LOCUS       NM_030641              10065 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens apolipoprotein L6 (APOL6), mRNA.
ACCESSION   NM_030641
VERSION     NM_030641.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10065)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 10065)
  AUTHORS   Maertens,A., Tran,V.P., Maertens,M., Kleensang,A.,
            Luechtefeld,T.H., Hartung,T. and Paller,C.J.
  TITLE     Functionally Enigmatic Genes in Cancer: Using TCGA Data to Map the
            Limitations of Annotations
  JOURNAL   Sci Rep 10 (1), 4106 (2020)
   PUBMED   32139709
  REMARK    GeneRIF: APOL6 has a high ranking for tumor aggressiveness, and
            interacts with genes in the STAT pathway, and with genes annotated
            as being part of the defense response, and the interferon signaling
            pathway.
            Erratum:[Sci Rep. 2020 Jun 11;10(1):9718. doi:
            10.1038/s41598-020-66767-3.. PMID: 32528098]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10065)
  AUTHORS   Tan,Y., Gan,M., Fan,Y., Li,L., Zhong,Z., Li,X., Bai,L., Zhao,Y.,
            Niu,L., Shang,Y., Zhang,S. and Zhu,L.
  TITLE     miR-10b-5p regulates 3T3-L1 cells differentiation by targeting
            Apol6
  JOURNAL   Gene 687, 39-46 (2019)
   PUBMED   30423386
  REMARK    GeneRIF: High APOL6 expression is associated with obesity and
            obesity-related cancers.
REFERENCE   4  (bases 1 to 10065)
  AUTHORS   Ye,Q., Zhao,X., Xu,K., Li,Q., Cheng,J., Gao,Y., Du,J., Shi,H. and
            Zhou,L.
  TITLE     Polymorphisms in lipid metabolism related miRNA binding sites and
            risk of metabolic syndrome
  JOURNAL   Gene 528 (2), 132-138 (2013)
   PUBMED   23911300
  REMARK    GeneRIF: Polymorphisms in FABP2 and APOL6, located at the predicted
            miRNAs binding sites, are identified to contribute to
            susceptibility to MetS in the Chinese Han population.
REFERENCE   5  (bases 1 to 10065)
  AUTHORS   Zhaorigetu,S., Yang,Z., Toma,I., McCaffrey,T.A. and Hu,C.A.
  TITLE     Apolipoprotein L6, induced in atherosclerotic lesions, promotes
            apoptosis and blocks Beclin 1-dependent autophagy in
            atherosclerotic cells
  JOURNAL   J Biol Chem 286 (31), 27389-27398 (2011)
   PUBMED   21646352
  REMARK    GeneRIF: results suggest that ApoL6 regulates both apoptosis and
            autophagy in SMCs. IFNgamma-initiated, ApoL6-induced apoptosis in
            vascular cells may be an important factor causing plaque
            instability
REFERENCE   6  (bases 1 to 10065)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   7  (bases 1 to 10065)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 10065)
  AUTHORS   Page,N.M., Butlin,D.J., Lomthaisong,K. and Lowry,P.J.
  TITLE     The human apolipoprotein L gene cluster: identification,
            classification, and sites of distribution
  JOURNAL   Genomics 74 (1), 71-78 (2001)
   PUBMED   11374903
  REMARK    GeneRIF: APOL6 has been found only in humans
REFERENCE   9  (bases 1 to 10065)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 10065)
  AUTHORS   Dominguez,O., Ashhab,Y., Sabater,L., Belloso,E., Caro,P. and
            Pujol-Borrell,R.
  TITLE     Cloning of ARE-containing genes by AU-motif-directed display
  JOURNAL   Genomics 54 (2), 278-286 (1998)
   PUBMED   9828130
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC047864.1, Z79996.2 and
            BM982940.1.
            
            On Nov 23, 2018 this sequence version replaced NM_030641.3.
            
            Summary: This gene is a member of the apolipoprotein L gene family.
            The encoded protein is found in the cytoplasm, where it may affect
            the movement of lipids or allow the binding of lipids to
            organelles. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA833881.1, AL834420.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409652.5/ ENSP00000386280.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2105              BC047864.1         52-2156
            2106-9474           Z79996.2           11626-18994
            9475-10065          BM982940.1         23-613              c
FEATURES             Location/Qualifiers
     source          1..10065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..10065
                     /gene="APOL6"
                     /gene_synonym="APOL-VI; APOLVI"
                     /note="apolipoprotein L6"
                     /db_xref="GeneID:80830"
                     /db_xref="HGNC:HGNC:14870"
                     /db_xref="MIM:607256"
     exon            1..178
                     /gene="APOL6"
                     /gene_synonym="APOL-VI; APOLVI"
                     /inference="alignment:Splign:2.1.0"
     exon            179..275
                     /gene="APOL6"
                     /gene_synonym="APOL-VI; APOLVI"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1257
                     /gene="APOL6"
                     /gene_synonym="APOL-VI; APOLVI"
                     /note="apolipoprotein L-VI; apolipoprotein L, 6"
                     /codon_start=1
                     /product="apolipoprotein L6"
                     /protein_id="NP_085144.1"
                     /db_xref="CCDS:CCDS13919.1"
                     /db_xref="GeneID:80830"
                     /db_xref="HGNC:HGNC:14870"
                     /db_xref="MIM:607256"
                     /translation="MDNQAERESEAGVGLQRDEDDAPLCEDVELQDGDLSPEEKIFLR
                     EFPRLKEDLKGNIDKLRALADDIDKTHKKFTKANMVATSTAVISGVMSLLGLALAPAT
                     GGGSLLLSTAGQGLATAAGVTSIVSGTLERSKNKEAQARAEDILPTYDQEDREDEEEK
                     ADYVTAAGKIIYNLRNTLKYAKKNVRAFWKLRANPRLANATKRLLTTGQVSSRSRVQV
                     QKAFAGTTLAMTKNARVLGGVMSAFSLGYDLATLSKEWKHLKEGARTKFAEELRAKAL
                     ELERKLTELTQLYKSLQQKVRSRARGVGKDLTGTCETEAYWKELREHVWMWLWLCVCL
                     CVCVYVQFT"
     exon            276..10065
                     /gene="APOL6"
                     /gene_synonym="APOL-VI; APOLVI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7810..7815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOL6"
                     /gene_synonym="APOL-VI; APOLVI"
                     /note="hexamer: ATTAAA"
     polyA_site      7842
                     /gene="APOL6"
                     /gene_synonym="APOL-VI; APOLVI"
                     /note="major polyA site"
     regulatory      8760..8765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOL6"
                     /gene_synonym="APOL-VI; APOLVI"
                     /note="hexamer: AATAAA"
     polyA_site      8787
                     /gene="APOL6"
                     /gene_synonym="APOL-VI; APOLVI"
                     /note="major polyA site"
     regulatory      10048..10053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOL6"
                     /gene_synonym="APOL-VI; APOLVI"
                     /note="hexamer: AATAAA"
     polyA_site      10065
                     /gene="APOL6"
                     /gene_synonym="APOL-VI; APOLVI"
ORIGIN      
        1 agttttgcaa tcaattcctg ttcaaaggcc accctactct tcctatccgt ctttctccag
       61 cccagacact cacagccccc tgccagacca ggggacctcg gagaggcaag gacagaggtt
      121 caggatcttc ctctccctcg ggacccaagg ccacaaagga gagctccgtg gagagaagaa
      181 aatcatttga ctcctgggga cacagatttg ctgccacaga ggctgatgga caaccaggcg
      241 gagagagaaa gtgaggctgg tgttggtttg caaagggatg aggatgacgc tcctctgtgt
      301 gaagacgtgg agctacaaga cggagatctg tcccccgaag aaaaaatatt tttgagagaa
      361 tttcccagat tgaaagaaga tctgaaaggg aacattgaca agctccgtgc cctcgcagac
      421 gatattgaca aaacccacaa gaaattcacc aaggctaaca tggtggccac ctctactgct
      481 gtcatctctg gagtgatgag cctcctgggt ttagcccttg ccccagcaac aggaggagga
      541 agcctgctgc tctccaccgc tggtcaaggt ttggcaacag cagctggggt caccagcatc
      601 gtgagtggta cgttggaacg ctccaaaaat aaagaagccc aagcacgggc ggaagacata
      661 ctgcccacct acgaccaaga ggacagggag gatgaggaag agaaggcaga ctatgtcaca
      721 gctgctggaa agattatcta taatcttaga aacaccttga agtatgccaa gaaaaacgtc
      781 cgtgcatttt ggaaactcag agccaaccca cgcttggcca atgctaccaa gcgtcttctg
      841 accactggcc aagtctcctc ccggagccgc gtgcaggtgc aaaaggcctt tgcgggaaca
      901 acactggcga tgaccaaaaa tgctcgcgtg ctgggaggtg tgatgtccgc cttctccctt
      961 ggctatgact tggccactct ctcaaaggaa tggaagcacc tgaaggaagg agcaaggaca
     1021 aagtttgcgg aagagttgag agccaaggcc ttggagctgg agaggaaact cacagaactc
     1081 acccagctct acaagagctt gcagcagaaa gtgaggtcaa gggccagagg ggtggggaag
     1141 gatttaactg ggacctgcga aaccgaggct tactggaagg agttaaggga gcatgtgtgg
     1201 atgtggctgt ggctgtgtgt gtgtctgtgt gtctgtgtgt atgtacagtt tacatgaatg
     1261 ttcctcagga catggcatac aatggccttg gaggtccaaa taatatcaag tacatcttgg
     1321 agatgagggt gcctgtcctg gacagacctc ggcatgcctt ctgtttctcc ttcaatgctc
     1381 cttaaggcct atgtgctggg aaaagggtct tccctgtttg tttgtttgtt tgtttgtttg
     1441 tttgttttga gacagggtct ctgttgccca ggctggagtg cagtggcgta atctcggctc
     1501 actgcaacct ctgcctcctg agtgcaagca agtctcctgc ctcagcctcc caagtagctg
     1561 ggattacagg cacgcaccac cacgcccagc taattttggt atttttttgt agagacaggg
     1621 tttcaccatt ttggccaggc tggtctcgaa ttcctgacct caagtgatcc acccaccttg
     1681 gcctcccaaa atgctgggat tacaagcgtg agctaccctg cccagccggg tcttcccagt
     1741 tttaacaaag aggtcacaga gccacaggcg gagttaggaa ctaaattgtc tcctcctccc
     1801 aattcatatg ttgaagtcct aaaccaaaat gtggctgtat ttagagatgg accctttggg
     1861 aggtaattag ggttgactga ggccataggg tgaggtccta acccgatgga attgacttct
     1921 ttataagagg aggaggaaat acaagagggc ctccccaccc ctgctgcaca cctacactga
     1981 aggaaggcta tttgcagatg cagcaagaag gcagccatct gcaaggcaga agaagagagc
     2041 cctcaccagg aactgaataa gtcagtcagt ctgggacttc cagcctctag aactgtgaaa
     2101 caataaattt ctgtggtgta agcaactcaa tctatagtag tttgttacta ttttgttata
     2161 gcaaccaaag atgactaagc cagacaggtt atgtcactcg ccaagtgtct tagtctgttt
     2221 gtgctgctat aacaaaatac cttagactgg gtaatttaca aacaacagag atgtatccag
     2281 agatccacag ttctggaggc tgagaagtct aaaatcaagg caccagcaga ttccacatct
     2341 cgtgaaggct cactctctgc ttcacagatg gcactgtctt gctgtgttct cacatggcag
     2401 aaggggcaaa caagcccccc tgggcctctt ttataaaggc actaactcta tgcctaaagg
     2461 cagggccctc atgactctat cacctaccaa aaggctccac ttctttatac tattggaggg
     2521 gtagaaggaa cttcctttct agaccttgaa ggtttaagaa tttgaatcta taaaacaagc
     2581 tgacaataga cagattaaca ggagaaaaag catatacatt ttttaatgtg ggccagatgg
     2641 cagaagctta aataacaccc caagctacag gaagtgaggc ctctgatggg gaggtagtga
     2701 cacaggctgt gggagggggt agggggagga agtctgtggt gagcaaagtt tgccttatta
     2761 cactgataaa gtgtaattac actaataaag ctggatcacc tgaggttagg agtttgagaa
     2821 cagcctggcc aacatggcaa aaccctgtct ctactataaa tacaaaaatt agccaggtgt
     2881 agtggcaggg cacttgtaat cctatctact cgggaggctg aggcaggaga atcgcttgaa
     2941 cccaggctgt aaaggttgca gtgagccaag atcatgccac tgcactccag tctgggtgtc
     3001 agaatgagac cccatctcaa aaaaaaaaaa aaaaaaaaaa aagaagaaga atacagtcat
     3061 gtatctcttg gtgacaggga cgcattctga taaatgtgtc attaggcaat tgcattgtag
     3121 tgtgattatc acagattgta cttatacaaa acttagatgg catagcctac tgcataccta
     3181 ggctatatgg gagagcctat tgctcccagg ctacgcacct gtacagcatg tgactactga
     3241 atactatagg caattgcagc acaatgggaa atatttgtgt atctaaacat atgtaaacag
     3301 agaaaaagga aagtaaaaat atggcataaa agataagaat tggctctcct gtacagggca
     3361 cttactacga atggagcttg cagggctgag agttgctcca gatgagtcag tgagtggtga
     3421 atgaatgtga aggcctaggg cattactgta tactactgta ggctttataa acacagcaca
     3481 cttagggtac acaaaatgca tattaaaaca ttttcttcct tcagtatatt aggcaatagg
     3541 aatttttcaa gtccactata aatcttatca aaccatggtt gtatatgcag ttgaccgaaa
     3601 cattgttatt ggacacataa ctatagttga aagaataagc aaaaagtcta tctaggtgtg
     3661 ctgtcttgag caacttttaa ttattctcct gtcctgcaat atgagttaat cttctctgat
     3721 cgatgtagat tccaggaagg ggtgtccagg acaattacct tccttctgga gaaacttccc
     3781 ttaatcaaat aagagaactt caaagaaaat ccctccctgt gctttggaag ggaagggagg
     3841 tgggcagcag tgggtcagag atagaccttt gttctcttat ttctgaggcc cttcagtctc
     3901 ctttattcaa agcactcagc atgccaaagc accctatttt agggtatctt tttctgagcc
     3961 ctaaacactg tgttggggat gtcaactgtg acaggaaaat atcttggggc cccagaatca
     4021 ctaaggaaaa ctcaagctta gggaaacttc ttagggcaaa cccacctccc actctattca
     4081 aagttatctc tctgctcact gagatagata catatctgat tgcctccttt ggaaaggcta
     4141 atcagaaact caaaagaatg caactgtttg tgtctcacct atctgtgacc tggaagctcc
     4201 ctccccactg aaccaatgtt cttcttacat atattgatta atgtcttatg tctccctaaa
     4261 atgtataaaa ccaaggtatg ccccaaccat cttggccaca tgtcatcagg acttcctgag
     4321 tctgtgtcac agtgtgtcct caaccttggc aaaataaact ttctaaatta actgagacct
     4381 gtctcggatt ttctgggttc acattttgga aaccatgaat ggattctggg tggagatgcc
     4441 cctgaccctt gacaaatcta tcggtgcttg gtaccagcat gagctaactt tatggctcaa
     4501 accaatagga caatttgctg aggtctgaga ggactccctc cagaaaatcc ctgatctctt
     4561 aaaatttggt agagatcgga agtttatttt gctgtacaac acctcttttt ttggagtttt
     4621 acttgctccc aacaaggaag gcaagttttc ctgctttcat gatgatggaa ggcaggtgat
     4681 gtttttatgg agtttcagct ttcttccaat gcacttagag cactcagaaa ttgtataatt
     4741 tgtgtgacca ttgttagttt tgcttaactg ttttgttgtt tgtttctgtc ttagtcaaat
     4801 ctgaagggga accctaaatt acggggtcaa ggactctgaa gtggtaggaa aacagccagc
     4861 ttaaaaaact ttttttaaat tttaattact ataggggctt tatttacata acacagccag
     4921 ctttttgcta gccagaccaa actcaaagag caatggctgt acttctgaaa tagcaacact
     4981 ttgtcctagc tgagatttgg taataagatt ttttttttaa gtttttaaag aagctcagtg
     5041 gttgaaagtc tgcttaactg aaacagtaac atccatgatg tgtgttttgt gcatgtttgt
     5101 atttgaaagg ccttcatgtt tttgtttctt gtttgttttt ctctcctaag accttgtctt
     5161 ttttttgtag caaaagtttt tttttttttt ttccttttac ttctcagttg actgaattct
     5221 gttttcaccg gattttttga ctaaaatagc tattgcaaca gaggctactc ttgggttaag
     5281 gaagaatgta gtttcgtttt atgtttaata tcgctcaaag aaaaataaaa gcatctccct
     5341 ctaacaccac cagacttttc ctctctgtac cttatcatgt aaattttgct atttgatttt
     5401 cacctgggtt gtttccttta atgtgcaaaa atttaaggct atttagctga caactgccta
     5461 gggttgtaaa acaggttatc aagaatctga aagtctaaga taggaaaaaa aagtgggggg
     5521 gcattataaa tctataaaat gtacttctat tggcatgcct aatacgtctt tatatgtatg
     5581 tatgtgttgt gtacacgatg ttttagtgct aaaaatatgt aaaagagctc tacttggctt
     5641 aaagaaaaat aaaagtgctt aaatcagata ctaaaaaaga aaaggctagt caaatgcttt
     5701 ttcaaattta tgtaacttaa gtaaaatctt taataaataa agtagcttta aaattattgg
     5761 taaagtagta ttagaaatgt cttaagaatt gccagcatac atttttgttt gcattatatt
     5821 aatcaaacag ttttatactt atccctgcca aataccagaa ggtgtcaaaa tttggcatag
     5881 gggttataaa actataaacc cagcccaaaa cagaatgatc tttgcttgtg taatttttaa
     5941 taaataagac attgatatgg gtttaatgaa aacagctgca tcttgaattt agtaagatta
     6001 ccataacttc taatcctgtg gctttaggca gtttagtcca cagacaataa ggaggtttgt
     6061 tttgggaaag gactgttatt gtcattgttt cgaagctgaa cttaaactag gttcctccca
     6121 aagttcattc ggcctatgcc caggaatgaa caaggacagc ttggaagtta agagcaaggt
     6181 ggagtcagtt aggtcaaatc gtttttcact gtctcagttg taattttgca atggaagttt
     6241 cataacttta aatcatgact atcacagttt ttataaataa tctaggtaaa caattaataa
     6301 aataactagg taaatgtaat gggataaata cttatagacc aactggacat aatttagaat
     6361 ataaagtcat attaaattaa ataatagata atttattatt tgggtatttt ccaataaata
     6421 tatcttgtag gaaaacattg ttgcttaaaa aaaagtgtgt ccttttttaa aaaaatggtg
     6481 aacaagtttt gtctaattca aagcttatta aaaggttata tataaaacaa ggtaaaagga
     6541 accagaaaag aaaaaaaatg taaataaagt tataaaaata aagaattttt tcaaggttaa
     6601 aaagctgaaa aagaaataat tttatataag aaagaatttt atatggtaaa tttagtccta
     6661 aaataaaata actggttgtt taacaaggag ggatgttcag gacaaaccag aaagtccaag
     6721 catgtcatga acattggtgt aagtcatgat aagattttat atatatatat acacacacac
     6781 acacacaccc caaaagcttt tatataatca agttgtcata ttattattaa gttttggttt
     6841 gcttagggaa gaaagagcta atttttaaaa aatcaaggtt attacatcca tgtatcttcc
     6901 tgtgtatgct tttaaagtcc ttgtaacatt gagttacagg gctttaactc ctgtgtctga
     6961 aaaatcacaa acactgatga caatcaaagc ctcatcttaa ggccccgtag aagatgccaa
     7021 tcaaaataaa ctgcattcct gaggcactag gcaagaaatt aaagctattc aactcctcaa
     7081 ggcccaggga ctattgcgga agaggtgggc gcgtaagatt gtaagggccg attttgaaag
     7141 atccagtaag ttcagtttct ctatgaacta atcattcaag tcaaaggcac actgatgcaa
     7201 aatcagtata tggacccctg tgtctgatta gcaaggtttt cttgaagcat taaccaactc
     7261 cttcataaag gttataaaag gcttatggaa gttatatttt ataatcaaga ttaaatctta
     7321 tagtttgttt acaaaatttt gaaaatcaaa tgtgattggc ttcaggctgt ttttattagg
     7381 gcttcttgtt tagaaagtta agtcacctct ctcaaagaat gaaggttttt gctttttttg
     7441 aaatccttga attatcactt ggattaaata aatgacttta cgatgacctg taattttatt
     7501 ttgtaatgtc aagtgtttta aaccttttgt atttgacaag ctttccaaaa tcaaattata
     7561 aattatgtat ttttctaacc taattaatcc tttaagatct tagtttccct aaagtcctaa
     7621 aatgacataa tttggcttat ttggtataaa aattatatag gaagcattgt caaatgtgaa
     7681 atggtgtttg gttttctttg ggctgtattt gtataaatat gttattggtg tatgttccaa
     7741 aattatgtga aactcctata attctaatat aacttagtgt acattatcag taataatcat
     7801 aattgttata ttaaaattat tgtgtgccac agaggtaaaa aatttccttg tcagttttgt
     7861 cttttgacta tggctgcctt aaaacttttt tcttccatgc acaattgttg ttttggtcct
     7921 cttttttaaa tatattttta ttattatttt tgagatgggg actcactctg ttgcccaggc
     7981 tggagtgcag cggcacgatc ttggctcact gcaactgcca cctcccaggt tcaagcggtt
     8041 ctcctgcctc agcctcccga gtagctggga ttacaggcat acaccaccat gcccagctaa
     8101 tttttttgta ttttcagtag agatggggtt tcaccatgtt ggccaggctg gtcttgaact
     8161 cctgacctca ggtgatcagc ccaccttggc ctctcaaagt gctgaaatta cagatgtgag
     8221 ccacacacct ggcctatttt ggtcctcttt agaaggtggt tttataatca gctgtaaaac
     8281 tccaacaggt gctcttacat gcaggtttct gataactttg gagattgtga catcagaata
     8341 gagggaaaag tttcaggact catggagagc taaaatgttc atgagtatca agcagaacag
     8401 gaattaactg catagactga accaatcttt ttgacttttt gcttaaaatg tttgctgatc
     8461 ctttgttttg tgtttcagtc ttaaaacttt tcttttgagc tattgacagc ttttaacaat
     8521 ttagtatact cctatgacaa aatttggagc atatttgttt ctctctacct gatttctcca
     8581 gaattcagaa actatttgta agtattctta acttatggtg atacagttat ttgcataagt
     8641 gcaataagaa tctgttctaa tttgtaacag gacacgattg gagaaattgg ttgttttact
     8701 aagactttga ctggaatggt gtgcttttct ttaaggaatc aaacttgact tatggaacca
     8761 ataaagtcct tggaaaaact ggccccatat tttgtgtaca cagtctccgt acaagatttc
     8821 tgacctgtag taagtaaaga atgtcacttt ctgacaggca cataagcccc aggtttacct
     8881 cagaacctca agaggagagg aaattcaccc aatttataag tatttgatgg cacaaatcca
     8941 tggctgggca tggctttaag aaagtcttat ctgagattcc tcctgtggaa caaagttaat
     9001 tggttccaga gattcaaagc cagagttgct gtcagttcat tggtagagat gccatcactg
     9061 ggcaagtgtt ctgaaaacat cttatctgaa taacagcagt cctggagaac atctagggat
     9121 ctagcaaagc gagagataca tgaaggacat aaaaacgttt ttagaaagtc cttggaaaca
     9181 gttctcattt cagacatgta agcatgagct aggatgaaaa gtgatttcat cctggtatct
     9241 gcaattttca cattcattag gtttcaacat ataaactttc aggggacaca gacattcaga
     9301 ctatagcacc aagctgtaga agctacatag ttgtagacca gggtcagcaa cccaagaagc
     9361 ctgacttcca agctgtgctt ttaacttccc caccatgttg cacctaaagc tttggagttt
     9421 tcctgtgatt agtgtttttg gtgttgtttt attttttttc ttacaggaac tcttgcaaga
     9481 agaaaggact atgagttcaa ctttagaggg agccatgggg actaaacaaa attctgaggc
     9541 cccctcaacc atctaaatgg acttccttct gggccaggac actcgaaaat taaacctgaa
     9601 agactggttc aggccatgat gggaagtggg agtcgaacat gcctcatcat accctccagc
     9661 attaacatca acacagacct taaggctgat aagaagcatt tacaatctat tctctctgaa
     9721 gtcttctacc tggaggcttc atctgcatga taaaactttg gtctccacaa cctcttacaa
     9781 cccaggcatt cctttctatc gataattact ctttcaacca attgccaatc agaaaattgt
     9841 tatatctacc tataatctag aagcccccac atcaagttgt tttgcctttc tggacaggac
     9901 caatgtatat cttaaatgta tttgattgat ctctcatgtc tccctaaaat gtataaaacc
     9961 acgctgttcc ccgaccacct ggagcacatg ttctcagggt ctcctgaggg ctgtgtcaca
    10021 ggccatgttc acttacattt ggctcagaat aaatctcttc aaata
//
