LOCUS       NM_001645                514 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens apolipoprotein C1 (APOC1), transcript variant 1, mRNA.
ACCESSION   NM_001645
VERSION     NM_001645.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Yang,S., Du,J., Wang,W., Zhou,D. and Xi,X.
  TITLE     APOC1 is a prognostic biomarker associated with M2 macrophages in
            ovarian cancer
  JOURNAL   BMC Cancer 24 (1), 364 (2024)
   PUBMED   38515073
  REMARK    GeneRIF: APOC1 is a prognostic biomarker associated with M2
            macrophages in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Manco,L., Albuquerque,D., Rodrigues,D., Machado-Rodrigues,A.M. and
            Padez,C.
  TITLE     Protective Association of APOC1/rs4420638 with Risk of Obesity: A
            case-control Study in Portuguese Children
  JOURNAL   Biochem Genet 62 (1), 254-263 (2024)
   PUBMED   37328602
  REMARK    GeneRIF: Protective Association of APOC1/rs4420638 with Risk of
            Obesity: A case-control Study in Portuguese Children.
REFERENCE   3  (bases 1 to 514)
  AUTHORS   Yang,Z., Yang,L., Sun,Z., Rong,Y., Bai,C., Dong,Q. and Jian,L.
  TITLE     miRNA-660-3p inhibits malignancy in glioblastoma via negative
            regulation of APOC1-TGFbeta2 signaling pathway
  JOURNAL   Cancer Biol Ther 24 (1), 2281459 (2023)
   PUBMED   37981873
  REMARK    GeneRIF: miRNA-660-3p inhibits malignancy in glioblastoma via
            negative regulation of APOC1-TGFbeta2 signaling pathway.
REFERENCE   4  (bases 1 to 514)
  AUTHORS   Landry,J.R. and Mager,D.L.
  TITLE     Functional analysis of the endogenous retroviral promoter of the
            human endothelin B receptor gene
  JOURNAL   J Virol 77 (13), 7459-7466 (2003)
   PUBMED   12805445
  REMARK    GeneRIF: The endogenous retroviral promoters (LTRs) of the human
            endothelin B receptor (EDNRB) and apolipoprotein C1 (APOC1) genes
            have high sequence identity but differ in activity and tissue
            specificity.
REFERENCE   5  (bases 1 to 514)
  AUTHORS   Ki,C.S., Na,D.L., Kim,D.K., Kim,H.J. and Kim,J.W.
  TITLE     Genetic association of an apolipoprotein C-I (APOC1) gene
            polymorphism with late-onset Alzheimer's disease
  JOURNAL   Neurosci Lett 319 (2), 75-78 (2002)
   PUBMED   11825674
  REMARK    GeneRIF: APOC1 might be an additional susceptibility gene for late
            onset Alzheimer disease.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 514)
  AUTHORS   Medstrand,P., Landry,J.R. and Mager,D.L.
  TITLE     Long terminal repeats are used as alternative promoters for the
            endothelin B receptor and apolipoprotein C-I genes in humans
  JOURNAL   J Biol Chem 276 (3), 1896-1903 (2001)
   PUBMED   11054415
REFERENCE   7  (bases 1 to 514)
  AUTHORS   Lauer,S.J., Walker,D., Elshourbagy,N.A., Reardon,C.A.,
            Levy-Wilson,B. and Taylor,J.M.
  TITLE     Two copies of the human apolipoprotein C-I gene are linked closely
            to the apolipoprotein E gene
  JOURNAL   J Biol Chem 263 (15), 7277-7286 (1988)
   PUBMED   2835369
REFERENCE   8  (bases 1 to 514)
  AUTHORS   Tata,F., Henry,I., Markham,A.F., Wallis,S.C., Weil,D.,
            Grzeschik,K.H., Junien,C., Williamson,R. and Humphries,S.E.
  TITLE     Isolation and characterisation of a cDNA clone for human
            apolipoprotein CI and assignment of the gene to chromosome 19
  JOURNAL   Hum Genet 69 (4), 345-349 (1985)
   PUBMED   2985493
REFERENCE   9  (bases 1 to 514)
  AUTHORS   Kinnunen,P.K. and Ehnolm,C.
  TITLE     Effect of serum and C-apoproteins from very low density
            lipoproteins on human postheparin plasma hepatic lipase
  JOURNAL   FEBS Lett 65 (3), 354-357 (1976)
   PUBMED   182536
REFERENCE   10 (bases 1 to 514)
  AUTHORS   Shulman,R.S., Herbert,P.N., Wehrly,K. and Fredrickson,D.S.
  TITLE     Thf complete amino acid sequence of C-I (apoLp-Ser), an
            apolipoprotein from human very low density lipoproteins
  JOURNAL   J Biol Chem 250 (1), 182-190 (1975)
   PUBMED   166984
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011481.4, AK312036.1 and
            CA445083.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001645.4.
            
            Summary: This gene encodes a member of the apolipoprotein C1
            family. This gene is expressed primarily in the liver, and it is
            activated when monocytes differentiate into macrophages. The
            encoded protein plays a central role in high density lipoprotein
            (HDL) and very low density lipoprotein (VLDL) metabolism. This
            protein has also been shown to inhibit cholesteryl ester transfer
            protein in plasma. A pseudogene of this gene is located 4 kb
            downstream in the same orientation, on the same chromosome. This
            gene is mapped to chromosome 19, where it resides within a
            apolipoprotein gene cluster. Alternative splicing and the use of
            alternative promoters results in multiple transcript variants.
            [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1), as well as variants 2 and 3,
            encodes isoform a. This transcript is expressed primarily in the
            liver.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD365683.1, BU603900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000592535.6/ ENSP00000468276.2
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC011481.4         57432-57501
            71-398              AK312036.1         5-332
            399-431             AC011481.4         62055-62087
            432-514             CA445083.1         22-104              c
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..514
                     /gene="APOC1"
                     /gene_synonym="Apo-CI; apo-CIB; ApoC-I; apoC-IB; APOC1B"
                     /note="apolipoprotein C1"
                     /db_xref="GeneID:341"
                     /db_xref="HGNC:HGNC:607"
                     /db_xref="MIM:107710"
     exon            1..126
                     /gene="APOC1"
                     /gene_synonym="Apo-CI; apo-CIB; ApoC-I; apoC-IB; APOC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            127..204
                     /gene="APOC1"
                     /gene_synonym="Apo-CI; apo-CIB; ApoC-I; apoC-IB; APOC1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..398
                     /gene="APOC1"
                     /gene_synonym="Apo-CI; apo-CIB; ApoC-I; apoC-IB; APOC1B"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; apolipoprotein C-I"
                     /codon_start=1
                     /product="apolipoprotein C-I isoform a precursor"
                     /protein_id="NP_001636.1"
                     /db_xref="CCDS:CCDS12648.1"
                     /db_xref="GeneID:341"
                     /db_xref="HGNC:HGNC:607"
                     /db_xref="MIM:107710"
                     /translation="MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSALDKLKEFGNTL
                     EDKARELISRIKQSELSAKMREWFSETFQKVKEKLKIDS"
     exon            205..340
                     /gene="APOC1"
                     /gene_synonym="Apo-CI; apo-CIB; ApoC-I; apoC-IB; APOC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            341..514
                     /gene="APOC1"
                     /gene_synonym="Apo-CI; apo-CIB; ApoC-I; apoC-IB; APOC1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      495..500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOC1"
                     /gene_synonym="Apo-CI; apo-CIB; ApoC-I; apoC-IB; APOC1B"
                     /note="hexamer: AATAAA"
     polyA_site      514
                     /gene="APOC1"
                     /gene_synonym="Apo-CI; apo-CIB; ApoC-I; apoC-IB; APOC1B"
                     /note="major polyA site"
ORIGIN      
        1 aggcggtcag gggaaggctc aggaggaggg agatcaacat caacctgccc cgccccctcc
       61 ccagcctgat aaaggtcctg cgggcaggac aggacctccc aaccaagccc tccagcaagg
      121 attcagagtg cccctccggc ctcgccatga ggctcttcct gtcgctcccg gtcctggtgg
      181 tggttctgtc gatcgtcttg gaaggcccag ccccagccca ggggacccca gacgtctcca
      241 gtgccttgga taagctgaag gagtttggaa acacactgga ggacaaggct cgggaactca
      301 tcagccgcat caaacagagt gaactttctg ccaagatgcg ggagtggttt tcagagacat
      361 ttcagaaagt gaaggagaaa ctcaagattg actcatgagg acctgaaggg tgacatccca
      421 ggaggggcct ctgaaatttc ccacacccca gcgcctgtgc tgaggactcc ctccatgtgg
      481 ccccaggtgc caccaataaa aatcctacag aaaa
//
