LOCUS       NM_001393591            2044 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens apolipoprotein L3 (APOL3), transcript variant 11,
            mRNA.
ACCESSION   NM_001393591 XM_017028946
VERSION     NM_001393591.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2044)
  AUTHORS   Lv,Y., Tang,W., Xu,Y., Chang,W., Zhang,Z., Lin,Q., Ji,M., Feng,Q.,
            He,G. and Xu,J.
  TITLE     Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of
            colorectal cancer by promoting LDHA-mediated ferroptosis
  JOURNAL   Int J Biol Sci 19 (4), 1284-1298 (2023)
   PUBMED   36923931
  REMARK    GeneRIF: Apolipoprotein L3 enhances CD8+ T cell antitumor immunity
            of colorectal cancer by promoting LDHA-mediated ferroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2044)
  AUTHORS   Gaudet,R.G., Zhu,S., Halder,A., Kim,B.H., Bradfield,C.J., Huang,S.,
            Xu,D., Maminska,A., Nguyen,T.N., Lazarou,M., Karatekin,E., Gupta,K.
            and MacMicking,J.D.
  TITLE     A human apolipoprotein L with detergent-like activity kills
            intracellular pathogens
  JOURNAL   Science 373 (6552) (2021)
   PUBMED   34437126
  REMARK    GeneRIF: A human apolipoprotein L with detergent-like activity
            kills intracellular pathogens.
REFERENCE   3  (bases 1 to 2044)
  AUTHORS   Pays,E.
  TITLE     The function of apolipoproteins L (APOLs): relevance for kidney
            disease, neurotransmission disorders, cancer and viral infection
  JOURNAL   FEBS J 288 (2), 360-381 (2021)
   PUBMED   32530132
  REMARK    GeneRIF: The function of apolipoproteins L (APOLs): relevance for
            kidney disease, neurotransmission disorders, cancer and viral
            infection.
            Review article
REFERENCE   4  (bases 1 to 2044)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2044)
  AUTHORS   Uzureau,S., Lecordier,L., Uzureau,P., Hennig,D., Graversen,J.H.,
            Homble,F., Mfutu,P.E., Oliveira Arcolino,F., Ramos,A.R., La
            Rovere,R.M., Luyten,T., Vermeersch,M., Tebabi,P., Dieu,M.,
            Cuypers,B., Deborggraeve,S., Rabant,M., Legendre,C., Moestrup,S.K.,
            Levtchenko,E., Bultynck,G., Erneux,C., Perez-Morga,D. and Pays,E.
  TITLE     APOL1 C-Terminal Variants May Trigger Kidney Disease through
            Interference with APOL3 Control of Actomyosin
  JOURNAL   Cell Rep 30 (11), 3821-3836 (2020)
   PUBMED   32187552
  REMARK    GeneRIF: APOL1 C-Terminal Variants May Trigger Kidney Disease
            through Interference with APOL3 Control of Actomyosin.
REFERENCE   6  (bases 1 to 2044)
  AUTHORS   Mimmack,M.L., Ryan,M., Baba,H., Navarro-Ruiz,J., Iritani,S.,
            Faull,R.L., McKenna,P.J., Jones,P.B., Arai,H., Starkey,M.,
            Emson,P.C. and Bahn,S.
  TITLE     Gene expression analysis in schizophrenia: reproducible
            up-regulation of several members of the apolipoprotein L family
            located in a high-susceptibility locus for schizophrenia on
            chromosome 22
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4680-4685 (2002)
   PUBMED   11930015
REFERENCE   7  (bases 1 to 2044)
  AUTHORS   Monajemi,H., Fontijn,R.D., Pannekoek,H. and Horrevoets,A.J.
  TITLE     The apolipoprotein L gene cluster has emerged recently in evolution
            and is expressed in human vascular tissue
  JOURNAL   Genomics 79 (4), 539-546 (2002)
   PUBMED   11944986
  REMARK    GeneRIF: APOL3 has been found only in humans and African green
            monkeys
REFERENCE   8  (bases 1 to 2044)
  AUTHORS   Page,N.M., Butlin,D.J., Lomthaisong,K. and Lowry,P.J.
  TITLE     The human apolipoprotein L gene cluster: identification,
            classification, and sites of distribution
  JOURNAL   Genomics 74 (1), 71-78 (2001)
   PUBMED   11374903
REFERENCE   9  (bases 1 to 2044)
  AUTHORS   Duchateau,P.N., Pullinger,C.R., Cho,M.H., Eng,C. and Kane,J.P.
  TITLE     Apolipoprotein L gene family: tissue-specific expression, splicing,
            promoter regions; discovery of a new gene
  JOURNAL   J Lipid Res 42 (4), 620-630 (2001)
   PUBMED   11290834
REFERENCE   10 (bases 1 to 2044)
  AUTHORS   Horrevoets,A.J., Fontijn,R.D., van Zonneveld,A.J., de Vries,C.J.,
            ten Cate,J.W. and Pannekoek,H.
  TITLE     Vascular endothelial genes that are responsive to tumor necrosis
            factor-alpha in vitro are expressed in atherosclerotic lesions,
            including inhibitor of apoptosis protein-1, stannin, and two novel
            genes
  JOURNAL   Blood 93 (10), 3418-3431 (1999)
   PUBMED   10233894
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z95114.19.
            
            On Feb 22, 2021 this sequence version replaced XM_017028946.1.
            
            Summary: This gene is a member of the apolipoprotein L gene family,
            and it is present in a cluster with other family members on
            chromosome 22. The encoded protein is found in the cytoplasm, where
            it may affect the movement of lipids, including cholesterol, and/or
            allow the binding of lipids to organelles. In addition, expression
            of this gene is up-regulated by tumor necrosis factor-alpha in
            endothelial cells lining the normal and atherosclerotic iliac
            artery and aorta. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Mar 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA956739.1, DA945993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                Z95114.19          145178-145264       c
            88-184              Z95114.19          133555-133651       c
            185-314             Z95114.19          129982-130111       c
            315-2044            Z95114.19          124838-126567       c
FEATURES             Location/Qualifiers
     source          1..2044
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..2044
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /note="apolipoprotein L3"
                     /db_xref="GeneID:80833"
                     /db_xref="HGNC:HGNC:14868"
                     /db_xref="MIM:607253"
     exon            1..87
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..184
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1173
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /note="isoform 4 is encoded by transcript variant 11;
                     TNF-inducible protein CG12-1; apolipoprotein L, 3;
                     apolipoprotein L-III"
                     /codon_start=1
                     /product="apolipoprotein L3 isoform 4"
                     /protein_id="NP_001380520.1"
                     /db_xref="GeneID:80833"
                     /db_xref="HGNC:HGNC:14868"
                     /db_xref="MIM:607253"
                     /translation="MDSVEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAE
                     LPRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRA
                     LANGIEEVHRGCTISNVVSSSTGAASGIMSLAGLVLAPFTAGTSLALTAAGVGLGAAS
                     AVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSLLNNYYEAT
                     QTIGSEIRAIRQARARARLPVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSG
                     IFLALDVVNLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQIYQRLNPCHTH"
     exon            185..314
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /inference="alignment:Splign:2.1.0"
     exon            315..2044
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2023..2028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /note="hexamer: AATAAA"
     polyA_site      2044
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /note="major polyA site"
ORIGIN      
        1 attatgcaga tgcacggctg gaggtgggat ccacacagct cagaacagct ggatcttgct
       61 cacactcttt caagagaagc ttccttgggt taagaaaaaa aacgaaccct tccagtcagg
      121 tcagtgactg gagagctcca tggaaagtct ctcagtgacc tggctgctgg caccatggac
      181 tcagtagaaa agaaacgctt tactgaagag gccaccaaat acttccggga gagagtcagc
      241 ccagtgcatc tgcaaatcct gctgactaac aatgaagcct ggaagagatt cgtgactgcg
      301 gctgaattgc ccagggatga ggcagatgct ctctacgaag ctctgaagaa gcttagaaca
      361 tatgcagcta ttgaggacga atatgtgcag cagaaagatg agcagtttag ggaatggttt
      421 ttgaaagagt ttccccaagt caagaggaag atccaggagt ccatagaaaa gcttcgtgcc
      481 cttgcaaatg gtattgaaga ggtccacaga ggctgcacca tctccaatgt ggtgtccagc
      541 tccactggcg ctgcctctgg catcatgtcc cttgctggtc ttgttttggc accatttaca
      601 gcagggacga gtctggccct tactgcagct ggggtagggc tgggagcagc gtctgctgtg
      661 actgggatca ccaccagcat cgtggagcac tcatacacat catcagcaga agctgaagcc
      721 agcaggctga ctgcaaccag cattgaccga ttgaaggtat ttaaggaagt tatgcgtgac
      781 atcacaccca acttactttc ccttcttaat aattattacg aagccacaca aaccattggg
      841 agtgaaatcc gtgccatcag gcaagccaga gccagggccc gactccctgt gaccacctgg
      901 cgaatctcag ctggaagtgg tggtcaagca gagagaacga ttgcaggcac cacccgggca
      961 gtgagcagag gagcccggat cctgagtgcg accacttcag gcatcttcct tgcactggat
     1021 gtggtcaacc ttgtatacga gtcaaagcac ttgcatgagg gggcaaagtc tgcatctgct
     1081 gaggagctga ggcggcaggc tcaggagctg gaggagaatc taatggagct cactcagatc
     1141 tatcagcgtc tgaatccatg ccatacccac tgaccccaga ccagtgcagc cagcagggga
     1201 ggtgagccat acacaggcca cgacaaaatg caggcatttt attaggggga taaagagggc
     1261 aaggtaaagt ttatggagct gagtgttagt gactttggca tttctgtagc tgagcacagc
     1321 aggggagggg ttaatgcaga tggcaagtgc accaaggaga aggcaggaat gctggagcct
     1381 ggaataaggg aggagagggg actggagagt gtggggaata ggaagaagaa atttccttta
     1441 gactaacgaa tatattgggg ggaggaatag aggggaggtg tgcaggaacc agcaatgaga
     1501 aggccaggaa aagaaagagc tgaaaatgca gaaagccgaa gagttagaac ttttggatac
     1561 agcagaagaa acagcggctc cactaccgac ctgcccccgg ttcgatgtcc ttccaagaat
     1621 gaagtctttc cctggtgatg gtcccctgcc ctgtctttcc agcatccact ctgtcttgtc
     1681 ctcctggaag tgtatctcag tcagccagtg gcttcttgat gatggcggtg gaggtggtgg
     1741 ttgtagtgtg atggatcccc tttaggttat ttaggggtat atgtcccctg cttgaaccct
     1801 gaaggccagg taatgagcca tggccattgt ccccagctga ggaccaggtg tctctaaaaa
     1861 cccaaacatc ctggagagta tgcgagaacc taccaagaaa aacagtctca ttactcatat
     1921 acagcaggca aagagacaga aaattaactg aaaagcagtt tagagactgg gggaggccgg
     1981 atctctagag ccatcctgct gagtgccctg tgtgtaagtc ctaataaact cacctactca
     2041 ccaa
//
