LOCUS       NM_001638               1750 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens apolipoprotein F (APOF), mRNA.
ACCESSION   NM_001638
VERSION     NM_001638.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1750)
  AUTHORS   Shi,X., Feng,D., Li,D., Han,P., Yang,L. and Wei,W.
  TITLE     A pan-cancer analysis of the oncogenic and immunological roles of
            apolipoprotein F (APOF) in human cancer
  JOURNAL   Eur J Med Res 28 (1), 190 (2023)
   PUBMED   37312170
  REMARK    GeneRIF: A pan-cancer analysis of the oncogenic and immunological
            roles of apolipoprotein F (APOF) in human cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1750)
  AUTHORS   Deprince,A., Hennuyer,N., Kooijman,S., Pronk,A.C.M., Bauge,E.,
            Lienard,V., Verrijken,A., Dirinck,E., Vonghia,L., Woitrain,E.,
            Kloosterhuis,N.J., Marez,E., Jacquemain,P., Wolters,J.C.,
            Lalloyer,F., Eberle,D., Quemener,S., Vallez,E., Tailleux,A.,
            Kouach,M., Goossens,J.F., Raverdy,V., Derudas,B., Kuivenhoven,J.A.,
            Croyal,M., van de Sluis,B., Francque,S., Pattou,F., Rensen,P.C.N.,
            Staels,B. and Haas,J.T.
  TITLE     Apolipoprotein F is reduced in humans with steatosis and controls
            plasma triglyceride-rich lipoprotein metabolism
  JOURNAL   Hepatology 77 (4), 1287-1302 (2023)
   PUBMED   35735979
  REMARK    GeneRIF: Apolipoprotein F is reduced in humans with steatosis and
            controls plasma triglyceride-rich lipoprotein metabolism.
REFERENCE   3  (bases 1 to 1750)
  AUTHORS   Morton,R.E. and Mihna,D.
  TITLE     Apolipoprotein F concentration, activity, and the properties of LDL
            controlling ApoF activation in hyperlipidemic plasma
  JOURNAL   J Lipid Res 63 (2), 100166 (2022)
   PUBMED   35016907
  REMARK    GeneRIF: Apolipoprotein F concentration, activity, and the
            properties of LDL controlling ApoF activation in hyperlipidemic
            plasma.
REFERENCE   4  (bases 1 to 1750)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1750)
  AUTHORS   Kumar,A., Gangadharan,B., Cobbold,J., Thursz,M. and Zitzmann,N.
  TITLE     Absolute quantitation of disease protein biomarkers in a single
            LC-MS acquisition using apolipoprotein F as an example
  JOURNAL   Sci Rep 7 (1), 12072 (2017)
   PUBMED   28935895
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1750)
  AUTHORS   Paromov,V.M. and Morton,R.E.
  TITLE     Lipid transfer inhibitor protein defines the participation of high
            density lipoprotein subfractions in lipid transfer reactions
            mediated by cholesterol ester transfer protein (CETP)
  JOURNAL   J Biol Chem 278 (42), 40859-40866 (2003)
   PUBMED   12907677
  REMARK    GeneRIF: LTIP tailors CETP-mediated remodeling of HDL3 and HDL2
            particles in subclass-specific ways, strongly implicating it as a
            regulator of HDL metabolism
REFERENCE   7  (bases 1 to 1750)
  AUTHORS   Wang,X., Driscoll,D.M. and Morton,R.E.
  TITLE     Molecular cloning and expression of lipid transfer inhibitor
            protein reveals its identity with apolipoprotein F
  JOURNAL   J Biol Chem 274 (3), 1814-1820 (1999)
   PUBMED   9880564
REFERENCE   8  (bases 1 to 1750)
  AUTHORS   Day,J.R., Albers,J.J., Gilbert,T.L., Whitmore,T.E., McConathy,W.J.
            and Wolfbauer,G.
  TITLE     Purification and molecular cloning of human apolipoprotein F
  JOURNAL   Biochem Biophys Res Commun 203 (2), 1146-1151 (1994)
   PUBMED   8093033
REFERENCE   9  (bases 1 to 1750)
  AUTHORS   Koren,E., McConathy,W.J. and Alaupovic,P.
  TITLE     Isolation and characterization of simple and complex lipoproteins
            containing apolipoprotein F from human plasma
  JOURNAL   Biochemistry 21 (21), 5347-5351 (1982)
   PUBMED   6816269
REFERENCE   10 (bases 1 to 1750)
  AUTHORS   Olofsson,S.O., McConathy,W.J. and Alaupovic,P.
  TITLE     Isolation and partial characterization of a new acidic
            apolipoprotein (apolipoprotein F) from high density lipoproteins of
            human plasma
  JOURNAL   Biochemistry 17 (6), 1032-1036 (1978)
   PUBMED   204339
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025574.19.
            
            On Nov 22, 2018 this sequence version replaced NM_001638.3.
            
            Summary: The product of this gene is one of the minor
            apolipoproteins found in plasma. This protein forms complexes with
            lipoproteins and may be involved in transport and/or esterification
            of cholesterol. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.61956.1,
                                           SRR5189664.103843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000398189.4/
                                                ENSP00000381250.3
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC025574.19        29078-29205
            129-1750            AC025574.19        29746-31367
FEATURES             Location/Qualifiers
     source          1..1750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..1750
                     /gene="APOF"
                     /gene_synonym="Apo-F; LTIP"
                     /note="apolipoprotein F"
                     /db_xref="GeneID:319"
                     /db_xref="HGNC:HGNC:615"
                     /db_xref="MIM:107760"
     exon            1..128
                     /gene="APOF"
                     /gene_synonym="Apo-F; LTIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1093
                     /gene="APOF"
                     /gene_synonym="Apo-F; LTIP"
                     /note="lipid transfer inhibitor protein"
                     /codon_start=1
                     /product="apolipoprotein F preproprotein"
                     /protein_id="NP_001629.1"
                     /db_xref="CCDS:CCDS44923.1"
                     /db_xref="GeneID:319"
                     /db_xref="HGNC:HGNC:615"
                     /db_xref="MIM:107760"
                     /translation="MTGLCGYSAPDMRGLRLIMIPVELLLCYLLLHPVDATSYGKQTN
                     VLMHFPLSLESQTPSSDPLSCQFLHPKSLPGFSHMAPLPKFLVSLALRNALEEAGCQA
                     DVWALQLQLYRQGGVNATQVLIQHLRGLQKGRSTERNVSVEALASALQLLAREQQSTG
                     RVGRSLPTEDCENEKEQAVHNVVQLLPGVGTFYNLGTALYYATQNCLGKARERGRDGA
                     IDLGYDLLMTMAGMSGGPMGLAISAALKPALRSGVQQLIQYYQDQKDANISQPETTKE
                     GLRAISDVSDLEETTTLASFISEVVSSAPYWGWAIIKSYDLDPGAGSLEI"
     exon            129..1750
                     /gene="APOF"
                     /gene_synonym="Apo-F; LTIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1420..1425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOF"
                     /gene_synonym="Apo-F; LTIP"
                     /note="hexamer: AATAAA"
     polyA_site      1440
                     /gene="APOF"
                     /gene_synonym="Apo-F; LTIP"
                     /note="major polyA site"
     regulatory      1727..1732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOF"
                     /gene_synonym="Apo-F; LTIP"
                     /note="hexamer: AATAAA"
     polyA_site      1750
                     /gene="APOF"
                     /gene_synonym="Apo-F; LTIP"
ORIGIN      
        1 atccttcact gatcataggg gaaagcaaat atctcctttc ctcatgggac acagaactag
       61 gcagaacagg atcaggaagc gatcaaacct accaaggcag tctcacttct caatgactgg
      121 actgtgtggg tactctgctc cagacatgcg tggcctcaga ctcatcatga taccagttga
      181 gctgctactt tgctacctcc tgctgcaccc tgtggatgcc acttcatatg gaaagcagac
      241 aaatgtcttg atgcactttc ccttgtcctt ggaatcccag acaccctcct cagacccctt
      301 gtcctgccaa tttctgcacc caaagtcact gcctggtttc agccacatgg cccctctacc
      361 caagttcttg gtaagcctgg ctctaaggaa tgccctggag gaagctggtt gtcaggctga
      421 tgtttgggct ctacagctac agctctaccg ccagggtggt gtgaatgcta cacaggtcct
      481 catccagcat cttcgagggc tccagaaagg cagaagcaca gagaggaacg tgtcagtgga
      541 agccctggcc tctgctctgc agctgttagc cagggagcag caaagcacag gaagggtcgg
      601 gcgctccctc ccgacagagg actgtgagaa tgagaaggag caagctgtgc acaatgtagt
      661 ccagctgctg ccaggagtgg gaaccttcta caacctgggc acagctttgt attatgctac
      721 tcaaaactgc ctgggcaagg ccagggaacg aggccgagat ggggccatag atctgggata
      781 tgaccttctg atgaccatgg ctgggatgtc aggggggcct atgggtctag cgatcagtgc
      841 tgcacttaaa cctgcattaa ggtctggggt tcagcagttg atccagtatt accaagatca
      901 gaaagacgca aacatctctc agccggagac caccaaggag ggtttgaggg ccatctcaga
      961 tgtgagtgac ttggaagaaa caactactct ggcttctttc atatcagaag tagtaagttc
     1021 agctccctac tgggggtggg ccataatcaa gagctatgac ttagatcctg gggctgggag
     1081 tcttgagata taaaagaatg tggtaaccac agaattaata actgtactac cctgacaagc
     1141 tatatacatg tcttcaaaat tttaatctga tttatccagg aggaaggctg tacagtaaaa
     1201 cgtaagaacg taaatgtttg ggtgttgaag tcacagggtt tggtttcgaa tctaggctcc
     1261 acttgttaga gcctcggtga tcactgaata gtaacttctt tcttgaacta agatcagttt
     1321 tgaagtttct aaaggagata gaatgatttt aacctcaatg agttgccctg taaatttaaa
     1381 atgatacaat gaatctaaaa tgcttatcac agtactttca ataaatagct attagccagg
     1441 tgcggtggct cacgcctgta atcccagcac tgtgagaggc tgaggcggga tgatcacctg
     1501 aggtcaggag ttcaagatca gcctgggcaa catggcgaaa ccccgtctct acaataaata
     1561 caaaaaatta tcctggcgga gttatgcacg cttgtagtcc caactacctg ggaggctgag
     1621 gcgggagaat cacctgagcc tgggaggtcg aggctgcagc gagccgagat cgcgccgctg
     1681 cattccagcc tgggtgacag agcgagacca tgtctcaaaa aataaaaata aaaaaaaatt
     1741 gttttcatta
//
