LOCUS       NM_145660               3232 bp    mRNA    linear   PRI 03-JUN-2024
DEFINITION  Homo sapiens apolipoprotein L4 (APOL4), transcript variant b, mRNA.
ACCESSION   NM_145660
VERSION     NM_145660.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3232)
  AUTHORS   Barallobre-Barreiro,J., Didangelos,A., Schoendube,F.A., Drozdov,I.,
            Yin,X., Fernandez-Caggiano,M., Willeit,P., Puntmann,V.O.,
            Aldama-Lopez,G., Shah,A.M., Domenech,N. and Mayr,M.
  TITLE     Proteomics analysis of cardiac extracellular matrix remodeling in a
            porcine model of ischemia/reperfusion injury
  JOURNAL   Circulation 125 (6), 789-802 (2012)
   PUBMED   22261194
REFERENCE   2  (bases 1 to 3232)
  AUTHORS   Takahashi,S., Cui,Y.H., Han,Y.H., Fagerness,J.A., Galloway,B.,
            Shen,Y.C., Kojima,T., Uchiyama,M., Faraone,S.V. and Tsuang,M.T.
  TITLE     Association of SNPs and haplotypes in APOL1, 2 and 4 with
            schizophrenia
  JOURNAL   Schizophr Res 104 (1-3), 153-164 (2008)
   PUBMED   18632255
  REMARK    GeneRIF: An association of APOL1, 2 and 4 with schizophrenia was
            establised.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3232)
  AUTHORS   McGhee,K.A., Morris,D.W., Schwaiger,S., Nangle,J.M., Donohoe,G.,
            Clarke,S., Meagher,D., Quinn,J., Scully,P., Waddington,J.L.,
            Gill,M. and Corvin,A.
  TITLE     Investigation of the apolipoprotein-L (APOL) gene family and
            schizophrenia using a novel DNA pooling strategy for public
            database SNPs
  JOURNAL   Schizophr Res 76 (2-3), 231-238 (2005)
   PUBMED   15949655
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3232)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   5  (bases 1 to 3232)
  AUTHORS   Monajemi,H., Fontijn,R.D., Pannekoek,H. and Horrevoets,A.J.
  TITLE     The apolipoprotein L gene cluster has emerged recently in evolution
            and is expressed in human vascular tissue
  JOURNAL   Genomics 79 (4), 539-546 (2002)
   PUBMED   11944986
  REMARK    GeneRIF: APOL4 has been found only in humans and African green
            monkeys
REFERENCE   6  (bases 1 to 3232)
  AUTHORS   Page,N.M., Butlin,D.J., Lomthaisong,K. and Lowry,P.J.
  TITLE     The human apolipoprotein L gene cluster: identification,
            classification, and sites of distribution
  JOURNAL   Genomics 74 (1), 71-78 (2001)
   PUBMED   11374903
REFERENCE   7  (bases 1 to 3232)
  AUTHORS   Duchateau,P.N., Pullinger,C.R., Cho,M.H., Eng,C. and Kane,J.P.
  TITLE     Apolipoprotein L gene family: tissue-specific expression, splicing,
            promoter regions; discovery of a new gene
  JOURNAL   J Lipid Res 42 (4), 620-630 (2001)
   PUBMED   11290834
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY014915.1, AY014914.1,
            DA865632.1, Z95114.19 and AW627682.1.
            
            On Sep 12, 2013 this sequence version replaced NM_145660.1.
            
            Summary: This gene encodes a member of the apolipoprotein L family.
            The encoded protein may play a role in lipid exchange and transport
            throughout the body, as well as in reverse cholesterol transport
            from peripheral cells to the liver. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2020].
            
            Transcript Variant: This variant (b) lacks an internal exon in the
            5' region, which results in upstream AUG start codon, compared to
            variant a. The resulting isoform (2) has a longer and distinct
            N-terminus, compared to isoform 1. Isoform 2 is thought to be a
            secreted protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY014915.1, AK313637.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AY014915.1         1-50
            51-269              AY014914.1         52-270
            270-537             DA865632.1         243-510
            538-1465            AY014915.1         538-1465
            1466-2819           Z95114.19          174046-175399       c
            2820-3232           AW627682.1         1-413               c
FEATURES             Location/Qualifiers
     source          1..3232
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..3232
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /note="apolipoprotein L4"
                     /db_xref="GeneID:80832"
                     /db_xref="HGNC:HGNC:14867"
                     /db_xref="MIM:607254"
     exon            1..206
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            207..269
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1281
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /note="isoform 2 precursor is encoded by transcript
                     variant b; apolipoprotein L-IV; apolipoprotein L, 4"
                     /codon_start=1
                     /product="apolipoprotein L4 isoform 2 precursor"
                     /protein_id="NP_663693.1"
                     /db_xref="CCDS:CCDS74852.1"
                     /db_xref="GeneID:80832"
                     /db_xref="HGNC:HGNC:14867"
                     /db_xref="MIM:607254"
                     /translation="MEGAALLKIFVVCIWVQQNHPGWTVAGQFQEKKRFTEEVIEYFQ
                     KKVSPVHLKILLTSDEAWKRFVRVAELPREEADALYEALKNLTPYVAIEDKDMQQKEQ
                     QFREWFLKEFPQIRWKIQESIERLRVIANEIEKVHRGCVIANVVSGSTGILSVIGVML
                     APFTAGLSLSITAAGVGLGIASATAGIASSIVENTYTRSAELTASRLTATSTDQLEAL
                     RDILRDITPNVLSFALDFDEATKMIANDVHTLRRSKATVGRPLIAWRYVPINVVETLR
                     TRGAPTRIVRKVARNLGKATSGVLVVLDVVNLVQDSLDLHKGAKSESAESLRQWAQEL
                     EENLNELTHIHQSLKAG"
     exon            270..316
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            317..443
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            444..3228
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3207..3212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /note="hexamer: AATAAA"
     polyA_site      3228
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /note="major polyA site"
ORIGIN      
        1 gaggtgctgg ggagcagcgt gtttgctgtg cttgattgtg agctgctggg aagttgtgac
       61 tttcatttta cctttcgaat tcctgggtat atcttggggg ctggaggacg tgtctggtta
      121 ttatataggt gcacagctgg aggtgagatc cacacagctc agaccagctg gatcttgctc
      181 agtctctgtc agaggaagat cccttggagg aggccccgca gcgacatgga gggagctgct
      241 ttgctgaaaa tctttgtcgt ctgcatctgg gtgcagcaaa accatccagg ctggacagtg
      301 gctggacagt tccaagaaaa gaaacgcttc actgaagaag tcattgaata cttccagaag
      361 aaagttagcc cagtgcatct gaaaatcctg ctgactagcg atgaagcctg gaagagattt
      421 gtgcgtgtgg ctgaattgcc cagggaagag gcagatgctc tctatgaagc tctgaagaat
      481 cttacaccat atgtggctat tgaggacaaa gacatgcagc aaaaagaaca gcagtttagg
      541 gagtggtttt tgaaagagtt tcctcaaatc agatggaaga ttcaggagtc catagaaagg
      601 cttcgtgtca ttgcaaatga gattgaaaag gtccacagag gctgcgtcat cgccaatgtg
      661 gtgtctggct ccactggcat cctgtctgtc attggcgtta tgttggcacc atttacagca
      721 gggctgagcc tgagcattac tgcagctggg gtagggctgg gaatagcatc tgccacggct
      781 gggatcgcct ccagcatcgt ggagaacaca tacacaaggt cagcagaact cacagccagc
      841 aggctgactg caaccagcac tgaccaattg gaggcattaa gggacattct gcgtgacatc
      901 acacccaatg tgctttcttt tgcacttgat tttgacgaag ccacaaaaat gattgcgaat
      961 gatgtccata cactcaggag atctaaagcc actgttggac gccctttgat tgcttggcga
     1021 tatgtaccta taaatgttgt tgagacactg agaacacgtg gggcccccac ccggatagtg
     1081 agaaaagtag cccggaacct gggcaaggcc acttcaggtg tccttgttgt gctggatgta
     1141 gtcaaccttg tgcaagactc actggacttg cacaaggggg caaaatccga gtctgctgag
     1201 tcgctgaggc agtgggctca ggagctggag gagaatctca atgagctcac ccatatccat
     1261 cagagtctaa aagcaggcta ggcccaattg ttgcgggaag tcagggaccc caaacggagg
     1321 gactggctga agccatggca gaagaacgtg gattgtgaag atttcatgga catttattag
     1381 ttccccaaat taatactttt ataatttcct atgcctgtct ttaccgcaat ctctaaacac
     1441 aaattgtgaa gatttcatgg acactgatca cttccccaat caataccctt gtgatttctt
     1501 atgcctgtct ttactttaat ctcctaatcc tgtcagctga ggaggatgta tgtcacctca
     1561 ggaccatgtg ataattgcgt taactgcaca aattgtagag catgtgtgtt tgaacaatat
     1621 gaaatctggg caccttgaaa aaagaacagg ataacagcaa ttgttcaggg aataagagag
     1681 ataaccttaa actctgacca acagtgagcc tggtggaaca gagtcatatt tctcttcttt
     1741 caaaagcaaa tgggagaaat atcgctgaat tctttttctc agcaaggaac atccctgaga
     1801 aagagaatgc acccctgagg gtgggtctat aaatggcctc cttgggtgtg gccatcttct
     1861 atggtcgaga ctgtagggat gaaataaacc ccagtctccc atagcgctcc caggcttatt
     1921 aggaagagga aattcccgcc taataaattt tggtcagacc ggttgctctc aaaaccctgt
     1981 ctcctgataa gatgttatca atgacaatgg tgcccgaaac ctcattagca attttaattt
     2041 ctccccggtc ctgtgttcct gtgatctcgc cctgcctcca cttgccttgt gatattctat
     2101 taccttgtga agtaggtgat ctttgtgacc cacacccaca ccctattcat acactccctc
     2161 cccttttgaa agtccctaat aaaaacttgc tggttttgcg gcttgtgagg catcacggaa
     2221 cctaccgatg tgtgatgtct cccctggaca cctagcttta aaatttctct cttttgtact
     2281 ctgtgccttt atttctcaaa ccggccaaca cttagggaaa atagaaaaga acctacgtga
     2341 ccatcggggc aggttccccg atacccaatg accccagagc agtgcagcca ccagggaagg
     2401 tgagccagac acaggccggg acaaaacgca gacatttttt aggggaataa agagggcgag
     2461 gtaaagttta tggaactcag tgttaggaac tttggcatct gtagctgagc acagcagggg
     2521 aggggttact caagatggca agtgcgccaa ggagaaggca gaaatgctgg ggcctggaat
     2581 aagggaggag aggggactgg agagtgtggg gaatggaaag aagcagttta ctctagacta
     2641 aagagtatat tgggggagga agagagggag gcacgtagga acaagcaatg agaagaccag
     2701 gaaaagaaag agctgaaaat ggagaaagcc acagttagaa ctgttggata caggagaaga
     2761 aacagcggct ccactaaaga cccgcccccc ggttggatgt ccttccaaga atggaatcct
     2821 tccctggtga tggtctctca ccctgtctta ccagcatcca ctctcccttg tcctcccggg
     2881 ggtgtatctg agtcagccag tggcttcttg atgatggtgg tggtggttgt agtgtgacag
     2941 gtccccttta ggttatttaa gggtgcatgt cccctgcttg aaccctgaag gccgggtaat
     3001 gagccatttc catggtgccc agctgaggac caggtgtctc tgagaatcca aacatcctgg
     3061 agagtatctg agaaccaacc aagtaaaagt ctcgttgctc atatatagta gacaaagagc
     3121 cagaaaatta actgaaaagc agtttagaca ttgggggagg ctggatctct cgagctgtct
     3181 tgctgagtgc cctgtgtgta agtcctaata aacttagcta ctcgccaaaa aa
//
