LOCUS       NM_014508               2644 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens apolipoprotein B mRNA editing enzyme catalytic subunit
            3C (APOBEC3C), mRNA.
ACCESSION   NM_014508
VERSION     NM_014508.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Brown,G.W.
  TITLE     The cytidine deaminase APOBEC3C has unique sequence and genome
            feature preferences
  JOURNAL   Genetics 227 (4) (2024)
   PUBMED   38946641
  REMARK    GeneRIF: The cytidine deaminase APOBEC3C has unique sequence and
            genome feature preferences.
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Zhao,S., Li,Y., Xu,J. and Shen,L.
  TITLE     APOBEC3C is a novel target for the immune treatment of lower-grade
            gliomas
  JOURNAL   Neurol Res 46 (3), 227-242 (2024)
   PUBMED   38007705
  REMARK    GeneRIF: APOBEC3C is a novel target for the immune treatment of
            lower-grade gliomas.
REFERENCE   3  (bases 1 to 2644)
  AUTHORS   Zhang,S., Guo,Y., Hu,Y., Gao,X., Bai,F., Ding,Q., Hou,K., Wang,Z.,
            Sun,X., Zhao,H., Qu,Z. and Xu,Q.
  TITLE     The role of APOBEC3C in modulating the tumor microenvironment and
            stemness properties of glioma: evidence from pancancer analysis
  JOURNAL   Front Immunol 14, 1242972 (2023)
   PUBMED   37809064
  REMARK    GeneRIF: The role of APOBEC3C in modulating the tumor
            microenvironment and stemness properties of glioma: evidence from
            pancancer analysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2644)
  AUTHORS   Jin,J.S., Tsai,Y.L., Chang,Y.C. and Tsai,W.C.
  TITLE     Low Expression of A3C and PLP2 Indicating a Favorable Prognosis in
            Human Gliomas
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (7), 71-79 (2023)
   PUBMED   37715423
  REMARK    GeneRIF: Low Expression of A3C and PLP2 Indicating a Favorable
            Prognosis in Human Gliomas.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2644)
  AUTHORS   McIlroy,D., Peltier,C., Nguyen,M.L., Manceau,L., Mobuchon,L., Le
            Baut,N., Nguyen,N.K., Tran,M.C., Nguyen,T.C. and
            Bressollette-Bodin,C.
  TITLE     Quantification of APOBEC3 Mutation Rates Affecting the VP1 Gene of
            BK Polyomavirus In Vivo
  JOURNAL   Viruses 14 (9), 2077 (2022)
   PUBMED   36146883
  REMARK    GeneRIF: Quantification of APOBEC3 Mutation Rates Affecting the VP1
            Gene of BK Polyomavirus In Vivo.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2644)
  AUTHORS   Mariani,R., Chen,D., Schrofelbauer,B., Navarro,F., Konig,R.,
            Bollman,B., Munk,C., Nymark-McMahon,H. and Landau,N.R.
  TITLE     Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif
  JOURNAL   Cell 114 (1), 21-31 (2003)
   PUBMED   12859895
REFERENCE   7  (bases 1 to 2644)
  AUTHORS   Wedekind,J.E., Dance,G.S., Sowden,M.P. and Smith,H.C.
  TITLE     Messenger RNA editing in mammals: new members of the APOBEC family
            seeking roles in the family business
  JOURNAL   Trends Genet 19 (4), 207-216 (2003)
   PUBMED   12683974
  REMARK    Review article
            Erratum:[Trends Genet. 2003 Jul;19(7):369]
REFERENCE   8  (bases 1 to 2644)
  AUTHORS   Jarmuz,A., Chester,A., Bayliss,J., Gisbourne,J., Dunham,I.,
            Scott,J. and Navaratnam,N.
  TITLE     An anthropoid-specific locus of orphan C to U RNA-editing enzymes
            on chromosome 22
  JOURNAL   Genomics 79 (3), 285-296 (2002)
   PUBMED   11863358
REFERENCE   9  (bases 1 to 2644)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 2644)
  AUTHORS   Madsen,P., Anant,S., Rasmussen,H.H., Gromov,P., Vorum,H.,
            Dumanski,J.P., Tommerup,N., Collins,J.E., Wright,C.L., Dunham,I.,
            MacGinnitie,A.J., Davidson,N.O. and Celis,J.E.
  TITLE     Psoriasis upregulated phorbolin-1 shares structural but not
            functional similarity to the mRNA-editing protein apobec-1
  JOURNAL   J Invest Dermatol 113 (2), 162-169 (1999)
   PUBMED   10469298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL022318.2.
            
            On Nov 25, 2018 this sequence version replaced NM_014508.2.
            
            Summary: This gene is a member of the cytidine deaminase gene
            family. It is one of seven related genes or pseudogenes found in a
            cluster thought to result from gene duplication, on chromosome 22.
            Members of the cluster encode proteins that are structurally and
            functionally related to the C to U RNA-editing cytidine deaminase
            APOBEC1. It is thought that the proteins may be RNA editing enzymes
            and have roles in growth or cell cycle control. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU158817.1, SRR1163658.245793.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361441.5/ ENSP00000355340.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AL022318.2         130064-130186
            124-280             AL022318.2         131402-131558
            281-560             AL022318.2         133573-133852
            561-2644            AL022318.2         134076-136159
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2644
                     /gene="APOBEC3C"
                     /gene_synonym="A3C; APOBEC1L; ARDC2; ARDC4; ARP5;
                     bK150C2.3; PBI"
                     /note="apolipoprotein B mRNA editing enzyme catalytic
                     subunit 3C"
                     /db_xref="GeneID:27350"
                     /db_xref="HGNC:HGNC:17353"
                     /db_xref="MIM:607750"
     exon            1..123
                     /gene="APOBEC3C"
                     /gene_synonym="A3C; APOBEC1L; ARDC2; ARDC4; ARP5;
                     bK150C2.3; PBI"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..679
                     /gene="APOBEC3C"
                     /gene_synonym="A3C; APOBEC1L; ARDC2; ARDC4; ARP5;
                     bK150C2.3; PBI"
                     /EC_number="3.5.4.38"
                     /note="probable DNA dC->dU-editing enzyme APOBEC-3C;
                     phorbolin I; apolipoprotein B editing enzyme catalytic
                     polypeptide-like 3C; apolipoprotein B mRNA editing enzyme,
                     catalytic polypeptide-like 3C"
                     /codon_start=1
                     /product="DNA dC->dU-editing enzyme APOBEC-3C"
                     /protein_id="NP_055323.2"
                     /db_xref="CCDS:CCDS13983.1"
                     /db_xref="GeneID:27350"
                     /db_xref="HGNC:HGNC:17353"
                     /db_xref="MIM:607750"
                     /translation="MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKR
                     RSVVSWKTGVFRNQVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAG
                     EVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENF
                     VYNDNEPFKPWKGLKTNFRLLKRRLRESLQ"
     exon            124..280
                     /gene="APOBEC3C"
                     /gene_synonym="A3C; APOBEC1L; ARDC2; ARDC4; ARP5;
                     bK150C2.3; PBI"
                     /inference="alignment:Splign:2.1.0"
     exon            281..560
                     /gene="APOBEC3C"
                     /gene_synonym="A3C; APOBEC1L; ARDC2; ARDC4; ARP5;
                     bK150C2.3; PBI"
                     /inference="alignment:Splign:2.1.0"
     exon            561..2644
                     /gene="APOBEC3C"
                     /gene_synonym="A3C; APOBEC1L; ARDC2; ARDC4; ARP5;
                     bK150C2.3; PBI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2621..2626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOBEC3C"
                     /gene_synonym="A3C; APOBEC1L; ARDC2; ARDC4; ARP5;
                     bK150C2.3; PBI"
                     /note="hexamer: AATAAA"
     polyA_site      2644
                     /gene="APOBEC3C"
                     /gene_synonym="A3C; APOBEC1L; ARDC2; ARDC4; ARP5;
                     bK150C2.3; PBI"
                     /note="major polyA site"
ORIGIN      
        1 actttaaaga gggctgctca actgcaagga cgctgtaagc aggaagagaa gccacagcgc
       61 ttcagaaaag agtgggacag ggacaagcat atctaagagg ctgaacatga atccacagat
      121 cagaaacccg atgaaggcaa tgtatccagg cacattctac ttccaattta aaaacctatg
      181 ggaagccaac gatcggaacg aaacttggct gtgcttcacc gtggaaggta taaagcgccg
      241 ctcagttgtc tcctggaaga cgggcgtctt ccgaaaccag gtggattctg agacccattg
      301 tcatgcagaa aggtgcttcc tctcttggtt ctgcgacgac atactgtctc ctaacacaaa
      361 gtaccaggtc acctggtaca catcttggag cccttgccca gactgtgcag gggaggtggc
      421 cgagttcctg gccaggcaca gcaacgtgaa tctcaccatc ttcaccgccc gcctctacta
      481 cttccagtat ccatgttacc aggaggggct ccgcagcctg agtcaggaag gggtcgctgt
      541 ggagatcatg gactatgaag attttaaata ttgttgggaa aactttgtgt acaatgataa
      601 tgagccattc aagccttgga agggattaaa aaccaacttt cgacttctga aaagaaggct
      661 acgggagagt ctccagtgag gggtctccct gggcctcatg gtctgtctcc tctagcctcc
      721 tgctcatgct gcacgggcct cccctccacc ctggacccgc tctgtttctg cctggtcatc
      781 ctgagcccct cctggcctca gggccattcc acagtgctcc cctgcctcac cgcttcctcc
      841 tcgctcttcc agactcttcc tgcagaggct cctttctgcc tccatggcta tccatccacc
      901 cccacagacc ccgttcctcc agcctgcgtg cccctaacct ggcttttccc atctccccag
      961 cataaccaaa tcttactaaa ctcatcctag gctgggcatg gtgactcacg cctgtaatcc
     1021 cccagcaatt tgggaggcaa aggtgggaga atcgcgtgag cccaggagtt ccagaccagg
     1081 ctgggtcaca tgacaaagcc ccatctctac aaaaaaaaaa aaaaaaaaaa aaaaaaagcc
     1141 agatgtggtg gcatgcatct gtagtccaag ctacttggga ggctgaagtg ggaggattac
     1201 ttgagcccga gaggtggagg ctggagtgaa cagagatcgc gccactgaac tcgggtctgg
     1261 gcaacagata gagaccctgc ctgaaaataa atcgataaat aaactcaacc taaacaggtg
     1321 tgaatatatg taagttgaaa acccgaagtt ttgagaaaca tcctttgtaa atttcatcct
     1381 atgaattggg tcattcatgt cctacccagc taaaacagag gccaggagcc agggaggaaa
     1441 agcagtcagg ccacacaaca ttgtttccga aatggacttc tctgcaagcc tgactcctga
     1501 gactgtgcat tgtaccctga aaccagcttt atccatagct tctgcgataa atggctgtaa
     1561 gtcttggact ccttgctcca aacgcagcga ctcagcaata gaacctccca gctcccagcc
     1621 cttcctagtg cccatgggct ttacataggg caagagaaca tttctccttc tataattgcc
     1681 atctctttgc tctctcaaca tggtgaacac catccggact ccgtgtatgt ctcaaattac
     1741 aattctttct ttgcaaatga aatatgaaat ttagaggctc ttctaaacac tttaaatttg
     1801 atttgacatt ttcaaagcag atgtaagttt tagagaatga gattctccat aaaaatgacc
     1861 ctttcatgct gtggcctcca tagaagatgt cccaggccag gtgcccacat ggcaggcatt
     1921 tattttctca cagatctgga agctgcaggt ccaacttcga ggggtgggtg gggttgtttc
     1981 ctctgaggcc gctccttctg gctggcaggg agtctcttcc agccgtgtcc tctgtggcct
     2041 ttcctctatg cacacgcacc tctgggatct ctctgcctcc aaatatcatc tttttttttt
     2101 tttttttttt ttttgagaca gagtgttgct cctcttgtcc aggctggaat gcaatggcac
     2161 aatctggact cactgcaacc tccgcctccc gagtttaagc gattcttctg cttcagcctc
     2221 ccgagtaaaa ggcatgcatc accacacctg gttaattttg tagttttagt agagatgggg
     2281 tctcaccatg ttggccagac tggtctcgaa ctcctgacct caggtgatcc gcctgtctca
     2341 gcctctccaa gtgctgggat tacaggcatc agccactatg cccggctggg atcatatgtt
     2401 ccacacatgt ttgttcaata agcatggact gcaaccacct acatgaatat tcatagctcc
     2461 tcctgtagcc tgttgaatat gtatgtttag ccaacctctt cagcataaag ctcctgccca
     2521 aacccctcct gctcctaaat gtctgtctct ggtgttaacc agaggctgct cttcccaggc
     2581 tgctggatgg ctaccttgca ggctgtcacc cttaacaaga aataaagtgt cctttgcaaa
     2641 tgca
//
