LOCUS       NM_000040                535 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens apolipoprotein C3 (APOC3), mRNA.
ACCESSION   NM_000040
VERSION     NM_000040.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 535)
  AUTHORS   Xiao,Q., Wang,L., Wang,J., Wang,M., Wang,D.W. and Ding,H.
  TITLE     A novel lncRNA GM47544 modulates triglyceride metabolism by
            inducing ubiquitination-dependent protein degradation of APOC3
  JOURNAL   Mol Metab 88, 102011 (2024)
   PUBMED   39173944
  REMARK    GeneRIF: A novel lncRNA GM47544 modulates triglyceride metabolism
            by inducing ubiquitination-dependent protein degradation of APOC3.
REFERENCE   2  (bases 1 to 535)
  AUTHORS   Naber,A., Demus,D., Slieker,R.C., Nicolardi,S., Beulens,J.W.J.,
            Elders,P.J.M., Lieverse,A.G., Sijbrands,E.J.G., 't Hart,L.M.,
            Wuhrer,M. and van Hoek,M.
  TITLE     Apolipoprotein-CIII O-Glycosylation Is Associated with Micro- and
            Macrovascular Complications of Type 2 Diabetes
  JOURNAL   Int J Mol Sci 25 (10), 5365 (2024)
   PUBMED   38791405
  REMARK    GeneRIF: Apolipoprotein-CIII O-Glycosylation Is Associated with
            Micro- and Macrovascular Complications of Type 2 Diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 535)
  AUTHORS   Packard,C.J., Pirillo,A., Tsimikas,S., Ference,B.A. and
            Catapano,A.L.
  TITLE     Exploring apolipoprotein C-III: pathophysiological and
            pharmacological relevance
  JOURNAL   Cardiovasc Res 119 (18), 2843-2857 (2024)
   PUBMED   38039351
  REMARK    GeneRIF: Exploring apolipoprotein C-III: pathophysiological and
            pharmacological relevance.
            Review article
REFERENCE   4  (bases 1 to 535)
  AUTHORS   Pu,Z., Wang,W., Xie,H. and Wang,W.
  TITLE     Apolipoprotein C3 (ApoC3) facilitates NLRP3 mediated pyroptosis of
            macrophages through mitochondrial damage by accelerating of the
            interaction between SCIMP and SYK pathway in acute lung injury
  JOURNAL   Int Immunopharmacol 128, 111537 (2024)
   PUBMED   38232538
  REMARK    GeneRIF: Apolipoprotein C3 (ApoC3) facilitates NLRP3 mediated
            pyroptosis of macrophages through mitochondrial damage by
            accelerating of the interaction between SCIMP and SYK pathway in
            acute lung injury.
REFERENCE   5  (bases 1 to 535)
  AUTHORS   Yan,S., Ding,Z.Y., Gao,Y., Mao,W.J. and Cheng,X.Y.
  TITLE     [The role of apolipoprotein C3 in the regulation of nonalcoholic
            fatty liver disease, glucose and lipid metabolism, and islet beta
            cell function]
  JOURNAL   Sheng Li Xue Bao 75 (6), 767-778 (2023)
   PUBMED   38151342
  REMARK    GeneRIF: [The role of apolipoprotein C3 in the regulation of
            nonalcoholic fatty liver disease, glucose and lipid metabolism, and
            islet beta cell function].
            Review article
REFERENCE   6  (bases 1 to 535)
  AUTHORS   Norata,G.D., Tsimikas,S., Pirillo,A. and Catapano,A.L.
  TITLE     Apolipoprotein C-III: From Pathophysiology to Pharmacology
  JOURNAL   Trends Pharmacol Sci 36 (10), 675-687 (2015)
   PUBMED   26435212
  REMARK    Review article
REFERENCE   7  (bases 1 to 535)
  AUTHORS   Sehayek,E. and Eisenberg,S.
  TITLE     Mechanisms of inhibition by apolipoprotein C of apolipoprotein
            E-dependent cellular metabolism of human triglyceride-rich
            lipoproteins through the low density lipoprotein receptor pathway
  JOURNAL   J Biol Chem 266 (27), 18259-18267 (1991)
   PUBMED   1917954
REFERENCE   8  (bases 1 to 535)
  AUTHORS   von Eckardstein,A., Holz,H., Sandkamp,M., Weng,W., Funke,H. and
            Assmann,G.
  TITLE     Apolipoprotein C-III(Lys58----Glu). Identification of an
            apolipoprotein C-III variant in a family with
            hyperalphalipoproteinemia
  JOURNAL   J Clin Invest 87 (5), 1724-1731 (1991)
   PUBMED   2022742
REFERENCE   9  (bases 1 to 535)
  AUTHORS   Karathanasis,S.K., Zannis,V.I. and Breslow,J.L.
  TITLE     Isolation and characterization of cDNA clones corresponding to two
            different human apoC-III alleles
  JOURNAL   J Lipid Res 26 (4), 451-456 (1985)
   PUBMED   2989400
REFERENCE   10 (bases 1 to 535)
  AUTHORS   Kinnunen,P.K. and Ehnolm,C.
  TITLE     Effect of serum and C-apoproteins from very low density
            lipoproteins on human postheparin plasma hepatic lipase
  JOURNAL   FEBS Lett 65 (3), 354-357 (1976)
   PUBMED   182536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from H74029.1, X01388.1 and
            AV657170.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000040.2.
            
            Summary: This gene encodes a protein component of triglyceride
            (TG)-rich lipoproteins (TRLs) including very low density
            lipoproteins (VLDL), high density lipoproteins (HDL) and
            chylomicrons. The encoded protein plays a role in role in the
            metabolism of these TRLs through multiple modes. This protein has
            been shown to promote the secretion of VLDL1, inhibit lipoprotein
            lipase enzyme activity, and delay catabolism of TRL remnants.
            Mutations in this gene are associated with low plasma triglyceride
            levels and reduced risk of ischemic cardiovascular disease, and
            hyperalphalipoproteinemia, which is characterized by elevated
            levels of high density lipoprotein (HDL) and HDL cholesterol in
            human patients. This gene and other related genes comprise an
            apolipoprotein gene cluster on chromosome 11. [provided by RefSeq,
            Sep 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027977.1, X01388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227667.8/ ENSP00000227667.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 H74029.1           16-16
            2-534               X01388.1           26-558
            535-535             AV657170.1         343-343
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..535
                     /gene="APOC3"
                     /gene_synonym="Apo-C3; ApoC-3; APOCIII"
                     /note="apolipoprotein C3"
                     /db_xref="GeneID:345"
                     /db_xref="HGNC:HGNC:610"
                     /db_xref="MIM:107720"
     exon            1..34
                     /gene="APOC3"
                     /gene_synonym="Apo-C3; ApoC-3; APOCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            35..102
                     /gene="APOC3"
                     /gene_synonym="Apo-C3; ApoC-3; APOCIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..347
                     /gene="APOC3"
                     /gene_synonym="Apo-C3; ApoC-3; APOCIII"
                     /note="apolipoprotein C-III"
                     /codon_start=1
                     /product="apolipoprotein C-III precursor"
                     /protein_id="NP_000031.1"
                     /db_xref="CCDS:CCDS8377.1"
                     /db_xref="GeneID:345"
                     /db_xref="HGNC:HGNC:610"
                     /db_xref="MIM:107720"
                     /translation="MQPRVLLVVALLALLASARASEAEDASLLSFMQGYMKHATKTAK
                     DALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA"
     exon            103..226
                     /gene="APOC3"
                     /gene_synonym="Apo-C3; ApoC-3; APOCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            227..535
                     /gene="APOC3"
                     /gene_synonym="Apo-C3; ApoC-3; APOCIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      508..513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOC3"
                     /gene_synonym="Apo-C3; ApoC-3; APOCIII"
                     /note="hexamer: AATAAA"
     polyA_site      535
                     /gene="APOC3"
                     /gene_synonym="Apo-C3; ApoC-3; APOCIII"
                     /note="major polyA site"
ORIGIN      
        1 ctgctcagtt catccctaga ggcagctgct ccaggaacag aggtgccatg cagccccggg
       61 tactccttgt tgttgccctc ctggcgctcc tggcctctgc ccgagcttca gaggccgagg
      121 atgcctccct tctcagcttc atgcagggtt acatgaagca cgccaccaag accgccaagg
      181 atgcactgag cagcgtgcag gagtcccagg tggcccagca ggccaggggc tgggtgaccg
      241 atggcttcag ttccctgaaa gactactgga gcaccgttaa ggacaagttc tctgagttct
      301 gggatttgga ccctgaggtc agaccaactt cagccgtggc tgcctgagac ctcaataccc
      361 caagtccacc tgcctatcca tcctgcgagc tccttgggtc ctgcaatctc cagggctgcc
      421 cctgtaggtt gcttaaaagg gacagtattc tcagtgctct cctaccccac ctcatgcctg
      481 gcccccctcc aggcatgctg gcctcccaat aaagctggac aagaagctgc tatga
//
