LOCUS       NM_000482               1471 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens apolipoprotein A4 (APOA4), mRNA.
ACCESSION   NM_000482
VERSION     NM_000482.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1471)
  AUTHORS   MacKeigan,D.T., Yu,S.Y., Chazot,N., Zhang,D., Khoury,C.J., Lei,X.,
            Bhoria,P., Shen,C., Chen,P., Zhu,G., Rand,M.L., Heximer,S. and
            Ni,H.
  TITLE     Apolipoprotein A-IV polymorphisms Q360H and T347S attenuate its
            endogenous inhibition of thrombosis
  JOURNAL   Biochem Biophys Res Commun 712-713, 149946 (2024)
   PUBMED   38643717
  REMARK    GeneRIF: Apolipoprotein A-IV polymorphisms Q360H and T347S
            attenuate its endogenous inhibition of thrombosis.
REFERENCE   2  (bases 1 to 1471)
  AUTHORS   Kmochova,T., Kidd,K.O., Orr,A., Hnizda,A., Hartmannova,H.,
            Hodanova,K., Vyletal,P., Nausova,K., Brinsa,V., Treslova,H.,
            Sovova,J., Baresova,V., Svojsova,K., Vrbacka,A., Stranecky,V.,
            Robins,V.C., Taylor,A., Martin,L., Rivas-Chavez,A., Payne,R.,
            Bleyer,H.A., Williams,A., Rennke,H.G., Weins,A., Short,P.J.,
            Agrawal,V., Storsley,L.J., Waikar,S.S., McPhail,E.D., Dasari,S.,
            Leung,N., Hewlett,T., Yorke,J., Gaston,D., Geldenhuys,L.,
            Samuels,M., Levine,A.P., West,M., Hulkova,H., Pompach,P., Novak,P.,
            Weinberg,R.B., Bedard,K., Zivna,M., Sikora,J., Bleyer,A.J. Sr. and
            Kmoch,S.
  TITLE     Autosomal dominant ApoA4 mutations present as tubulointerstitial
            kidney disease with medullary amyloidosis
  JOURNAL   Kidney Int 105 (4), 799-811 (2024)
   PUBMED   38096951
  REMARK    GeneRIF: Autosomal dominant ApoA4 mutations present as
            tubulointerstitial kidney disease with medullary amyloidosis.
REFERENCE   3  (bases 1 to 1471)
  AUTHORS   Andraski,A.B., Singh,S.A., Higashi,H., Lee,L.H., Aikawa,M. and
            Sacks,F.M.
  TITLE     The distinct metabolism between large and small HDL indicates
            unique origins of human apolipoprotein A4
  JOURNAL   JCI Insight 8 (8), e162481 (2023)
   PUBMED   37092549
  REMARK    GeneRIF: The distinct metabolism between large and small HDL
            indicates unique origins of human apolipoprotein A4.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1471)
  AUTHORS   Ji,J., Zhao,X., Huang,J., Wu,X., Xie,F., Li,L., Wang,T. and Mi,S.
  TITLE     Apolipoprotein A-IV of diabetic-foot patients upregulates tumor
            necrosis factor alpha expression in microfluidic arterial models
  JOURNAL   Exp Biol Med (Maywood) 248 (8), 691-701 (2023)
   PUBMED   36775868
  REMARK    GeneRIF: Apolipoprotein A-IV of diabetic-foot patients upregulates
            tumor necrosis factor alpha expression in microfluidic arterial
            models.
REFERENCE   5  (bases 1 to 1471)
  AUTHORS   Li,W.H., Zhang,L., Li,Y.Y., Wang,X.Y., Li,J.L., Zhao,S.N., Ni,M.Q.,
            Li,Q. and Sun,H.
  TITLE     Apolipoprotein A-IV Has Bi-Functional Actions in Alcoholic
            Hepatitis by Regulating Hepatocyte Injury and Immune Cell
            Infiltration
  JOURNAL   Int J Mol Sci 24 (1), 670 (2022)
   PUBMED   36614113
  REMARK    GeneRIF: Apolipoprotein A-IV Has Bi-Functional Actions in Alcoholic
            Hepatitis by Regulating Hepatocyte Injury and Immune Cell
            Infiltration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1471)
  AUTHORS   von Eckardstein,A., Funke,H., Schulte,M., Erren,M., Schulte,H. and
            Assmann,G.
  TITLE     Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV
            gene are associated with changes in the concentration of apo B- and
            apo A-I-containing lipoproteins in a normal population
  JOURNAL   Am J Hum Genet 50 (5), 1115-1128 (1992)
   PUBMED   1349197
REFERENCE   7  (bases 1 to 1471)
  AUTHORS   Tenkanen,H., Koskinen,P., Metso,J., Baumann,M., Lukka,M.,
            Kauppinen-Makelin,R., Kontula,K., Taskinen,M.R., Manttari,M.,
            Manninen,V. et al.
  TITLE     A novel polymorphism of apolipoprotein A-IV is the result of an
            asparagine to serine substitution at residue 127
  JOURNAL   Biochim Biophys Acta 1138 (1), 27-33 (1992)
   PUBMED   1737067
REFERENCE   8  (bases 1 to 1471)
  AUTHORS   Kamboh,M.I., Williams,E.R., Law,J.C., Aston,C.E., Bunker,C.H.,
            Ferrell,R.E. and Pollitzer,W.S.
  TITLE     Molecular basis of a unique African variant (A-IV 5) of human
            apolipoprotein A-IV and its significance in lipid metabolism
  JOURNAL   Genet Epidemiol 9 (6), 379-388 (1992)
   PUBMED   1487136
REFERENCE   9  (bases 1 to 1471)
  AUTHORS   Duverger,N., Murry-Brelier,A., Latta,M., Reboul,S., Castro,G.,
            Mayaux,J.F., Fruchart,J.C., Taylor,J.M., Steinmetz,A. and
            Denefle,P.
  TITLE     Functional characterization of human recombinant apolipoprotein AIV
            produced in Escherichia coli
  JOURNAL   Eur J Biochem 201 (2), 373-383 (1991)
   PUBMED   1935934
REFERENCE   10 (bases 1 to 1471)
  AUTHORS   Lohse,P., Kindt,M.R., Rader,D.J. and Brewer,H.B. Jr.
  TITLE     Three genetic variants of human plasma apolipoprotein A-IV.
            apoA-IV-1(Thr347----Ser), apoA-IV-0(Lys167----Glu,Gln360----His),
            and apoA-IV-3(Glu165----Lys)
  JOURNAL   J Biol Chem 266 (21), 13513-13518 (1991)
   PUBMED   1677358
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP006216.1 and AL531739.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000482.3.
            
            Summary: Apoliprotein (apo) A-IV gene contains 3 exons separated by
            two introns. A sequence polymorphism has been identified in the
            3'UTR of the third exon.  The primary translation product is a
            396-residue preprotein which after proteolytic processing is
            secreted its primary site of synthesis, the intestine, in
            association with chylomicron particles.  Although its precise
            function is not known, apo A-IV is a potent activator of
            lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.60539.1,
                                           SRR5189664.98251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357780.5/ ENSP00000350425.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AP006216.1         112344-112352       c
            10-343              AL531739.3         1-334
            344-1469            AP006216.1         109750-110875       c
            1470-1471           AP006216.1         109748-109749       c
FEATURES             Location/Qualifiers
     source          1..1471
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..1471
                     /gene="APOA4"
                     /note="apolipoprotein A4"
                     /db_xref="GeneID:337"
                     /db_xref="HGNC:HGNC:602"
                     /db_xref="MIM:107690"
     exon            1..162
                     /gene="APOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            163..289
                     /gene="APOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            290..1471
                     /gene="APOA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1444..1449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOA4"
                     /note="hexamer: AATAAA"
     polyA_site      1471
                     /gene="APOA4"
                     /note="major polyA site"
ORIGIN      
        1 agttcccact gcagcgcagg tgagctctcc tgaggacctc tctgtcagct cccctgattg
       61 tagggaggat ccagtgtggc aagaaactcc tccagcccag caagcagctc aggatgttcc
      121 tgaaggccgt ggtcctgacc ctggccctgg tggctgtcgc cggagccagg gctgaggtca
      181 gtgctgacca ggtggccacg gtgatgtggg actacttcag ccagctgagc aacaatgcca
      241 aggaggccgt ggaacatctc cagaaatctg aactcaccca gcaactcaat gccctcttcc
      301 aggacaaact tggagaagtg aacacttacg caggtgacct gcagaagaag ctggtgccct
      361 ttgccaccga gctgcatgaa cgcctggcca aggactcgga gaaactgaag gaggagattg
      421 ggaaggagct ggaggagctg agggcccggc tgctgcccca tgccaatgag gtgagccaga
      481 agatcgggga caacctgcga gagcttcagc agcgcctgga gccctacgcg gaccagctgc
      541 gcacccaggt cagcacgcag gccgagcagc tgcggcgcca gctgaccccc tacgcacagc
      601 gcatggagag agtgctgcgg gagaacgccg acagcctgca ggcctcgctg aggccccacg
      661 ccgacgagct caaggccaag atcgaccaga acgtggagga gctcaaggga cgccttacgc
      721 cctacgctga cgaattcaaa gtcaagattg accagaccgt ggaggagctg cgccgcagcc
      781 tggctcccta tgctcaggac acgcaggaga agctcaacca ccagcttgag ggcctgacct
      841 tccagatgaa gaagaacgcc gaggagctca aggccaggat ctcggccagt gccgaggagc
      901 tgcggcagag gctggcgccc ttggccgagg acgtgcgtgg caacctgagg ggcaacaccg
      961 aggggctgca gaagtcactg gcagagctgg gtgggcacct ggaccagcag gtggaggagt
     1021 tccgacgccg ggtggagccc tacggggaaa acttcaacaa agccctggtg cagcagatgg
     1081 aacagctcag gcagaaactg ggcccccatg cgggggacgt ggaaggccac ttgagcttcc
     1141 tggagaagga cctgagggac aaggtcaact ccttcttcag caccttcaag gagaaagaga
     1201 gccaggacaa gactctctcc ctccctgagc tggagcaaca gcaggaacag cagcaggagc
     1261 agcagcagga gcaggtgcag atgctggccc ctttggagag ctgagctgcc cctggtgcac
     1321 tggccccacc ctcgtggaca cctgccctgc cctgccacct gtctgtctgt ctgtcccaaa
     1381 gaagttctgg tatgaacttg aggacacatg tccagtggga ggtgagacca cctctcaata
     1441 ttcaataaag ctgctgagaa tctagcctca a
//
