LOCUS       NM_152426               2515 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens apolipoprotein B mRNA editing enzyme catalytic subunit
            3D (APOBEC3D), transcript variant 1, mRNA.
ACCESSION   NM_152426
VERSION     NM_152426.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2515)
  AUTHORS   Takei,H., Fukuda,H., Pan,G., Yamazaki,H., Matsumoto,T., Kazuma,Y.,
            Fujii,M., Nakayama,S., Kobayashi,I.S., Shindo,K., Yamashita,R.,
            Shirakawa,K., Takaori-Kondo,A. and Kobayashi,S.S.
  TITLE     Alternative splicing of APOBEC3D generates functional diversity and
            its role as a DNA mutator
  JOURNAL   Int J Hematol 112 (3), 395-408 (2020)
   PUBMED   32533515
  REMARK    GeneRIF: Alternative splicing of APOBEC3D generates functional
            diversity and its role as a DNA mutator.
REFERENCE   2  (bases 1 to 2515)
  AUTHORS   Desimmie,B.A., Burdick,R.C., Izumi,T., Doi,H., Shao,W.,
            Alvord,W.G., Sato,K., Koyanagi,Y., Jones,S., Wilson,E., Hill,S.,
            Maldarelli,F., Hu,W.S. and Pathak,V.K.
  TITLE     APOBEC3 proteins can copackage and comutate HIV-1 genomes
  JOURNAL   Nucleic Acids Res 44 (16), 7848-7865 (2016)
   PUBMED   27439715
  REMARK    GeneRIF: These results indicate that APOBEC3 proteins can be
            copackaged and can comutate the same genomes, and can cooperate to
            inhibit HIV replication.
REFERENCE   3  (bases 1 to 2515)
  AUTHORS   Bouzidi,M.S., Caval,V., Suspene,R., Hallez,C., Pineau,P.,
            Wain-Hobson,S. and Vartanian,J.P.
  TITLE     APOBEC3DE Antagonizes Hepatitis B Virus Restriction Factors
            APOBEC3F and APOBEC3G
  JOURNAL   J Mol Biol 428 (17), 3514-3528 (2016)
   PUBMED   27289067
  REMARK    GeneRIF: APOBEC3DE binds to itself, APOBEC3F, and APOBEC3G and
            antagonizes APOBEC3F and, to a lesser extent, APOBEC3G restriction
            of hepatitis B virus replication.
REFERENCE   4  (bases 1 to 2515)
  AUTHORS   Liang,W., Xu,J., Yuan,W., Song,X., Zhang,J., Wei,W., Yu,X.F. and
            Yang,Y.
  TITLE     APOBEC3DE Inhibits LINE-1 Retrotransposition by Interacting with
            ORF1p and Influencing LINE Reverse Transcriptase Activity
  JOURNAL   PLoS One 11 (7), e0157220 (2016)
   PUBMED   27428332
  REMARK    GeneRIF: APOBEC3DE inhibits human LINE-1 retrotransposition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2515)
  AUTHORS   Sato,K., Takeuchi,J.S., Misawa,N., Izumi,T., Kobayashi,T.,
            Kimura,Y., Iwami,S., Takaori-Kondo,A., Hu,W.S., Aihara,K., Ito,M.,
            An,D.S., Pathak,V.K. and Koyanagi,Y.
  TITLE     APOBEC3D and APOBEC3F potently promote HIV-1 diversification and
            evolution in humanized mouse model
  JOURNAL   PLoS Pathog 10 (10), e1004453 (2014)
   PUBMED   25330146
  REMARK    GeneRIF: APOBEC3D/F and APOBEC3G fundamentally work as restriction
            factors against HIV-1 in vivo
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2515)
  AUTHORS   Conticello,S.G., Thomas,C.J., Petersen-Mahrt,S.K. and
            Neuberger,M.S.
  TITLE     Evolution of the AID/APOBEC family of polynucleotide
            (deoxy)cytidine deaminases
  JOURNAL   Mol Biol Evol 22 (2), 367-377 (2005)
   PUBMED   15496550
REFERENCE   7  (bases 1 to 2515)
  AUTHORS   Harris,R.S. and Liddament,M.T.
  TITLE     Retroviral restriction by APOBEC proteins
  JOURNAL   Nat Rev Immunol 4 (11), 868-877 (2004)
   PUBMED   15516966
  REMARK    Review article
REFERENCE   8  (bases 1 to 2515)
  AUTHORS   Sawyer,S.L., Emerman,M. and Malik,H.S.
  TITLE     Ancient adaptive evolution of the primate antiviral DNA-editing
            enzyme APOBEC3G
  JOURNAL   PLoS Biol 2 (9), E275 (2004)
   PUBMED   15269786
REFERENCE   9  (bases 1 to 2515)
  AUTHORS   Wedekind,J.E., Dance,G.S., Sowden,M.P. and Smith,H.C.
  TITLE     Messenger RNA editing in mammals: new members of the APOBEC family
            seeking roles in the family business
  JOURNAL   Trends Genet 19 (4), 207-216 (2003)
   PUBMED   12683974
  REMARK    Review article
            Erratum:[Trends Genet. 2003 Jul;19(7):369]
REFERENCE   10 (bases 1 to 2515)
  AUTHORS   Jarmuz,A., Chester,A., Bayliss,J., Gisbourne,J., Dunham,I.,
            Scott,J. and Navaratnam,N.
  TITLE     An anthropoid-specific locus of orphan C to U RNA-editing enzymes
            on chromosome 22
  JOURNAL   Genomics 79 (3), 285-296 (2002)
   PUBMED   11863358
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB121958.1, DA287097.1,
            EU527884.1, BC017022.1, BX340829.2 and AL022318.2.
            
            On Nov 22, 2018 this sequence version replaced NM_152426.3.
            
            Summary: This gene is a member of the cytidine deaminase gene
            family. It is one of a group of related genes found in a cluster,
            thought to result from gene duplication, on chromosome 22. Members
            of the cluster encode proteins that are structurally and
            functionally related to the C to U RNA-editing cytidine deaminase
            APOBEC1 and inhibit retroviruses, such as HIV, by deaminating
            cytosine residues in nascent retroviral cDNA. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq was created from transcript and genomic
            sequence data to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017022.1, SRR1803613.102281.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216099.13/ ENSP00000216099.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               DB121958.1         15-144
            131-393             DA287097.1         140-402
            394-998             EU527884.1         1-605
            999-1355            BC017022.1         635-991
            1356-1670           BX340829.2         436-750
            1671-2442           AL022318.2         148240-149011
            2443-2489           BC017022.1         2062-2108
            2490-2515           AL022318.2         149059-149084
FEATURES             Location/Qualifiers
     source          1..2515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2515
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /note="apolipoprotein B mRNA editing enzyme catalytic
                     subunit 3D"
                     /db_xref="GeneID:140564"
                     /db_xref="HGNC:HGNC:17354"
                     /db_xref="MIM:609900"
     exon            1..410
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             394..1554
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /EC_number="3.5.4.38"
                     /note="isoform 1 is encoded by transcript variant 1;
                     apolipoprotein B mRNA editing enzyme, catalytic
                     polypeptide-like 3E pseudogene; probable DNA
                     dC->dU-editing enzyme APOBEC-3D; apolipoprotein B mRNA
                     editing enzyme, catalytic polypeptide-like 3D"
                     /codon_start=1
                     /product="DNA dC->dU-editing enzyme APOBEC-3D isoform 1"
                     /protein_id="NP_689639.2"
                     /db_xref="CCDS:CCDS46709.1"
                     /db_xref="GeneID:140564"
                     /db_xref="HGNC:HGNC:17354"
                     /db_xref="MIM:609900"
                     /translation="MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRG
                     RSNLLWDTGVFRGPVLPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITW
                     FVSWNPCLPCVVKVTKFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIM
                     DYEDFAYCWENFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFK
                     NLLKACGRNESWLCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDIL
                     SPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSL
                     SQEGASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ"
     exon            411..603
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /inference="alignment:Splign:2.1.0"
     exon            604..883
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /inference="alignment:Splign:2.1.0"
     exon            884..998
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1155
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1435
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..2515
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2457..2462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /note="hexamer: AATAAA"
     regulatory      2469..2474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /note="hexamer: AATACA"
     polyA_site      2479
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /note="major polyA site"
     polyA_site      2485
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /note="major polyA site"
     regulatory      2494..2499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
                     /note="hexamer: AATATA"
     polyA_site      2515
                     /gene="APOBEC3D"
                     /gene_synonym="A3D; A3DE; APOBEC3DE; APOBEC3E; ARP6"
ORIGIN      
        1 agaggaagcc tcgctctctc acccaggctg gagtgcagtg gcaggaactt ggctcactgc
       61 aacctccgct tcccaggttc aagtgattct cctgcctcag cctccagagt agctgggatt
      121 acaggcgcac gtcaccacac ctggctaatt tttgtatttt tagtagagac ggggtttctc
      181 catgttggtc aggctggtct cgaactcctg acctcgtgat ccgcccgcct cggcctccca
      241 aagtgctggg attacaggcg tgagccaccg tgcccggccg ggaggtcact ttaaggaggg
      301 ctgtccaact gcaaggagcc gcaagcagga agtgaaacca cagcacttca aaaaaagagg
      361 gagactggga caagcgtatc taagaggctg aacatgaatc cacagatcag aaatccgatg
      421 gagcggatgt atcgagacac attctacgac aactttgaaa acgaacccat cctctatggt
      481 cggagctaca cttggctgtg ctatgaagtg aaaataaaga ggggccgctc aaatctcctt
      541 tgggacacag gggtctttcg aggcccggta ctacccaaac gtcagtcgaa tcacaggcag
      601 gaggtgtatt tccggtttga gaaccacgca gaaatgtgct tcttatcttg gttctgtggc
      661 aaccgactgc ctgctaacag gcgcttccag atcacctggt ttgtatcatg gaacccctgc
      721 ctgccctgtg tggtgaaggt gaccaaattc ttggctgagc accccaatgt caccctgacc
      781 atctctgccg cccgcctcta ctactaccgg gatagagatt ggcggtgggt gctcctcagg
      841 ctgcataagg caggggcccg tgtgaagatc atggactatg aagactttgc atactgctgg
      901 gaaaactttg tgtgcaatga aggtcagcca ttcatgcctt ggtacaaatt cgatgacaat
      961 tatgcatccc tgcaccgcac gctaaaggag attctcagaa acccgatgga ggcaatgtac
     1021 ccacacatat tctacttcca ctttaaaaac ctactgaaag cctgtggtcg gaacgaaagc
     1081 tggctgtgct tcaccatgga agttacaaag caccactcag ctgtcttccg gaagaggggc
     1141 gtcttccgaa accaggtgga tcctgagacc cattgtcatg cagaaaggtg cttcctctct
     1201 tggttctgtg acgacatact gtctcctaac acaaactacg aggtcacctg gtacacatct
     1261 tggagccctt gcccagagtg tgcaggggag gtggccgagt tcctggccag gcacagcaac
     1321 gtgaatctca ccatcttcac cgcccgcctc tgctacttct gggatacaga ttaccaggag
     1381 gggctctgca gcctgagtca ggaaggggcc tccgtgaaga tcatgggcta caaagatttt
     1441 gtatcttgtt ggaaaaactt tgtgtacagt gatgatgagc cattcaagcc ttggaaggga
     1501 ctacaaacca actttcgact tctgaaaaga aggctacggg agattctcca gtgaggggtc
     1561 tccctgggcc tcatggtctg tctcttctag cctcctgctc atgctgcacg ggcctcccct
     1621 ccatcctgca ccagctgtgc ttttgcctgg tcatcctgag cccctcctgg cctcagggcc
     1681 attccatagt gcccccctgc ctcaccacct cctccccgct ctcccaggct cttcttgtag
     1741 aggctctcca tccacctccc cagtcctgtt cccccagcct gggtgcccct aacttgactc
     1801 ttcccatctc cccagcataa ccaaatcttt tttttttttt tttttttttg agacggagtt
     1861 tcactctgtc gcccagacta gagtgcaatg gctggatctc agctcactgc aaactctgct
     1921 tactgggttc aagtgattct cctgtctcag cttctgagta gctgggatta cagatgcctg
     1981 ccaccacgcc cagctaattt tttttttttt tttttttttt ttttgtattt ttagtagtga
     2041 ctgggtttca ccatgttggc caggctggtc ttgaactcct gacctcaggt gatctgccca
     2101 tctctgtctc ccaaagtgct gggattacgg gcgtgagcca cccggctcgg ccgcacaacc
     2161 aaatcttatt aaactcaatc tagtctggcc ctggtgactc acgcctttcg gaggcagagg
     2221 tgggagaatc gcttgagccc agaagtttga gaccagcctg ggccacacga caaagcccca
     2281 tttctacaaa aaaaaatacc aaaaaaaagc cagatgtggt ggcatgcacc tgtagtttaa
     2341 gctacttggg aggatgaagt gggaggactg cttgagccgg ggaggtggag gctggagtaa
     2401 actgagatcg cgccacagaa ctccagtttg agcaacagat caagaccctg cctgaaaata
     2461 aatcaataaa tacactcaac ctaaatggat atgaatatat gtaagttgaa aacca
//
