LOCUS       NM_006380               6492 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens amyloid beta precursor protein binding protein 2
            (APPBP2), transcript variant 1, mRNA.
ACCESSION   NM_006380
VERSION     NM_006380.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6492)
  AUTHORS   Huang,D., Zhao,Q., Yang,K., Lei,J., Jing,Y., Li,H., Zhang,C.,
            Ma,S., Sun,S., Cai,Y., Wang,G., Qu,J., Zhang,W., Wang,S. and
            Liu,G.H.
  TITLE     CRL2APPBP2-mediated TSPYL2 degradation counteracts human
            mesenchymal stem cell senescence
  JOURNAL   Sci China Life Sci 67 (3), 460-474 (2024)
   PUBMED   38170390
  REMARK    GeneRIF: CRL2[APPBP2]-mediated TSPYL2 degradation counteracts human
            mesenchymal stem cell senescence.
REFERENCE   2  (bases 1 to 6492)
  AUTHORS   Sheng,J., Liu,L., Dong,T. and Wu,X.
  TITLE     Circ_SETD3 regulates gefitinib sensitivity and tumor progression by
            miR-873-5p-dependent regulation of APPBP2 in non-small cell lung
            cancer
  JOURNAL   J Chemother 34 (6), 401-413 (2022)
   PUBMED   34861803
  REMARK    GeneRIF: Circ_SETD3 regulates gefitinib sensitivity and tumor
            progression by miR-873-5p-dependent regulation of APPBP2 in
            non-small cell lung cancer.
REFERENCE   3  (bases 1 to 6492)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 6492)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6492)
  AUTHORS   Lin,H.C., Ho,S.C., Chen,Y.Y., Khoo,K.H., Hsu,P.H. and Yen,H.C.
  TITLE     SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins
            produced by failed UGA/Sec decoding
  JOURNAL   Science 349 (6243), 91-95 (2015)
   PUBMED   26138980
REFERENCE   6  (bases 1 to 6492)
  AUTHORS   Benboudjema,L., Mulvey,M., Gao,Y., Pimplikar,S.W. and Mohr,I.
  TITLE     Association of the herpes simplex virus type 1 Us11 gene product
            with the cellular kinesin light-chain-related protein PAT1 results
            in the redistribution of both polypeptides
  JOURNAL   J Virol 77 (17), 9192-9203 (2003)
   PUBMED   12915535
  REMARK    GeneRIF: Association of the herpes simplex virus type 1 Us11 gene
            product with the cellular kinesin light-chain-related protein PAT1
            results in the redistribution of both polypeptides.
REFERENCE   7  (bases 1 to 6492)
  AUTHORS   Gao,Y. and Pimplikar,S.W.
  TITLE     The gamma -secretase-cleaved C-terminal fragment of amyloid
            precursor protein mediates signaling to the nucleus
  JOURNAL   Proc Natl Acad Sci U S A 98 (26), 14979-14984 (2001)
   PUBMED   11742091
REFERENCE   8  (bases 1 to 6492)
  AUTHORS   Monni,O., Barlund,M., Mousses,S., Kononen,J., Sauter,G.,
            Heiskanen,M., Paavola,P., Avela,K., Chen,Y., Bittner,M.L. and
            Kallioniemi,A.
  TITLE     Comprehensive copy number and gene expression profiling of the
            17q23 amplicon in human breast cancer
  JOURNAL   Proc Natl Acad Sci U S A 98 (10), 5711-5716 (2001)
   PUBMED   11331760
REFERENCE   9  (bases 1 to 6492)
  AUTHORS   Barlund,M., Monni,O., Kononen,J., Cornelison,R., Torhorst,J.,
            Sauter,G., Kallioniemi,O.L.L.I.-P. and Kallioniemi,A.
  TITLE     Multiple genes at 17q23 undergo amplification and overexpression in
            breast cancer
  JOURNAL   Cancer Res 60 (19), 5340-5344 (2000)
   PUBMED   11034067
REFERENCE   10 (bases 1 to 6492)
  AUTHORS   Zheng,P., Eastman,J., Vande Pol,S. and Pimplikar,S.W.
  TITLE     PAT1, a microtubule-interacting protein, recognizes the basolateral
            sorting signal of amyloid precursor protein
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 14745-14750 (1998)
   PUBMED   9843960
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011921.14 and AC037475.9.
            
            On Aug 31, 2019 this sequence version replaced NM_006380.4.
            
            Summary: The protein encoded by this gene interacts with
            microtubules and is functionally associated with beta-amyloid
            precursor protein transport and/or processing. The beta-amyloid
            precursor protein is a cell surface protein with signal-transducing
            properties, and it is thought to play a role in the pathogenesis of
            Alzheimer's disease. The encoded protein may be involved in
            regulating cell death. This gene has been found to be highly
            expressed in breast cancer. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2383361.1, D86981.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000083182.8/ ENSP00000083182.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AC011921.14        78263-78711         c
            450-538             AC011921.14        52868-52956         c
            539-690             AC011921.14        46935-47086         c
            691-814             AC011921.14        31617-31740         c
            815-983             AC011921.14        18760-18928         c
            984-1073            AC011921.14        16490-16579         c
            1074-1141           AC037475.9         1627-1694
            1142-1247           AC037475.9         1773-1878
            1248-1372           AC037475.9         2901-3025
            1373-1458           AC037475.9         7307-7392
            1459-1649           AC037475.9         9196-9386
            1650-1815           AC037475.9         11643-11808
            1816-6492           AC037475.9         15854-20530
FEATURES             Location/Qualifiers
     source          1..6492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.2"
     gene            1..6492
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /note="amyloid beta precursor protein binding protein 2"
                     /db_xref="GeneID:10513"
                     /db_xref="HGNC:HGNC:622"
                     /db_xref="MIM:605324"
     exon            1..449
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..2069
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein interacting with APP tail 1; amyloid
                     protein-binding protein 2; amyloid beta precursor protein
                     (cytoplasmic tail) binding protein 2"
                     /codon_start=1
                     /product="amyloid protein-binding protein 2 isoform 1"
                     /protein_id="NP_006371.2"
                     /db_xref="CCDS:CCDS32699.1"
                     /db_xref="GeneID:10513"
                     /db_xref="HGNC:HGNC:622"
                     /db_xref="MIM:605324"
                     /translation="MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVY
                     YKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFS
                     RRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWF
                     RAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFA
                     KSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLA
                     RDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHE
                     DLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAID
                     CHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEE
                     MHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGE
                     GYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQS
                     TEEVVQSFLISQNVEGPSC"
     exon            450..538
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..690
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..814
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..983
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1073
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1141
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1247
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1372
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1458
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1649
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1815
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..6492
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4163..4168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /note="hexamer: AATAAA"
     polyA_site      4182
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /note="major polyA site"
     regulatory      6472..6477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
                     /note="hexamer: AATAAA"
     polyA_site      6492
                     /gene="APPBP2"
                     /gene_synonym="APP-BP2; HS.84084; PAT1"
ORIGIN      
        1 gcacacgcag ccccgcccct gcagagatca gcgctgggac ggaacccggg ttcctctcga
       61 accgggattg tgacgctttt ggcctggctg gccgctgttt tctgtcccac tttttactcg
      121 ggcctgcgtc cgctgccgcc gtccctcagt ttgcccccgg aggaggcagg gcggccgtgc
      181 cttctgccgt gcgcccgcgt ggctgccacc gcccctccga atcctccggg gccgcagagg
      241 ggttcgctac ggagggaggt gggggccttc gggaggagga ggcggaggag gcggaggagg
      301 agggaaggaa gatggcggcc gtggaactag agtggatccc agagactctc tataacaccg
      361 ccatctccgc tgtcgtggac aactacatcc gctcccgccg agacatccgc tccttgcccg
      421 agaacatcca gtttgatgtt tactacaagc tttaccaaca gggacgctta tgtcaactgg
      481 gcagtgaatt ttgtgaattg gaagtttttg ctaaagtact gagagctttg gataaaagac
      541 atttgcttca tcattgtttt caggctttga tggatcatgg tgttaaagtt gcttcagtct
      601 tggcctactc attcagtagg cggtgctctt atatagcaga atcagatgct gcagtaaagg
      661 aaaaagccat tcaggttggc tttgttttag gtggctttct ttcagatgca ggctggtaca
      721 gtgatgctga gaaagttttt ctgtcctgcc ttcagttgtg tactctacac gatgagatgc
      781 ttcattggtt tcgtgcagta gaatgttgtg tgaggttgct tcatgtgcga aatggaaact
      841 gcaaatatca tttgggtgaa gaaacattta aattagctca gacatatatg gataaactat
      901 caaaacatgg ccagcaagca aataaagctg cactctatgg agaactgtgt gcactcctat
      961 ttgcaaaaag tcactatgat gaggcataca aatggtgcat cgaggcaatg aaagaaatta
     1021 cagcaggctt accagtgaaa gttgtggtgg atgtcttaag acaagcttct aaggcttgtg
     1081 tagtaaaacg tgaatttaag aaggcagaac agttaattaa acatgcagtg tatttggcac
     1141 gggatcattt tggatccaaa cacccaaaat attctgatac actgctagat tatgggttct
     1201 acttactcaa tgtagataat atctgtcagt ctgttgcaat ttatcaggca gcccttgaca
     1261 ttagacagtc agtgtttggt ggcaaaaata tccacgtagc aacagctcat gaagatttgg
     1321 cctactcttc ttatgtccac cagtatagct ctgggaaatt tgacaatgca ctatttcatg
     1381 cagaaagagc tattggtatc attacccaca tcctacctga agatcatctt cttttggctt
     1441 cttcaaagag ggtgaaagca cttattttag aggagattgc aattgattgt cataataagg
     1501 aaactgaaca gaggctgctt caagaagctc atgatttgca cctgtcttca ctccaactag
     1561 ctaaaaaagc ttttggggaa tttaatgtac agactgcaaa acactatgga aaccttggaa
     1621 gactttatca gtcaatgaga aaatttaagg aagctgaaga aatgcacatc aaagcaattc
     1681 agattaaaga acaacttctt ggtcaagaag attatgaagt agccctttca gtgggacatc
     1741 tggcttcttt atataattat gacatgaatc agtatgaaaa tgctgagaaa ctttatttgc
     1801 gatctatagc aattgggaag aaactttttg gtgagggcta cagtggacta gaatatgatt
     1861 atcgaggtct cattaaactt tacaactcca ttggaaatta cgagaaagtg tttgaatatc
     1921 acaatgttct gtctaactgg aaccggttgc gagatcggca atattcagtg acagatgctc
     1981 ttgaagatgt cagcaccagc ccccagtcca ctgaagaagt ggtgcagtcc ttcctgattt
     2041 ctcagaatgt cgagggaccg agctgctgag ggaggacctc agttaaccaa ttaccttttc
     2101 ccggattcca gggaattcat actgtgaaat caaaaccatg ttgttttggg gggctggaat
     2161 ttgcattgaa acactggtcc agtccattga agaccctatt ttgggtgatc cctatcttgc
     2221 agaatgtctg taggaataag catatattca gttatattca gcatgtaccg catgtgtaag
     2281 tagtctggcc cacattttca acctagtaga acaaacaaca ggaaatcttt tttttgttgt
     2341 ttttaaaaaa ttcattttgc agaaagcctg aaagaaaaaa aataccccta aataaaacta
     2401 tttaagagtt taaaagagtt gcattcttat tatgtaagga tgattttaac aactttttaa
     2461 tatgtaattc ttccatgtgg aggtattcaa tactgtagtg taaagaaatt ttatgcggaa
     2521 aatctttata tgcagtatag aaaagttaac acaagtacta ataaaagagg gacatcccga
     2581 cttacgtttt tctaccttgc ccagataagt ggatacaacc actctatatt acaaggaaag
     2641 gactgtcaga ttcatctgaa ctggaccagt gttgatctgt aatgtaatag aaaatctgat
     2701 agaccagcac ttctgacttt tttttttttg gtacaacaat gcaagatgct ctgatagcat
     2761 ttgctaacag gaccaggagg atctaaaaag gaccagccta atgtagaagg tggttacttg
     2821 gaccagaggc tttagattat tattttagat cctacatata cttttatcag tagaatgatt
     2881 tcatttagat gtataatgaa aaaggataat gcaaaaatta tgtaatagat accaaattag
     2941 ggaagtttgg caatttcaat ggcatatttt tagtcaaggt acacagatgg cagtgccata
     3001 agcaagtcta taaatatcgg ctgcagccat ccccctcatt ttaaatgttg ccctaataat
     3061 caatgcagtt aacaagtata ttggctgtgt gtcatgaaat agttcatgtt cagatggaaa
     3121 tgttaggtta ctgtatggtt tatggagatt aatgaaaatg aatgcccaaa aataagtctt
     3181 agaaaatcct ccatttttat ggtaaatagt aatacaacta ggtcatttca tttgaaatct
     3241 aggagtcaaa tggaaagatc ccctaataat acacctattt cactaacttg tctttctgtt
     3301 tattgggttt tgatttgatt ttttgtaagc cagtcaggtt atttaatgat gaggtaataa
     3361 tcaaatttaa gaatttgtga catgtagcaa ttcaagaaac aaaaaggtat tttgctgtta
     3421 cctcaattct tactgtagta gcccatctga tgcttctata gttaagaatc tgggttcccc
     3481 ccctattttc aggggttcat gacttggctg ttaaagatgt tgctcctagc taatgcttgg
     3541 agtagtctgt gggtgaatgg atgtgtgttg aattttagtt ttcttttaac atgcatgttg
     3601 ggtgagaggg gaaaaaaatc taagctgtct gccacattga gtacagaaaa gttgtagatt
     3661 tcaaatttta ttaatatttt aagcactttt ttgaacttcc caaccttgtt tgaagctgtt
     3721 atttgcagtc ctattagttt tgagccattg catttaagtt ccctaggagg gggttggttg
     3781 ggggatgtac tgaaagagat gaagcaaacc cacaccctaa gatggtaact gtgtgattta
     3841 gaaacctgag tttactcctc aaatcgaatt attttctttt taaattttgg aaagagtaaa
     3901 ttgacgtact tgcagtttat gaagctgccc cccacccctc agttaattgc agtctaatgt
     3961 caagaggcac ttctttatta attaccaaat agtctttgtg accaaggact aacattttta
     4021 agttactcag ctctatcctc atgggcctat atatttaata cctccaaaga tattttcagg
     4081 ataggctttg tatactttta ttggttattt agaatccagt ggtatgtttg tggtatagga
     4141 atgtcatggt aaattgtttt tcaataaata ttttgaaaca tgtttccata tgaagttttt
     4201 ttttcaatct gtattttttg gttttgtgca catacagcat ttcctaggat aaaaataaac
     4261 aaatgactta cagcctcatc ctccctaact ccatttgaac tcaacttagc tcacactcag
     4321 tgataaaaca acatggtatg tagaagccta ggatcacagg gtgataatgt caattggcag
     4381 ccagttgtgt ttttttgaaa catcattatt ggcagtttct ccttatcacc actgctttaa
     4441 tgtagttttt ttgtaaatcc atatacttta atgcatacac tctagcttaa gaaaacattg
     4501 ccattttggt tagggatatg acttaatgtg ctattatttc tggttctaat gaagaataat
     4561 accctatgac tttaagtgta agattcatcc tttaagtagg gatgtttagg ataagttaga
     4621 tgtgtgccac tatgatttat tgggtttctt aaaaatcttg aagaaaataa taaaatttat
     4681 ctcacaataa gttaacttgc gcaaactttt tacatatggt gaggtgcgta aggaagccct
     4741 ggccaactta aagatttttc tggaggttca gcaaagttat gttaaattag gggcctttgg
     4801 tctcatcctt ctctgactct tctacccagt cttttcctaa agttcggtgc tactccagtt
     4861 gggtgcatca gggagctccg tcagcactcg catgtgtcgc tcaggtggcc actcatgcct
     4921 gcattccatt taatagagtc aattggaatt tttagagcat aatctttatg gatcctcaaa
     4981 gctgactttg ccaaagggat tgagaccctt actaccatca aatctctgtc tctgcttggt
     5041 taaaaattgg ctcactattg ctttgtagta acccctgccc aggtattttt tcacttgtga
     5101 aaataatttg agaaagacct ttgttcctag cctgttggga aaagtttata attttatgaa
     5161 aattaagtac agaggctgcg atcttagaaa taatgaaggt gccatttggc tgctccttaa
     5221 tagtgcagac agaaaactgc agtgaacaca tgccaaaaca tgattgaagc ctttggctga
     5281 aactttatac atagaaataa tgatttgctc ataacaggta tcattaactg ccacttttta
     5341 tgttttccct agaatttgta gccttgctgc ttgcttttct tctgggtggc aaagttacta
     5401 ctggaaaaac actataagta caaagttttt ggggttttat ctttgcttta gaagtggatg
     5461 tgtacttcac ctcttggctg tggaggaact tagttgccag gaaatttttt tttttttttt
     5521 cagacggagt ttcgctcttg ttgcccaggc tgggagggca atggcaccgt cttggctcac
     5581 tgcaacctcc gcctcccggg ttccagcgat tctcctgcct cagccttccg agtagctggg
     5641 attacaggct cctgccacca cgcctggcta ggaaattttt tgttgttaat atgacatttg
     5701 gattaatctc cagcttcaac agtacttctt ttgtccataa atctcaggaa tgttttaggc
     5761 agaaaactgg ttttaccctg ttgataatca gaaggagtgt gctttaggat ttattgcata
     5821 atactattct ttaattgcaa tcctaggtat ctatagcatg agtggcctta gtgagtttgt
     5881 tgaagtgcac atgtttttca agagtaaaat ttaagattaa aaatatatcc tatatataga
     5941 tatctagaaa acttggtttg tggtgcacag ttaagtgttg gatcactaaa taaccattgc
     6001 aggtaccgtt tgtgtaacat tactcatttc tgtatattcc ttttatggga agatattttg
     6061 ccatggtaac taaaactttt cagttctact tttatgatgt gaatgaatgc tacgttttat
     6121 taaatattac caggtcagta ctatttttat actttattaa gcaacagggg attttagttt
     6181 aataggctca aaataaaaag ttcttaatgg aacagttaaa aacaaaacac taacaatctt
     6241 tacgtgaaaa tccccactaa tagtgccaca ataatttcta tagaaatatc taaggtcatt
     6301 aaatagattt ttgaagacgg ttcttcattg tgtcaggatg acctttcata tcattctcac
     6361 caacttgtag tgcccaccgt tatttgtaac tattaaacca tactaagtat gtttgtaacc
     6421 agcattgtga tatattctgt acttgtattg ctaaaaatga attattgacc taataaatat
     6481 agtgttcctg ca
//
