LOCUS       NM_001386885            3069 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens apolipoprotein L4 (APOL4), transcript variant d, mRNA.
ACCESSION   NM_001386885
VERSION     NM_001386885.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3069)
  AUTHORS   Barallobre-Barreiro,J., Didangelos,A., Schoendube,F.A., Drozdov,I.,
            Yin,X., Fernandez-Caggiano,M., Willeit,P., Puntmann,V.O.,
            Aldama-Lopez,G., Shah,A.M., Domenech,N. and Mayr,M.
  TITLE     Proteomics analysis of cardiac extracellular matrix remodeling in a
            porcine model of ischemia/reperfusion injury
  JOURNAL   Circulation 125 (6), 789-802 (2012)
   PUBMED   22261194
REFERENCE   2  (bases 1 to 3069)
  AUTHORS   Takahashi,S., Cui,Y.H., Han,Y.H., Fagerness,J.A., Galloway,B.,
            Shen,Y.C., Kojima,T., Uchiyama,M., Faraone,S.V. and Tsuang,M.T.
  TITLE     Association of SNPs and haplotypes in APOL1, 2 and 4 with
            schizophrenia
  JOURNAL   Schizophr Res 104 (1-3), 153-164 (2008)
   PUBMED   18632255
  REMARK    GeneRIF: An association of APOL1, 2 and 4 with schizophrenia was
            establised.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3069)
  AUTHORS   McGhee,K.A., Morris,D.W., Schwaiger,S., Nangle,J.M., Donohoe,G.,
            Clarke,S., Meagher,D., Quinn,J., Scully,P., Waddington,J.L.,
            Gill,M. and Corvin,A.
  TITLE     Investigation of the apolipoprotein-L (APOL) gene family and
            schizophrenia using a novel DNA pooling strategy for public
            database SNPs
  JOURNAL   Schizophr Res 76 (2-3), 231-238 (2005)
   PUBMED   15949655
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3069)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   5  (bases 1 to 3069)
  AUTHORS   Monajemi,H., Fontijn,R.D., Pannekoek,H. and Horrevoets,A.J.
  TITLE     The apolipoprotein L gene cluster has emerged recently in evolution
            and is expressed in human vascular tissue
  JOURNAL   Genomics 79 (4), 539-546 (2002)
   PUBMED   11944986
  REMARK    GeneRIF: APOL4 has been found only in humans and African green
            monkeys
REFERENCE   6  (bases 1 to 3069)
  AUTHORS   Page,N.M., Butlin,D.J., Lomthaisong,K. and Lowry,P.J.
  TITLE     The human apolipoprotein L gene cluster: identification,
            classification, and sites of distribution
  JOURNAL   Genomics 74 (1), 71-78 (2001)
   PUBMED   11374903
REFERENCE   7  (bases 1 to 3069)
  AUTHORS   Duchateau,P.N., Pullinger,C.R., Cho,M.H., Eng,C. and Kane,J.P.
  TITLE     Apolipoprotein L gene family: tissue-specific expression, splicing,
            promoter regions; discovery of a new gene
  JOURNAL   J Lipid Res 42 (4), 620-630 (2001)
   PUBMED   11290834
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z95114.19 and KF459718.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the apolipoprotein L family.
            The encoded protein may play a role in lipid exchange and transport
            throughout the body, as well as in reverse cholesterol transport
            from peripheral cells to the liver. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2020].
            
            Transcript Variant: This variant (d) differs in the 5' UTR,
            compared to variant a. Both variants a and d encode the same
            isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017313.2, AF305226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920, SAMEA2467150
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683024.1/ ENSP00000507418.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               Z95114.19          186207-186316       c
            111-157             Z95114.19          183837-183883       c
            158-284             Z95114.19          179818-179944       c
            285-335             Z95114.19          176369-176419       c
            336-495             KF459718.1         1-160
            496-3069            Z95114.19          173637-176210       c
FEATURES             Location/Qualifiers
     source          1..3069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..3069
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /note="apolipoprotein L4"
                     /db_xref="GeneID:80832"
                     /db_xref="HGNC:HGNC:14867"
                     /db_xref="MIM:607254"
     exon            1..110
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1122
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /note="isoform 1 is encoded by transcript variant d;
                     apolipoprotein L-IV; apolipoprotein L, 4"
                     /codon_start=1
                     /product="apolipoprotein L4 isoform 1"
                     /protein_id="NP_001373814.1"
                     /db_xref="CCDS:CCDS74851.1"
                     /db_xref="GeneID:80832"
                     /db_xref="HGNC:HGNC:14867"
                     /db_xref="MIM:607254"
                     /translation="MGSWVQLITSVGVQQNHPGWTVAGQFQEKKRFTEEVIEYFQKKV
                     SPVHLKILLTSDEAWKRFVRVAELPREEADALYEALKNLTPYVAIEDKDMQQKEQQFR
                     EWFLKEFPQIRWKIQESIERLRVIANEIEKVHRGCVIANVVSGSTGILSVIGVMLAPF
                     TAGLSLSITAAGVGLGIASATAGIASSIVENTYTRSAELTASRLTATSTDQLEALRDI
                     LRDITPNVLSFALDFDEATKMIANDVHTLRRSKATVGRPLIAWRYVPINVVETLRTRG
                     APTRIVRKVARNLGKATSGVLVVLDVVNLVQDSLDLHKGAKSESAESLRQWAQELEEN
                     LNELTHIHQSLKAG"
     exon            111..157
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            158..284
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            285..3069
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3048..3053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /note="hexamer: AATAAA"
     polyA_site      3069
                     /gene="APOL4"
                     /gene_synonym="APOL-IV; APOLIV"
                     /note="major polyA site"
ORIGIN      
        1 agtcagtatc cagcctcaac attcagcaga ggccccagat cagcgtctga gccaggccaa
       61 caatgaccaa ggaggatggg atcctgggtg cagctcatca caagcgtcgg ggtgcagcaa
      121 aaccatccag gctggacagt ggctggacag ttccaagaaa agaaacgctt cactgaagaa
      181 gtcattgaat acttccagaa gaaagttagc ccagtgcatc tgaaaatcct gctgactagc
      241 gatgaagcct ggaagagatt tgtgcgtgtg gctgaattgc ccagggaaga ggcagatgct
      301 ctctatgaag ctctgaagaa tcttacacca tatgtggcta ttgaggacaa agacatgcag
      361 caaaaagaac agcagtttag ggagtggttt ttgaaagagt ttcctcaaat cagatggaag
      421 attcaggagt ccatagaaag gcttcgtgtc attgcaaatg agattgaaaa ggtccacaga
      481 ggctgcgtca tcgccaatgt ggtgtctggc tccactggca tcctgtctgt cattggcgtt
      541 atgttggcac catttacagc agggctgagc ctgagcatta ctgcagctgg ggtagggctg
      601 ggaatagcat ctgccacggc tgggatcgcc tccagcatcg tggagaacac atacacaagg
      661 tcagcagaac tcacagccag caggctgact gcaaccagca ctgaccaatt ggaggcatta
      721 agggacattc tgcgtgacat cacacccaat gtgctttctt ttgcacttga ttttgacgaa
      781 gccacaaaaa tgattgcgaa tgatgtccat acactcagga gatctaaagc cactgttgga
      841 cgccctttga ttgcttggcg atatgtacct ataaatgttg ttgagacact gagaacacgt
      901 ggggccccca cccggatagt gagaaaagta gcccggaacc tgggcaaggc cacttcaggt
      961 gtccttgttg tgctggatgt agtcaacctt gtgcaagact cactggactt gcacaagggg
     1021 gcaaaatccg agtctgctga gtcgctgagg cagtgggctc aggagctgga ggagaatctc
     1081 aatgagctca cccatatcca tcagagtcta aaagcaggct aggcccaatt gttgcgggaa
     1141 gtcagggacc ccaaacggag ggactggctg aagccatggc agaagaacgt ggattgtgaa
     1201 gatttcatgg acatttatta gttccccaaa ttaatacttt tataatttcc tatgcctgtc
     1261 tttaccgcaa tctctaaaca caaattgtga agatttcatg gacactgatc acttccccaa
     1321 tcaataccct tgtgatttct tatgcctgtc tttactttaa tctcctaatc ctgtcagctg
     1381 aggaggatgt atgtcacctc aggaccatgt gataattgcg ttaactgcac aaattgtaga
     1441 gcatgtgtgt ttgaacaata tgaaatctgg gcaccttgaa aaaagaacag gataacagca
     1501 attgttcagg gaataagaga gataacctta aactctgacc aacagtgagc ctggtggaac
     1561 agagtcatat ttctcttctt tcaaaagcaa atgggagaaa tatcgctgaa ttctttttct
     1621 cagcaaggaa catccctgag aaagagaatg cacccctgag ggtgggtcta taaatggcct
     1681 ccttgggtgt ggccatcttc tatggtcgag actgtaggga tgaaataaac cccagtctcc
     1741 catagcgctc ccaggcttat taggaagagg aaattcccgc ctaataaatt ttggtcagac
     1801 cggttgctct caaaaccctg tctcctgata agatgttatc aatgacaatg gtgcccgaaa
     1861 cctcattagc aattttaatt tctccccggt cctgtgttcc tgtgatctcg ccctgcctcc
     1921 acttgccttg tgatattcta ttaccttgtg aagtaggtga tctttgtgac ccacacccac
     1981 accctattca tacactccct ccccttttga aagtccctaa taaaaacttg ctggttttgc
     2041 ggcttgtgag gcatcacgga acctaccgat gtgtgatgtc tcccctggac acctagcttt
     2101 aaaatttctc tcttttgtac tctgtgcctt tatttctcaa accggccaac acttagggaa
     2161 aatagaaaag aacctacgtg accatcgggg caggttcccc gatacccaat gaccccagag
     2221 cagtgcagcc accagggaag gtgagccaga cacaggccgg gacaaaacgc agacattttt
     2281 taggggaata aagagggcga ggtaaagttt atggaactca gtgttaggaa ctttggcatc
     2341 tgtagctgag cacagcaggg gaggggttac tcaagatggc aagtgcgcca aggagaaggc
     2401 agaaatgctg gggcctggaa taagggagga gaggggactg gagagtgtgg ggaatggaaa
     2461 gaagcagttt actctagact aaagagtata ttgggggagg aagagaggga ggcacgtagg
     2521 aacaagcaat gagaagacca ggaaaagaaa gagctgaaaa tggagaaagc cacagttaga
     2581 actgttggat acaggagaag aaacagcggc tccactaaag acccgccccc cggttggatg
     2641 tccttccaag aatggaatcc ttccctggtg atggtctctc accctgtctt accagcatcc
     2701 actctccctt gtcctcccgg gggtgtatct gagtcagcca gtggcttctt gatgatggtg
     2761 gtggtggttg tagtgtgaca ggtccccttt aggttattta agggtgcatg tcccctgctt
     2821 gaaccctgaa ggccgggtaa tgagccattt ccatggtgcc cagctgagga ccaggtgtct
     2881 ctgagaatcc aaacatcctg gagagtatct gagaaccaac caagtaaaag tctcgttgct
     2941 catatatagt agacaaagag ccagaaaatt aactgaaaag cagtttagac attgggggag
     3001 gctggatctc tcgagctgtc ttgctgagtg ccctgtgtgt aagtcctaat aaacttagct
     3061 actcgccaa
//
