LOCUS       NM_019101                761 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens apolipoprotein M (APOM), transcript variant 1, mRNA.
ACCESSION   NM_019101
VERSION     NM_019101.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 761)
  AUTHORS   Muendlein,A., Heinzle,C., Brandtner,E.M., Leiherer,A., Geiger,K.,
            Gaenger,S., Drexel,H., Dechow,T. and Decker,T.
  TITLE     Plasma apolipoprotein M predicts overall survival in metastatic
            breast cancer patients
  JOURNAL   Breast Cancer Res Treat 201 (3), 571-576 (2023)
   PUBMED   37490173
  REMARK    GeneRIF: Plasma apolipoprotein M predicts overall survival in
            metastatic breast cancer patients.
REFERENCE   2  (bases 1 to 761)
  AUTHORS   Xu,T., Wei,D., Yang,Z., Xie,S., Yan,Z., Chen,C., Hu,W., Shi,Z.,
            Zhao,Y., Cui,M., Xu,Z. and Wang,J.
  TITLE     ApoM suppresses kidney renal clear cell carcinoma growth and
            metastasis via the Hippo-YAP signaling pathway
  JOURNAL   Arch Biochem Biophys 743, 109642 (2023)
   PUBMED   37211224
  REMARK    GeneRIF: ApoM suppresses kidney renal clear cell carcinoma growth
            and metastasis via the Hippo-YAP signaling pathway.
REFERENCE   3  (bases 1 to 761)
  AUTHORS   Borup,A., Donkin,I., Boon,M.R., Frydland,M., Martinez-Tellez,B.,
            Loft,A., Keller,S.H., Kjaer,A., Kjaergaard,J., Hassager,C.,
            Barres,R., Rensen,P.C.N. and Christoffersen,C.
  TITLE     Association of apolipoprotein M and sphingosine-1-phosphate with
            brown adipose tissue after cold exposure in humans
  JOURNAL   Sci Rep 12 (1), 18753 (2022)
   PUBMED   36335116
  REMARK    GeneRIF: Association of apolipoprotein M and
            sphingosine-1-phosphate with brown adipose tissue after cold
            exposure in humans.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 761)
  AUTHORS   Zhou,Y., Yao,S., Yu,M., Wei,J., Fang,Q., Xu,N. and Luo,G.
  TITLE     The effects and possible mechanism of action of apolipoprotein M on
            the growth of breast cancer cells
  JOURNAL   Mol Biol Rep 49 (2), 1171-1179 (2022)
   PUBMED   34775573
  REMARK    GeneRIF: The effects and possible mechanism of action of
            apolipoprotein M on the growth of breast cancer cells.
REFERENCE   5  (bases 1 to 761)
  AUTHORS   Velagapudi,S., Rohrer,L., Poti,F., Feuerborn,R., Perisa,D.,
            Wang,D., Panteloglou,G., Potapenko,A., Yalcinkaya,M.,
            Hulsmeier,A.J., Hesse,B., Lukasz,A., Liu,M., Parks,J.S.,
            Christoffersen,C., Stoffel,M., Simoni,M., Nofer,J.R. and von
            Eckardstein,A.
  TITLE     Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the
            Transendothelial Transport of High-Density Lipoprotein
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (10), e468-e479 (2021)
   PUBMED   34407633
  REMARK    GeneRIF: Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1
            Promote the Transendothelial Transport of High-Density Lipoprotein.
REFERENCE   6  (bases 1 to 761)
  AUTHORS   Zhang,X.Y., Dong,X., Zheng,L., Luo,G.H., Liu,Y.H., Ekstrom,U.,
            Nilsson-Ehle,P., Ye,Q. and Xu,N.
  TITLE     Specific tissue expression and cellular localization of human
            apolipoprotein M as determined by in situ hybridization
  JOURNAL   Acta Histochem 105 (1), 67-72 (2003)
   PUBMED   12666989
REFERENCE   7  (bases 1 to 761)
  AUTHORS   Xu,N., Zhang,X.Y., Dong,X., Ekstrom,U., Ye,Q. and Nilsson-Ehle,P.
  TITLE     Effects of platelet-activating factor, tumor necrosis factor, and
            interleukin-1alpha on the expression of apolipoprotein M in HepG2
            cells
  JOURNAL   Biochem Biophys Res Commun 292 (4), 944-950 (2002)
   PUBMED   11944906
REFERENCE   8  (bases 1 to 761)
  AUTHORS   Duan,J., Dahlback,B. and Villoutreix,B.O.
  TITLE     Proposed lipocalin fold for apolipoprotein M based on
            bioinformatics and site-directed mutagenesis
  JOURNAL   FEBS Lett 499 (1-2), 127-132 (2001)
   PUBMED   11418126
REFERENCE   9  (bases 1 to 761)
  AUTHORS   Xu,N. and Dahlback,B.
  TITLE     A novel human apolipoprotein (apoM)
  JOURNAL   J Biol Chem 274 (44), 31286-31290 (1999)
   PUBMED   10531326
REFERENCE   10 (bases 1 to 761)
  AUTHORS   Albertella,M.R., Jones,H., Thomson,W., Olavesen,M.G. and
            Campbell,R.D.
  TITLE     Localization of eight additional genes in the human major
            histocompatibility complex, including the gene encoding the casein
            kinase II beta subunit (CSNK2B)
  JOURNAL   Genomics 36 (2), 240-251 (1996)
   PUBMED   8812450
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662801.7.
            
            On Nov 26, 2018 this sequence version replaced NM_019101.2.
            
            Summary: The protein encoded by this gene is an apolipoprotein and
            member of the lipocalin protein family. It is found associated with
            high density lipoproteins and to a lesser extent with low density
            lipoproteins and triglyceride-rich lipoproteins. The encoded
            protein is secreted through the plasma membrane but remains
            membrane-bound, where it is involved in lipid transport. Alternate
            splicing results in both coding and non-coding variants of this
            gene. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.114582.1,
                                           SRR5189664.116055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375916.4/ ENSP00000365081.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               AL662801.7         128565-128751
            188-342             AL662801.7         129143-129297
            343-416             AL662801.7         129896-129969
            417-515             AL662801.7         130051-130149
            516-614             AL662801.7         130296-130394
            615-761             AL662801.7         130735-130881
FEATURES             Location/Qualifiers
     source          1..761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..761
                     /gene="APOM"
                     /gene_synonym="apo-M; G3a; HSPC336; NG20"
                     /note="apolipoprotein M"
                     /db_xref="GeneID:55937"
                     /db_xref="HGNC:HGNC:13916"
                     /db_xref="MIM:606907"
     exon            1..187
                     /gene="APOM"
                     /gene_synonym="apo-M; G3a; HSPC336; NG20"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..640
                     /gene="APOM"
                     /gene_synonym="apo-M; G3a; HSPC336; NG20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NG20-like protein; alternative name: G3a, NG20; protein
                     G3a"
                     /codon_start=1
                     /product="apolipoprotein M isoform 1"
                     /protein_id="NP_061974.2"
                     /db_xref="CCDS:CCDS4710.1"
                     /db_xref="GeneID:55937"
                     /db_xref="HGNC:HGNC:13916"
                     /db_xref="MIM:606907"
                     /translation="MFHQIWAALLYFYGIILNSIYQCPEHSQLTTLGVDGKEFPEVHL
                     GQWYFIAGAAPTKEELATFDPVDNIVFNMAAGSAPMQLHLRATIRMKDGLCVPRKWIY
                     HLTEGSTDLRTEGRPDMKTELFSSSCPGGIMLNETGQGYQRFLLYNRSPHPPEKCVEE
                     FKSLTSCLDSKAFLLTPRNQEACELSNN"
     exon            188..342
                     /gene="APOM"
                     /gene_synonym="apo-M; G3a; HSPC336; NG20"
                     /inference="alignment:Splign:2.1.0"
     exon            343..416
                     /gene="APOM"
                     /gene_synonym="apo-M; G3a; HSPC336; NG20"
                     /inference="alignment:Splign:2.1.0"
     exon            417..515
                     /gene="APOM"
                     /gene_synonym="apo-M; G3a; HSPC336; NG20"
                     /inference="alignment:Splign:2.1.0"
     exon            516..614
                     /gene="APOM"
                     /gene_synonym="apo-M; G3a; HSPC336; NG20"
                     /inference="alignment:Splign:2.1.0"
     exon            615..761
                     /gene="APOM"
                     /gene_synonym="apo-M; G3a; HSPC336; NG20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      737..742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOM"
                     /gene_synonym="apo-M; G3a; HSPC336; NG20"
                     /note="hexamer: AATAAA"
     polyA_site      761
                     /gene="APOM"
                     /gene_synonym="apo-M; G3a; HSPC336; NG20"
                     /note="major polyA site"
ORIGIN      
        1 agagtggact gagcagccag taggggagag agcagttaag gcacacagag caccagctcc
       61 ctcctgcctg aagatgttcc accaaatttg ggcagctctg ctctacttct atggtattat
      121 ccttaactcc atctaccagt gccctgagca cagtcaactg acaactctgg gcgtggatgg
      181 gaaggagttc ccagaggtcc acttgggcca gtggtacttt atcgcagggg cagctcccac
      241 caaggaggag ttggcaactt ttgaccctgt ggacaacatt gtcttcaata tggctgctgg
      301 ctctgccccg atgcagctcc accttcgtgc taccatccgc atgaaagatg ggctctgtgt
      361 gccccggaaa tggatctacc acctgactga agggagcaca gatctcagaa ctgaaggccg
      421 ccctgacatg aagactgagc tcttttccag ctcatgccca ggtggaatca tgctgaatga
      481 gacaggccag ggttaccagc gctttctcct ctacaatcgc tcaccacatc ctcccgaaaa
      541 gtgtgtggag gaattcaagt ccctgacttc ctgcctggac tccaaagcct tcttattgac
      601 tcctaggaat caagaggcct gtgagctgtc caataactga cctgtaactt catctaagtc
      661 cccagatggg tacaatggga gctgagttgt tggagggaga agctggagac ttccagctcc
      721 agctcccact caagataata aagataattt ttcaatcctc a
//
