LOCUS       NM_001643                474 bp    mRNA    linear   PRI 09-JAN-2024
DEFINITION  Homo sapiens apolipoprotein A2 (APOA2), mRNA.
ACCESSION   NM_001643
VERSION     NM_001643.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Kim M, Lee S, Cho E, Hong KW, You SJ and Choi HJ.
  TITLE     CETP and APOA2 polymorphisms are associated with weight loss and
            healthy eating behavior changes in response to digital lifestyle
            modifications
  JOURNAL   Sci Rep 13 (1), 21615 (2023)
   PUBMED   38062157
  REMARK    GeneRIF: CETP and APOA2 polymorphisms are associated with weight
            loss and healthy eating behavior changes in response to digital
            lifestyle modifications.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Futagami S, Agawa S, Nakamura K, Watanabe Y, Habiro M, Kawawa R,
            Yamawaki H, Tsushima R, Kirita K, Akimoto T, Ueki N, Tomohide T,
            Itokawa N, Suzuki N, Naito Y, Takeuchi K, Kashiro A, Ohta R,
            Mizutani S, Taniai N, Yoshida H, Iwakiri K and Honda K.
  TITLE     Apolipoprotein A2 isoforms associated with exocrine pancreatic
            insufficiency in early chronic pancreatitis
  JOURNAL   J Gastroenterol Hepatol 38 (11), 1949-1957 (2023)
   PUBMED   37501507
  REMARK    GeneRIF: Apolipoprotein A2 isoforms associated with exocrine
            pancreatic insufficiency in early chronic pancreatitis.
REFERENCE   3  (bases 1 to 474)
  AUTHORS   Wilkins JT and Rohatgi A.
  TITLE     Resolution of apolipoprotein A1 and A2 proteoforms: their
            cardiometabolic correlates and implications for future research
  JOURNAL   Curr Opin Lipidol 33 (4), 264-269 (2022)
   PUBMED   36082946
  REMARK    GeneRIF: Resolution of apolipoprotein A1 and A2 proteoforms: their
            cardiometabolic correlates and implications for future research.
            Review article
REFERENCE   4  (bases 1 to 474)
  AUTHORS   Abaj F, Esmaeily Z, Naeini Z, Rafiee M and Koohdani F.
  TITLE     Dietary acid load modifies the effects of ApoA2-265 T > C
            polymorphism on lipid profile and serum leptin and ghrelin levels
            among type 2 diabetic patients
  JOURNAL   BMC Endocr Disord 22 (1), 190 (2022)
   PUBMED   35883173
  REMARK    GeneRIF: Dietary acid load modifies the effects of ApoA2-265 T > C
            polymorphism on lipid profile and serum leptin and ghrelin levels
            among type 2 diabetic patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 474)
  AUTHORS   Wilkins JT, Seckler HS, Rink J, Compton PD, Fornelli L, Thaxton CS,
            LeDuc R, Jacobs D, Doubleday PF, Sniderman A, Lloyd-Jones DM and
            Kelleher NL.
  TITLE     Spectrum of Apolipoprotein AI and Apolipoprotein AII Proteoforms
            and Their Associations With Indices of Cardiometabolic Health: The
            CARDIA Study
  JOURNAL   J Am Heart Assoc 10 (17), e019890 (2021)
   PUBMED   34472376
  REMARK    GeneRIF: Spectrum of Apolipoprotein AI and Apolipoprotein AII
            Proteoforms and Their Associations With Indices of Cardiometabolic
            Health: The CARDIA Study.
REFERENCE   6  (bases 1 to 474)
  AUTHORS   Bekaert ED, Alaupovic P, Knight-Gibson C, Norum RA, Laux MJ and
            Ayrault-Jarrier M.
  TITLE     Isolation and partial characterization of lipoprotein A-II
            (LP-A-II) particles of human plasma
  JOURNAL   Biochim Biophys Acta 1126 (1), 105-113 (1992)
   PUBMED   1606170
  REMARK    Erratum:[Biochim Biophys Acta 1992 Jul 9;1127(1):103]
REFERENCE   7  (bases 1 to 474)
  AUTHORS   Vollmer E, Brust J, Roessner A, Bosse A, Burwikel F, Kaesberg B,
            Harrach B, Robenek H and Bocker W.
  TITLE     Distribution patterns of apolipoproteins A1, A2, and B in the wall
            of atherosclerotic vessels
  JOURNAL   Virchows Arch A Pathol Anat Histopathol 419 (2), 79-88 (1991)
   PUBMED   1908160
REFERENCE   8  (bases 1 to 474)
  AUTHORS   Deeb SS, Takata K, Peng RL, Kajiyama G and Albers JJ.
  TITLE     A splice-junction mutation responsible for familial apolipoprotein
            A-II deficiency
  JOURNAL   Am J Hum Genet 46 (4), 822-827 (1990)
   PUBMED   2107739
REFERENCE   9  (bases 1 to 474)
  AUTHORS   Ritter,M.C. and Scanu,A.M.
  TITLE     Apolipoprotein A-II and structure of human serum high density
            lipoproteins. An approach by reassembly techniques
  JOURNAL   J Biol Chem 254 (7), 2517-2525 (1979)
   PUBMED   218942
REFERENCE   10 (bases 1 to 474)
  AUTHORS   Weisgraber,K.H. and Mahley,R.W.
  TITLE     Apoprotein (E--A-II) complex of human plasma lipoproteins. I.
            Characterization of this mixed disulfide and its identification in
            a high density lipoprotein subfraction
  JOURNAL   J Biol Chem 253 (17), 6281-6288 (1978)
   PUBMED   210174
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590714.27.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_001643.1.
            
            Summary: This gene encodes apolipoprotein (apo-) A-II, which is the
            second most abundant protein of the high density lipoprotein
            particles. The protein is found in plasma as a monomer, homodimer,
            or heterodimer with apolipoprotein D. Defects in this gene may
            result in apolipoprotein A-II deficiency or hypercholesterolemia.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV681656.1, AV682018.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367990.7/ ENSP00000356969.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AL590714.27        78775-78808         c
            35-110              AL590714.27        78530-78605         c
            111-243             AL590714.27        78098-78230         c
            244-474             AL590714.27        77472-77702         c
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..474
                     /gene="APOA2"
                     /gene_synonym="Apo-AII; ApoA-II; apoAII"
                     /note="apolipoprotein A2"
                     /db_xref="GeneID:336"
                     /db_xref="HGNC:HGNC:601"
                     /db_xref="MIM:107670"
     exon            1..34
                     /gene="APOA2"
                     /gene_synonym="Apo-AII; ApoA-II; apoAII"
                     /inference="alignment:Splign:2.1.0"
     exon            35..110
                     /gene="APOA2"
                     /gene_synonym="Apo-AII; ApoA-II; apoAII"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..361
                     /gene="APOA2"
                     /gene_synonym="Apo-AII; ApoA-II; apoAII"
                     /note="apolipoprotein A-II"
                     /codon_start=1
                     /product="apolipoprotein A-II preproprotein"
                     /protein_id="NP_001634.1"
                     /db_xref="CCDS:CCDS1226.1"
                     /db_xref="GeneID:336"
                     /db_xref="HGNC:HGNC:601"
                     /db_xref="MIM:107670"
                     /translation="MKLLAATVLLLTICSLEGALVRRQAKEPCVESLVSQYFQTVTDY
                     GKDLMEKVKSPELQAEAKSYFEKSKEQLTPLIKKAGTELVNFLSYFVELGTQPATQ"
     exon            111..243
                     /gene="APOA2"
                     /gene_synonym="Apo-AII; ApoA-II; apoAII"
                     /inference="alignment:Splign:2.1.0"
     exon            244..474
                     /gene="APOA2"
                     /gene_synonym="Apo-AII; ApoA-II; apoAII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      454..459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APOA2"
                     /gene_synonym="Apo-AII; ApoA-II; apoAII"
                     /note="hexamer: AATAAA"
     polyA_site      474
                     /gene="APOA2"
                     /gene_synonym="Apo-AII; ApoA-II; apoAII"
                     /note="major polyA site"
ORIGIN      
        1 aggcacagac accaaggaca gagacgctgg ctaggccgcc ctccccactg ttaccaacat
       61 gaagctgctc gcagcaactg tgctactcct caccatctgc agccttgaag gagctttggt
      121 tcggagacag gcaaaggagc catgtgtgga gagcctggtt tctcagtact tccagaccgt
      181 gactgactat ggcaaggacc tgatggagaa ggtcaagagc ccagagcttc aggccgaggc
      241 caagtcttac tttgaaaagt caaaggagca gctgacaccc ctgatcaaga aggctggaac
      301 ggaactggtt aacttcttga gctatttcgt ggaacttgga acacagcctg ccacccagtg
      361 aagtgtccag accattgtct tccaacccca gctggcctct agaacaccca ctggccagtc
      421 ctagagctcc tgtccctacc cactctttgc tacaataaat gctgaatgaa tcca
//
