LOCUS       NM_198450               6480 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens apolipoprotein O like (APOOL), mRNA.
ACCESSION   NM_198450 XM_060024
VERSION     NM_198450.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6480)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 6480)
  AUTHORS   Anand,R., Kondadi,A.K., Meisterknecht,J., Golombek,M., Nortmann,O.,
            Riedel,J., Peifer-Weiss,L., Brocke-Ahmadinejad,N., Schlutermann,D.,
            Stork,B., Eichmann,T.O., Wittig,I. and Reichert,A.S.
  TITLE     MIC26 and MIC27 cooperate to regulate cardiolipin levels and the
            landscape of OXPHOS complexes
  JOURNAL   Life Sci Alliance 3 (10), e202000711 (2020)
   PUBMED   32788226
  REMARK    GeneRIF: MIC26 and MIC27 cooperate to regulate cardiolipin levels
            and the landscape of OXPHOS complexes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6480)
  AUTHORS   Huynen,M.A., Muhlmeister,M., Gotthardt,K., Guerrero-Castillo,S. and
            Brandt,U.
  TITLE     Evolution and structural organization of the mitochondrial contact
            site (MICOS) complex and the mitochondrial intermembrane space
            bridging (MIB) complex
  JOURNAL   Biochim Biophys Acta 1863 (1), 91-101 (2016)
   PUBMED   26477565
REFERENCE   4  (bases 1 to 6480)
  AUTHORS   Koob,S., Barrera,M., Anand,R. and Reichert,A.S.
  TITLE     The non-glycosylated isoform of MIC26 is a constituent of the
            mammalian MICOS complex and promotes formation of crista junctions
  JOURNAL   Biochim Biophys Acta 1853 (7), 1551-1563 (2015)
   PUBMED   25764979
REFERENCE   5  (bases 1 to 6480)
  AUTHORS   Guarani,V., McNeill,E.M., Paulo,J.A., Huttlin,E.L., Frohlich,F.,
            Gygi,S.P., Van Vactor,D. and Harper,J.W.
  TITLE     QIL1 is a novel mitochondrial protein required for MICOS complex
            stability and cristae morphology
  JOURNAL   Elife 4, e06265 (2015)
   PUBMED   25997101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6480)
  AUTHORS   Ott,C., Dorsch,E., Fraunholz,M., Straub,S. and Kozjak-Pavlovic,V.
  TITLE     Detailed analysis of the human mitochondrial contact site complex
            indicate a hierarchy of subunits
  JOURNAL   PLoS One 10 (3), e0120213 (2015)
   PUBMED   25781180
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6480)
  AUTHORS   Weber,T.A., Koob,S., Heide,H., Wittig,I., Head,B., van der
            Bliek,A., Brandt,U., Mittelbronn,M. and Reichert,A.S.
  TITLE     APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS
            protein complex determining cristae morphology in mammalian
            mitochondria
  JOURNAL   PLoS One 8 (5), e63683 (2013)
   PUBMED   23704930
  REMARK    GeneRIF: APOOL is a cardiolipin-binding component of the
            Mitofilin/MINOS protein complex.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6480)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   9  (bases 1 to 6480)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z83820.2, AK130506.1, Z99571.2
            and BE328646.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_198450.5.
            
            Summary: This gene encodes a protein which contains an
            apolipoprotein O superfamily domain. This domain is found on
            proteins in circulating lipoprotein complexes. [provided by RefSeq,
            Sep 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.425100.1,
                                           SRR1803615.409934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373173.7/ ENSP00000362268.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                Z83820.2           83220-83234
            16-1230             AK130506.1         67-1281
            1231-5458           Z83820.2           167409-171636
            5459-6030           Z99571.2           2001-2572
            6031-6480           BE328646.1         23-472              c
FEATURES             Location/Qualifiers
     source          1..6480
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..6480
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /note="apolipoprotein O like"
                     /db_xref="GeneID:139322"
                     /db_xref="HGNC:HGNC:24009"
                     /db_xref="MIM:300955"
     exon            1..51
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..843
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /note="AAIR8193; MICOS complex subunit MIC27; family with
                     sequence similarity 121A; mitochondrial contact site and
                     cristae organizing system subunit 27"
                     /codon_start=1
                     /product="MICOS complex subunit MIC27 precursor"
                     /protein_id="NP_940852.3"
                     /db_xref="CCDS:CCDS48138.1"
                     /db_xref="GeneID:139322"
                     /db_xref="HGNC:HGNC:24009"
                     /db_xref="MIM:300955"
                     /translation="MAAIRMGKLTTMPAGLIYASVSVHAAKQEESKKQLVKPEQLPIY
                     TAPPLQSKYVEEQPGHLQMGFASIRTATGCYIGWCKGVYVFVKNGIMDTVQFGKDAYV
                     YLKNPPRDFLPKMGVITVSGLAGLVSARKGSKFKKITYPLGLATLGATVCYPVQSVII
                     AKVTAKKVYATSQQIFGAVKSLWTKSSKEESLPKPKEKTKLGSSSEIEVPAKTTHVLK
                     HSVPLPTELSSEAKTKSESTSGATQFMPDPKLMDHGQSHPEDIDMYSTRS"
     exon            52..156
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /inference="alignment:Splign:2.1.0"
     exon            157..276
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /inference="alignment:Splign:2.1.0"
     exon            277..331
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /inference="alignment:Splign:2.1.0"
     exon            332..430
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /inference="alignment:Splign:2.1.0"
     exon            431..522
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /inference="alignment:Splign:2.1.0"
     exon            523..636
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /inference="alignment:Splign:2.1.0"
     exon            637..754
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /inference="alignment:Splign:2.1.0"
     exon            755..6480
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /inference="alignment:Splign:2.1.0"
     regulatory      909..914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /note="hexamer: AATAAA"
     polyA_site      933
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /note="major polyA site"
     regulatory      6458..6463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /note="hexamer: AATAAA"
     polyA_site      6480
                     /gene="APOOL"
                     /gene_synonym="CXorf33; FAM121A; Mic27; MICOS27; UNQ8193"
                     /note="major polyA site"
ORIGIN      
        1 ctccgtctga aaaccttggc cgaaagggtt gtagacatgg cggccatcag gatgggaaaa
       61 ctgacaacca tgcctgcagg tctgatatat gcatctgtaa gtgtacatgc agccaaacaa
      121 gaggaatcca aaaagcagct agtgaaacca gagcagctcc ccatatatac tgcaccaccg
      181 ctccagtcta aatatgttga agagcagcct ggtcatttac aaatgggctt tgcttccatc
      241 cgcactgcaa ctggttgtta cattggctgg tgcaagggtg tttatgtctt tgtgaaaaat
      301 gggataatgg atacagtaca atttggaaaa gatgcttatg tctatctgaa gaatcctcct
      361 cgagattttc ttccgaaaat gggagttatt acagtttcag gattggcggg cttggtttca
      421 gcgagaaaag gttccaagtt taagaaaatt acttatcctc tgggactggc cactttagga
      481 gcaactgttt gctacccagt tcagtccgta ataattgcta aggtaacagc aaaaaaggta
      541 tatgctacaa gccagcaaat ttttggagca gttaaatcat tgtggacaaa aagcagcaaa
      601 gaagagtcac tccctaaacc taaagaaaaa actaagctag gatcctcttc cgaaatagaa
      661 gtacctgcaa aaacaactca cgtcttgaaa cactcagtgc ccttgccaac agaactcagc
      721 tctgaagcaa agaccaaatc agaatccact tcaggtgcaa cccagtttat gcctgacccc
      781 aagctcatgg atcacgggca gtcccaccca gaagatatag atatgtacag cactagaagc
      841 tgaagtagac tgcatgcaga gactacacag aaaactacaa gatgtgtggc gttgcaaata
      901 atgatgaaaa taaatcatgt aatgggtaac tgatacatag agtattacct aaaccaagtt
      961 tctcccttac atttccaaat atgccatttg ataaattaca taagtggtta acacacaaac
     1021 tgtgaatgca gtgtaaacaa tattaaatga ttgatgagga gacttaggta gaagtattag
     1081 cttgcatttg atgaccttta agggcactta aaaaaaaatg aagacatgaa ttctagtgag
     1141 attaaaatct aaaaatacat atatatatat gtatgtataa atacatacat atttatacat
     1201 gtataaatac gtatttatac atatatgtat aaatacatat acatatatgt ataaatacat
     1261 atacatattt atacatatat gtataaatac atacatattt atacatatat gtataaatac
     1321 atacatattt atacatatat gtataaatac atacatattt atacatatat atgtataaat
     1381 acatacatat ttatacatat aaacatatat ttctgctcta gctttcccag attaatgcta
     1441 gttaaattag aatggtgtat ggaaaggtgt gtttccctct gttttttttt tttttttttt
     1501 tttttttttt cccatttcct agagctggaa taaaatatcc atgttttatg ggacttgagc
     1561 ttggctttgt cccttggttt tgttaatgtt aattcctctt aaatatctaa aaacatctct
     1621 acctatttga gagggccata tgctacacag gcttcctaat actgcttagc aatccttcta
     1681 ctggttccta agtggtttac tattgtgttc cctggaagag gtattacaaa cgttttattc
     1741 ttctcaagcc tcttagaact gtcaaagttg actgtgcctc ctatttcata gagaaaaaac
     1801 taaattatta gatatgacca ttcccaaaac ttcttcccat ctaccttcaa gacttacctc
     1861 ttttcagcca tgcatccccc ttttctaaga catgcttctc tttgtgttct tgacctcatt
     1921 ccttcccatc taagaccata ttccaccctg tttaatttct agtcttcggt ttctcttttt
     1981 acagtgagca aattagaaga ataggttaga agaatagggt agtagatact gtagtttctt
     2041 tcctccacct ctacatagct gcaggtcttc tctgtcttaa atcaacaata acaaaacaag
     2101 acaaaaacct ttccttaact tggcctcttc ccttgaacta ttttttctct ctccttccta
     2161 taattgttat acttctttaa aaagtaattg ttactttttg acaaaagtaa atattgtccc
     2221 ttttttccct actttcaagt cctctctgtc ttgtgacatt ctggcctcca tacctgctta
     2281 attttttttg agatggggtc ttgctctgtt gcccaggctg gagtgcagtg gcacaaacac
     2341 agctcactgc aacctccacc tcccaggatc aagcaatcct cccatctcac cctcccaagt
     2401 agctgggact ataggcaccc gccaccatgc ctaatttttt gtatttttgg tagtgacagg
     2461 gtttcaccat gttgtccagg ctggtctcga actcctgagc tcaagcatct gtccgactca
     2521 gcctaccaca gtgttgggat tacaggcgtg agccaccgca cccagcccct acttgaattt
     2581 ttatgtcatt attgactctt caccactctc tccttgagac tcacttatcc ctttgctctc
     2641 tatttttcct gcttttgtta ttcttcattt ttcttctctt gctctgaatc ccttaaatgc
     2701 tgaggctgct caagtttcat ccctagtcct attttctcat tctatatgca cactcatttt
     2761 tcatttaaca gacttcactg gcttcaggca ccatttgttt tattattcat attttcaacc
     2821 cccatatctc tctagtgctg tagaccttta tttctactta ctagttatat tcacctaaca
     2881 tcccatagat atgccaatgt caatgtgcct aaaacaaaat tgtctctacc tcccgctcct
     2941 tcaaatctat tctgtcttct ctaatcctat aattactctc cctcaagtca tcatcatcac
     3001 ttttctgggt tactgtaata gccttcaggc taatttgctc actgtcaatc ttgctgtctc
     3061 tcatttcaga atatgttctg cttgcaggtg acagtaaact agttaaacaa atatttaata
     3121 ttagcttaag caaaaaaaaa aaaaaaggcc tatcctattt atagcctaga attaggcagt
     3181 atagggttgg gacagtggct cattggtgct atcaaggacg tagacttttt ctctttccac
     3241 tctgtcctct acagcatgct ggtttgtcac ctcatggtca caagatgtct gctgtacctc
     3301 cagggagcag atacacattc aaagtaggaa atagcagata aaaatgtaca caagatgcgt
     3361 ctgactccct tttaccagaa aagtaaatgc tttcttagaa tctcctcaga agacctctgt
     3421 gtatatctca accagtactt gtcatatagc cacacactta gctcaaggaa gatagggaat
     3481 agggaaatca tgtttctttt cccctgtggt gaggaaggca aggggtaagg ggttgggaac
     3541 aggtgctgaa ttaaagctaa catacagtat ctactaccct attcttctaa cccatttgtc
     3601 tattatgata tagttgtctt gacaactata atgaatagct gtctttctga aatctttagt
     3661 ggctcatcat tgcctgcaga atcaaaactc cttagtctga tatacaaggc ccttcatatc
     3721 tgattccagc ttaccttcta atcctatctt ccctctcctt acccacccta ctgctaatgt
     3781 gtattatatt gtctttatga cataccattt gtttcttgaa catgctttgc tcattattgc
     3841 ctctttctct gcctgtgcta gtgtgtcctc ttagaatgtt cttccatctt atcctgctct
     3901 acattctaac ttctacccat cctacaagtc caattccagt gtcatgttcc ctttctcaat
     3961 cctccagggt agaatttaga tgttctgtct tttagagata ggtattgcta tgttgcccag
     4021 gctggtctca aactcatggc ctcaagcgat cctcccacct cagccaacca gacatgagtg
     4081 actgtgctca gcctttttta aaaaaatgaa ggtatttggt atggccgggt atggtggctc
     4141 acacctataa tcccagcact ttgggaggcc aaggtgggtg aatcacctga ggtcaggagt
     4201 ttgagaccag cctgaccaac atagtgaaac cctgtctcta ctaaaaacac gcaaaaagtg
     4261 caaaattagc taggcgtggt ggctcatgcc tgtaattcca gctacttggg aggctgaggc
     4321 aggagaatca cttgaatccg ggaggtggag gctgcagtga gccgagatcg tgccattgca
     4381 cttcagcctg ggcacaagaa caaaactcag tctcaaaaaa taaataataa aaaataaagg
     4441 tatataatat gtcttagatt tgatgaaata tgagtgtgtt tgagatctga tccaaggttt
     4501 taaaaaattc atttcaaatc ctggagataa attctgagga gcttacttat gaaaaactag
     4561 caagtgatag ctggtattta cagatatggt actttacaca atttatgtaa ttaatatttt
     4621 ctcacagaca aggttccttg tggatatcac tgaataattt ttgtgtagtt tctatgccca
     4681 tgaagtgcct ggtaggtagt aggaactcac acgttctgct atgctggttg cagcacagga
     4741 cacaaaagtt agaattattt caaaggactt atactctact aggaaagaga gaaacataga
     4801 aatatagtgt tgtatgtggt atcttcccta agataagtac aaccaaagag ctatggatgt
     4861 tcagagatag aatgtagtac tgggatgatg tcaaggaggc agtggtactt aagctgctca
     4921 aggtagggaa gcagtttact tgctagtttt tcataagtaa gctcttcaga atttatctcc
     4981 agtatttgaa atgaattttt ttaaacctca gatctgaata tattcaaaca cccatatttc
     5041 atcaaatcta aggcatatca tataccttta atttaaaaaa aaatgctgag cagagttgct
     5101 tatgtctggg aggctgaagt gggaggattg cttgaggcca aaagtttgag accagcctga
     5161 gcaacatagc aagatcctgc ctctaaaaac aaacaaacaa aaaatgctgc cagttgatca
     5221 ttacatttat cccgacatca gatatgtcaa attgtgaaaa gcaccttaat tttgatgaaa
     5281 tatgataggt aaaaaatagc gcaaagctaa gtataagtga cttttaaatt atctgctctt
     5341 ttggattatc actactgcta ctagccgtta gaatattggt ttggataatg gaaagttgac
     5401 tagagctaca aaatctgttt caaaataaaa gatctgctca aacaagaatg tgatgatcac
     5461 ttgctgtatt gtacaacaaa gtcaaactgc tgttagactc aggtgacagt caaatgttgg
     5521 aggctgtgtt gggatgagtt gttacaaagc ctctttcatt cttcccatgc catgtccagg
     5581 agttcttctc tgttaaacct gaagagatgc cagccctcct cagaggaaag gtctaaagcc
     5641 cctcgactag tatagtagtt gatagaagcc tggttccaaa tgacgacaag aaagtgcatg
     5701 cagttacatt gagttgtgat ggctatctgt ttaaaaacaa acaagcaaat attactttca
     5761 tttgaaagta taatcttcgt taacacatat attttattga aggtctactc tatgcaagac
     5821 actatgtgtg aataatactt ccaaatatag tagttacctt ttgaactttt ctatagctgt
     5881 aaaaagaaaa aagtctcact gttctgagct ttaaagccct ctttaaaatc tcaaaactga
     5941 tttgcaaagc ctttatcata cagaaaaggt gtacctaaaa gaacacatgt tctcatatgt
     6001 ttccaaaata caagaagatc ttgcttttat agtcttgtaa tattcatact gtgagcctgt
     6061 gtttttgaat aaaaatgctt tctaatctcc ctccttctta ctttcccttg atagcaaaaa
     6121 gggtgtatag tgtggttgtg gattatatat aaatcaattt taattgacta taattcatat
     6181 actgtatatg atcatctgat ttgaaaatcc agtttaattt gggtagaaat ttgaagtata
     6241 tgttggggtt atgttcaaat ggtgagatta atgatttaat ttatgccctg tgaatattta
     6301 ttaagaaaag gttaatgtat agaatatcaa tactaattgt aatacatacc tgacttagcc
     6361 tcttcagcat ttcagctcca atacctaggc cttttaaata gacaatgcaa agtgaaaact
     6421 gcaaatttca cttaacttgt tatttgcttt agtttaaaat aaataatatc taaaactctg
//
