LOCUS       NM_145298               4496 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens apolipoprotein B mRNA editing enzyme catalytic subunit
            3F (APOBEC3F), transcript variant 1, mRNA.
ACCESSION   NM_145298
VERSION     NM_145298.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4496)
  AUTHORS   Suspene,R., Raymond,K.A., Boutin,L., Guillier,S., Lemoine,F.,
            Ferraris,O., Tournier,J.N., Iseni,F., Simon-Loriere,E. and
            Vartanian,J.P.
  TITLE     APOBEC3F Is a Mutational Driver of the Human Monkeypox Virus
            Identified in the 2022 Outbreak
  JOURNAL   J Infect Dis 228 (10), 1421-1429 (2023)
   PUBMED   37224627
  REMARK    GeneRIF: APOBEC3F Is a Mutational Driver of the Human Monkeypox
            Virus Identified in the 2022 Outbreak.
REFERENCE   2  (bases 1 to 4496)
  AUTHORS   Yousefi,M., Annan Sudarsan,A.K., Gaba,A. and Chelico,L.
  TITLE     Stability of APOBEC3F in the Presence of the APOBEC3 Antagonist
            HIV-1 Vif Increases at the Expense of Co-Expressed APOBEC3H
            Haplotype I
  JOURNAL   Viruses 15 (2), 463 (2023)
   PUBMED   36851677
  REMARK    GeneRIF: Stability of APOBEC3F in the Presence of the APOBEC3
            Antagonist HIV-1 Vif Increases at the Expense of Co-Expressed
            APOBEC3H Haplotype I.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4496)
  AUTHORS   Meissner,M.E., Willkomm,N.A., Lucas,J., Arndt,W.G., Aitken,S.F.,
            Julik,E.J., Baliga,S. and Mansky,L.M.
  TITLE     Differential Activity of APOBEC3F, APOBEC3G, and APOBEC3H in the
            Restriction of HIV-2
  JOURNAL   J Mol Biol 434 (2), 167355 (2022)
   PUBMED   34774569
  REMARK    GeneRIF: Differential Activity of APOBEC3F, APOBEC3G, and APOBEC3H
            in the Restriction of HIV-2.
REFERENCE   4  (bases 1 to 4496)
  AUTHORS   Wan,L., Kamba,K., Nagata,T. and Katahira,M.
  TITLE     An insight into the dependence of the deamination rate of human
            APOBEC3F on the length of single-stranded DNA, which is affected by
            the concentrations of APOBEC3F and single-stranded DNA
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (2), 129346 (2020)
   PUBMED   30986508
  REMARK    GeneRIF: analysis of the dependence of the deamination rate of
            human APOBEC3F on the length of single-stranded DNA, which is
            affected by the concentrations of APOBEC3F and single-stranded DNA
REFERENCE   5  (bases 1 to 4496)
  AUTHORS   Hu,Y., Desimmie,B.A., Nguyen,H.C., Ziegler,S.J., Cheng,T.C.,
            Chen,J., Wang,J., Wang,H., Zhang,K., Pathak,V.K. and Xiong,Y.
  TITLE     Structural basis of antagonism of human APOBEC3F by HIV-1 Vif
  JOURNAL   Nat Struct Mol Biol 26 (12), 1176-1183 (2019)
   PUBMED   31792451
  REMARK    GeneRIF: The cryo-EM structure of the Vif-targeted C-terminal
            domain of human A3F in complex with HIV-1 Vif and the cellular
            cofactor core-binding factor beta (CBFbeta) at 3.9-A resolution
            shows that Vif and CBFbeta form a platform to recruit A3F,
            revealing a direct A3F-recruiting role of CBFbeta beyond Vif
            stabilization, and it captures multiple independent A3F-Vif
            interfaces.
REFERENCE   6  (bases 1 to 4496)
  AUTHORS   Zhang,H., Yang,B., Pomerantz,R.J., Zhang,C., Arunachalam,S.C. and
            Gao,L.
  TITLE     The cytidine deaminase CEM15 induces hypermutation in newly
            synthesized HIV-1 DNA
  JOURNAL   Nature 424 (6944), 94-98 (2003)
   PUBMED   12808465
REFERENCE   7  (bases 1 to 4496)
  AUTHORS   Wedekind,J.E., Dance,G.S., Sowden,M.P. and Smith,H.C.
  TITLE     Messenger RNA editing in mammals: new members of the APOBEC family
            seeking roles in the family business
  JOURNAL   Trends Genet 19 (4), 207-216 (2003)
   PUBMED   12683974
  REMARK    Review article
            Erratum:[Trends Genet. 2003 Jul;19(7):369]
REFERENCE   8  (bases 1 to 4496)
  AUTHORS   Sheehy,A.M., Gaddis,N.C., Choi,J.D. and Malim,M.H.
  TITLE     Isolation of a human gene that inhibits HIV-1 infection and is
            suppressed by the viral Vif protein
  JOURNAL   Nature 418 (6898), 646-650 (2002)
   PUBMED   12167863
REFERENCE   9  (bases 1 to 4496)
  AUTHORS   Jarmuz,A., Chester,A., Bayliss,J., Gisbourne,J., Dunham,I.,
            Scott,J. and Navaratnam,N.
  TITLE     An anthropoid-specific locus of orphan C to U RNA-editing enzymes
            on chromosome 22
  JOURNAL   Genomics 79 (3), 285-296 (2002)
   PUBMED   11863358
REFERENCE   10 (bases 1 to 4496)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA221480.1, BC038808.1,
            CX165430.1, AL022318.2 and BQ182066.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145298.5.
            
            Summary: This gene is a member of the cytidine deaminase gene
            family. It is one of seven related genes or pseudogenes found in a
            cluster, thought to result from gene duplication, on chromosome 22.
            Members of the cluster encode proteins that are structurally and
            functionally related to the C to U RNA-editing cytidine deaminase
            APOBEC1. It is thought that the proteins may be RNA editing enzymes
            and have roles in growth or cell cycle control. Alternatively
            spliced transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript, and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038808.1, SRR1163655.505379.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308521.10/ ENSP00000309749.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA221480.1         261-279
            20-418              BC038808.1         1-399
            419-813             CX165430.1         406-800
            814-1229            BC038808.1         795-1210
            1230-3947           AL022318.2         168513-171230
            3948-4496           BQ182066.1         15-563              c
FEATURES             Location/Qualifiers
     source          1..4496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..4496
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /note="apolipoprotein B mRNA editing enzyme catalytic
                     subunit 3F"
                     /db_xref="GeneID:200316"
                     /db_xref="HGNC:HGNC:17356"
                     /db_xref="MIM:608993"
     exon            1..114
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1219
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /EC_number="3.5.4.38"
                     /note="isoform a is encoded by transcript variant 1;
                     induced upon T-cell activation; DNA dC->dU-editing enzyme
                     APOBEC-3F; apolipoprotein B mRNA-editing enzyme catalytic
                     polypeptide-like 3F; apolipoprotein B mRNA editing enzyme
                     cytidine deaminase; apolipoprotein B editing enzyme
                     catalytic polypeptide-like 3F"
                     /codon_start=1
                     /product="DNA dC->dU-editing enzyme APOBEC-3F isoform a"
                     /protein_id="NP_660341.2"
                     /db_xref="CCDS:CCDS33648.1"
                     /db_xref="GeneID:200316"
                     /db_xref="HGNC:HGNC:17356"
                     /db_xref="MIM:608993"
                     /translation="MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGP
                     SRPRLDAKIFRGQVYSQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAK
                     LAEFLAEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFV
                     YSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWL
                     CFTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTS
                     WSPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYK
                     DFKYCWENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE"
     exon            115..268
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /inference="alignment:Splign:2.1.0"
     exon            269..548
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /inference="alignment:Splign:2.1.0"
     exon            549..663
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /inference="alignment:Splign:2.1.0"
     exon            664..820
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1100
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..4496
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2412..2417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /note="hexamer: AATAAA"
     polyA_site      2434
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /note="major polyA site"
     regulatory      4473..4478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /note="hexamer: ATTAAA"
     polyA_site      4496
                     /gene="APOBEC3F"
                     /gene_synonym="A3F; ARP8; BK150C2.4.MRNA; KA6"
                     /note="major polyA site"
ORIGIN      
        1 actttaggga gggctgtcct gaaacctgga gcctggagca gaaagtgaaa ccctggtgct
       61 ccagacaaag atcttagtcg ggactagccg gccaaggatg aagcctcact tcagaaacac
      121 agtggagcga atgtatcgag acacattctc ctacaacttt tataatagac ccatcctttc
      181 tcgtcggaat accgtctggc tgtgctacga agtgaaaaca aagggtccct caaggccccg
      241 tttggacgca aagatctttc gaggccaggt gtattcccag cctgagcacc acgcagaaat
      301 gtgcttcctc tcttggttct gtggcaacca gctgcctgct tacaagtgtt tccagatcac
      361 ctggtttgta tcctggaccc cctgcccgga ctgtgtggcg aagctggccg aattcctggc
      421 tgagcacccc aatgtcaccc tgaccatctc cgccgcccgc ctctactact actgggaaag
      481 agattaccga agggcgctct gcaggctgag tcaggcaggg gcccgcgtga agattatgga
      541 cgatgaagaa tttgcatact gctgggaaaa ctttgtgtac agtgaaggtc agccattcat
      601 gccttggtac aaattcgatg acaattatgc attcctgcac cgcacgctaa aggagattct
      661 cagaaacccg atggaggcaa tgtatccaca catattctac ttccacttta aaaacctacg
      721 caaagcctat ggtcggaacg aaagctggct gtgcttcacc atggaagttg taaagcacca
      781 ctcacctgtc tcctggaaga ggggcgtctt ccgaaaccag gtggatcctg agacccattg
      841 tcatgcagaa aggtgcttcc tctcttggtt ctgtgacgac atactgtctc ctaacacaaa
      901 ctacgaggtc acctggtaca catcttggag cccttgccca gagtgtgcag gggaggtggc
      961 cgagttcctg gccaggcaca gcaacgtgaa tctcaccatc ttcaccgccc gcctctacta
     1021 cttctgggat acagattacc aggaggggct ccgcagcctg agtcaggaag gggcctccgt
     1081 ggagatcatg ggctacaaag attttaaata ttgttgggaa aactttgtgt acaatgatga
     1141 tgagccattc aagccttgga aaggactaaa atacaacttt ctattcctgg acagcaagct
     1201 gcaggagatt ctcgagtgag gggtctcccc gggcctcatg gtctgtctcc tctagcctcc
     1261 tgctcatgtt gtgcaggcct cccctccatc ctggaccagc tgtgcttttg cctggtcatc
     1321 ctgagcccct cctggcctca gggccattcc atagtgctcc cctgcctcac cacctcctct
     1381 ccgctctccc aggctcttcc tgcagaggcc tctttctgcc tccatggcta tccatccacc
     1441 caccaagacc ctgttccctg agcctgcatg cccctaacct gccttttccc atctccccag
     1501 cataacctaa tatttttttt ttttttttga gacggaattt cgctctgtca cccagactgg
     1561 agtgcaatgg cttgatcttg gctcactgca aactctgcct accaggttca agcgattctc
     1621 ctgcctccgc ctcccgagta gctggaatta cagacgcctg ccaccacgca cagctaactt
     1681 tttttttttt tgtattttta gtagtgactg ggtttcacca tgttggccag gctggtcttg
     1741 aactcctgac ctcaggtgat ccgcctatct cagcctccca aagtgctggg attacaggcg
     1801 tgagccactg gcccggcggc acaaccaaat cttattaaac tcaccctagg ctggccgcgg
     1861 tgactcatgc ctataatccc ccagcaattt gggaggcaga ggtgagagaa tcgcttgagc
     1921 ccaggaattc gagaccagcc tgggccacat gacaaagccc catctctaca aaaaaattac
     1981 aaaaaaaaaa aaaacaggtg tggtggcatg cacctgtagt tgaagctact tggaaggatg
     2041 aagtgggagg attgcttgag ccggggaggt ggaggctgca gtgaactgag atcacgtcac
     2101 tgaactccag tctgagcaac agatcgagac cctgcctgaa aataaatcaa taaataaact
     2161 caaccgaaat gggtatgaaa gttgaaatgg gtatgtaagt tgaaaaccag aagttttgag
     2221 aaacatcctt tgttaacttt catcctacaa attgggtcat tcatgtccta cgcagctaaa
     2281 acagagccca ggagccaggg aggaaaagca gtcaggccac acaccattgc tcccaaaatg
     2341 gacttctctg caagcctgac tcctgaaact gtgcattgta ccctgaaacc agctttatcc
     2401 atagcttctg caataaatgg ctgtaagtct tggactcctt gctataatcg cagctattca
     2461 gcaatggaac ctcccagttc ccaacccttc ctagtgccca tgggctttcc cataggacaa
     2521 gagaacattt ctccttttct tttttttttt ctttgaaatg gagtctcgcc ctgtcaccca
     2581 ggctggagtg caatggtgcg gtctcggctc actgcaacct ctgcctccct tgttcaagtg
     2641 attctcctgt ctcagcctcc cgagtagctg ggattacagg cgtccaccac caaaccaggc
     2701 taatttttgt atttttcata aaaacgggtt tcatcatgtt tcccaggctg gtcttatttt
     2761 tattttattt tttgagatgg agtcttgctc tgttgcccag gctggggtgc agtggtgcaa
     2821 tctgggttca ctgcagcctc tgccgcctga gttcaagcta ttttcctacc taagcctccc
     2881 aagtagctgg gattacatgc gcgtgccacc acgcctagct aatttttgtg tttttagtag
     2941 agacggggtt tcaacatctt gaccaggctg gtcttgaact cctgacctcg tgatccaccc
     3001 gtctcggcct cccaaagtgc tgggattaca ggcgtgagcc acctggccag gcttaggctg
     3061 gtcttaaact cctgacctca agtgatccaa cctccttggc ctcccaaatt gctgggattg
     3121 ctggtgtgag ccacagcgcc tagcccattt ctccttttaa taggacctgt tgctgtctct
     3181 gttctcccaa catggtgaac accacccgga ctgcgtgtat gtcccaaatt acaattcttt
     3241 ctttgcaaat gaaatgtgaa atttagaggc ccttctccac actttaaatt tgacttgaca
     3301 ttttctaggc agatataagt tattagagaa tgagattctc tataaaaatg atcccttcat
     3361 gctgtggcct ccacagaaga tgccctgggc caggtgccca catgaataat gcgggccaca
     3421 ggcaggcatt tattttctca cagatatgga ggctacaagt ccaaggtgga ggggtcggcg
     3481 gggttgtttg ctctgaggcc gctcctcctg gatggcaggg atcccttctg gctgtgtcct
     3541 ctgtggcctt tcctctatga acctgtactg tacctctggg gtctctctgc ttccaaatat
     3601 cttttttttt tttttcagac agttttgctc ttgttttcta ggctggagtg caatggcaca
     3661 atctcagctc actgcaacct ctgccttccg agttcaagcg attctcgtgc ctcagcctcc
     3721 tgagtagctg ggactacagg cgtgtgccac cacgcctggc taattttgta gttttagtag
     3781 agacggggtt tctccatgtt gctcaggctg gtcttgaact catgagctca ggcgatccac
     3841 tctcctcagc ctcccaaagt gctgggatta cagatataag ccaccataca caactttttt
     3901 ttttttttga gatggagttt cactctgttg cccaggctgg agtgctaaat agcagaatca
     3961 ctgctcactg caacctctgc ctgctgggtt caagcaattc tcccacctca gcctcctgag
     4021 tagctgggat tacagatgcc cagaaccaat ctctgctaat ttttctattt tttagtagag
     4081 atggggtttc actgaggaag gagaccacct ctctcattgt ctcctatttc agaaggaagc
     4141 aaaaagttag aaagatgcag aagtaagatc aatggccaga ctgtttggcg ctgctacctg
     4201 ggcctggtag ttaaagatca actcctgacc tgaccgcttg ttttatctaa agattccaga
     4261 cattgtatga ggaagcattg tgaaactttc tggtctgttc tgctagcccc caccactgat
     4321 gcatgtagcc ccccagtcac gtagcccacg cttgcacaat ctatcacgac cctttcacgt
     4381 ggacccctta gaattgtaag cccttaaaag ggccagggac ttcttcaggg agctccaatc
     4441 ttcagatgca agtctgtcaa cgctcccagc tgattaaagc ctcttccttc ctaaaa
//
