LOCUS       NM_021822               1564 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens apolipoprotein B mRNA editing enzyme catalytic subunit
            3G (APOBEC3G), transcript variant 1, mRNA.
ACCESSION   NM_021822
VERSION     NM_021822.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1564)
  AUTHORS   Belbacha,I., Bensghir,R., Filali Marhoum,K., Laboudi,M.,
            Hajoutt,K., Elharti,E., Sadki,K. and Oumzil,H.
  TITLE     Prevalence of HBsAg among Moroccan HIV-1 infected patients and
            APOBEC3G variant frequencies in HIV-1/HBV co-infection
  JOURNAL   J Infect Dev Ctries 18 (5), 779-786 (2024)
   PUBMED   38865405
  REMARK    GeneRIF: Prevalence of HBsAg among Moroccan HIV-1 infected patients
            and APOBEC3G variant frequencies in HIV-1/HBV co-infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1564)
  AUTHORS   Shandilya,S.M., Nalam,M.N., Nalivaika,E.A., Gross,P.J.,
            Valesano,J.C., Shindo,K., Li,M., Munson,M., Royer,W.E., Harjes,E.,
            Kono,T., Matsuo,H., Harris,R.S., Somasundaran,M. and Schiffer,C.A.
  TITLE     Crystal structure of the APOBEC3G catalytic domain reveals
            potential oligomerization interfaces
  JOURNAL   Structure 18 (1), 28-38 (2010)
   PUBMED   20152150
  REMARK    GeneRIF: crystal structure of the catalytically active C-terminal
            domain of APOBEC3G was determined to 2.25 A.
REFERENCE   3  (bases 1 to 1564)
  AUTHORS   Furukawa,A., Nagata,T., Matsugami,A., Habu,Y., Sugiyama,R.,
            Hayashi,F., Kobayashi,N., Yokoyama,S., Takaku,H. and Katahira,M.
  TITLE     Structure, interaction and real-time monitoring of the enzymatic
            reaction of wild-type APOBEC3G
  JOURNAL   EMBO J 28 (4), 440-451 (2009)
   PUBMED   19153609
  REMARK    GeneRIF: analysis of the enzymatic reaction of wild-type APOBEC3G
REFERENCE   4  (bases 1 to 1564)
  AUTHORS   Stenglein,M.D., Matsuo,H. and Harris,R.S.
  TITLE     Two regions within the amino-terminal half of APOBEC3G cooperate to
            determine cytoplasmic localization
  JOURNAL   J Virol 82 (19), 9591-9599 (2008)
   PUBMED   18667511
  REMARK    GeneRIF: two regions of APOBEC3G combine to mediate an
            intermolecular interaction that controls subcellular localization
REFERENCE   5  (bases 1 to 1564)
  AUTHORS   Gooch,B.D. and Cullen,B.R.
  TITLE     Functional domain organization of human APOBEC3G
  JOURNAL   Virology 379 (1), 118-124 (2008)
   PUBMED   18639915
  REMARK    GeneRIF: Here, the authors demonstrate that the ability to bind to
            Gag and package into HIV-1 virions is entirely contained within the
            amino-terminal half of A3G.
REFERENCE   6  (bases 1 to 1564)
  AUTHORS   Zhang,K.L., Mangeat,B., Ortiz,M., Zoete,V., Trono,D., Telenti,A.
            and Michielin,O.
  TITLE     Model structure of human APOBEC3G
  JOURNAL   PLoS One 2 (4), e378 (2007)
   PUBMED   17440614
  REMARK    GeneRIF: structure model identifies a cluster of residues important
            for packaging of APOBEC3G into virions, and may serve to guide
            functional analysis of APOBEC3G
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1564)
  AUTHORS   Chelico,L., Pham,P., Calabrese,P. and Goodman,M.F.
  TITLE     APOBEC3G DNA deaminase acts processively 3' --> 5' on
            single-stranded DNA
  JOURNAL   Nat Struct Mol Biol 13 (5), 392-399 (2006)
   PUBMED   16622407
  REMARK    GeneRIF: G --> A mutational gradient generated in viral genomic DNA
            in vivo could result from an intrinsic processive directional
            attack by APOBEC3G on single-stranded cDNA
REFERENCE   8  (bases 1 to 1564)
  AUTHORS   An,P., Bleiber,G., Duggal,P., Nelson,G., May,M., Mangeat,B.,
            Alobwede,I., Trono,D., Vlahov,D., Donfield,S., Goedert,J.J.,
            Phair,J., Buchbinder,S., O'Brien,S.J., Telenti,A. and Winkler,C.A.
  TITLE     APOBEC3G genetic variants and their influence on the progression to
            AIDS
  JOURNAL   J Virol 78 (20), 11070-11076 (2004)
   PUBMED   15452227
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1564)
  AUTHORS   Li,J., Potash,M.J. and Volsky,D.J.
  TITLE     Functional domains of APOBEC3G required for antiviral activity
  JOURNAL   J Cell Biochem 92 (3), 560-572 (2004)
   PUBMED   15156567
  REMARK    GeneRIF: APOBEC3G inhibits HIV-1 infection through interference
            with reverse transcription.
REFERENCE   10 (bases 1 to 1564)
  AUTHORS   Wedekind,J.E., Dance,G.S., Sowden,M.P. and Smith,H.C.
  TITLE     Messenger RNA editing in mammals: new members of the APOBEC family
            seeking roles in the family business
  JOURNAL   Trends Genet 19 (4), 207-216 (2003)
   PUBMED   12683974
  REMARK    Review article
            Erratum:[Trends Genet. 2003 Jul;19(7):369]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL022318.2, AL078641.2 and
            BC009683.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021822.3.
            
            Summary: This gene is a member of the cytidine deaminase gene
            family. It is one of seven related genes or pseudogenes found in a
            cluster, thought to result from gene duplication, on chromosome 22.
            Members of the cluster encode proteins that are structurally and
            functionally related to the C to U RNA-editing cytidine deaminase
            APOBEC1. The protein encoded by this gene catalyzes site-specific
            deamination of both RNA and single-stranded DNA. The encoded
            protein has been found to be a specific inhibitor of human
            immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq,
            Mar 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF182420.1, SRR1163658.137014.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407997.4/ ENSP00000385057.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AL022318.2         193082-193185
            105-258             AL022318.2         194739-194892
            259-553             AL022318.2         196740-197034
            554-668             AL022318.2         197278-197392
            669-822             AL022318.2         199538-199691
            823-1111            AL078641.2         1043-1331
            1112-1227           AL078641.2         1775-1890
            1228-1505           AL078641.2         2171-2448
            1506-1564           BC009683.1         1477-1535
FEATURES             Location/Qualifiers
     source          1..1564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..1564
                     /gene="APOBEC3G"
                     /gene_synonym="A3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15;
                     CEM15; dJ494G10.1; MDS019"
                     /note="apolipoprotein B mRNA editing enzyme catalytic
                     subunit 3G"
                     /db_xref="GeneID:60489"
                     /db_xref="HGNC:HGNC:17357"
                     /db_xref="MIM:607113"
     exon            1..104
                     /gene="APOBEC3G"
                     /gene_synonym="A3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15;
                     CEM15; dJ494G10.1; MDS019"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1242
                     /gene="APOBEC3G"
                     /gene_synonym="A3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15;
                     CEM15; dJ494G10.1; MDS019"
                     /EC_number="3.5.4.38"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phorbolin-like protein MDS019; deoxycytidine deaminase;
                     apolipoprotein B editing enzyme catalytic polypeptide-like
                     3G; apolipoprotein B mRNA-editing enzyme catalytic
                     polypeptide 3G; apolipoprotein B mRNA editing enzyme,
                     catalytic polypeptide-like 3G; DNA dC->dU-editing enzyme
                     APOBEC-3G; DNA dC->dU editing enzyme; APOBEC-related
                     protein 9; APOBEC-related cytidine deaminase;
                     apolipoprotein B mRNA editing enzyme cytidine deaminase"
                     /codon_start=1
                     /product="DNA dC->dU-editing enzyme APOBEC-3G isoform 1"
                     /protein_id="NP_068594.1"
                     /db_xref="CCDS:CCDS13984.1"
                     /db_xref="GeneID:60489"
                     /db_xref="HGNC:HGNC:17357"
                     /db_xref="MIM:607113"
                     /translation="MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGP
                     SRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTR
                     DMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHC
                     WSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHET
                     YLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQD
                     YRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAK
                     ISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN"
     exon            105..258
                     /gene="APOBEC3G"
                     /gene_synonym="A3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15;
                     CEM15; dJ494G10.1; MDS019"
                     /inference="alignment:Splign:2.1.0"
     exon            259..553
                     /gene="APOBEC3G"
                     /gene_synonym="A3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15;
                     CEM15; dJ494G10.1; MDS019"
                     /inference="alignment:Splign:2.1.0"
     exon            554..668
                     /gene="APOBEC3G"
                     /gene_synonym="A3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15;
                     CEM15; dJ494G10.1; MDS019"
                     /inference="alignment:Splign:2.1.0"
     exon            669..822
                     /gene="APOBEC3G"
                     /gene_synonym="A3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15;
                     CEM15; dJ494G10.1; MDS019"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1111
                     /gene="APOBEC3G"
                     /gene_synonym="A3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15;
                     CEM15; dJ494G10.1; MDS019"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1227
                     /gene="APOBEC3G"
                     /gene_synonym="A3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15;
                     CEM15; dJ494G10.1; MDS019"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1564
                     /gene="APOBEC3G"
                     /gene_synonym="A3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15;
                     CEM15; dJ494G10.1; MDS019"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1536..1541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOBEC3G"
                     /gene_synonym="A3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15;
                     CEM15; dJ494G10.1; MDS019"
                     /note="hexamer: AATAAA"
     polyA_site      1564
                     /gene="APOBEC3G"
                     /gene_synonym="A3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15;
                     CEM15; dJ494G10.1; MDS019"
                     /note="major polyA site"
ORIGIN      
        1 gggctgtcct aaaaccagaa gcttggagca gaaagtgaaa ccctggtgct ccagacaaag
       61 atcttagtcg ggactagccg gccaaggatg aagcctcact tcagaaacac agtggagcga
      121 atgtatcgag acacattctc ctacaacttt tataatagac ccatcctttc tcgtcggaat
      181 accgtctggc tgtgctacga agtgaaaaca aagggtccct caaggccccc tttggacgca
      241 aagatctttc gaggccaggt gtattccgaa cttaagtacc acccagagat gagattcttc
      301 cactggttca gcaagtggag gaagctgcat cgtgaccagg agtatgaggt cacctggtac
      361 atatcctgga gcccctgcac aaagtgtaca agggatatgg ccacgttcct ggccgaggac
      421 ccgaaggtta ccctgaccat ctttgttgcc cgcctctact acttctggga cccagattac
      481 caggaggcgc ttcgcagcct gtgtcagaaa agagacggtc cgcgtgccac catgaagatc
      541 atgaattatg acgaatttca gcactgttgg agcaagttcg tgtacagcca aagagagcta
      601 tttgagcctt ggaataatct gcctaaatat tatatattac tgcacatcat gctgggggag
      661 attctcagac actcgatgga tccacccaca ttcactttca actttaacaa tgaaccttgg
      721 gtcagaggac ggcatgagac ttacctgtgt tatgaggtgg agcgcatgca caatgacacc
      781 tgggtcctgc tgaaccagcg caggggcttt ctatgcaacc aggctccaca taaacacggt
      841 ttccttgaag gccgccatgc agagctgtgc ttcctggacg tgattccctt ttggaagctg
      901 gacctggacc aggactacag ggttacctgc ttcacctcct ggagcccctg cttcagctgt
      961 gcccaggaaa tggctaaatt catttcaaaa aacaaacacg tgagcctgtg catcttcact
     1021 gcccgcatct atgatgatca aggaagatgt caggaggggc tgcgcaccct ggccgaggct
     1081 ggggccaaaa tttcaataat gacatacagt gaatttaagc actgctggga cacctttgtg
     1141 gaccaccagg gatgtccctt ccagccctgg gatggactag atgagcacag ccaagacctg
     1201 agtgggaggc tgcgggccat tctccagaat caggaaaact gaaggatggg cctcagtctc
     1261 taaggaaggc agagacctgg gttgagcctc agaataaaag atcttcttcc aagaaatgca
     1321 aacaggctgt tcaccaccat ctccagctga tcacagacac cagcaaagca atgcactcct
     1381 gaccaagtag attcttttaa aaattagagt gcattacttt gaatcaaaaa tttatttata
     1441 tttcaagaat aaagtactaa gattgtgctc aatacacaga aaagtttcaa acctactaat
     1501 ccagcgacaa tttgaatcgg ttttgtaggt agaggaataa aatgaaatac taaatctttc
     1561 tgta
//
