LOCUS       NM_145699               1358 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens apolipoprotein B mRNA editing enzyme catalytic subunit
            3A (APOBEC3A), transcript variant 1, mRNA.
ACCESSION   NM_145699
VERSION     NM_145699.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1358)
  AUTHORS   Fingerman,D.F., O'Leary,D.R., Hansen,A.R., Tran,T., Harris,B.R.,
            DeWeerd,R.A., Hayer,K.E., Fan,J., Chen,E., Tennakoon,M., Meroni,A.,
            Szeto,J.H., Devenport,J., LaVigne,D., Weitzman,M.D., Shalem,O.,
            Bednarski,J., Vindigni,A., Zhao,X. and Green,A.M.
  TITLE     The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated
            replication stress
  JOURNAL   EMBO J 43 (15), 3240-3255 (2024)
   PUBMED   38886582
  REMARK    GeneRIF: The SMC5/6 complex prevents genotoxicity upon
            APOBEC3A-mediated replication stress.
REFERENCE   2  (bases 1 to 1358)
  AUTHORS   McCool,M.A., Bryant,C.J., Abriola,L., Surovtseva,Y.V. and
            Baserga,S.J.
  TITLE     The cytidine deaminase APOBEC3A regulates nucleolar function to
            promote cell growth and ribosome biogenesis
  JOURNAL   PLoS Biol 22 (7), e3002718 (2024)
   PUBMED   38976757
  REMARK    GeneRIF: The cytidine deaminase APOBEC3A regulates nucleolar
            function to promote cell growth and ribosome biogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1358)
  AUTHORS   Dennis,M., Hurley,A., Bray,N., Cordero,C., Ilagan,J., Mertz,T.M.
            and Roberts,S.A.
  TITLE     Her2 amplification, Rel-A, and Bach1 can influence APOBEC3A
            expression in breast cancer cells
  JOURNAL   PLoS Genet 20 (5), e1011293 (2024)
   PUBMED   38805570
  REMARK    GeneRIF: Her2 amplification, Rel-A, and Bach1 can influence
            APOBEC3A expression in breast cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1358)
  AUTHORS   Butt,Y., Sakhtemani,R., Mohamad-Ramshan,R., Lawrence,M.S. and
            Bhagwat,A.S.
  TITLE     Distinguishing preferences of human APOBEC3A and APOBEC3B for
            cytosines in hairpin loops, and reflection of these preferences in
            APOBEC-signature cancer genome mutations
  JOURNAL   Nat Commun 15 (1), 2369 (2024)
   PUBMED   38499553
  REMARK    GeneRIF: Distinguishing preferences of human APOBEC3A and APOBEC3B
            for cytosines in hairpin loops, and reflection of these preferences
            in APOBEC-signature cancer genome mutations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1358)
  AUTHORS   Zhang,K., Chen,F., Shen,H.Y., Zhang,P.P., Gao,H., Peng,H., Luo,Y.S.
            and Cheng,Z.S.
  TITLE     Regulatory variants of APOBEC3 genes potentially associate with
            COVID-19 severity in populations with African ancestry
  JOURNAL   Sci Rep 13 (1), 22435 (2023)
   PUBMED   38105291
  REMARK    GeneRIF: Regulatory variants of APOBEC3 genes potentially associate
            with COVID-19 severity in populations with African ancestry.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1358)
  AUTHORS   Kidd,J.M., Newman,T.L., Tuzun,E., Kaul,R. and Eichler,E.E.
  TITLE     Population stratification of a common APOBEC gene deletion
            polymorphism
  JOURNAL   PLoS Genet 3 (4), e63 (2007)
   PUBMED   17447845
REFERENCE   7  (bases 1 to 1358)
  AUTHORS   Jarmuz,A., Chester,A., Bayliss,J., Gisbourne,J., Dunham,I.,
            Scott,J. and Navaratnam,N.
  TITLE     An anthropoid-specific locus of orphan C to U RNA-editing enzymes
            on chromosome 22
  JOURNAL   Genomics 79 (3), 285-296 (2002)
   PUBMED   11863358
REFERENCE   8  (bases 1 to 1358)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   9  (bases 1 to 1358)
  AUTHORS   Madsen,P., Anant,S., Rasmussen,H.H., Gromov,P., Vorum,H.,
            Dumanski,J.P., Tommerup,N., Collins,J.E., Wright,C.L., Dunham,I.,
            MacGinnitie,A.J., Davidson,N.O. and Celis,J.E.
  TITLE     Psoriasis upregulated phorbolin-1 shares structural but not
            functional similarity to the mRNA-editing protein apobec-1
  JOURNAL   J Invest Dermatol 113 (2), 162-169 (1999)
   PUBMED   10469298
REFERENCE   10 (bases 1 to 1358)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI029063.1, BC126416.1,
            DB322320.1, U03891.2 and AL022318.2.
            
            On Nov 22, 2018 this sequence version replaced NM_145699.3.
            
            Summary: This gene is a member of the cytidine deaminase gene
            family. It is one of seven related genes or pseudogenes found in a
            cluster, thought to result from gene duplication, on chromosome 22.
            Members of the cluster encode proteins that are structurally and
            functionally related to the C to U RNA-editing cytidine deaminase
            APOBEC1. The protein encoded by this gene lacks the zinc binding
            activity of other family members. The protein plays a role in
            immunity, by restricting transmission of foreign DNA such as
            viruses. One mechanism of foreign DNA restriction is deamination of
            foreign double-stranded DNA cytidines to uridines, which leads to
            DNA degradation. However, other mechanisms are also thought to be
            involved, as anti-viral effect is not dependent on deaminase
            activity. Two transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U03891.2, ERR279847.6931.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249116.7/ ENSP00000249116.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BI029063.1         88-110
            24-788              BC126416.1         1-765
            789-1189            DB322320.1         116-516             c
            1190-1303           DB322320.1         1-114               c
            1304-1357           U03891.2           1295-1348
            1358-1358           AL022318.2         78991-78991
FEATURES             Location/Qualifiers
     source          1..1358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..1358
                     /gene="APOBEC3A"
                     /gene_synonym="A3A; ARP3; bK150C2.1; PHRBN"
                     /note="apolipoprotein B mRNA editing enzyme catalytic
                     subunit 3A"
                     /db_xref="GeneID:200315"
                     /db_xref="HGNC:HGNC:17343"
                     /db_xref="MIM:607109"
     exon            1..112
                     /gene="APOBEC3A"
                     /gene_synonym="A3A; ARP3; bK150C2.1; PHRBN"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..683
                     /gene="APOBEC3A"
                     /gene_synonym="A3A; ARP3; bK150C2.1; PHRBN"
                     /EC_number="3.5.4.38"
                     /note="isoform a is encoded by transcript variant 1;
                     probable DNA dC->dU-editing enzyme APOBEC-3A; phorbolin-1;
                     apolipoprotein B mRNA editing enzyme, catalytic
                     polypeptide-like 3A"
                     /codon_start=1
                     /product="DNA dC->dU-editing enzyme APOBEC-3A isoform a"
                     /protein_id="NP_663745.1"
                     /db_xref="CCDS:CCDS13981.1"
                     /db_xref="GeneID:200315"
                     /db_xref="HGNC:HGNC:17343"
                     /db_xref="MIM:607109"
                     /translation="MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGT
                     SVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCF
                     SWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKH
                     CWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN"
     exon            113..257
                     /gene="APOBEC3A"
                     /gene_synonym="A3A; ARP3; bK150C2.1; PHRBN"
                     /inference="alignment:Splign:2.1.0"
     exon            258..552
                     /gene="APOBEC3A"
                     /gene_synonym="A3A; ARP3; bK150C2.1; PHRBN"
                     /inference="alignment:Splign:2.1.0"
     exon            553..668
                     /gene="APOBEC3A"
                     /gene_synonym="A3A; ARP3; bK150C2.1; PHRBN"
                     /inference="alignment:Splign:2.1.0"
     exon            669..1358
                     /gene="APOBEC3A"
                     /gene_synonym="A3A; ARP3; bK150C2.1; PHRBN"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1358
                     /gene="APOBEC3A"
                     /gene_synonym="A3A; ARP3; bK150C2.1; PHRBN"
                     /note="major polyA site"
ORIGIN      
        1 gttggtgaag atcttaacac cacgccttga gcaagtcgca agagcgggag gacacagacc
       61 aggaaccgag aagggacaag cacatggaag ccagcccagc atccgggccc agacacttga
      121 tggatccaca catattcact tccaacttta acaatggcat tggaaggcat aagacctacc
      181 tgtgctacga agtggagcgc ctggacaatg gcacctcggt caagatggac cagcacaggg
      241 gctttctaca caaccaggct aagaatcttc tctgtggctt ttacggccgc catgcggagc
      301 tgcgcttctt ggacctggtt ccttctttgc agttggaccc ggcccagatc tacagggtca
      361 cttggttcat ctcctggagc ccctgcttct cctggggctg tgccggggaa gtgcgtgcgt
      421 tccttcagga gaacacacac gtgagactgc gtatcttcgc tgcccgcatc tatgattacg
      481 accccctata taaggaggca ctgcaaatgc tgcgggatgc tggggcccaa gtctccatca
      541 tgacctacga tgaatttaag cactgctggg acacctttgt ggaccaccag ggatgtccct
      601 tccagccctg ggatggacta gatgagcaca gccaagccct gagtgggagg ctgcgggcca
      661 ttctccagaa tcagggaaac tgaaggatgg gcctcagtct ctaaggaagg cagagacctg
      721 ggttgagcag cagaataaaa gatcttcttc caagaaatgc aaacagaccg ttcaccacca
      781 tctccagctg ctcacagacg ccagcaaagc agtatgctcc cgatcaagta gatttttaaa
      841 aaatcagagt gggccgggcg cggtggctca cgcctgtaat cccagcactt tggaggccaa
      901 ggcgggtgga tcacgaggtc aggagatcga gaccatcctg gctaacacgg tgaaaccctg
      961 tctctactaa aaatacaaaa aattagccag gcgtggtggc gggcgcctgt agtcccagct
     1021 actctggagg ctgaggcagg agagtagcgt gaacccggga ggcagagctt gcggtgagcc
     1081 gagattgcgc tactgcactc cagcctgggc gacagtacca gactccatct caaaaaaaaa
     1141 aaaaccagac tgaattaatt ttaactgaaa atttctctta tgttccaagt acacaatagt
     1201 aagattatgc tcaatattct cagaataatt ttcaatgtat taatgaaatg aaatgataat
     1261 ttggcttcat atctagacta acacaaaatt aagaatcttc cataattgct tttgctcagt
     1321 aactgtgtca tgaattgcaa gagtttccac aaacacta
//
