LOCUS       NM_181773               1029 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens apolipoprotein B mRNA editing enzyme catalytic subunit
            3H (APOBEC3H), transcript variant SV-183, mRNA.
ACCESSION   NM_181773
VERSION     NM_181773.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1029)
  AUTHORS   Meissner,M.E., Willkomm,N.A., Lucas,J., Arndt,W.G., Aitken,S.F.,
            Julik,E.J., Baliga,S. and Mansky,L.M.
  TITLE     Differential Activity of APOBEC3F, APOBEC3G, and APOBEC3H in the
            Restriction of HIV-2
  JOURNAL   J Mol Biol 434 (2), 167355 (2022)
   PUBMED   34774569
  REMARK    GeneRIF: Differential Activity of APOBEC3F, APOBEC3G, and APOBEC3H
            in the Restriction of HIV-2.
REFERENCE   2  (bases 1 to 1029)
  AUTHORS   Liu,Q., Luo,Y.W., Cao,R.Y., Pan,X., Chen,X.J., Zhang,S.Y.,
            Zhang,W.L., Zhou,J.Y., Cheng,B. and Ren,X.Y.
  TITLE     Association between APOBEC3H-Mediated Demethylation and Immune
            Landscape in Head and Neck Squamous Carcinoma
  JOURNAL   Biomed Res Int 2020, 4612375 (2020)
   PUBMED   32775421
  REMARK    GeneRIF: Association between APOBEC3H-Mediated Demethylation and
            Immune Landscape in Head and Neck Squamous Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1029)
  AUTHORS   Bohn,J.A., DaSilva,J., Kharytonchyk,S., Mercedes,M., Vosters,J.,
            Telesnitsky,A., Hatziioannou,T. and Smith,J.L.
  TITLE     Flexibility in Nucleic Acid Binding Is Central to APOBEC3H
            Antiviral Activity
  JOURNAL   J Virol 93 (24), e01275-19 (2019)
   PUBMED   31578294
  REMARK    GeneRIF: APOBEC3 proteins APOBEC3F (A3F), APOBEC3G (A3G), and
            APOBEC3H (A3H) are host restriction factors that inhibit HIV-1
            through DNA cytidine deaminase-dependent and -independent
            mechanisms and have either one (A3H) or two (A3F and A3G)
            zinc-binding domains.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1029)
  AUTHORS   Kanagaraj,A., Sakamoto,N., Que,L., Li,Y., Mohiuddin,M., Koura,M.,
            Wakae,K., Kurachi,M., Muramatsu,M. and Kitamura,K.
  TITLE     Different antiviral activities of natural APOBEC3C, APOBEC3G, and
            APOBEC3H variants against hepatitis B virus
  JOURNAL   Biochem Biophys Res Commun 518 (1), 26-31 (2019)
   PUBMED   31400856
  REMARK    GeneRIF: genetic variations in APOBEC3 genes may affect the
            efficiency of hepatitis b virus elimination in humans.
REFERENCE   5  (bases 1 to 1029)
  AUTHORS   He,X., Xu,H., Wang,X., Wu,J., Niu,J. and Gao,P.
  TITLE     Associations between the single nucleotide polymorphisms of
            APOBEC3A, APOBEC3B and APOBEC3H, and chronic hepatitis B
            progression and hepatocellular carcinoma in a Chinese population
  JOURNAL   Mol Med Rep 20 (3), 2177-2188 (2019)
   PUBMED   31322199
  REMARK    GeneRIF: These findings suggested that there was no relationship
            between A3A, A3B and A3H single nucleotide polymorphisms and
            chronic hepatitis B progression or hepatocellular carcinoma
            development in the Han Chinese population.
REFERENCE   6  (bases 1 to 1029)
  AUTHORS   Harari,A., Ooms,M., Mulder,L.C. and Simon,V.
  TITLE     Polymorphisms and splice variants influence the antiretroviral
            activity of human APOBEC3H
  JOURNAL   J Virol 83 (1), 295-303 (2009)
   PUBMED   18945781
  REMARK    GeneRIF: the anti-HIV activity of APOBEC3H seems to be regulated by
            a combination of genomic variation and alternative splicing.
REFERENCE   7  (bases 1 to 1029)
  AUTHORS   Dang,Y., Siew,L.M., Wang,X., Han,Y., Lampen,R. and Zheng,Y.H.
  TITLE     Human cytidine deaminase APOBEC3H restricts HIV-1 replication
  JOURNAL   J Biol Chem 283 (17), 11606-11614 (2008)
   PUBMED   18299330
  REMARK    GeneRIF: A3H inhibits HIV-1 replication potently by a cytidine
            deamination-independent mechanism
REFERENCE   8  (bases 1 to 1029)
  AUTHORS   Vartanian,J.P., Guetard,D., Henry,M. and Wain-Hobson,S.
  TITLE     Evidence for editing of human papillomavirus DNA by APOBEC3 in
            benign and precancerous lesions
  JOURNAL   Science 320 (5873), 230-233 (2008)
   PUBMED   18403710
  REMARK    GeneRIF: study provides evidence of editing of human papillomavirus
            1a and 16 DNA by APOBEC3 in plantar warts and precancerous cervix
            biopsies
REFERENCE   9  (bases 1 to 1029)
  AUTHORS   OhAinle,M., Kerns,J.A., Malik,H.S. and Emerman,M.
  TITLE     Adaptive evolution and antiviral activity of the conserved
            mammalian cytidine deaminase APOBEC3H
  JOURNAL   J Virol 80 (8), 3853-3862 (2006)
   PUBMED   16571802
REFERENCE   10 (bases 1 to 1029)
  AUTHORS   Wedekind,J.E., Dance,G.S., Sowden,M.P. and Smith,H.C.
  TITLE     Messenger RNA editing in mammals: new members of the APOBEC family
            seeking roles in the family business
  JOURNAL   Trends Genet 19 (4), 207-216 (2003)
   PUBMED   12683974
  REMARK    Review article
            Erratum:[Trends Genet. 2003 Jul;19(7):369]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU585251.1, BQ052182.1 and
            BC069023.1.
            
            On Jun 2, 2019 this sequence version replaced NM_181773.4.
            
            Summary: This gene encodes a member of the apolipoprotein B
            mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The
            encoded protein is a cytidine deaminase that has antiretroviral
            activity by generating lethal hypermutations in viral genomes.
            Polymorphisms and alternative splicing in this gene influence its
            antiretroviral activity and are associated with increased
            resistence to human immunodeficiency virus type 1 infection in
            certain populations. Alternative splicing results in multiple
            transcript variants.[provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (SV-183) lacks an alternate exon,
            resulting in an alternate 3' coding region and 3' UTR, compared to
            variant SV-200. The encoded isoform (SV-183) has a distinct
            C-terminus and is shorter than isoform SV-200.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.27751.1,
                                           SRR1163657.253248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442487.8/ ENSP00000411754.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BU585251.1         21-61
            42-774              BQ052182.1         1-733
            775-1029            BC069023.1         777-1031
FEATURES             Location/Qualifiers
     source          1..1029
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..1029
                     /gene="APOBEC3H"
                     /gene_synonym="A3H; ARP-10; ARP10"
                     /note="apolipoprotein B mRNA editing enzyme catalytic
                     subunit 3H"
                     /db_xref="GeneID:164668"
                     /db_xref="HGNC:HGNC:24100"
                     /db_xref="MIM:610976"
     exon            1..100
                     /gene="APOBEC3H"
                     /gene_synonym="A3H; ARP-10; ARP10"
                     /inference="alignment:Splign:2.1.0"
     exon            101..257
                     /gene="APOBEC3H"
                     /gene_synonym="A3H; ARP-10; ARP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..659
                     /gene="APOBEC3H"
                     /gene_synonym="A3H; ARP-10; ARP10"
                     /EC_number="3.5.4.38"
                     /note="isoform SV-183 is encoded by transcript variant
                     SV-183; DNA dC->dU-editing enzyme APOBEC-3H;
                     APOBEC-related protein 10; apolipoprotein B mRNA editing
                     enzyme, catalytic polypeptide-like 3H"
                     /codon_start=1
                     /product="DNA dC->dU-editing enzyme APOBEC-3H isoform
                     SV-183"
                     /protein_id="NP_861438.3"
                     /db_xref="CCDS:CCDS13985.1"
                     /db_xref="GeneID:164668"
                     /db_xref="HGNC:HGNC:24100"
                     /db_xref="MIM:610976"
                     /translation="MALLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTR
                     GYFENKKKCHAEICFINEIKSMGLDETQCYQVTCYLTWSPCSSCAWELVDFIKAHDHL
                     NLGIFASRLYYHWCKPQQKGLRLLCGSQVPVEVMGFPEFADCWENFVDHEKPLSFNPY
                     KMLEELDKNSRAIKRRLERIKQS"
     exon            258..525
                     /gene="APOBEC3H"
                     /gene_synonym="A3H; ARP-10; ARP10"
                     /inference="alignment:Splign:2.1.0"
     exon            526..650
                     /gene="APOBEC3H"
                     /gene_synonym="A3H; ARP-10; ARP10"
                     /inference="alignment:Splign:2.1.0"
     exon            651..1029
                     /gene="APOBEC3H"
                     /gene_synonym="A3H; ARP-10; ARP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      928..933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOBEC3H"
                     /gene_synonym="A3H; ARP-10; ARP10"
                     /note="hexamer: GATAAA"
     polyA_site      946
                     /gene="APOBEC3H"
                     /gene_synonym="A3H; ARP-10; ARP10"
                     /note="major polyA site"
     regulatory      1007..1012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOBEC3H"
                     /gene_synonym="A3H; ARP-10; ARP10"
                     /note="hexamer: AATAAA"
     polyA_site      1029
                     /gene="APOBEC3H"
                     /gene_synonym="A3H; ARP-10; ARP10"
                     /note="major polyA site"
ORIGIN      
        1 cttttgtgac ttttgggaga gctgccaaaa gtgaaactta gtgcctcaga caagcagggg
       61 caagtctgct aaggaagctg tggccagaag cacagatcag aaacacgatg gctctgttaa
      121 cagccgaaac attccgctta cagtttaaca acaagcgccg cctcagaagg ccttactacc
      181 cgaggaaggc cctcttgtgt taccagctga cgccgcagaa tggctccacg cccacgagag
      241 gctactttga aaacaagaaa aagtgccatg cagaaatttg ctttattaac gagatcaagt
      301 ccatgggact ggacgaaacg cagtgctacc aagtcacctg ttacctcacg tggagcccct
      361 gctcctcctg tgcctgggag ctggttgact tcatcaaggc tcacgaccat ctgaacctgg
      421 gcatcttcgc ctcccgcctg tactaccact ggtgcaagcc ccagcagaag gggctgcggc
      481 ttctgtgtgg atcccaggtc ccggtggagg tcatgggctt cccagagttt gctgactgct
      541 gggaaaactt tgtggaccac gagaaaccgc tttccttcaa cccctataag atgttagagg
      601 agctagataa aaacagtcga gccataaagc gacggcttga gaggataaag cagtcctgaa
      661 gtgtggatgt tttagagaat gacttaagaa gtttgcagct tggacccgta tcccactcat
      721 tatcaagaag caactcaaga tgactttccc tggggcatgt cagttgcctc atagcctgct
      781 ggtcctgtaa gcaagcacta agctccacag tgccagttcc ttgccccaac ctggccccat
      841 ccaagtacag aagaccttcc tttcctcctt tttccatatt gctttctgtt ctaagtgggt
      901 gaataatttt ataattgaaa aaataaagat aaagtctgta aatccagccg ggtacggtgg
      961 ctcacgcctg taatcctagc actttgggag gctgagatgc tcggccaata aatttctatt
     1021 gtttatgaa
//
