LOCUS       NM_030642               1438 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens apolipoprotein L5 (APOL5), mRNA.
ACCESSION   NM_030642 XM_940740
VERSION     NM_030642.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1438)
  AUTHORS   Namjou,B., Keddache,M., Marsolo,K., Wagner,M., Lingren,T., Cobb,B.,
            Perry,C., Kennebeck,S., Holm,I.A., Li,R., Crimmins,N.A., Martin,L.,
            Solti,I., Kohane,I.S. and Harley,J.B.
  TITLE     EMR-linked GWAS study: investigation of variation landscape of loci
            for body mass index in children
  JOURNAL   Front Genet 4, 268 (2013)
   PUBMED   24348519
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1438)
  AUTHORS   Jagannathan,K., Calhoun,V.D., Gelernter,J., Stevens,M.C., Liu,J.,
            Bolognani,F., Windemuth,A., Ruano,G., Assaf,M. and Pearlson,G.D.
  TITLE     Genetic associations of brain structural networks in schizophrenia:
            a preliminary study
  JOURNAL   Biol Psychiatry 68 (7), 657-666 (2010)
   PUBMED   20691427
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1438)
  AUTHORS   Ruano,G., Thompson,P.D., Kane,J.P., Pullinger,C.R., Windemuth,A.,
            Seip,R.L., Kocherla,M., Holford,T.R. and Wu,A.H.
  TITLE     Physiogenomic analysis of statin-treated patients: domain-specific
            counter effects within the ACACB gene on low-density lipoprotein
            cholesterol?
  JOURNAL   Pharmacogenomics 11 (7), 959-971 (2010)
   PUBMED   20602615
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1438)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   5  (bases 1 to 1438)
  AUTHORS   Page,N.M., Butlin,D.J., Lomthaisong,K. and Lowry,P.J.
  TITLE     The human apolipoprotein L gene cluster: identification,
            classification, and sites of distribution
  JOURNAL   Genomics 74 (1), 71-78 (2001)
   PUBMED   11374903
  REMARK    GeneRIF: APOL5 has been found only in humans
REFERENCE   6  (bases 1 to 1438)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY014878.1.
            
            On Mar 4, 2006 this sequence version replaced XM_940740.1.
            
            Summary: This gene is a member of the apolipoprotein L gene family.
            The encoded protein is found in the cytoplasm, where it may affect
            the movement of lipids or allow the binding of lipids to
            organelles. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY014878.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249044.2/ ENSP00000249044.2
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1438
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..1438
                     /gene="APOL5"
                     /gene_synonym="APOL-V; APOLV"
                     /note="apolipoprotein L5"
                     /db_xref="GeneID:80831"
                     /db_xref="HGNC:HGNC:14869"
                     /db_xref="MIM:607255"
     CDS             1..1302
                     /gene="APOL5"
                     /gene_synonym="APOL-V; APOLV"
                     /note="apolipoprotein L-V; apolipoprotein L, 5"
                     /codon_start=1
                     /product="apolipoprotein L5"
                     /protein_id="NP_085145.1"
                     /db_xref="CCDS:CCDS13920.1"
                     /db_xref="GeneID:80831"
                     /db_xref="HGNC:HGNC:14869"
                     /db_xref="MIM:607255"
                     /translation="MPCGKQGNLQVPGSKVLPGLGEGCKEMWLRKVIYGGEVWGKSPE
                     PEFPSLVNLCQSWKINNLMSTVHSDEAGMLSYFLFEELMRCDKDSMPDGNLSEEEKLF
                     LSYFPLHKFELEQNIKELNTLADQVDTTHELLTKTSLVASSSGAVSGVMNILGLALAP
                     VTAGGSLMLSATGTGLGAAAAITNIVTNVLENRSNSAARDKASRLGPLTTSHEAFGGI
                     NWSEIEAAGFCVNKCVKAIQGIKDLHAYQMAKSNSGFMAMVKNFVAKRHIPFWTARGV
                     QRAFEGTTLAMTNGAWVMGAAGAGFLLMKDMSSFLQSWKHLEDGARTETAEELRALAK
                     KLEQELDRLTQHHRHLPQKASQTCSSSRGRAVRGSRVVKPEGSRSPLPWPVVEHQPRL
                     GPGVALRTPKRTVSAPRMLGHQPAPPAPARKGRQAPGRHRQ"
     exon            1..55
                     /gene="APOL5"
                     /gene_synonym="APOL-V; APOLV"
                     /inference="alignment:Splign:2.1.0"
     exon            56..142
                     /gene="APOL5"
                     /gene_synonym="APOL-V; APOLV"
                     /inference="alignment:Splign:2.1.0"
     exon            143..1126
                     /gene="APOL5"
                     /gene_synonym="APOL-V; APOLV"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1308
                     /gene="APOL5"
                     /gene_synonym="APOL-V; APOLV"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1438
                     /gene="APOL5"
                     /gene_synonym="APOL-V; APOLV"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1438
                     /gene="APOL5"
                     /gene_synonym="APOL-V; APOLV"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
        1 atgccatgtg gcaaacaagg aaatttgcaa gttcccggtt ccaaggtgtt acctggcttg
       61 ggagaaggtt gtaaagaaat gtggcttcga aaggtaatct acggaggtga ggtctggggg
      121 aagtccccag aacctgagtt cccctcactc gtgaacctgt gccagagttg gaaaattaac
      181 aatttgatgt caactgtcca cagtgatgag gctggtatgc tgtcctactt tctgtttgaa
      241 gagctgatgc gatgtgacaa agattccatg ccagatggaa atctgtcaga ggaggaaaaa
      301 ttgtttctct catattttcc tttgcacaag tttgagctag aacagaacat caaagaactt
      361 aacacccttg cggaccaagt tgacaccact cacgagttgc ttaccaagac cagcctggtg
      421 gccagctctt ccggggctgt ttctggggtc atgaacatcc tgggtttggc cctagcacct
      481 gtgacagcag gaggcagtct catgctctca gcaactggga cagggttggg ggcagcagct
      541 gccatcacca acatagtaac aaatgtctta gaaaatagaa gcaattcagc agcaagagac
      601 aaagccagcc gactggggcc tctgacaaca tcacatgagg ctttcggagg aataaattgg
      661 tctgaaatcg aggctgctgg cttttgtgtt aataagtgtg taaaagctat ccagggcatc
      721 aaggatcttc atgcctacca gatggccaaa tccaactctg gcttcatggc tatggtcaag
      781 aattttgtgg ccaagagaca catccctttc tggacggcta gaggggtgca gagagccttt
      841 gagggcacaa ctctggccat gaccaatggt gcctgggtga tgggtgctgc tggggctggc
      901 ttcttactta tgaaagacat gagcagcttc ctgcagagct ggaagcacct ggaggatggg
      961 gcaaggacgg agacagcaga ggaactgaga gcacttgcta agaagctgga gcaggagctg
     1021 gaccggctca cccagcacca ccggcacctg ccgcagaagg cgagccagac ctgttccagc
     1081 tcccggggca gggctgttcg aggatcccgt gtggttaaac cagaagggtc tcgctcacct
     1141 ctcccctggc ctgttgtgga gcaccagcct aggctgggcc ctggcgtggc actgaggaca
     1201 ccaaagagga cagtctctgc cccaaggatg cttggccacc agccagcccc accagcacca
     1261 gcaagaaagg ggagacaggc cccgggaaga caccgacaat gagaagagtt ggtcaccctg
     1321 tcaccactga accttgattt aacagaggca aaatgcaagt cttccctgaa gaatactggg
     1381 ggtagggaaa cttctagtgg caatgataaa accagcagca atgataatag aaggcaaa
//
