LOCUS       NM_203454               2782 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens apolipoprotein B mRNA editing enzyme catalytic
            polypeptide like 4 (APOBEC4), mRNA.
ACCESSION   NM_203454
VERSION     NM_203454.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2782)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2782)
  AUTHORS   Marino,D., Perkovic,M., Hain,A., Jaguva Vasudevan,A.A., Hofmann,H.,
            Hanschmann,K.M., Muhlebach,M.D., Schumann,G.G., Konig,R.,
            Cichutek,K., Haussinger,D. and Munk,C.
  TITLE     APOBEC4 Enhances the Replication of HIV-1
  JOURNAL   PLoS One 11 (6), e0155422 (2016)
   PUBMED   27249646
  REMARK    GeneRIF: APOBEC4 was capable of similarly enhancing transcription
            from a broad spectrum of promoters, regardless of whether they were
            viral or mammalian
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2782)
  AUTHORS   Yang,W., Tang,H., Zhang,Y., Tang,X., Zhang,J., Sun,L., Yang,J.,
            Cui,Y., Zhang,L., Hirankarn,N., Cheng,H., Pan,H.F., Gao,J.,
            Lee,T.L., Sheng,Y., Lau,C.S., Li,Y., Chan,T.M., Yin,X., Ying,D.,
            Lu,Q., Leung,A.M., Zuo,X., Chen,X., Tong,K.L., Zhou,F., Diao,Q.,
            Tse,N.K., Xie,H., Mok,C.C., Hao,F., Wong,S.N., Shi,B., Lee,K.W.,
            Hui,Y., Ho,M.H., Liang,B., Lee,P.P., Cui,H., Guo,Q., Chung,B.H.,
            Pu,X., Liu,Q., Zhang,X., Zhang,C., Chong,C.Y., Fang,H., Wong,R.W.,
            Sun,Y., Mok,M.Y., Li,X.P., Avihingsanon,Y., Zhai,Z.,
            Rianthavorn,P., Deekajorndej,T., Suphapeetiporn,K., Gao,F.,
            Shotelersuk,V., Kang,X., Ying,S.K., Zhang,L., Wong,W.H., Zhu,D.,
            Fung,S.K., Zeng,F., Lai,W.M., Wong,C.M., Ng,I.O.,
            Garcia-Barcelo,M.M., Cherny,S.S., Shen,N., Tam,P.K., Sham,P.C.,
            Ye,D.Q., Yang,S., Zhang,X. and Lau,Y.L.
  TITLE     Meta-analysis followed by replication identifies loci in or near
            CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic
            lupus erythematosus in Asians
  JOURNAL   Am J Hum Genet 92 (1), 41-51 (2013)
   PUBMED   23273568
REFERENCE   4  (bases 1 to 2782)
  AUTHORS   Prochnow,C., Bransteitter,R. and Chen,X.S.
  TITLE     APOBEC deaminases-mutases with defensive roles for immunity
  JOURNAL   Sci China C Life Sci 52 (10), 893-902 (2009)
   PUBMED   19911124
  REMARK    GeneRIF: Studies indicate the APOBEC family consists of 11 members:
            APOBEC-1 (Apo1), APOBEC-2 (Apo2), activation induced cytidine
            deaminase (AID), APOBEC- 3A, -3B, -3C, -3DE, -3F, -3H (Apo3A-H) and
            APOBEC- 4 (Apo4).
            Review article
REFERENCE   5  (bases 1 to 2782)
  AUTHORS   Rogozin,I.B., Basu,M.K., Jordan,I.K., Pavlov,Y.I. and Koonin,E.V.
  TITLE     APOBEC4, a new member of the AID/APOBEC family of polynucleotide
            (deoxy)cytidine deaminases predicted by computational analysis
  JOURNAL   Cell Cycle 4 (9), 1281-1285 (2005)
   PUBMED   16082223
  REMARK    GeneRIF: APOBEC4 is expressed primarily in testis which suggests
            the possibility that it is an editing enzyme for mRNAs involved in
            spermatogenesis
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL137800.12, BC021711.2 and
            AI961390.1.
            
            On Nov 22, 2018 this sequence version replaced NM_203454.2.
            
            Summary: This gene encodes a member of the AID/APOBEC family of
            polynucleotide (deoxy)cytidine deaminases, which convert cytidine
            to uridine. Other AID/APOBEC family members are involved in mRNA
            editing, somatic hypermutation and recombination of immunoglobulin
            genes, and innate immunity to retroviral infection. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021711.2, SRR5189667.353799.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308641.6/ ENSP00000310622.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL137800.12        153858-153860       c
            4-2651              BC021711.2         1-2648
            2652-2782           AI961390.1         8-138               c
FEATURES             Location/Qualifiers
     source          1..2782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..2782
                     /gene="APOBEC4"
                     /gene_synonym="C1orf169"
                     /note="apolipoprotein B mRNA editing enzyme catalytic
                     polypeptide like 4"
                     /db_xref="GeneID:403314"
                     /db_xref="HGNC:HGNC:32152"
                     /db_xref="MIM:609908"
     exon            1..245
                     /gene="APOBEC4"
                     /gene_synonym="C1orf169"
                     /inference="alignment:Splign:2.1.0"
     exon            246..2782
                     /gene="APOBEC4"
                     /gene_synonym="C1orf169"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1379
                     /gene="APOBEC4"
                     /gene_synonym="C1orf169"
                     /note="apolipoprotein B mRNA editing enzyme, catalytic
                     polypeptide-like 4 (putative)"
                     /codon_start=1
                     /product="putative C->U-editing enzyme APOBEC-4"
                     /protein_id="NP_982279.1"
                     /db_xref="CCDS:CCDS1358.1"
                     /db_xref="GeneID:403314"
                     /db_xref="HGNC:HGNC:32152"
                     /db_xref="MIM:609908"
                     /translation="MEPIYEEYLANHGTIVKPYYWLSFSLDCSNCPYHIRTGEEARVS
                     LTEFCQIFGFPYGTTFPQTKHLTFYELKTSSGSLVQKGHASSCTGNYIHPESMLFEMN
                     GYLDSAIYNNDSIRHIILYSNNSPCNEANHCCISKMYNFLITYPGITLSIYFSQLYHT
                     EMDFPASAWNREALRSLASLWPRVVLSPISGGIWHSVLHSFISGVSGSHVFQPILTGR
                     ALADRHNAYEINAITGVKPYFTDVLLQTKRNPNTKAQEALESYPLNNAFPGQFFQMPS
                     GQLQPNLPPDLRAPVVFVLVPLRDLPPMHMGQNPNKPRNIVRHLNMPQMSFQETKDLG
                     RLPTGRSVEIVEITEQFASSKEADEKKKKKGKK"
     regulatory      2578..2583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOBEC4"
                     /gene_synonym="C1orf169"
                     /note="hexamer: AAGAAA"
     polyA_site      2602
                     /gene="APOBEC4"
                     /gene_synonym="C1orf169"
                     /note="major polyA site"
     regulatory      2763..2768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOBEC4"
                     /gene_synonym="C1orf169"
                     /note="hexamer: AATAAA"
     polyA_site      2782
                     /gene="APOBEC4"
                     /gene_synonym="C1orf169"
                     /note="major polyA site"
ORIGIN      
        1 aacagtgttc ttagaggtag ccacacctca gcaagggctt tctaacttgg aacagcaaag
       61 ttcaaatgaa cgaatagaca caaactgtga aagagtcctg aacccattac aaggtgaatc
      121 tttacagcac aattgccttc tgaagctact tgaaacaggg catgggactt aaaggagaaa
      181 aaaaaggaaa tggaccatct cttctaacac ctggaatgtg atccaagcct ggagacaaat
      241 tgatggtttg cagctagaag acagtaaatc tagcaatgga gcccatatat gaggagtacc
      301 tagcaaatca tggaacaata gtaaaaccat attactggct aagcttctct ctcgattgct
      361 ctaattgtcc ttaccatatt cgaacaggtg aagaagcaag agtttccctc acagaatttt
      421 gtcagatttt tggattccct tatgggacaa catttcctca aacaaaacac ctcacatttt
      481 atgaactaaa aacttcttct ggtagcctgg tgcaaaaggg ccatgctagc agttgcactg
      541 ggaattatat ccatccagaa tcaatgctct ttgaaatgaa tggttatctt gactcagcca
      601 tatacaataa tgacagcatc aggcatatca ttctgtattc caacaactcc ccttgtaatg
      661 aagctaacca ctgctgcatc agcaaaatgt ataatttcct gattacgtat ccaggcatca
      721 ctcttagtat ttatttttct cagctctatc atactgagat ggactttcct gcctcagcat
      781 ggaaccgcga agctctccgg agcctggcca gcttatggcc gcgggttgtt ttgagtccaa
      841 taagtggtgg gatctggcat tctgttctcc acagctttat aagtggtgtc tcaggatcac
      901 atgtttttca gcccatttta actgggagag cactggctga caggcacaac gcatatgaaa
      961 tcaatgccat aacaggcgta aaaccttact tcactgatgt tcttctccag acaaaaagga
     1021 atccaaacac aaaagctcag gaggctttag agagctaccc cttaaacaat gcctttcctg
     1081 gacagttttt tcaaatgccg agtggacaac tccaacccaa cctacctcca gacctcaggg
     1141 ctcctgttgt ttttgtgcta gtgcctctca gggacttacc accaatgcat atgggccaaa
     1201 acccaaataa acccaggaat atcgtaaggc acttaaatat gcctcaaatg tcattccagg
     1261 aaaccaagga ccttggaagg cttcccactg gaaggtcagt ggagatagtg gaaatcacag
     1321 aacagtttgc aagtagcaag gaggcagatg aaaagaagaa gaagaaaggg aagaaataaa
     1381 atctacattc ctacagcatg aaaccaatta ccaagggact tattagatag gcaataaaaa
     1441 tctggaaact ttctctctca gggctgagcc aagatggaga taaactgatg cactaaaagc
     1501 aaaccttgaa ttatttacca tatcaactat tataaagtta cactatttta aacataatcc
     1561 aaaatgtttc cataagcaac ttgatctctc tcctttattt tgaaagtggc agtatcaaaa
     1621 tggaaccatt agcagcttgc taatattttg atgcagaaaa ggaatctcat tattctattt
     1681 tactcacatc atctttccac tacaaaagcc catggacaaa atagctacct aaatttgttt
     1741 cggtaaaaaa tttactgtaa aattgaaaaa cagcctgaag ctactgacat taagtgctgt
     1801 ttgcaggagc aaaccagtga ttttctatta attgttaatc atggacagaa gattttaggc
     1861 agctcatttt tttctaaagt gattcaaaat agttttgtgt gggaaaaagc tcttctgctg
     1921 attacatata gctataaaga ttaaaaccta gccacctgct cagtttgatc ttccccagct
     1981 cagacctctc ccttctgagc agatgataga ggtaagatga tacatgagaa cctccaatgg
     2041 ctcctgtcat cacatactgt ataaaatcca agttcctctt actggctttc aaggatcctc
     2101 ctttaacttc ctgttgcctt gtctcatcag caagatcata agtacctaca ggtcaagcac
     2161 tgtctctccc ttctctttag cttttccctt aggatctagc acattaccca gcaaaatgtg
     2221 agtagcaagg ctgaaatgac atctcaataa cttcaccaat gattgtaact cagcatccct
     2281 tctccatccc agctgaaagc ctgcttcacc atcctgcaag agatgttttt tctttttgtt
     2341 agcatccatt cccctttcta atgcagctcc caatgcataa tgtgtgtttt acttccctct
     2401 ttctgactcc atcctcgtca ccagtgaata tttgtacctt ctcttaaaat cttcaaaaca
     2461 cacttctagg aagtgctcct tgattaatcc tctaagcact taaatgaaag cactttgctt
     2521 atgcttattt cacatttgct gccacttgcc tctttgaaat atgtaaagat acattacaag
     2581 aaaaatgtac attttctcgt aacttgctat taattttttt ctttatatat atatataaag
     2641 taatcctaag ctaataaaag agtttgccat gacattaaaa catttaatac tccataaggg
     2701 aggaggagaa agaaaaacat attttaggaa tagcaattag tattgtggtt aaaataaaca
     2761 tgaataaaaa ttttaaaaca aa
//
