LOCUS       NM_001647                862 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens apolipoprotein D (APOD), mRNA.
ACCESSION   NM_001647
VERSION     NM_001647.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 862)
  AUTHORS   Xu,W., Gu,S., Zhang,G., Wang,R., Lv,S., Yan,J. and Qin,Y.
  TITLE     APOD acts on fibroblast-like synoviocyte and chondrocyte to
            alleviate the process of osteoarthritis in vitro
  JOURNAL   J Orthop Res 42 (2), 296-305 (2024)
   PUBMED   37728985
  REMARK    GeneRIF: APOD acts on fibroblast-like synoviocyte and chondrocyte
            to alleviate the process of osteoarthritis in vitro.
REFERENCE   2  (bases 1 to 862)
  AUTHORS   Takaya,K., Asou,T. and Kishi,K.
  TITLE     Identification of Apolipoprotein D as a Dermal Fibroblast Marker of
            Human Aging for Development of Skin Rejuvenation Therapy
  JOURNAL   Rejuvenation Res 26 (2), 42-50 (2023)
   PUBMED   36571249
  REMARK    GeneRIF: Identification of Apolipoprotein D as a Dermal Fibroblast
            Marker of Human Aging for Development of Skin Rejuvenation Therapy.
REFERENCE   3  (bases 1 to 862)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 862)
  AUTHORS   Martinez-Pinilla,E., Rubio-Sardon,N., Pelaez,R., Garcia-Alvarez,E.,
            Del Valle,E., Tolivia,J., Larrayoz,I.M. and Navarro,A.
  TITLE     Neuroprotective Effect of Apolipoprotein D in Cuprizone-Induced
            Cell Line Models: A Potential Therapeutic Approach for Multiple
            Sclerosis and Demyelinating Diseases
  JOURNAL   Int J Mol Sci 22 (3), 1260 (2021)
   PUBMED   33514021
  REMARK    GeneRIF: Neuroprotective Effect of Apolipoprotein D in
            Cuprizone-Induced Cell Line Models: A Potential Therapeutic
            Approach for Multiple Sclerosis and Demyelinating Diseases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 862)
  AUTHORS   Santana,M.F.M., Lira,A.L.A., Pinto,R.S., Minanni,C.A.,
            Silva,A.R.M., Sawada,M.I.B.A.C., Nakandakare,E.R.,
            Correa-Giannella,M.L.C., Queiroz,M.S., Ronsein,G.E. and
            Passarelli,M.
  TITLE     Enrichment of apolipoprotein A-IV and apolipoprotein D in the HDL
            proteome is associated with HDL functions in diabetic kidney
            disease without dialysis
  JOURNAL   Lipids Health Dis 19 (1), 205 (2020)
   PUBMED   32921312
  REMARK    GeneRIF: Enrichment of apolipoprotein A-IV and apolipoprotein D in
            the HDL proteome is associated with HDL functions in diabetic
            kidney disease without dialysis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 862)
  AUTHORS   Balbin,M., Freije,J.M., Fueyo,A., Sanchez,L.M. and Lopez-Otin,C.
  TITLE     Apolipoprotein D is the major protein component in cyst fluid from
            women with human breast gross cystic disease
  JOURNAL   Biochem J 271 (3), 803-807 (1990)
   PUBMED   2244881
REFERENCE   7  (bases 1 to 862)
  AUTHORS   Peitsch,M.C. and Boguski,M.S.
  TITLE     Is apolipoprotein D a mammalian bilin-binding protein?
  JOURNAL   New Biol 2 (2), 197-206 (1990)
   PUBMED   2083249
REFERENCE   8  (bases 1 to 862)
  AUTHORS   Drayna,D., Scott,J.D. and Lawn,R.
  TITLE     Multiple RFLPs at the human apolipoprotein D (APOD) locus
  JOURNAL   Nucleic Acids Res 15 (22), 9617 (1987)
   PUBMED   2891117
REFERENCE   9  (bases 1 to 862)
  AUTHORS   Drayna,D.T., McLean,J.W., Wion,K.L., Trent,J.M., Drabkin,H.A. and
            Lawn,R.M.
  TITLE     Human apolipoprotein D gene: gene sequence, chromosome
            localization, and homology to the alpha 2u-globulin superfamily
  JOURNAL   DNA 6 (3), 199-204 (1987)
   PUBMED   2439269
REFERENCE   10 (bases 1 to 862)
  AUTHORS   McConathy,W.J. and Alaupovic,P.
  TITLE     Studies on the isolation and partial characterization of
            apolipoprotein D and lipoprotein D of human plasma
  JOURNAL   Biochemistry 15 (3), 515-520 (1976)
   PUBMED   56198
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA892855.1, BC007402.2 and
            BU727194.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001647.3.
            
            Summary: This gene encodes a component of high density lipoprotein
            that has no marked similarity to other apolipoprotein sequences. It
            has a high degree of homology to plasma retinol-binding protein and
            other members of the alpha 2 microglobulin protein superfamily of
            carrier proteins, also known as lipocalins. This glycoprotein is
            closely associated with the enzyme lecithin:cholesterol
            acyltransferase - an enzyme involved in lipoprotein metabolism.
            [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279845.5713.1,
                                           SRR5189652.131213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343267.8/ ENSP00000345179.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA892855.1         266-285
            21-729              BC007402.2         1-709
            730-841             BC007402.2         715-826
            842-862             BU727194.1         22-42               c
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..862
                     /gene="APOD"
                     /note="apolipoprotein D"
                     /db_xref="GeneID:347"
                     /db_xref="HGNC:HGNC:612"
                     /db_xref="MIM:107740"
     exon            1..63
                     /gene="APOD"
                     /inference="alignment:Splign:2.1.0"
     exon            64..220
                     /gene="APOD"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..667
                     /gene="APOD"
                     /note="apo-D"
                     /codon_start=1
                     /product="apolipoprotein D precursor"
                     /protein_id="NP_001638.1"
                     /db_xref="CCDS:CCDS33925.1"
                     /db_xref="GeneID:347"
                     /db_xref="HGNC:HGNC:612"
                     /db_xref="MIM:107740"
                     /translation="MVMLLLLLSALAGLFGAAEGQAFHLGKCPNPPVQENFDVNKYLG
                     RWYEIEKIPTTFENGRCIQANYSLMENGKIKVLNQELRADGTVNQIEGEATPVNLTEP
                     AKLEVKFSWFMPSAPYWILATDYENYALVYSCTCIIQLFHVDFAWILARNPNLPPETV
                     DSLKNILTSNNIDVKKMTVTDQVNCPKLS"
     exon            221..342
                     /gene="APOD"
                     /inference="alignment:Splign:2.1.0"
     exon            343..431
                     /gene="APOD"
                     /inference="alignment:Splign:2.1.0"
     exon            432..862
                     /gene="APOD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      820..825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOD"
                     /note="hexamer: AATAAA"
     polyA_site      862
                     /gene="APOD"
                     /note="major polyA site"
ORIGIN      
        1 aagacaggca tctcaaatcg gctgattctg catctggaaa ctgccttcat cttgaaagaa
       61 aagctccagg tcccttctcc agccacccag ccccaagatg gtgatgctgc tgctgctgct
      121 ttccgcactg gctggcctct tcggtgcggc agagggacaa gcatttcatc ttgggaagtg
      181 ccccaatcct ccggtgcagg agaattttga cgtgaataag tatctcggaa gatggtacga
      241 aattgagaag atcccaacaa cctttgagaa tggacgctgc atccaggcca actactcact
      301 aatggaaaac ggaaagatca aagtgttaaa ccaggagttg agagctgatg gaactgtgaa
      361 tcaaatcgaa ggtgaagcca ccccagttaa cctcacagag cctgccaagc tggaagttaa
      421 gttttcctgg tttatgccat cggcaccgta ctggatcctg gccaccgact atgagaacta
      481 tgccctcgtg tattcctgta cctgcatcat ccaacttttt cacgtggatt ttgcttggat
      541 cttggcaaga aaccctaatc tccctccaga aacagtggac tctctaaaaa atatcctgac
      601 ttctaataac attgatgtca agaaaatgac ggtcacagac caggtgaact gccccaagct
      661 ctcgtaacca ggttctacag ggaggctgca cccactccat gttacttctg cttcgctttc
      721 ccctaccccc cccccataaa gacaaaccaa tcaaccacga caaaggaagt tgacctgaac
      781 atgtaaccat gccctaccct gttaccttgc tagctgcaaa ataaacttgt tgctgacctg
      841 ctgtgctcgc agtagattcc aa
//
