcctgg aacgccgatt caattcgata ttgtgcttcc
     1741 tgctacagaa ttccttgatc agaacagagg gagcaggcgt accaaccctt ttggtgaaac
     1801 tgaggatgaa tcatttccag aagcagaaga ttctcttttg cagcagatgt ttatagttcg
     1861 gtttttggga tcaatggcag ttaaaacaga cagcactact gaagtgattt atgaagcgat
     1921 gagacaagta ttggctgctc gggctattca taacatcttc cgcatgacag aatcccatct
     1981 gatggtcacc agtcaatctt tgaggttgat agatccacag actcaagtat caagggccaa
     2041 ttttgaactt accagtgtca cacaatttgc tgctcatcaa gaaaacaaga gactggttgg
     2101 ttttgtcatc cgtgttcctg aatccactgg agaagaatct ctgagtacat acatttttga
     2161 aagcaactca gaaggcgaaa agatatgtta tgctattaat ttgggaaaag aaattattga
     2221 ggttcagaag gatccagaag cactggctca attaatgctg tccataccac taaccaatga
     2281 cggaaaatat gtactgttaa acgatcaacc agatgacgat gatggaaatc caaacgaaca
     2341 tagaggcgca gaatccgaag cataactcac ttgcgcctgt gggggaagag caaacaggaa
     2401 ggagagctac ctcctaaggg ttttaacgtc tctgacatac aggcacactg acctgatttc
     2461 cgaaggctga caatcgtttg tggaatgtaa tcttgatgcc ttgatactga gacttgggag
     2521 ggaaactaag aaatggttga cagcgttccc acccatctac aatgttattt taggtgcttt
     2581 gtggtaagtc ttttttctta gattgcgcta aaatttctta gattgttcag cgctcagaac
     2641 aaaagtttga aaaatgcatt gttcatatga atgtcatctc ttttcagttt ccagtatcct
     2701 ttttaaaaaa tggcaaaagc ctagatttac aatttgatga acactaaata tttcttatta
     2761 atataatcta tttttgtatt ttacttaatg agctttaagt gcctgtcgtt ctgaaaattg
     2821 tgtatttata attcagctta tctcataatt ggacctaata gcatttcttt gtgcagttag
     2881 gtgatgagca ctgctttgag gcccaagcac tagtagagat gcgcgataca ggtctagttt
     2941 cggtaactgt tccagacatc aagcaataaa aaaatgaata ccacaaaaga tgtttgattt
     3001 tacagtggag ccttactgaa ccagcattca gaagtttaag gtcctcctag gtatgagtat
     3061 ttttagtagt ggatcactgt ggacagggtg cagctctacc agttcctgtt tcttctgagc
     3121 cagaccctct tcagggaagg gaccaattaa ttttaaaact cacttgaagc acagctggtc
     3181 atggggcttg gtataaagtt cctatttcca ccctgatact tccaattcct ggaaccccag
     3241 cccactcccc catccctcct ccctatcaaa ctagtataat gattttgaat cggtacagtg
     3301 tgtttaactg taactaagtt caacagacta ttattatctt tgtaataaat taacctagca
     3361 ataaaaaata ttctgtttc
//
