LOCUS       NM_000384              14121 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens apolipoprotein B (APOB), mRNA.
ACCESSION   NM_000384
VERSION     NM_000384.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14121)
  AUTHORS   Danner,R., Prochniak,L.M., Pereckas,M., Rouse,J.R., Wahhab,A.,
            Hackner,L.G. and Lochhead,R.B.
  TITLE     Identification of Major Histocompatibility Complex Class II
            Epitopes From Lyme Autoantigen Apolipoprotein B-100 and Borrelia
            burgdorferi Mcp4 in Murine Lyme Arthritis
  JOURNAL   J Infect Dis 230 (Supplement_1), S27-S39 (2024)
   PUBMED   39140726
  REMARK    GeneRIF: Identification of Major Histocompatibility Complex Class
            II Epitopes From Lyme Autoantigen Apolipoprotein B-100 and Borrelia
            burgdorferi Mcp4 in Murine Lyme Arthritis.
REFERENCE   2  (bases 1 to 14121)
  AUTHORS   Kothari,V., Ho,T.W.W., Cabodevilla,A.G., He,Y., Kramer,F.,
            Shimizu-Albergine,M., Kanter,J.E., Snell-Bergeon,J., Fisher,E.A.,
            Shao,B., Heinecke,J.W., Wobbrock,J.O., Lee,W.L., Goldberg,I.J.,
            Vaisar,T. and Bornfeldt,K.E.
  TITLE     Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes
            Drives Atherosclerosis
  JOURNAL   Circ Res 135 (2), 335-349 (2024)
   PUBMED   38828596
  REMARK    GeneRIF: Imbalance of APOB Lipoproteins and Large HDL in Type 1
            Diabetes Drives Atherosclerosis.
REFERENCE   3  (bases 1 to 14121)
  AUTHORS   De Oliveira-Gomes,D., Joshi,P.H., Peterson,E.D., Rohatgi,A.,
            Khera,A. and Navar,A.M.
  TITLE     Apolipoprotein B: Bridging the Gap Between Evidence and Clinical
            Practice
  JOURNAL   Circulation 150 (1), 62-79 (2024)
   PUBMED   38950110
  REMARK    GeneRIF: Apolipoprotein B: Bridging the Gap Between Evidence and
            Clinical Practice.
            Review article
REFERENCE   4  (bases 1 to 14121)
  AUTHORS   Mahsoub,N., Almenshawy,A., Taki Eldin,A.M., Abdel Hay,N.M.,
            Youssef,A.R., El-Farahaty,R.M., El-Sayed,K., Osman,A.M. and
            Elhennawy,E.S.
  TITLE     Association between Apo B, LDL-R and PCSK9 gene polymorphisms with
            coronary artery diseases in Egyptians
  JOURNAL   Mol Biol Rep 51 (1), 752 (2024)
   PUBMED   38874786
  REMARK    GeneRIF: Association between Apo B, LDL-R and PCSK9 gene
            polymorphisms with coronary artery diseases in Egyptians.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 14121)
  AUTHORS   Burnett,J.R., Hooper,A.J. and Hegele,R.A.
  TITLE     APOB-Related Familial Hypobetalipoproteinemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   33983694
REFERENCE   6  (bases 1 to 14121)
  AUTHORS   Ison,H.E., Clarke,S.L. and Knowles,J.W.
  TITLE     Familial Hypercholesterolemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24404629
REFERENCE   7  (bases 1 to 14121)
  AUTHORS   Deeb,S.S., Failor,R.A., Brown,B.G., Brunzell,J.D., Albers,J.J.,
            Motulsky,A.G. and Wijsman,E.
  TITLE     Association of apolipoprotein B gene variants with plasma apoB and
            low density lipoprotein (LDL) cholesterol levels
  JOURNAL   Hum Genet 88 (4), 463-470 (1992)
   PUBMED   1346774
REFERENCE   8  (bases 1 to 14121)
  AUTHORS   Sehayek,E. and Eisenberg,S.
  TITLE     Mechanisms of inhibition by apolipoprotein C of apolipoprotein
            E-dependent cellular metabolism of human triglyceride-rich
            lipoproteins through the low density lipoprotein receptor pathway
  JOURNAL   J Biol Chem 266 (27), 18259-18267 (1991)
   PUBMED   1917954
REFERENCE   9  (bases 1 to 14121)
  AUTHORS   Navajas,M., Laurent,A.M., Moreel,J.F., Ragab,A., Cambou,J.P.,
            Cuny,G., Cambien,F. and Roizes,G.
  TITLE     Detection by denaturing gradient gel electrophoresis of a new
            polymorphism in the apolipoprotein B gene
  JOURNAL   Hum Genet 86 (1), 91-93 (1990)
   PUBMED   1979313
REFERENCE   10 (bases 1 to 14121)
  AUTHORS   Higuchi,K., Hospattankar,A.V., Law,S.W., Meglin,N., Cortright,J.
            and Brewer,H.B. Jr.
  TITLE     Human apolipoprotein B (apoB) mRNA: identification of two distinct
            apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA
            containing a premature in-frame translational stop codon, in both
            liver and intestine
  JOURNAL   Proc Natl Acad Sci U S A 85 (6), 1772-1776 (1988)
   PUBMED   2450346
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010872.8, KF456638.1 and
            AC115619.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000384.2.
            
            Summary: This gene product is the main apolipoprotein of
            chylomicrons and low density lipoproteins (LDL), and is the ligand
            for the LDL receptor. It occurs in plasma as two main isoforms,
            apoB-48 and apoB-100: the former is synthesized exclusively in the
            gut and the latter in the liver. The intestinal and the hepatic
            forms of apoB are encoded by a single gene from a single, very long
            mRNA. The two isoforms share a common N-terminal sequence. The
            shorter apoB-48 protein is produced after RNA editing of the
            apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the
            creation of a stop codon, and early translation termination.
            Mutations in this gene or its regulatory region cause
            hypobetalipoproteinemia, normotriglyceridemic
            hypobetalipoproteinemia, and hypercholesterolemia due to
            ligand-defective apoB, diseases affecting plasma cholesterol and
            apoB levels. [provided by RefSeq, Dec 2019].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X04506.1, HM487065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233242.5/ ENSP00000233242.1
            RefSeq Select criteria :: based on single protein-coding transcript
            undergoes RNA editing  :: PMID: 16920700, 11727199
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AC010872.8         39114-39323         c
            211-249             AC010872.8         38763-38801         c
            250-365             AC010872.8         37611-37726         c
            366-511             AC010872.8         36188-36333         c
            512-665             AC010872.8         33208-33361         c
            666-821             AC010872.8         32350-32505         c
            822-946             AC010872.8         30834-30958         c
            947-1032            AC010872.8         30066-30151         c
            1033-1252           AC010872.8         28549-28768         c
            1253-1480           AC010872.8         27604-27831         c
            1481-1598           AC010872.8         25148-25265         c
            1599-1745           AC010872.8         24889-25035         c
            1746-1957           AC010872.8         23577-23788         c
            1958-2195           AC010872.8         23078-23315         c
            2196-2372           AC010872.8         22038-22214         c
            2373-2564           AC010872.8         20183-20374         c
            2565-2732           AC010872.8         18775-18942         c
            2733-2944           AC010872.8         18081-18292         c
            2945-3127           AC010872.8         14973-15155         c
            3128-3249           AC010872.8         14242-14363         c
            3250-3460           AC010872.8         11689-11899         c
            3461-3636           AC010872.8         10620-10795         c
            3637-3824           AC010872.8         10323-10510         c
            3825-3970           AC010872.8         9698-9843           c
            3971-4344           AC010872.8         8410-8783           c
            4345-4587           KF456638.1         147-389
            4588-11916          AC010872.8         330-7658            c
            11917-12031         AC115619.3         43367-43481         c
            12032-12215         AC115619.3         43075-43258         c
            12216-14121         AC115619.3         40235-42140         c
FEATURES             Location/Qualifiers
     source          1..14121
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.1"
     gene            1..14121
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /note="apolipoprotein B"
                     /db_xref="GeneID:338"
                     /db_xref="HGNC:HGNC:603"
                     /db_xref="MIM:107730"
     exon            1..210
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..13820
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /note="apolipoprotein B-100; apolipoprotein B48;
                     apolipoprotein B (including Ag(x) antigen)"
                     /codon_start=1
                     /product="apolipoprotein B-100 precursor"
                     /protein_id="NP_000375.3"
                     /db_xref="CCDS:CCDS1703.1"
                     /db_xref="GeneID:338"
                     /db_xref="HGNC:HGNC:603"
                     /db_xref="MIM:107730"
                     /translation="MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDAT
                     RFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEV
                     YGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGI
                     ISALLVPPETEEAKQVLFLDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPI
                     RTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFLPFSYKNKY
                     GMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKK
                     LTISEQNIQRANLFNKLVTELRGLSDEAVTSLLPQLIEVSSPITLQALVQCGQPQCST
                     HILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHAVN
                     NYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKS
                     SILKCVQSTKPSLMIQKAAIQALRKMEPKDKDQEVLLQTFLDDASPGDKRLAAYLMLM
                     RSPSQADINKIVQILPWEQNEQVKNFVASHIANILNSEELDIQDLKKLVKEALKESQL
                     PTVMDFRKFSRNYQLYKSVSLPSLDPASAKIEGNLIFDPNNYLPKESMLKTTLTAFGF
                     ASADLIEIGLEGKGFEPTLEALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGY
                     TKDDKHEQDMVNGIMLSVEKLIKDLKSKEVPEARAYLRILGEELGFASLHDLQLLGKL
                     LLMGARTLQGIPQMIGEVIRKGSKNDFFLHYIFMENAFELPTGAGLQLQISSSGVIAP
                     GAKAGVKLEVANMQAELVAKPSVSVEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAH
                     VALKAGKLKFIIPSPKRPVKLLSGGNTLHLVSTTKTEVIPPLIENRQSWSVCKQVFPG
                     LNYCTSGAYSNASSTDSASYYPLTGDTRLELELRPTGEIEQYSVSATYELQREDRALV
                     DTLKFVTQAEGAKQTEATMTFKYNRQSMTLSSEVQIPDFDVDLGTILRVNDESTEGKT
                     SYRLTLDIQNKKITEVALMGHLSCDTKEERKIKGVISIPRLQAEARSEILAHWSPAKL
                     LLQMDSSATAYGSTVSKRVAWHYDEEKIEFEWNTGTNVDTKKMTSNFPVDLSDYPKSL
                     HMYANRLLDHRVPQTDMTFRHVGSKLIVAMSSWLQKASGSLPYTQTLQDHLNSLKEFN
                     LQNMGLPDFHIPENLFLKSDGRVKYTLNKNSLKIEIPLPFGGKSSRDLKMLETVRTPA
                     LHFKSVGFHLPSREFQVPTFTIPKLYQLQVPLLGVLDLSTNVYSNLYNWSASYSGGNT
                     STDHFSLRARYHMKADSVVDLLSYNVQGSGETTYDHKNTFTLSCDGSLRHKFLDSNIK
                     FSHVEKLGNNPVSKGLLIFDASSSWGPQMSASVHLDSKKKQHLFVKEVKIDGQFRVSS
                     FYAKGTYGLSCQRDPNTGRLNGESNLRFNSSYLQGTNQITGRYEDGTLSLTSTSDLQS
                     GIIKNTASLKYENYELTLKSDTNGKYKNFATSNKMDMTFSKQNALLRSEYQADYESLR
                     FFSLLSGSLNSHGLELNADILGTDKINSGAHKATLRIGQDGISTSATTNLKCSLLVLE
                     NELNAELGLSGASMKLTTNGRFREHNAKFSLDGKAALTELSLGSAYQAMILGVDSKNI
                     FNFKVSQEGLKLSNDMMGSYAEMKFDHTNSLNIAGLSLDFSSKLDNIYSSDKFYKQTV
                     NLQLQPYSLVTTLNSDLKYNALDLTNNGKLRLEPLKLHVAGNLKGAYQNNEIKHIYAI
                     SSAALSASYKADTVAKVQGVEFSHRLNTDIAGLASAIDMSTNYNSDSLHFSNVFRSVM
                     APFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPLAFTFSHDYKGSTSHHLVSRK
                     SISAALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDAYNTKDKIGVELTGRTLAD
                     LTLLDSPIKVPLLLSEPINIIDALEMRDAVEKPQEFTIVAFVKYDKNQDVHSINLPFF
                     ETLQEYFERNRQTIIVVLENVQRNLKHINIDQFVRKYRAALGKLPQQANDYLNSFNWE
                     RQVSHAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYMIQFDQYIKDSYD
                     LHDLKIAIANIIDEIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIDFNKSGSSTASW
                     IQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAIDVRVLLDQLGTTIS
                     FERINDILEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLMDKLVEL
                     AHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKKLNELSFKTFIEDVNKFLDM
                     LIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELPQKAEALKLFLEETKATVAVY
                     LESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTRDRMYQMDIQQELQRYLSL
                     VGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRMKALVEQGFTVPEIKTILGT
                     MPAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKDLKNIKIPSRFSTPEFTILN
                     TFHIPSFTIDFVEMKVKIIRTIDQMLNSELQWPVPDIYLRDLKVEDIPLARITLPDFR
                     LPEIAIPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFT
                     LDANADIGNGTTSANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKINPLALKESV
                     KFSSKYLRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQLTLDSN
                     TKYFHKLNIPKLDFSSQADLRNEIKTLLKAGHIAWTSSGKGSWKWACPRFSDEGTHES
                     QISFTIEGPLTSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVL
                     TAKGMALFGEGKAEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVRF
                     PLRLTGKIDFLNNYALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGIN
                     GEANLDFLNIPLTIPEMRLPYTIITTPPLKDFSLWEKTGLKEFLKTTKQSFDLSVKAQ
                     YKKNKHRHSITNPLAVLCEFISQSIKSFDRHFEKNRNNALDFVTKSYNETKIKFDKYK
                     AEKSHDELPRTFQIPGYTVPVVNVEVSPFTIEMSAFGYVFPKAVSMPSFSILGSDVRV
                     PSYTLILPSLELPVLHVPRNLKLSLPDFKELCTISHIFIPAMGNITYDFSFKSSVITL
                     NTNAELFNQSDIVAHLLSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLSNKFVEG
                     SHNSTVSLTTKNMEVSVATTTKAQIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNS
                     SMLYSTAKGAVDHKLSLESLTSYFSIESSTKGDVKGSVLSREYSGTIASEANTYLNSK
                     STRSSVKLQGTSKIDDIWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGE
                     HTSKATLELSPWQMSALVQVHASQPSSFHDFPDLGQEVALNANTKNQKIRWKNEVRIH
                     SGSFQSQVELSNDQEKAHLDIAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGR
                     RQHLRVSTAFVYTKNPNGYSFSIPVKVLADKFIIPGLKLNDLNSVLVMPTFHVPFTDL
                     QVPSCKLDFREIQIYKKLRTSSFALNLPTLPEVKFPEVDVLTKYSQPEDSLIPFFEIT
                     VPESQLTVSQFTLPKSVSDGIAALDLNAVANKIADFELPTIIVPEQTIEIPSIKFSVP
                     AGIVIPSFQALTARFEVDSPVYNATWSASLKNKADYVETVLDSTCSSTVQFLEYELNV
                     LGTHKIEDGTLASKTKGTFAHRDFSAEYEEDGKYEGLQEWEGKAHLNIKSPAFTDLHL
                     RYQKDKKGISTSAASPAVGTVGMDMDEDDDFSKWNFYYSPQSSPDKKLTIFKTELRVR
                     ESDEETQIKVNWEEEAASGLLTSLKDNVPKATGVLYDYVNKYHWEHTGLTLREVSSKL
                     RRNLQNNAEWVYQGAIRQIDDIDVRFQKAASGTTGTYQEWKDKAQNLYQELLTQEGQA
                     SFQGLKDNVFDGLVRVTQEFHMKVKHLIDSLIDFLNFPRFQFPGKPGIYTREELCTMF
                     IREVGTVLSQVYSKVHNGSEILFSYFQDLVITLPFELRKHKLIDVISMYRELLKDLSK
                     EAQEVFKAIQSLKTTEVLRNLQDLLQFIFQLIEDNIKQLKEMKFTYLINYIQDEINTI
                     FSDYIPYVFKLLKENLCLNLHKFNEFIQNELQEASQELQQIHQYIMALREEYFDPSIV
                     GWTVKYYELEEKIVSLIKNLLVALKDFHSEYIVSASNFTSQLSSQVEQFLHRNIQEYL
                     SILTDPDGKGKEKIAELSATAQEIIKSQAIATKKIISDYHQQFRYKLQDFSDQLSDYY
                     EKFIAESKRLIDLSIQNYHTFLIYITELLKKLQSTTVMNPYMKLAPGELTIIL"
     exon            211..249
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            250..365
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            366..511
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            512..665
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            666..821
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            822..946
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1032
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1252
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1480
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1598
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1745
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1957
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2195
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2372
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2564
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2732
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2944
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3127
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3249
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3460
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3636
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3824
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3970
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            3971..4344
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            4345..11916
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            11917..12031
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            12032..12215
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     exon            12216..14121
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14093..14098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /note="hexamer: AATAAA"
     polyA_site      14121
                     /gene="APOB"
                     /gene_synonym="apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4"
                     /note="major polyA site"
ORIGIN      
        1 attcccaccg ggacctgcgg ggctgagtgc ccttctcggt tgctgccgct gaggagcccg
       61 cccagccagc cagggccgcg aggccgaggc caggccgcag cccaggagcc gccccaccgc
      121 agctggcgat ggacccgccg aggcccgcgc tgctggcgct gctggcgctg cctgcgctgc
      181 tgctgctgct gctggcgggc gccagggccg aagaggaaat gctggaaaat gtcagcctgg
      241 tctgtccaaa agatgcgacc cgattcaagc acctccggaa gtacacatac aactatgagg
      301 ctgagagttc cagtggagtc cctgggactg ctgattcaag aagtgccacc aggatcaact
      361 gcaaggttga gctggaggtt ccccagctct gcagcttcat cctgaagacc agccagtgca
      421 ccctgaaaga ggtgtatggc ttcaaccctg agggcaaagc cttgctgaag aaaaccaaga
      481 actctgagga gtttgctgca gccatgtcca ggtatgagct caagctggcc attccagaag
      541 ggaagcaggt tttcctttac ccggagaaag atgaacctac ttacatcctg aacatcaaga
      601 ggggcatcat ttctgccctc ctggttcccc cagagacaga agaagccaag caagtgttgt
      661 ttctggatac cgtgtatgga aactgctcca ctcactttac cgtcaagacg aggaagggca
      721 atgtggcaac agaaatatcc actgaaagag acctggggca gtgtgatcgc ttcaagccca
      781 tccgcacagg catcagccca cttgctctca tcaaaggcat gacccgcccc ttgtcaactc
      841 tgatcagcag cagccagtcc tgtcagtaca cactggacgc taagaggaag catgtggcag
      901 aagccatctg caaggagcaa cacctcttcc tgcctttctc ctacaagaat aagtatggga
      961 tggtagcaca agtgacacag actttgaaac ttgaagacac accaaagatc aacagccgct
     1021 tctttggtga aggtactaag aagatgggcc tcgcatttga gagcaccaaa tccacatcac
     1081 ctccaaagca ggccgaagct gttttgaaga ctctccagga actgaaaaaa ctaaccatct
     1141 ctgagcaaaa tatccagaga gctaatctct tcaataagct ggttactgag ctgagaggcc
     1201 tcagtgatga agcagtcaca tctctcttgc cacagctgat tgaggtgtcc agccccatca
     1261 ctttacaagc cttggttcag tgtggacagc ctcagtgctc cactcacatc ctccagtggc
     1321 tgaaacgtgt gcatgccaac ccccttctga tagatgtggt cacctacctg gtggccctga
     1381 tccccgagcc ctcagcacag cagctgcgag agatcttcaa catggcgagg gatcagcgca
     1441 gccgagccac cttgtatgcg ctgagccacg cggtcaacaa ctatcataag acaaacccta
     1501 cagggaccca ggagctgctg gacattgcta attacctgat ggaacagatt caagatgact
     1561 gcactgggga tgaagattac acctatttga ttctgcgggt cattggaaat atgggccaaa
     1621 ccatggagca gttaactcca gaactcaagt cttcaatcct gaaatgtgtc caaagtacaa
     1681 agccatcact gatgatccag aaagctgcca tccaggctct gcggaaaatg gagcctaaag
     1741 acaaggacca ggaggttctt cttcagactt tccttgatga tgcttctccg ggagataagc
     1801 gactggctgc ctatcttatg ttgatgagga gtccttcaca ggcagatatt aacaaaattg
     1861 tccaaattct accatgggaa cagaatgagc aagtgaagaa ctttgtggct tcccatattg
     1921 ccaatatctt gaactcagaa gaattggata tccaagatct gaaaaagtta gtgaaagaag
     1981 ctctgaaaga atctcaactt ccaactgtca tggacttcag aaaattctct cggaactatc
     2041 aactctacaa atctgtttct cttccatcac ttgacccagc ctcagccaaa atagaaggga
     2101 atcttatatt tgatccaaat aactaccttc ctaaagaaag catgctgaaa actaccctca
     2161 ctgcctttgg atttgcttca gctgacctca tcgagattgg cttggaagga aaaggctttg
     2221 agccaacatt ggaagctctt tttgggaagc aaggattttt cccagacagt gtcaacaaag
     2281 ctttgtactg ggttaatggt caagttcctg atggtgtctc taaggtctta gtggaccact
     2341 ttggctatac caaagatgat aaacatgagc aggatatggt aaatggaata atgctcagtg
     2401 ttgagaagct gattaaagat ttgaaatcca aagaagtccc ggaagccaga gcctacctcc
     2461 gcatcttggg agaggagctt ggttttgcca gtctccatga cctccagctc ctgggaaagc
     2521 tgcttctgat gggtgcccgc actctgcagg ggatccccca gatgattgga gaggtcatca
     2581 ggaagggctc aaagaatgac ttttttcttc actacatctt catggagaat gcctttgaac
     2641 tccccactgg agctggatta cagttgcaaa tatcttcatc tggagtcatt gctcccggag
     2701 ccaaggctgg agtaaaactg gaagtagcca acatgcaggc tgaactggtg gcaaaaccct
     2761 ccgtgtctgt ggagtttgtg acaaatatgg gcatcatcat tccggacttc gctaggagtg
     2821 gggtccagat gaacaccaac ttcttccacg agtcgggtct ggaggctcat gttgccctaa
     2881 aagctgggaa gctgaagttt atcattcctt ccccaaagag accagtcaag ctgctcagtg
     2941 gaggcaacac attacatttg gtctctacca ccaaaacgga ggtgatccca cctctcattg
     3001 agaacaggca gtcctggtca gtttgcaagc aagtctttcc tggcctgaat tactgcacct
     3061 caggcgctta ctccaacgcc agctccacag actccgcctc ctactatccg ctgaccgggg
     3121 acaccagatt agagctggaa ctgaggccta caggagagat tgagcagtat tctgtcagcg
     3181 caacctatga gctccagaga gaggacagag ccttggtgga taccctgaag tttgtaactc
     3241 aagcagaagg tgcgaagcag actgaggcta ccatgacatt caaatataat cggcagagta
     3301 tgaccttgtc cagtgaagtc caaattccgg attttgatgt tgacctcgga acaatcctca
     3361 gagttaatga tgaatctact gagggcaaaa cgtcttacag actcaccctg gacattcaga
     3421 acaagaaaat tactgaggtc gccctcatgg gccacctaag ttgtgacaca aaggaagaaa
     3481 gaaaaatcaa gggtgttatt tccatacccc gtttgcaagc agaagccaga agtgagatcc
     3541 tcgcccactg gtcgcctgcc aaactgcttc tccaaatgga ctcatctgct acagcttatg
     3601 gctccacagt ttccaagagg gtggcatggc attatgatga agagaagatt gaatttgaat
     3661 ggaacacagg caccaatgta gataccaaaa aaatgacttc caatttccct gtggatctct
     3721 ccgattatcc taagagcttg catatgtatg ctaatagact cctggatcac agagtccctc
     3781 aaacagacat gactttccgg cacgtgggtt ccaaattaat agttgcaatg agctcatggc
     3841 ttcagaaggc atctgggagt cttccttata cccagacttt gcaagaccac ctcaatagcc
     3901 tgaaggagtt caacctccag aacatgggat tgccagactt ccacatccca gaaaacctct
     3961 tcttaaaaag cgatggccgg gtcaaatata ccttgaacaa gaacagtttg aaaattgaga
     4021 ttcctttgcc ttttggtggc aaatcctcca gagatctaaa gatgttagag actgttagga
     4081 caccagccct ccacttcaag tctgtgggat tccatctgcc atctcgagag ttccaagtcc
     4141 ctacttttac cattcccaag ttgtatcaac tgcaagtgcc tctcctgggt gttctagacc
     4201 tctccacgaa tgtctacagc aacttgtaca actggtccgc ctcctacagt ggtggcaaca
     4261 ccagcacaga ccatttcagc cttcgggctc gttaccacat gaaggctgac tctgtggttg
     4321 acctgctttc ctacaatgtg caaggatctg gagaaacaac atatgaccac aagaatacgt
     4381 tcacactatc atgtgatggg tctctacgcc acaaatttct agattcgaat atcaaattca
     4441 gtcatgtaga aaaacttgga aacaacccag tctcaaaagg tttactaata ttcgatgcat
     4501 ctagttcctg gggaccacag atgtctgctt cagttcattt ggactccaaa aagaaacagc
     4561 atttgtttgt caaagaagtc aagattgatg ggcagttcag agtctcttcg ttctatgcta
     4621 aaggcacata tggcctgtct tgtcagaggg atcctaacac tggccggctc aatggagagt
     4681 ccaacctgag gtttaactcc tcctacctcc aaggcaccaa ccagataaca ggaagatatg
     4741 aagatggaac cctctccctc acctccacct ctgatctgca aagtggcatc attaaaaata
     4801 ctgcttccct aaagtatgag aactacgagc tgactttaaa atctgacacc aatgggaagt
     4861 ataagaactt tgccacttct aacaagatgg atatgacctt ctctaagcaa aatgcactgc
     4921 tgcgttctga atatcaggct gattacgagt cattgaggtt cttcagcctg ctttctggat
     4981 cactaaattc ccatggtctt gagttaaatg ctgacatctt aggcactgac aaaattaata
     5041 gtggtgctca caaggcgaca ctaaggattg gccaagatgg aatatctacc agtgcaacga
     5101 ccaacttgaa gtgtagtctc ctggtgctgg agaatgagct gaatgcagag cttggcctct
     5161 ctggggcatc tatgaaatta acaacaaatg gccgcttcag ggaacacaat gcaaaattca
     5221 gtctggatgg gaaagccgcc ctcacagagc tatcactggg aagtgcttat caggccatga
     5281 ttctgggtgt cgacagcaaa aacattttca acttcaaggt cagtcaagaa ggacttaagc
     5341 tctcaaatga catgatgggc tcatatgctg aaatgaaatt tgaccacaca aacagtctga
     5401 acattgcagg cttatcactg gacttctctt caaaacttga caacatttac agctctgaca
     5461 agttttataa gcaaactgtt aatttacagc tacagcccta ttctctggta actactttaa
     5521 acagtgacct gaaatacaat gctctggatc tcaccaacaa tgggaaacta cggctagaac
     5581 ccctgaagct gcatgtggct ggtaacctaa aaggagccta ccaaaataat gaaataaaac
     5641 acatctatgc catctcttct gctgccttat cagcaagcta taaagcagac actgttgcta
     5701 aggttcaggg tgtggagttt agccatcggc tcaacacaga catcgctggg ctggcttcag
     5761 ccattgacat gagcacaaac tataattcag actcactgca tttcagcaat gtcttccgtt
     5821 ctgtaatggc cccgtttacc atgaccatcg atgcacatac aaatggcaat gggaaactcg
     5881 ctctctgggg agaacatact gggcagctgt atagcaaatt cctgttgaaa gcagaacctc
     5941 tggcatttac tttctctcat gattacaaag gctccacaag tcatcatctc gtgtctagga
     6001 aaagcatcag tgcagctctt gaacacaaag tcagtgccct gcttactcca gctgagcaga
     6061 caggcacctg gaaactcaag acccaattta acaacaatga atacagccag gacttggatg
     6121 cttacaacac taaagataaa attggcgtgg agcttactgg acgaactctg gctgacctaa
     6181 ctctactaga ctccccaatt aaagtgccac ttttactcag tgagcccatc aatatcattg
     6241 atgctttaga gatgagagat gccgttgaga agccccaaga atttacaatt gttgcttttg
     6301 taaagtatga taaaaaccaa gatgttcact ccattaacct cccatttttt gagaccttgc
     6361 aagaatattt tgagaggaat cgacaaacca ttatagttgt actggaaaac gtacagagaa
     6421 acctgaagca catcaatatt gatcaatttg taagaaaata cagagcagcc ctgggaaaac
     6481 tcccacagca agctaatgat tatctgaatt cattcaattg ggagagacaa gtttcacatg
     6541 ccaaggagaa actgactgct ctcacaaaaa agtatagaat tacagaaaat gatatacaaa
     6601 ttgcattaga tgatgccaaa atcaacttta atgaaaaact atctcaactg cagacatata
     6661 tgatacaatt tgatcagtat attaaagata gttatgattt acatgatttg aaaatagcta
     6721 ttgctaatat tattgatgaa atcattgaaa aattaaaaag tcttgatgag cactatcata
     6781 tccgtgtaaa tttagtaaaa acaatccatg atctacattt gtttattgaa aatattgatt
     6841 ttaacaaaag tggaagtagt actgcatcct ggattcaaaa tgtggatact aagtaccaaa
     6901 tcagaatcca gatacaagaa aaactgcagc agcttaagag acacatacag aatatagaca
     6961 tccagcacct agctggaaag ttaaaacaac acattgaggc tattgatgtt agagtgcttt
     7021 tagatcaatt gggaactaca atttcatttg aaagaataaa tgacattctt gagcatgtca
     7081 aacactttgt tataaatctt attggggatt ttgaagtagc tgagaaaatc aatgccttca
     7141 gagccaaagt ccatgagtta atcgagaggt atgaagtaga ccaacaaatc caggttttaa
     7201 tggataaatt agtagagttg gcccaccaat acaagttgaa ggagactatt cagaagctaa
     7261 gcaatgtcct acaacaagtt aagataaaag attactttga gaaattggtt ggatttattg
     7321 atgatgctgt caagaagctt aatgaattat cttttaaaac attcattgaa gatgttaaca
     7381 aattccttga catgttgata aagaaattaa agtcatttga ttaccaccag tttgtagatg
     7441 aaaccaatga caaaatccgt gaggtgactc agagactcaa tggtgaaatt caggctctgg
     7501 aactaccaca aaaagctgaa gcattaaaac tgtttttaga ggaaaccaag gccacagttg
     7561 cagtgtatct ggaaagccta caggacacca aaataacctt aatcatcaat tggttacagg
     7621 aggctttaag ttcagcatct ttggctcaca tgaaggccaa attccgagag accctagaag
     7681 atacacgaga ccgaatgtat caaatggaca ttcagcagga acttcaacga tacctgtctc
     7741 tggtaggcca ggtttatagc acacttgtca cctacatttc tgattggtgg actcttgctg
     7801 ctaagaacct tactgacttt gcagagcaat attctatcca agattgggct aaacgtatga
     7861 aagcattggt agagcaaggg ttcactgttc ctgaaatcaa gaccatcctt gggaccatgc
     7921 ctgcctttga agtcagtctt caggctcttc agaaagctac cttccagaca cctgatttta
     7981 tagtccccct aacagatttg aggattccat cagttcagat aaacttcaaa gacttaaaaa
     8041 atataaaaat cccatccagg ttttccacac cagaatttac catccttaac accttccaca
     8101 ttccttcctt tacaattgac tttgtagaaa tgaaagtaaa gatcatcaga accattgacc
     8161 agatgctgaa cagtgagctg cagtggcccg ttccagatat atatctcagg gatctgaagg
     8221 tggaggacat tcctctagcg agaatcaccc tgccagactt ccgtttacca gaaatcgcaa
     8281 ttccagaatt cataatccca actctcaacc ttaatgattt tcaagttcct gaccttcaca
     8341 taccagaatt ccagcttccc cacatctcac acacaattga agtacctact tttggcaagc
     8401 tatacagtat tctgaaaatc caatctcctc ttttcacatt agatgcaaat gctgacatag
     8461 ggaatggaac cacctcagca aacgaagcag gtatcgcagc ttccatcact gccaaaggag
     8521 agtccaaatt agaagttctc aattttgatt ttcaagcaaa tgcacaactc tcaaacccta
     8581 agattaatcc gctggctctg aaggagtcag tgaagttctc cagcaagtac ctgagaacgg
     8641 agcatgggag tgaaatgctg ttttttggaa atgctattga gggaaaatca aacacagtgg
     8701 caagtttaca cacagaaaaa aatacactgg agcttagtaa tggagtgatt gtcaagataa
     8761 acaatcagct taccctggat agcaacacta aatacttcca caaattgaac atccccaaac
     8821 tggacttctc tagtcaggct gacctgcgca acgagatcaa gacactgttg aaagctggcc
     8881 acatagcatg gacttcttct ggaaaagggt catggaaatg ggcctgcccc agattctcag
     8941 atgagggaac acatgaatca caaattagtt tcaccataga aggacccctc acttcctttg
     9001 gactgtccaa taagatcaat agcaaacacc taagagtaaa ccaaaacttg gtttatgaat
     9061 ctggctccct caacttttct aaacttgaaa ttcaatcaca agtcgattcc cagcatgtgg
     9121 gccacagtgt tctaactgct aaaggcatgg cactgtttgg agaagggaag gcagagttta
     9181 ctgggaggca tgatgctcat ttaaatggaa aggttattgg aactttgaaa aattctcttt
     9241 tcttttcagc ccagccattt gagatcacgg catccacaaa caatgaaggg aatttgaaag
     9301 ttcgttttcc attaaggtta acagggaaga tagacttcct gaataactat gcactgtttc
     9361 tgagtcccag tgcccagcaa gcaagttggc aagtaagtgc taggttcaat cagtataagt
     9421 acaaccaaaa tttctctgct ggaaacaacg agaacattat ggaggcccat gtaggaataa
     9481 atggagaagc aaatctggat ttcttaaaca ttcctttaac aattcctgaa atgcgtctac
     9541 cttacacaat aatcacaact cctccactga aagatttctc tctatgggaa aaaacaggct
     9601 tgaaggaatt cttgaaaacg acaaagcaat catttgattt aagtgtaaaa gctcagtata
     9661 agaaaaacaa acacaggcat tccatcacaa atcctttggc tgtgctttgt gagtttatca
     9721 gtcagagcat caaatccttt gacaggcatt ttgaaaaaaa cagaaacaat gcattagatt
     9781 ttgtcaccaa atcctataat gaaacaaaaa ttaagtttga taagtacaaa gctgaaaaat
     9841 ctcacgacga gctccccagg acctttcaaa ttcctggata cactgttcca gttgtcaatg
     9901 ttgaagtgtc tccattcacc atagagatgt cggcattcgg ctatgtgttc ccaaaagcag
     9961 tcagcatgcc tagtttctcc atcctaggtt ctgacgtccg tgtgccttca tacacattaa
    10021 tcctgccatc attagagctg ccagtccttc atgtccctag aaatctcaag ctttctcttc
    10081 cagatttcaa ggaattgtgt accataagcc atatttttat tcctgccatg ggcaatatta
    10141 cctatgattt ctcctttaaa tcaagtgtca tcacactgaa taccaatgct gaacttttta
    10201 accagtcaga tattgttgct catctccttt cttcatcttc atctgtcatt gatgcactgc
    10261 agtacaaatt agagggcacc acaagattga caagaaaaag gggattgaag ttagccacag
    10321 ctctgtctct gagcaacaaa tttgtggagg gtagtcataa cagtactgtg agcttaacca
    10381 cgaaaaatat ggaagtgtca gtggcaacaa ccacaaaagc ccaaattcca attttgagaa
    10441 tgaatttcaa gcaagaactt aatggaaata ccaagtcaaa acctactgtc tcttcctcca
    10501 tggaatttaa gtatgatttc aattcttcaa tgctgtactc taccgctaaa ggagcagttg
    10561 accacaagct tagcttggaa agcctcacct cttacttttc cattgagtca tctaccaaag
    10621 gagatgtcaa gggttcggtt ctttctcggg aatattcagg aactattgct agtgaggcca
    10681 acacttactt gaattccaag agcacacggt cttcagtgaa gctgcagggc acttccaaaa
    10741 ttgatgatat ctggaacctt gaagtaaaag aaaattttgc tggagaagcc acactccaac
    10801 gcatatattc cctctgggag cacagtacga aaaaccactt acagctagag ggcctctttt
    10861 tcaccaacgg agaacataca agcaaagcca ccctggaact ctctccatgg caaatgtcag
    10921 ctcttgttca ggtccatgca agtcagccca gttccttcca tgatttccct gaccttggcc
    10981 aggaagtggc cctgaatgct aacactaaga accagaagat cagatggaaa aatgaagtcc
    11041 ggattcattc tgggtctttc cagagccagg tcgagctttc caatgaccaa gaaaaggcac
    11101 accttgacat tgcaggatcc ttagaaggac acctaaggtt cctcaaaaat atcatcctac
    11161 cagtctatga caagagctta tgggatttcc taaagctgga tgtaaccacc agcattggta
    11221 ggagacagca tcttcgtgtt tcaactgcct ttgtgtacac caaaaacccc aatggctatt
    11281 cattctccat ccctgtaaaa gttttggctg ataaattcat tattcctggg ctgaaactaa
    11341 atgatctaaa ttcagttctt gtcatgccta cgttccatgt cccatttaca gatcttcagg
    11401 ttccatcgtg caaacttgac ttcagagaaa tacaaatcta taagaagctg agaacttcat
    11461 catttgccct caacctacca acactccccg aggtaaaatt ccctgaagtt gatgtgttaa
    11521 caaaatattc tcaaccagaa gactccttga ttcccttttt tgagataacc gtgcctgaat
    11581 ctcagttaac tgtgtcccag ttcacgcttc caaaaagtgt ttcagatggc attgctgctt
    11641 tggatctaaa tgcagtagcc aacaagatcg cagactttga gttgcccacc atcatcgtgc
    11701 ctgagcagac cattgagatt ccctccatta agttctctgt acctgctgga attgtcattc
    11761 cttcctttca agcactgact gcacgctttg aggtagactc tcccgtgtat aatgccactt
    11821 ggagtgccag tttgaaaaac aaagcagatt atgttgaaac agtcctggat tccacatgca
    11881 gctcaaccgt acagttccta gaatatgaac taaatgtttt gggaacacac aaaatcgaag
    11941 atggtacgtt agcctctaag actaaaggaa catttgcaca ccgtgacttc agtgcagaat
    12001 atgaagaaga tggcaaatat gaaggacttc aggaatggga aggaaaagcg cacctcaata
    12061 tcaaaagccc agcgttcacc gatctccatc tgcgctacca gaaagacaag aaaggcatct
    12121 ccacctcagc agcctcccca gccgtaggca ccgtgggcat ggatatggat gaagatgacg
    12181 acttttctaa atggaacttc tactacagcc ctcagtcctc tccagataaa aaactcacca
    12241 tattcaaaac tgagttgagg gtccgggaat ctgatgagga aactcagatc aaagttaatt
    12301 gggaagaaga ggcagcttct ggcttgctaa cctctctgaa agacaacgtg cccaaggcca
    12361 caggggtcct ttatgattat gtcaacaagt accactggga acacacaggg ctcaccctga
    12421 gagaagtgtc ttcaaagctg agaagaaatc tgcagaacaa tgctgagtgg gtttatcaag
    12481 gggccattag gcaaattgat gatatcgacg tgaggttcca gaaagcagcc agtggcacca
    12541 ctgggaccta ccaagagtgg aaggacaagg cccagaatct gtaccaggaa ctgttgactc
    12601 aggaaggcca agccagtttc cagggactca aggataacgt gtttgatggc ttggtacgag
    12661 ttactcaaga attccatatg aaagtcaagc atctgattga ctcactcatt gattttctga
    12721 acttccccag attccagttt ccggggaaac ctgggatata cactagggag gaactttgca
    12781 ctatgttcat aagggaggta gggacggtac tgtcccaggt atattcgaaa gtccataatg
    12841 gttcagaaat actgttttcc tatttccaag acctagtgat tacacttcct ttcgagttaa
    12901 ggaaacataa actaatagat gtaatctcga tgtataggga actgttgaaa gatttatcaa
    12961 aagaagccca agaggtattt aaagccattc agtctctcaa gaccacagag gtgctacgta
    13021 atcttcagga ccttttacaa ttcattttcc aactaataga agataacatt aaacagctga
    13081 aagagatgaa atttacttat cttattaatt atatccaaga tgagatcaac acaatcttca
    13141 gtgattatat cccatatgtt tttaaattgt tgaaagaaaa cctatgcctt aatcttcata
    13201 agttcaatga atttattcaa aacgagcttc aggaagcttc tcaagagtta cagcagatcc
    13261 atcaatacat tatggccctt cgtgaagaat attttgatcc aagtatagtt ggctggacag
    13321 tgaaatatta tgaacttgaa gaaaagatag tcagtctgat caagaacctg ttagttgctc
    13381 ttaaggactt ccattctgaa tatattgtca gtgcctctaa ctttacttcc caactctcaa
    13441 gtcaagttga gcaatttctg cacagaaata ttcaggaata tcttagcatc cttaccgatc
    13501 cagatggaaa agggaaagag aagattgcag agctttctgc cactgctcag gaaataatta
    13561 aaagccaggc cattgcgacg aagaaaataa tttctgatta ccaccagcag tttagatata
    13621 aactgcaaga tttttcagac caactctctg attactatga aaaatttatt gctgaatcca
    13681 aaagattgat tgacctgtcc attcaaaact accacacatt tctgatatac atcacggagt
    13741 tactgaaaaa gctgcaatca accacagtca tgaaccccta catgaagctt gctccaggag
    13801 aacttactat catcctctaa ttttttaaaa gaaatcttca tttattcttc ttttccaatt
    13861 gaactttcac atagcacaga aaaaattcaa actgcctata ttgataaaac catacagtga
    13921 gccagccttg cagtaggcag tagactataa gcagaagcac atatgaactg gacctgcacc
    13981 aaagctggca ccagggctcg gaaggtctct gaactcagaa ggatggcatt ttttgcaagt
    14041 taaagaaaat caggatctga gttattttgc taaacttggg ggaggaggaa caaataaatg
    14101 gagtctttat tgtgtatcat a
//
