LOCUS       NM_145639               2041 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens apolipoprotein L3 (APOL3), transcript variant alpha/c,
            mRNA.
ACCESSION   NM_145639
VERSION     NM_145639.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2041)
  AUTHORS   Lv,Y., Tang,W., Xu,Y., Chang,W., Zhang,Z., Lin,Q., Ji,M., Feng,Q.,
            He,G. and Xu,J.
  TITLE     Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of
            colorectal cancer by promoting LDHA-mediated ferroptosis
  JOURNAL   Int J Biol Sci 19 (4), 1284-1298 (2023)
   PUBMED   36923931
  REMARK    GeneRIF: Apolipoprotein L3 enhances CD8+ T cell antitumor immunity
            of colorectal cancer by promoting LDHA-mediated ferroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2041)
  AUTHORS   Gaudet,R.G., Zhu,S., Halder,A., Kim,B.H., Bradfield,C.J., Huang,S.,
            Xu,D., Maminska,A., Nguyen,T.N., Lazarou,M., Karatekin,E., Gupta,K.
            and MacMicking,J.D.
  TITLE     A human apolipoprotein L with detergent-like activity kills
            intracellular pathogens
  JOURNAL   Science 373 (6552) (2021)
   PUBMED   34437126
  REMARK    GeneRIF: A human apolipoprotein L with detergent-like activity
            kills intracellular pathogens.
REFERENCE   3  (bases 1 to 2041)
  AUTHORS   Pays,E.
  TITLE     The function of apolipoproteins L (APOLs): relevance for kidney
            disease, neurotransmission disorders, cancer and viral infection
  JOURNAL   FEBS J 288 (2), 360-381 (2021)
   PUBMED   32530132
  REMARK    GeneRIF: The function of apolipoproteins L (APOLs): relevance for
            kidney disease, neurotransmission disorders, cancer and viral
            infection.
            Review article
REFERENCE   4  (bases 1 to 2041)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2041)
  AUTHORS   Uzureau,S., Lecordier,L., Uzureau,P., Hennig,D., Graversen,J.H.,
            Homble,F., Mfutu,P.E., Oliveira Arcolino,F., Ramos,A.R., La
            Rovere,R.M., Luyten,T., Vermeersch,M., Tebabi,P., Dieu,M.,
            Cuypers,B., Deborggraeve,S., Rabant,M., Legendre,C., Moestrup,S.K.,
            Levtchenko,E., Bultynck,G., Erneux,C., Perez-Morga,D. and Pays,E.
  TITLE     APOL1 C-Terminal Variants May Trigger Kidney Disease through
            Interference with APOL3 Control of Actomyosin
  JOURNAL   Cell Rep 30 (11), 3821-3836 (2020)
   PUBMED   32187552
  REMARK    GeneRIF: APOL1 C-Terminal Variants May Trigger Kidney Disease
            through Interference with APOL3 Control of Actomyosin.
REFERENCE   6  (bases 1 to 2041)
  AUTHORS   Mimmack,M.L., Ryan,M., Baba,H., Navarro-Ruiz,J., Iritani,S.,
            Faull,R.L., McKenna,P.J., Jones,P.B., Arai,H., Starkey,M.,
            Emson,P.C. and Bahn,S.
  TITLE     Gene expression analysis in schizophrenia: reproducible
            up-regulation of several members of the apolipoprotein L family
            located in a high-susceptibility locus for schizophrenia on
            chromosome 22
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4680-4685 (2002)
   PUBMED   11930015
REFERENCE   7  (bases 1 to 2041)
  AUTHORS   Monajemi,H., Fontijn,R.D., Pannekoek,H. and Horrevoets,A.J.
  TITLE     The apolipoprotein L gene cluster has emerged recently in evolution
            and is expressed in human vascular tissue
  JOURNAL   Genomics 79 (4), 539-546 (2002)
   PUBMED   11944986
  REMARK    GeneRIF: APOL3 has been found only in humans and African green
            monkeys
REFERENCE   8  (bases 1 to 2041)
  AUTHORS   Page,N.M., Butlin,D.J., Lomthaisong,K. and Lowry,P.J.
  TITLE     The human apolipoprotein L gene cluster: identification,
            classification, and sites of distribution
  JOURNAL   Genomics 74 (1), 71-78 (2001)
   PUBMED   11374903
REFERENCE   9  (bases 1 to 2041)
  AUTHORS   Duchateau,P.N., Pullinger,C.R., Cho,M.H., Eng,C. and Kane,J.P.
  TITLE     Apolipoprotein L gene family: tissue-specific expression, splicing,
            promoter regions; discovery of a new gene
  JOURNAL   J Lipid Res 42 (4), 620-630 (2001)
   PUBMED   11290834
REFERENCE   10 (bases 1 to 2041)
  AUTHORS   Horrevoets,A.J., Fontijn,R.D., van Zonneveld,A.J., de Vries,C.J.,
            ten Cate,J.W. and Pannekoek,H.
  TITLE     Vascular endothelial genes that are responsive to tumor necrosis
            factor-alpha in vitro are expressed in atherosclerotic lesions,
            including inhibitor of apoptosis protein-1, stannin, and two novel
            genes
  JOURNAL   Blood 93 (10), 3418-3431 (1999)
   PUBMED   10233894
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z95114.19.
            
            On Jun 2, 2019 this sequence version replaced NM_145639.1.
            
            Summary: This gene is a member of the apolipoprotein L gene family,
            and it is present in a cluster with other family members on
            chromosome 22. The encoded protein is found in the cytoplasm, where
            it may affect the movement of lipids, including cholesterol, and/or
            allow the binding of lipids to organelles. In addition, expression
            of this gene is up-regulated by tumor necrosis factor-alpha in
            endothelial cells lining the normal and atherosclerotic iliac
            artery and aorta. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (alpha/c) differs in the coding
            region but maintains the reading frame compared to variant alpha/d.
            This variant encodes isoform 2, which is shorter and which contains
            a unique N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050596.1, SRR1803615.190012.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155751 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424878.4/ ENSP00000415779.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                Z95114.19          145178-145264       c
            88-184              Z95114.19          133555-133651       c
            185-311             Z95114.19          129982-130108       c
            312-2041            Z95114.19          124838-126567       c
FEATURES             Location/Qualifiers
     source          1..2041
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..2041
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /note="apolipoprotein L3"
                     /db_xref="GeneID:80833"
                     /db_xref="HGNC:HGNC:14868"
                     /db_xref="MIM:607253"
     exon            1..87
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..184
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1170
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /note="isoform 2 is encoded by transcript variant alpha/c;
                     TNF-inducible protein CG12-1; apolipoprotein L, 3;
                     apolipoprotein L-III"
                     /codon_start=1
                     /product="apolipoprotein L3 isoform 2"
                     /protein_id="NP_663614.1"
                     /db_xref="CCDS:CCDS13923.1"
                     /db_xref="GeneID:80833"
                     /db_xref="HGNC:HGNC:14868"
                     /db_xref="MIM:607253"
                     /translation="MDSEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAEL
                     PRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRAL
                     ANGIEEVHRGCTISNVVSSSTGAASGIMSLAGLVLAPFTAGTSLALTAAGVGLGAASA
                     VTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSLLNNYYEATQ
                     TIGSEIRAIRQARARARLPVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSGI
                     FLALDVVNLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQIYQRLNPCHTH"
     exon            185..311
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..2041
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2020..2025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /note="hexamer: AATAAA"
     polyA_site      2041
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /note="major polyA site"
ORIGIN      
        1 attatgcaga tgcacggctg gaggtgggat ccacacagct cagaacagct ggatcttgct
       61 cacactcttt caagagaagc ttccttgggt taagaaaaaa aacgaaccct tccagtcagg
      121 tcagtgactg gagagctcca tggaaagtct ctcagtgacc tggctgctgg caccatggac
      181 tcagaaaaga aacgctttac tgaagaggcc accaaatact tccgggagag agtcagccca
      241 gtgcatctgc aaatcctgct gactaacaat gaagcctgga agagattcgt gactgcggct
      301 gaattgccca gggatgaggc agatgctctc tacgaagctc tgaagaagct tagaacatat
      361 gcagctattg aggacgaata tgtgcagcag aaagatgagc agtttaggga atggtttttg
      421 aaagagtttc cccaagtcaa gaggaagatc caggagtcca tagaaaagct tcgtgccctt
      481 gcaaatggta ttgaagaggt ccacagaggc tgcaccatct ccaatgtggt gtccagctcc
      541 actggcgctg cctctggcat catgtccctt gctggtcttg ttttggcacc atttacagca
      601 gggacgagtc tggcccttac tgcagctggg gtagggctgg gagcagcgtc tgctgtgact
      661 gggatcacca ccagcatcgt ggagcactca tacacatcat cagcagaagc tgaagccagc
      721 aggctgactg caaccagcat tgaccgattg aaggtattta aggaagttat gcgtgacatc
      781 acacccaact tactttccct tcttaataat tattacgaag ccacacaaac cattgggagt
      841 gaaatccgtg ccatcaggca agccagagcc agggcccgac tccctgtgac cacctggcga
      901 atctcagctg gaagtggtgg tcaagcagag agaacgattg caggcaccac ccgggcagtg
      961 agcagaggag cccggatcct gagtgcgacc acttcaggca tcttccttgc actggatgtg
     1021 gtcaaccttg tatacgagtc aaagcacttg catgaggggg caaagtctgc atctgctgag
     1081 gagctgaggc ggcaggctca ggagctggag gagaatctaa tggagctcac tcagatctat
     1141 cagcgtctga atccatgcca tacccactga ccccagacca gtgcagccag caggggaggt
     1201 gagccataca caggccacga caaaatgcag gcattttatt agggggataa agagggcaag
     1261 gtaaagttta tggagctgag tgttagtgac tttggcattt ctgtagctga gcacagcagg
     1321 ggaggggtta atgcagatgg caagtgcacc aaggagaagg caggaatgct ggagcctgga
     1381 ataagggagg agaggggact ggagagtgtg gggaatagga agaagaaatt tcctttagac
     1441 taacgaatat attgggggga ggaatagagg ggaggtgtgc aggaaccagc aatgagaagg
     1501 ccaggaaaag aaagagctga aaatgcagaa agccgaagag ttagaacttt tggatacagc
     1561 agaagaaaca gcggctccac taccgacctg cccccggttc gatgtccttc caagaatgaa
     1621 gtctttccct ggtgatggtc ccctgccctg tctttccagc atccactctg tcttgtcctc
     1681 ctggaagtgt atctcagtca gccagtggct tcttgatgat ggcggtggag gtggtggttg
     1741 tagtgtgatg gatccccttt aggttattta ggggtatatg tcccctgctt gaaccctgaa
     1801 ggccaggtaa tgagccatgg ccattgtccc cagctgagga ccaggtgtct ctaaaaaccc
     1861 aaacatcctg gagagtatgc gagaacctac caagaaaaac agtctcatta ctcatataca
     1921 gcaggcaaag agacagaaaa ttaactgaaa agcagtttag agactggggg aggccggatc
     1981 tctagagcca tcctgctgag tgccctgtgt gtaagtccta ataaactcac ctactcacca
     2041 a
//
