LOCUS       NM_030882               2429 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens apolipoprotein L2 (APOL2), transcript variant alpha,
            mRNA.
ACCESSION   NM_030882
VERSION     NM_030882.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2429)
  AUTHORS   Ultsch,M., Holliday,M.J., Gerhardy,S., Moran,P., Scales,S.J.,
            Gupta,N., Oltrabella,F., Chiu,C., Fairbrother,W., Eigenbrot,C. and
            Kirchhofer,D.
  TITLE     Structures of the ApoL1 and ApoL2 N-terminal domains reveal a
            non-classical four-helix bundle motif
  JOURNAL   Commun Biol 4 (1), 916 (2021)
   PUBMED   34316015
  REMARK    GeneRIF: Structures of the ApoL1 and ApoL2 N-terminal domains
            reveal a non-classical four-helix bundle motif.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2429)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2429)
  AUTHORS   Luo,A., Jung,J., Longley,M., Rosoff,D.B., Charlet,K., Muench,C.,
            Lee,J., Hodgkinson,C.A., Goldman,D., Horvath,S., Kaminsky,Z.A. and
            Lohoff,F.W.
  TITLE     Epigenetic aging is accelerated in alcohol use disorder and
            regulated by genetic variation in APOL2
  JOURNAL   Neuropsychopharmacology 45 (2), 327-336 (2020)
   PUBMED   31466081
  REMARK    GeneRIF: Epigenetic aging is accelerated in alcohol use disorder
            and regulated by genetic variation in APOL2.
REFERENCE   4  (bases 1 to 2429)
  AUTHORS   Galindo-Moreno,J., Iurlaro,R., El Mjiyad,N., Diez-Perez,J.,
            Gabaldon,T. and Munoz-Pinedo,C.
  TITLE     Apolipoprotein L2 contains a BH3-like domain but it does not behave
            as a BH3-only protein
  JOURNAL   Cell Death Dis 5 (6), e1275 (2014)
   PUBMED   24901046
  REMARK    GeneRIF: Apolipoprotein L2 contains a BH3-like domain but it does
            not behave as a BH3-only protein.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2429)
  AUTHORS   Liao,W., Goh,F.Y., Betts,R.J., Kemeny,D.M., Tam,J., Bay,B.H. and
            Wong,W.S.
  TITLE     A novel anti-apoptotic role for apolipoprotein L2 in
            IFN-gamma-induced cytotoxicity in human bronchial epithelial cells
  JOURNAL   J Cell Physiol 226 (2), 397-406 (2011)
   PUBMED   20665705
  REMARK    GeneRIF: Results reveal a novel function for ApoL2 in conferring
            anti-apoptotic ability of human bronchial epithelium to the
            cytotoxic effects of IFN-gamma, in maintaining airway epithelial
            layer integrity.
REFERENCE   6  (bases 1 to 2429)
  AUTHORS   Takahashi,S., Cui,Y.H., Han,Y.H., Fagerness,J.A., Galloway,B.,
            Shen,Y.C., Kojima,T., Uchiyama,M., Faraone,S.V. and Tsuang,M.T.
  TITLE     Association of SNPs and haplotypes in APOL1, 2 and 4 with
            schizophrenia
  JOURNAL   Schizophr Res 104 (1-3), 153-164 (2008)
   PUBMED   18632255
  REMARK    GeneRIF: An association of APOL1, 2 and 4 with schizophrenia was
            establised.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2429)
  AUTHORS   McGhee,K.A., Morris,D.W., Schwaiger,S., Nangle,J.M., Donohoe,G.,
            Clarke,S., Meagher,D., Quinn,J., Scully,P., Waddington,J.L.,
            Gill,M. and Corvin,A.
  TITLE     Investigation of the apolipoprotein-L (APOL) gene family and
            schizophrenia using a novel DNA pooling strategy for public
            database SNPs
  JOURNAL   Schizophr Res 76 (2-3), 231-238 (2005)
   PUBMED   15949655
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2429)
  AUTHORS   Monajemi,H., Fontijn,R.D., Pannekoek,H. and Horrevoets,A.J.
  TITLE     The apolipoprotein L gene cluster has emerged recently in evolution
            and is expressed in human vascular tissue
  JOURNAL   Genomics 79 (4), 539-546 (2002)
   PUBMED   11944986
  REMARK    GeneRIF: APOL2 has been found only in humans and African green
            monkeys
REFERENCE   9  (bases 1 to 2429)
  AUTHORS   Page,N.M., Butlin,D.J., Lomthaisong,K. and Lowry,P.J.
  TITLE     The human apolipoprotein L gene cluster: identification,
            classification, and sites of distribution
  JOURNAL   Genomics 74 (1), 71-78 (2001)
   PUBMED   11374903
REFERENCE   10 (bases 1 to 2429)
  AUTHORS   Duchateau,P.N., Pullinger,C.R., Cho,M.H., Eng,C. and Kane,J.P.
  TITLE     Apolipoprotein L gene family: tissue-specific expression, splicing,
            promoter regions; discovery of a new gene
  JOURNAL   J Lipid Res 42 (4), 620-630 (2001)
   PUBMED   11290834
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF324223.1, BC004395.1,
            AF305225.1 and HY306110.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_030882.3.
            
            Summary: This gene is a member of the apolipoprotein L gene family.
            The encoded protein is found in the cytoplasm, where it may affect
            the movement of lipids or allow the binding of lipids to
            organelles. Two transcript variants encoding the same protein have
            been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (alpha) is the predominant
            transcript. Variant alpha and variant beta encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.965482.1, AF324223.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358502.10/ ENSP00000351292.5
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-952               AF324223.1         117-1068
            953-1321            BC004395.1         937-1305
            1322-2013           AF305225.1         1322-2013
            2014-2429           HY306110.1         27-442              c
FEATURES             Location/Qualifiers
     source          1..2429
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..2429
                     /gene="APOL2"
                     /gene_synonym="APOL-II; APOL3"
                     /note="apolipoprotein L2"
                     /db_xref="GeneID:23780"
                     /db_xref="HGNC:HGNC:619"
                     /db_xref="MIM:607252"
     exon            1..87
                     /gene="APOL2"
                     /gene_synonym="APOL-II; APOL3"
                     /inference="alignment:Splign:2.1.0"
     exon            88..141
                     /gene="APOL2"
                     /gene_synonym="APOL-II; APOL3"
                     /inference="alignment:Splign:2.1.0"
     exon            142..230
                     /gene="APOL2"
                     /gene_synonym="APOL-II; APOL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1234
                     /gene="APOL2"
                     /gene_synonym="APOL-II; APOL3"
                     /note="apolipoprotein L-II; apolipoprotein L, 2"
                     /codon_start=1
                     /product="apolipoprotein L2"
                     /protein_id="NP_112092.2"
                     /db_xref="CCDS:CCDS43014.1"
                     /db_xref="GeneID:23780"
                     /db_xref="HGNC:HGNC:619"
                     /db_xref="MIM:607252"
                     /translation="MNPESSIFIEDYLKYFQDQVSRENLLQLLTDDEAWNGFVAAAEL
                     PRDEADELRKALNKLASHMVMKDKNRHDKDQQHRQWFLKEFPRLKRELEDHIRKLRAL
                     AEEVEQVHRGTTIANVVSNSVGTTSGILTLLGLGLAPFTEGISFVLLDTGMGLGAAAA
                     VAGITCSVVELVNKLRARAQARNLDQSGTNVAKVMKEFVGGNTPNVLTLVDNWYQVTQ
                     GIGRNIRAIRRARANPQLGAYAPPPHVIGRISAEGGEQVERVVEGPAQAMSRGTMIVG
                     AATGGILLLLDVVSLAYESKHLLEGAKSESAEELKKRAQELEGKLNFLTKIHEMLQPG
                     QDQ"
     exon            231..357
                     /gene="APOL2"
                     /gene_synonym="APOL-II; APOL3"
                     /inference="alignment:Splign:2.1.0"
     exon            358..2429
                     /gene="APOL2"
                     /gene_synonym="APOL-II; APOL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2408..2413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOL2"
                     /gene_synonym="APOL-II; APOL3"
                     /note="hexamer: AATAAA"
     polyA_site      2429
                     /gene="APOL2"
                     /gene_synonym="APOL-II; APOL3"
                     /note="major polyA site"
ORIGIN      
        1 attacacaga tgcacagctg gacgtgggat ccacacagct cagaacagtt ggatcttgct
       61 cagtctctgt cagaggaaga tcccttggac aagaggaccc tgccttggtg tgagagtgag
      121 ggaagaggaa gctggaacga gggttaagga aaaccttcca gtctggacag tgactggaga
      181 gctccaagga aagcccctcg gtaacccagc cgctggcacc atgaacccag agagcagtat
      241 ctttattgag gattacctta agtatttcca ggaccaagtg agcagagaga atctgctaca
      301 actgctgact gatgatgaag cctggaatgg attcgtggct gctgctgaac tgcccaggga
      361 tgaggcagat gagctccgta aagctctgaa caagcttgca agtcacatgg tcatgaagga
      421 caaaaaccgc cacgataaag accagcagca caggcagtgg tttttgaaag agtttcctcg
      481 gttgaaaagg gagcttgagg atcacataag gaagctccgt gcccttgcag aggaggttga
      541 gcaggtccac agaggcacca ccattgccaa tgtggtgtcc aactctgttg gcactacctc
      601 tggcatcctg accctcctcg gcctgggtct ggcacccttc acagaaggaa tcagttttgt
      661 gctcttggac actggcatgg gtctgggagc agcagctgct gtggctggga ttacctgcag
      721 tgtggtagaa ctagtaaaca aattgcgggc acgagcccaa gcccgcaact tggaccaaag
      781 cggcaccaat gtagcaaagg tgatgaagga gtttgtgggt gggaacacac ccaatgttct
      841 taccttagtt gacaattggt accaagtcac acaagggatt gggaggaaca tccgtgccat
      901 cagacgagcc agagccaacc ctcagttagg agcgtatgcc ccacccccgc atgtcattgg
      961 gcgaatctca gctgaaggcg gtgaacaggt tgagagggtt gttgaaggcc ccgcccaggc
     1021 aatgagcaga ggaaccatga tcgtgggtgc agccactgga ggcatcttgc ttctgctgga
     1081 tgtggtcagc cttgcatatg agtcaaagca cttgcttgag ggggcaaagt cagagtcagc
     1141 tgaggagctg aagaagcggg ctcaggagct ggaggggaag ctcaactttc tcaccaagat
     1201 ccatgagatg ctgcagccag gccaagacca atgaccccag agcagtgcag ccaccagggc
     1261 agaaatgccg ggcacaggcc aggacaaaat gcagactttt tttttttttt tttttttttt
     1321 ttgagatgga gtctcgctct atcgcccagg atggagtgca gtggctcaat ctcggctcac
     1381 tgcaaactcc gcctcccggg ttcacaccat tctccggcct cagtctcccg agtagctggg
     1441 actacaggca cctgccacca cgcccggcta atttttttgt attttcactg gagacggggt
     1501 ttcactgtgt tagccacgat ggtctccatc tcctgacctc gtgatctgcc cacctcggcc
     1561 tcccaaagtg ctgggattac aggcgtgagc caccgcgcct ggccaaaatg cagacatttt
     1621 attaggggga taaggagggc aaggtaaagc ttatggaact gagtgttagt gactttggca
     1681 tttgtgtagc tgagcacagc aagggagggg ttaatgcaga tggcaagtgc accaaggaga
     1741 aggcaggaac actggagcct gcaataaggg aggagagagg actggagagt gtggggaatg
     1801 ggaagaagta gtttactttg gactaaagaa tatattgggc gaagaataga gggggagctt
     1861 gcaggaacca gcaatgagaa ggccaggaaa agaaagagct gaaaatggag aaaaccagag
     1921 ttagaactgt tggatacagg agaagaaaca gcagctccac taccgacccc cccccaggtt
     1981 tgatgtcctt ccaagaataa agtctttccc tggtgatggt ctctcgctct gtctttccag
     2041 catccactct cccttgtcct tctgggggtg tatcacagtc agccagtggc ttcttcatga
     2101 tggtggttgg ggtggttgtc atgtgacggg tcccctccag gttactaaag ggtgcatgtc
     2161 ccctgcttga accctgagag gcaggtggta ggccatggcc acaatcccca gctgaggagc
     2221 aggtgtccct gagaacccaa acttcccaga gagtatctga gaaccaacca atgaaaacag
     2281 tcccatcgct cttagccggt aagtaaacag tcagaagatt agcatgaaag cagtttagca
     2341 ttgggaggaa gcacagatct ctagagctgt cctgtcgctg cccaggattg acctgtgtgt
     2401 aagtcccaat aaactcacct actcaccaa
//
