LOCUS       NM_000483                660 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens apolipoprotein C2 (APOC2), mRNA.
ACCESSION   NM_000483
VERSION     NM_000483.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 660)
  AUTHORS   Chen,J., Zhao,D., Wang,Y., Liu,M., Zhang,Y., Feng,T., Xiao,C.,
            Song,H., Miao,R., Xu,L., Chen,H., Qiu,X., Xu,Y., Xu,J., Cui,Z.,
            Wang,W., Quan,Y., Zhu,Y., Huang,C., Zheng,S.G., Zhao,J.Y., Zhu,T.,
            Sun,L. and Fan,G.
  TITLE     Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by
            Promoting Extracellular Lipolysis
  JOURNAL   Adv Sci (Weinh) 11 (38), e2406333 (2024)
   PUBMED   38981044
  REMARK    GeneRIF: Lactylated Apolipoprotein C-II Induces Immunotherapy
            Resistance by Promoting Extracellular Lipolysis.
REFERENCE   2  (bases 1 to 660)
  AUTHORS   Allan,C.M., Walker,D., Segrest,J.P. and Taylor,J.M.
  TITLE     Identification and characterization of a new human gene (APOC4) in
            the apolipoprotein E, C-I, and C-II gene locus
  JOURNAL   Genomics 28 (2), 291-300 (1995)
   PUBMED   8530039
  REMARK    GeneRIF: Includes the observation of APOC4-APOC2 read-through
            transcription
REFERENCE   3  (bases 1 to 660)
  AUTHORS   Das,H.K., Jackson,C.L., Miller,D.A., Leff,T. and Breslow,J.L.
  TITLE     The human apolipoprotein C-II gene sequence contains a novel
            chromosome 19-specific minisatellite in its third intron
  JOURNAL   J Biol Chem 262 (10), 4787-4793 (1987)
   PUBMED   3558370
REFERENCE   4  (bases 1 to 660)
  AUTHORS   Fojo,S.S., Law,S.W. and Brewer,H.B. Jr.
  TITLE     The human preproapolipoprotein C-II gene. Complete nucleic acid
            sequence and genomic organization
  JOURNAL   FEBS Lett 213 (1), 221-226 (1987)
   PUBMED   3030808
REFERENCE   5  (bases 1 to 660)
  AUTHORS   Fojo,S.S., Taam,L., Fairwell,T., Ronan,R., Bishop,C., Meng,M.S.,
            Hoeg,J.M., Sprecher,D.L. and Brewer,H.B. Jr.
  TITLE     Human preproapolipoprotein C-II. Analysis of major plasma isoforms
  JOURNAL   J Biol Chem 261 (21), 9591-9594 (1986)
   PUBMED   3525527
REFERENCE   6  (bases 1 to 660)
  AUTHORS   Wei,C.F., Tsao,Y.K., Robberson,D.L., Gotto,A.M. Jr., Brown,K. and
            Chan,L.
  TITLE     The structure of the human apolipoprotein C-II gene. Electron
            microscopic analysis of RNA:DNA hybrids, complete nucleotide
            sequence, and identification of 5' homologous sequences among
            apolipoprotein genes
  JOURNAL   J Biol Chem 260 (28), 15211-15221 (1985)
   PUBMED   2415514
  REMARK    Erratum:[J Biol Chem 1986 Mar 15;261(8):3910]
REFERENCE   7  (bases 1 to 660)
  AUTHORS   Fojo,S.S., Law,S.W. and Brewer,H.B. Jr.
  TITLE     Human apolipoprotein C-II: complete nucleic acid sequence of
            preapolipoprotein C-II
  JOURNAL   Proc Natl Acad Sci U S A 81 (20), 6354-6357 (1984)
   PUBMED   6593704
REFERENCE   8  (bases 1 to 660)
  AUTHORS   Jackson,C.L., Bruns,G.A. and Breslow,J.L.
  TITLE     Isolation and sequence of a human apolipoprotein CII cDNA clone and
            its use to isolate and map to human chromosome 19 the gene for
            apolipoprotein CII
  JOURNAL   Proc Natl Acad Sci U S A 81 (10), 2945-2949 (1984)
   PUBMED   6328478
REFERENCE   9  (bases 1 to 660)
  AUTHORS   Myklebost,O., Williamson,B., Markham,A.F., Myklebost,S.R.,
            Rogers,J., Woods,D.E. and Humphries,S.E.
  TITLE     The isolation and characterization of cDNA clones for human
            apolipoprotein CII
  JOURNAL   J Biol Chem 259 (7), 4401-4404 (1984)
   PUBMED   6546757
REFERENCE   10 (bases 1 to 660)
  AUTHORS   Jackson,R.L., Baker,H.N., Gilliam,E.B. and Gotto,A.M. Jr.
  TITLE     Primary structure of very low density apolipoprotein C-II of human
            plasma
  JOURNAL   Proc Natl Acad Sci U S A 74 (5), 1942-1945 (1977)
   PUBMED   194244
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU596546.1 and AA883870.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_000483.4.
            
            Summary: This gene encodes a lipid-binding protein belonging to the
            apolipoprotein gene family. The protein is secreted in plasma where
            it is a component of very low density lipoprotein. This protein
            activates the enzyme lipoprotein lipase, which hydrolyzes
            triglycerides and thus provides free fatty acids for cells.
            Mutations in this gene cause hyperlipoproteinemia type IB,
            characterized by hypertriglyceridemia, xanthomas, and increased
            risk of pancreatitis and early atherosclerosis. This gene is
            present in a cluster with other related apolipoprotein genes on
            chromosome 19. Naturally occurring read-through transcription
            exists between this gene and the neighboring upstream
            apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138522.323648.1,
                                           DRR138522.1680542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252490.7/ ENSP00000252490.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-495               BU596546.1         106-600
            496-660             AA883870.1         10-174              c
FEATURES             Location/Qualifiers
     source          1..660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..660
                     /gene="APOC2"
                     /gene_synonym="APO-CII; APOC-II"
                     /note="apolipoprotein C2"
                     /db_xref="GeneID:344"
                     /db_xref="HGNC:HGNC:609"
                     /db_xref="MIM:608083"
     exon            1..25
                     /gene="APOC2"
                     /gene_synonym="APO-CII; APOC-II"
                     /inference="alignment:Splign:2.1.0"
     exon            26..93
                     /gene="APOC2"
                     /gene_synonym="APO-CII; APOC-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..344
                     /gene="APOC2"
                     /gene_synonym="APO-CII; APOC-II"
                     /note="apolipoprotein C-II"
                     /codon_start=1
                     /product="apolipoprotein C-II precursor"
                     /protein_id="NP_000474.2"
                     /db_xref="CCDS:CCDS12650.1"
                     /db_xref="GeneID:344"
                     /db_xref="HGNC:HGNC:609"
                     /db_xref="MIM:608083"
                     /translation="MGTRLLPALFLVLLVLGFEVQGTQQPQQDEMPSPTFLTQVKESL
                     SSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE"
     exon            94..253
                     /gene="APOC2"
                     /gene_synonym="APO-CII; APOC-II"
                     /inference="alignment:Splign:2.1.0"
     exon            254..660
                     /gene="APOC2"
                     /gene_synonym="APO-CII; APOC-II"
                     /inference="alignment:Splign:2.1.0"
     regulatory      472..477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOC2"
                     /gene_synonym="APO-CII; APOC-II"
                     /note="hexamer: AATAAA"
     polyA_site      490
                     /gene="APOC2"
                     /gene_synonym="APO-CII; APOC-II"
                     /note="major polyA site"
     regulatory      644..649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOC2"
                     /gene_synonym="APO-CII; APOC-II"
                     /note="hexamer: AATAAT"
     polyA_site      660
                     /gene="APOC2"
                     /gene_synonym="APO-CII; APOC-II"
                     /note="major polyA site"
ORIGIN      
        1 ggtgaggaca gcctgccaga gtctggtctc tggacactat gggcacacga ctcctcccag
       61 ctctgtttct tgtcctcctg gtattgggat ttgaggtcca ggggacccaa cagccccagc
      121 aagatgagat gcctagcccg accttcctca cccaggtgaa ggaatctctc tccagttact
      181 gggagtcagc aaagacagcc gcccagaacc tgtacgagaa gacatacctg cccgctgtag
      241 atgagaaact cagggacttg tacagcaaaa gcacagcagc catgagcact tacacaggca
      301 tttttactga ccaagttctt tctgtgctga agggagagga gtaacagcca gaccccccat
      361 cagtggacaa ggggagagtc ccctactccc ctgatccccc aggttcagac tgagctcccc
      421 cttcccagta gctcttgcat cctcctccca actctagcct gaattctttt caataaaaaa
      481 tacaattcaa gttgcttctc atggatggca ctgcttttct gaggactcaa gggccaagat
      541 ggaggggctg actcagtcca gccaacattt aatgagcacc tactttatgt atggagctct
      601 aacccatggg tccatgggaa taaagcagtg aatagtaaca ataaataatc gtaacagcaa
//
