LOCUS       NM_001644                894 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens apolipoprotein B mRNA editing enzyme catalytic subunit
            1 (APOBEC1), transcript variant 1, mRNA.
ACCESSION   NM_001644
VERSION     NM_001644.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 894)
  AUTHORS   Wang,S., Kim,K., Gelvez,N., Chung,C., Gout,J.F., Fixman,B.,
            Vermulst,M. and Chen,X.S.
  TITLE     Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U
            RNA-editing activity
  JOURNAL   J Mol Biol 435 (24) (2023)
   PUBMED   38708190
  REMARK    GeneRIF: Identification of RBM46 as a novel APOBEC1 cofactor for
            C-to-U RNA-editing activity.
REFERENCE   2  (bases 1 to 894)
  AUTHORS   Wang,Y., Robinson,P.S., Coorens,T.H.H., Moore,L., Lee-Six,H.,
            Noorani,A., Sanders,M.A., Jung,H., Katainen,R., Heuschkel,R.,
            Brunton-Sim,R., Weston,R., Read,D., Nobbs,B., Fitzgerald,R.C.,
            Saeb-Parsy,K., Martincorena,I., Campbell,P.J., Rushbrook,S.,
            Zilbauer,M., Buczacki,S.J.A. and Stratton,M.R.
  TITLE     APOBEC mutagenesis is a common process in normal human small
            intestine
  JOURNAL   Nat Genet 55 (2), 246-254 (2023)
   PUBMED   36702998
  REMARK    GeneRIF: APOBEC mutagenesis is a common process in normal human
            small intestine.
REFERENCE   3  (bases 1 to 894)
  AUTHORS   Kim,K., Calabrese,P., Wang,S., Qin,C., Rao,Y., Feng,P. and
            Chen,X.S.
  TITLE     The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations,
            replication and fitness
  JOURNAL   Sci Rep 12 (1), 14972 (2022)
   PUBMED   36100631
  REMARK    GeneRIF: The roles of APOBEC-mediated RNA editing in SARS-CoV-2
            mutations, replication and fitness.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 894)
  AUTHORS   Yu,W., Li,J., Huang,S., Li,X., Li,P., Li,G., Liang,A., Chi,T. and
            Huang,X.
  TITLE     Harnessing A3G for efficient and selective C-to-T conversion at
            C-rich sequences
  JOURNAL   BMC Biol 19 (1), 34 (2021)
   PUBMED   33602235
  REMARK    GeneRIF: Harnessing A3G for efficient and selective C-to-T
            conversion at C-rich sequences.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 894)
  AUTHORS   Wong,L., Vizeacoumar,F.S., Vizeacoumar,F.J. and Chelico,L.
  TITLE     APOBEC1 cytosine deaminase activity on single-stranded DNA is
            suppressed by replication protein A
  JOURNAL   Nucleic Acids Res 49 (1), 322-339 (2021)
   PUBMED   33330905
  REMARK    GeneRIF: APOBEC1 cytosine deaminase activity on single-stranded DNA
            is suppressed by replication protein A.
REFERENCE   6  (bases 1 to 894)
  AUTHORS   Anant,S., MacGinnitie,A.J. and Davidson,N.O.
  TITLE     apobec-1, the catalytic subunit of the mammalian apolipoprotein B
            mRNA editing enzyme, is a novel RNA-binding protein
  JOURNAL   J Biol Chem 270 (24), 14762-14767 (1995)
   PUBMED   7782342
REFERENCE   7  (bases 1 to 894)
  AUTHORS   Navaratnam,N., Bhattacharya,S., Fujino,T., Patel,D., Jarmuz,A.L.
            and Scott,J.
  TITLE     Evolutionary origins of apoB mRNA editing: catalysis by a cytidine
            deaminase that has acquired a novel RNA-binding motif at its active
            site
  JOURNAL   Cell 81 (2), 187-195 (1995)
   PUBMED   7736571
REFERENCE   8  (bases 1 to 894)
  AUTHORS   Davidson,N.O., Innerarity,T.L., Scott,J., Smith,H., Driscoll,D.M.,
            Teng,B. and Chan,L.
  TITLE     Proposed nomenclature for the catalytic subunit of the mammalian
            apolipoprotein B mRNA editing enzyme: APOBEC-1
  JOURNAL   RNA 1 (1), 3 (1995)
   PUBMED   7489485
REFERENCE   9  (bases 1 to 894)
  AUTHORS   Espinosa,R. 3rd, Funahashi,T., Hadjiagapiou,C., Le Beau,M.M. and
            Davidson,N.O.
  TITLE     Assignment of the gene encoding the human apolipoprotein B mRNA
            editing enzyme (APOBEC1) to chromosome 12p13.1
  JOURNAL   Genomics 24 (2), 414-415 (1994)
   PUBMED   7698776
REFERENCE   10 (bases 1 to 894)
  AUTHORS   Lau,P.P., Zhu,H.J., Baldini,A., Charnsangavej,C. and Chan,L.
  TITLE     Dimeric structure of a human apolipoprotein B mRNA editing protein
            and cloning and chromosomal localization of its gene
  JOURNAL   Proc Natl Acad Sci U S A 91 (18), 8522-8526 (1994)
   PUBMED   8078915
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006927.27, BC144708.1,
            U72891.1 and AI380263.1.
            
            On Nov 29, 2018 this sequence version replaced NM_001644.4.
            
            Summary: This gene encodes a member of the cytidine deaminase
            enzyme family. The encoded protein forms a multiple-protein editing
            holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1
            stimulating protein (ASP). This holoenzyme is involved in the
            editing of C-to-U nucleotide bases in apolipoprotein B and
            neurofibromatosis-1 mRNAs. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U72891.1, L25877.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA2142586 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000229304.5/
                                                ENSP00000229304.4
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC006927.27        74378-74382         c
            6-25                BC144708.1         1-20
            26-597              U72891.1           12-583
            598-894             AI380263.1         12-308              c
FEATURES             Location/Qualifiers
     source          1..894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..894
                     /gene="APOBEC1"
                     /gene_synonym="APO1; APOBEC-1; BEDP; CDAR1; HEPR"
                     /note="apolipoprotein B mRNA editing enzyme catalytic
                     subunit 1"
                     /db_xref="GeneID:339"
                     /db_xref="HGNC:HGNC:604"
                     /db_xref="MIM:600130"
     exon            1..52
                     /gene="APOBEC1"
                     /gene_synonym="APO1; APOBEC-1; BEDP; CDAR1; HEPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..747
                     /gene="APOBEC1"
                     /gene_synonym="APO1; APOBEC-1; BEDP; CDAR1; HEPR"
                     /EC_number="3.5.4.36"
                     /note="isoform a is encoded by transcript variant 1;
                     C->U-editing enzyme APOBEC-1; apolipoprotein B mRNA
                     editing enzyme complex-1; apolipoprotein B mRNA-editing
                     enzyme 1; mRNA(cytosine(6666)) deaminase 1; apolipoprotein
                     B mRNA editing enzyme, catalytic polypeptide 1"
                     /codon_start=1
                     /product="C->U-editing enzyme APOBEC-1 isoform a"
                     /protein_id="NP_001635.2"
                     /db_xref="CCDS:CCDS8579.1"
                     /db_xref="GeneID:339"
                     /db_xref="HGNC:HGNC:604"
                     /db_xref="MIM:600130"
                     /translation="MTSEKGPSTGDPTLRRRIEPWEFDVFYDPRELRKEACLLYEIKW
                     GMSRKIWRSSGKNTTNHVEVNFIKKFTSERDFHPSMSCSITWFLSWSPCWECSQAIRE
                     FLSRHPGVTLVIYVARLFWHMDQQNRQGLRDLVNSGVTIQIMRASEYYHCWRNFVNYP
                     PGDEAHWPQYPPLWMMLYALELHCIILSLPPCLKISRRWQNHLTFFRLHLQNCHYQTI
                     PPHILLATGLIHPSVAWR"
     exon            53..80
                     /gene="APOBEC1"
                     /gene_synonym="APO1; APOBEC-1; BEDP; CDAR1; HEPR"
                     /inference="alignment:Splign:2.1.0"
     exon            81..478
                     /gene="APOBEC1"
                     /gene_synonym="APO1; APOBEC-1; BEDP; CDAR1; HEPR"
                     /inference="alignment:Splign:2.1.0"
     exon            479..597
                     /gene="APOBEC1"
                     /gene_synonym="APO1; APOBEC-1; BEDP; CDAR1; HEPR"
                     /inference="alignment:Splign:2.1.0"
     exon            598..894
                     /gene="APOBEC1"
                     /gene_synonym="APO1; APOBEC-1; BEDP; CDAR1; HEPR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      871..876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOBEC1"
                     /gene_synonym="APO1; APOBEC-1; BEDP; CDAR1; HEPR"
                     /note="hexamer: AATAAA"
     polyA_site      894
                     /gene="APOBEC1"
                     /gene_synonym="APO1; APOBEC-1; BEDP; CDAR1; HEPR"
                     /note="major polyA site"
ORIGIN      
        1 atgactccag aggaggaagt ccagagacag agcaccatga cttctgagaa aggtccttca
       61 accggtgacc ccactctgag gagaagaatc gaaccctggg agtttgacgt cttctatgac
      121 cccagagaac ttcgtaaaga ggcctgtctg ctctacgaaa tcaagtgggg catgagccgg
      181 aagatctggc gaagctcagg caaaaacacc accaatcacg tggaagttaa ttttataaaa
      241 aaatttacgt cagaaagaga ttttcaccca tccatgagct gctccatcac ctggttcttg
      301 tcctggagtc cctgctggga atgctcccag gctattagag agtttctgag tcggcaccct
      361 ggtgtgactc tagtgatcta cgtagctcgg cttttttggc acatggatca acaaaatcgg
      421 caaggtctca gggaccttgt taacagtgga gtaactattc agattatgag agcatcagag
      481 tattatcact gctggaggaa ttttgtcaac tacccacctg gggatgaagc tcactggcca
      541 caatacccac ctctgtggat gatgttgtac gcactggagc tgcactgcat aattctaagt
      601 cttccaccct gtttaaagat ttcaagaaga tggcaaaatc atcttacatt tttcagactt
      661 catcttcaaa actgccatta ccaaacgatt ccgccacaca tccttttagc tacagggctg
      721 atacatcctt ctgtggcttg gagatgaata ggatgattcc gtgtgtgtac tgattcaaga
      781 acaagcaatg atgacccact aaagagtgaa tgccatttag aatctagaaa tgttcacaag
      841 gtaccccaaa actctgtagc ttaaaccaac aataaatatg tattacctct ggca
//
