LOCUS       NM_001646                616 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens apolipoprotein C4 (APOC4), mRNA.
ACCESSION   NM_001646
VERSION     NM_001646.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 616)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 616)
  AUTHORS   Xu,S., Cheng,J., Li,N.H., Chen,Y.N., Cai,M.Y., Tang,S.S., Huang,H.,
            Zhang,B., Cen,J.M., Yang,X.L., Chen,C., Liu,X. and Xiong,X.D.
  TITLE     The association of APOC4 polymorphisms with premature coronary
            artery disease in a Chinese Han population
  JOURNAL   Lipids Health Dis 14, 63 (2015)
   PUBMED   26129832
  REMARK    GeneRIF: APOC4 rs1132899 polymorphism was associated with an
            increased risk of premature coronary artery disease in Chinese
            subjects.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 616)
  AUTHORS   Lemaitre,R.N., King,I.B., Kabagambe,E.K., Wu,J.H., McKnight,B.,
            Manichaikul,A., Guan,W., Sun,Q., Chasman,D.I., Foy,M., Wang,L.,
            Zhu,J., Siscovick,D.S., Tsai,M.Y., Arnett,D.K., Psaty,B.M.,
            Djousse,L., Chen,Y.D., Tang,W., Weng,L.C., Wu,H., Jensen,M.K.,
            Chu,A.Y., Jacobs,D.R. Jr., Rich,S.S., Mozaffarian,D., Steffen,L.,
            Rimm,E.B., Hu,F.B., Ridker,P.M., Fornage,M. and Friedlander,Y.
  TITLE     Genetic loci associated with circulating levels of very long-chain
            saturated fatty acids
  JOURNAL   J Lipid Res 56 (1), 176-184 (2015)
   PUBMED   25378659
REFERENCE   4  (bases 1 to 616)
  AUTHORS   Middelberg,R.P., Ferreira,M.A., Henders,A.K., Heath,A.C.,
            Madden,P.A., Montgomery,G.W., Martin,N.G. and Whitfield,J.B.
  TITLE     Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are
            associated with multiple cardiovascular-related traits
  JOURNAL   BMC Med Genet 12, 123 (2011)
   PUBMED   21943158
  REMARK    GeneRIF: variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are
            associated with multiple cardiovascular-related traits
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 616)
  AUTHORS   Kotite,L., Zhang,L.H., Yu,Z., Burlingame,A.L. and Havel,R.J.
  TITLE     Human apoC-IV: isolation, characterization, and immunochemical
            quantification in plasma and plasma lipoproteins
  JOURNAL   J Lipid Res 44 (7), 1387-1394 (2003)
   PUBMED   12700345
REFERENCE   6  (bases 1 to 616)
  AUTHORS   Mak,P.A., Laffitte,B.A., Desrumaux,C., Joseph,S.B., Curtiss,L.K.,
            Mangelsdorf,D.J., Tontonoz,P. and Edwards,P.A.
  TITLE     Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene
            cluster in murine and human macrophages. A critical role for
            nuclear liver X receptors alpha and beta
  JOURNAL   J Biol Chem 277 (35), 31900-31908 (2002)
   PUBMED   12032151
  REMARK    GeneRIF: regulated expression of gene cluster in macrophages
REFERENCE   7  (bases 1 to 616)
  AUTHORS   Kamboh,M.I., Aston,C.E. and Hamman,R.F.
  TITLE     DNA sequence variation in human apolipoprotein C4 gene and its
            effect on plasma lipid profile
  JOURNAL   Atherosclerosis 152 (1), 193-201 (2000)
   PUBMED   10996355
REFERENCE   8  (bases 1 to 616)
  AUTHORS   Dang,Q. and Taylor,J.
  TITLE     In vivo footprinting analysis of the hepatic control region of the
            human apolipoprotein E/C-I/C-IV/C-II gene locus
  JOURNAL   J Biol Chem 271 (45), 28667-28676 (1996)
   PUBMED   8910501
REFERENCE   9  (bases 1 to 616)
  AUTHORS   Allan,C.M. and Taylor,J.M.
  TITLE     Expression of a novel human apolipoprotein (apoC-IV) causes
            hypertriglyceridemia in transgenic mice
  JOURNAL   J Lipid Res 37 (7), 1510-1518 (1996)
   PUBMED   8827523
REFERENCE   10 (bases 1 to 616)
  AUTHORS   Allan,C.M., Walker,D., Segrest,J.P. and Taylor,J.M.
  TITLE     Identification and characterization of a new human gene (APOC4) in
            the apolipoprotein E, C-I, and C-II gene locus
  JOURNAL   Genomics 28 (2), 291-300 (1995)
   PUBMED   8530039
  REMARK    GeneRIF: Includes the observation of APOC4-APOC2 read-through
            transcription
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011481.4, DB185657.1,
            BC020723.1 and AV690709.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001646.2.
            
            Summary: This gene encodes a lipid-binding protein belonging to the
            apolipoprotein gene family. The protein is thought to play a role
            in lipid metabolism. Polymorphisms in this gene may influence
            circulating lipid levels and may be associated with coronary artery
            disease risk. This gene is present in a cluster with other related
            apolipoprotein genes on chromosome 19. Naturally occurring
            read-through transcription exists between this gene and the
            neighboring downstream apolipoprotein C-II (APOC2) gene. [provided
            by RefSeq, Mar 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB157508.1, SRR5189664.155939.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000592954.2/ ENSP00000468236.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC011481.4         85061-85061
            2-37                DB185657.1         1-36
            38-614              BC020723.1         1-577
            615-616             AV690709.1         562-563
FEATURES             Location/Qualifiers
     source          1..616
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..616
                     /gene="APOC4"
                     /gene_synonym="APO-CIV; APOC-IV"
                     /note="apolipoprotein C4"
                     /db_xref="GeneID:346"
                     /db_xref="HGNC:HGNC:611"
                     /db_xref="MIM:600745"
     exon            1..117
                     /gene="APOC4"
                     /gene_synonym="APO-CIV; APOC-IV"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..425
                     /gene="APOC4"
                     /gene_synonym="APO-CIV; APOC-IV"
                     /note="apolipoprotein C-IV"
                     /codon_start=1
                     /product="apolipoprotein C-IV precursor"
                     /protein_id="NP_001637.1"
                     /db_xref="CCDS:CCDS12649.1"
                     /db_xref="GeneID:346"
                     /db_xref="HGNC:HGNC:611"
                     /db_xref="MIM:600745"
                     /translation="MSLLRNRLQALPALCLCVLVLACIGACQPEAQEGTLSPPPKLKM
                     SRWSLVRGRMKELLETVVNRTRDGWQWFWSPSTFRGFMQTYYDDHLRDLGPLTKAWFL
                     ESKDSLLKKTHSLCPRLVCGDKDQG"
     exon            118..259
                     /gene="APOC4"
                     /gene_synonym="APO-CIV; APOC-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            260..616
                     /gene="APOC4"
                     /gene_synonym="APO-CIV; APOC-IV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      599..604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOC4"
                     /gene_synonym="APO-CIV; APOC-IV"
                     /note="hexamer: AATAAA"
     polyA_site      616
                     /gene="APOC4"
                     /gene_synonym="APO-CIV; APOC-IV"
                     /note="major polyA site"
ORIGIN      
        1 agagttgagc acagagggac agaggcacgg aacccccaga aatgtccctc ctcagaaaca
       61 ggctccaggc cctgcctgcc ctgtgcctct gcgtgctggt cctggcctgc attggggcat
      121 gccagccaga ggcccaggaa ggaaccctga gccccccacc aaagctaaag atgagtcgct
      181 ggagcctggt gaggggcagg atgaaggagc tgctggagac agtggtgaac aggaccagag
      241 acgggtggca atggttctgg agcccgagca ccttccgggg cttcatgcag acctactatg
      301 acgaccacct gagggacctg ggtccgctca ccaaggcctg gttcctcgaa tccaaagaca
      361 gcctcttgaa gaagacccac agcctgtgcc ccaggcttgt ctgtggggac aaggaccagg
      421 gttaaaatgt tcataaaagc caggtgtggt tgtggcgggt gcctgtagtc ccagctactc
      481 aggaggctga ggtaggatga tggcttgagc ccaggagttc gagaccagcc tgggcaacac
      541 agcgagatct cttgggggta aaacaaaaag aaaaaaaaaa gttcatactt ctccaataaa
      601 taaagtctca cctgtg
//
